Nano Convergence最新文献

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Surface passivation engineering for stable optoelectronic devices via hydroxyl-free ZnMgO nanoparticles. 无羟基氧化锌纳米颗粒稳定光电器件表面钝化工程。
IF 13.4 2区 材料科学
Nano Convergence Pub Date : 2025-06-09 DOI: 10.1186/s40580-025-00493-2
Seongkeun Oh, Jaehwi Choi, Junhyeok Park, Young Kyun Choi, Taesung Park, Awais Ali, Junhyuk Ahn, Jiwan Kim, Soong Ju Oh
{"title":"Surface passivation engineering for stable optoelectronic devices via hydroxyl-free ZnMgO nanoparticles.","authors":"Seongkeun Oh, Jaehwi Choi, Junhyeok Park, Young Kyun Choi, Taesung Park, Awais Ali, Junhyuk Ahn, Jiwan Kim, Soong Ju Oh","doi":"10.1186/s40580-025-00493-2","DOIUrl":"10.1186/s40580-025-00493-2","url":null,"abstract":"<p><p>ZnMgO nanoparticles (ZMO NPs) are widely used as electron transport layers in optoelectronic devices such as light-emitting diodes (LEDs) and photodiodes (PDs) primarily because of their facile synthesis and excellent electron transport properties. However, the surface hydroxyl groups (‒OH) on the ZMO NPs introduce charge traps, inhibit electron transport, and reduce device stability, particularly under ambient humidity and oxygen. Therefore, in this study, an alcohol treatment (AT) method was developed to remove surface ‒OH via proton transfer to effectively reduce trap states and dipole moments and enhance surface passivation. Quantum-dot-based LEDs and PDs fabricated using the AT-based ZMO NPs exhibited improved current density, luminance, and external quantum efficiency compared to the untreated devices. Notably, the methanol-treated devices achieved an operational lifetime of approximately 28 h under ambient conditions, representing a substantial advancement in device stability and performance. The AT approach is a simple and effective strategy for optimizing the ZMO NPs for next-generation optoelectronic applications.</p>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"12 1","pages":"28"},"PeriodicalIF":13.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective metal passivation by vapor-dosed phosphonic acid inhibitors for area-selective atomic layer deposition of SiO2 thin films. 气相剂量膦酸抑制剂在SiO2薄膜区域选择性原子层沉积中的选择性金属钝化。
IF 13.4 2区 材料科学
Nano Convergence Pub Date : 2025-05-30 DOI: 10.1186/s40580-025-00490-5
Jeong-Min Lee, Seo-Hyun Lee, Ji Hun Lee, Junghun Kwak, Jinhee Lee, Woo-Hee Kim
{"title":"Selective metal passivation by vapor-dosed phosphonic acid inhibitors for area-selective atomic layer deposition of SiO<sub>2</sub> thin films.","authors":"Jeong-Min Lee, Seo-Hyun Lee, Ji Hun Lee, Junghun Kwak, Jinhee Lee, Woo-Hee Kim","doi":"10.1186/s40580-025-00490-5","DOIUrl":"10.1186/s40580-025-00490-5","url":null,"abstract":"<p><p>Aiming for atomic-scale precision alignment for advanced semiconductor devices, area-selective atomic layer deposition (AS-ALD) has garnered substantial attention because of its bottom-up nature that allows precise control of material deposition exclusively on desired areas. In this study, we develop a surface treatment to hinder the adsorption of Si precursor on metal surfaces by using a vapor-phase functionalization of bulky phosphonic acid (PA) self-assembled monolayers (SAMs). Through the chemical vapor transport (CVT) method, the bulky solid PA inhibitor with a fluorocarbon terminal group was effectively vaporized, and the conditions for maximizing the blocking effect of the inhibitor were confirmed by optimizing the process temperature and dwelling time. The unintended PA inhibitors adsorbed on SiO<sub>2</sub> surfaces during the CVT process were selectively removed by post-HF treatment, thereby leading to selective deposition of SiO<sub>2</sub> thin films only on SiO<sub>2</sub> substrates. As a results, SiO<sub>2</sub> film growth on the PA SAM/HF-treated TiN surfaces was suppressed by up to 4 nm with just a single exposure to the long-chain inhibitor, even during the ALD process using highly reactive O<sub>3</sub> reactants. The proposed approach paves the way for highly selective deposition of dielectrics on dielectrics (DoD).</p>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"12 1","pages":"27"},"PeriodicalIF":13.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating interfacial challenges in lithium metal batteries: from fundamental understanding to practical realization. 导航锂金属电池的界面挑战:从基本理解到实际实现。
IF 13.4 2区 材料科学
Nano Convergence Pub Date : 2025-05-29 DOI: 10.1186/s40580-025-00491-4
Jimin Lee, Youngbin Park, Jang Wook Choi
{"title":"Navigating interfacial challenges in lithium metal batteries: from fundamental understanding to practical realization.","authors":"Jimin Lee, Youngbin Park, Jang Wook Choi","doi":"10.1186/s40580-025-00491-4","DOIUrl":"10.1186/s40580-025-00491-4","url":null,"abstract":"<p><p>Lithium metal batteries (LMBs) hold immense potential as next-generation energy storage systems due to their exceptionally high theoretical energy density. However, their commercialization is hindered by persistent interfacial instabilities that accelerate capacity degradation and limit cycle life. A major challenge lies in the solid-electrolyte interphase (SEI), whose composition and structure critically influence lithium deposition behavior, electrolyte stability, and overall battery performance. This review examines key aspects of SEI stability and its impact on battery performance, highlighting recent advancements in electrolyte engineering and surface modification strategies aimed at enhancing interfacial stability. Beyond laboratory-scale optimizations, we discuss key considerations for translating these advancements into industrial applications, highlighting the importance of practical testing protocols to bridge the gap between fundamental research and real-world deployment.</p>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"12 1","pages":"25"},"PeriodicalIF":13.4,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pnictide-based colloidal quantum dots for infrared sensing applications. 用于红外传感的胶体量子点。
IF 13.4 2区 材料科学
Nano Convergence Pub Date : 2025-05-29 DOI: 10.1186/s40580-025-00489-y
Jaeyoung Seo, Seongchan Kim, Dongjoon Yeo, Namyoung Gwak, Nuri Oh
{"title":"Pnictide-based colloidal quantum dots for infrared sensing applications.","authors":"Jaeyoung Seo, Seongchan Kim, Dongjoon Yeo, Namyoung Gwak, Nuri Oh","doi":"10.1186/s40580-025-00489-y","DOIUrl":"10.1186/s40580-025-00489-y","url":null,"abstract":"<p><p>Pnictide-based quantum dots (QDs) have emerged as promising materials for next-generation infrared photodetectors due to their superior physical and electrical properties. Among them, InAs and InSb QDs are particularly attractive for their tunable bandgaps in the short-wave infrared (SWIR) region, high carrier mobility, and compatibility with solution-based, large-area, and low-cost fabrication processes. This review discusses recent advancements in the synthesis of InAs and InSb QDs, focusing on precursor strategies and surface engineering techniques to enhance their optical and electronic properties. Additionally, we explore their integration into infrared photodetectors, analyzing current performance and limitations. Finally, we outline future research directions aimed at further enhancing material properties and device performance, paving the way for the broader adoption of III-V QDs in next-generation infrared technologies.</p>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"12 1","pages":"26"},"PeriodicalIF":13.4,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sacrificial layer concept interface engineering for robust, lossless monolithic integration of perovskite/Si tandem solar cells yielding high fill factor of 0.813 牺牲层概念界面工程,用于强健、无损的钙钛矿/硅串联太阳能电池单片集成,可获得0.813的高填充系数
IF 13.4 2区 材料科学
Nano Convergence Pub Date : 2025-05-27 DOI: 10.1186/s40580-025-00492-3
Yoon Hee Jang, Youngseok Lee, Hyeon Sik Seo, Haram Lee, Kyoung-jin Lim, Jung-Kun Lee, Jaeyeong Heo, Inho Kim, Doh-Kwon Lee
{"title":"Sacrificial layer concept interface engineering for robust, lossless monolithic integration of perovskite/Si tandem solar cells yielding high fill factor of 0.813","authors":"Yoon Hee Jang,&nbsp;Youngseok Lee,&nbsp;Hyeon Sik Seo,&nbsp;Haram Lee,&nbsp;Kyoung-jin Lim,&nbsp;Jung-Kun Lee,&nbsp;Jaeyeong Heo,&nbsp;Inho Kim,&nbsp;Doh-Kwon Lee","doi":"10.1186/s40580-025-00492-3","DOIUrl":"10.1186/s40580-025-00492-3","url":null,"abstract":"<div><p>Efficient monolithic perovskite/Si tandem solar cells require a robust recombination junction (RJ) with excellent electrical and optical properties. This study introduces an interface engineering method using an organic sacrificial layer to enable effective monolithic integration. An ultrathin layer of poly(3,4-ethylene-dioxythiophene):polystyrene sulfonate (PEDOT:PSS) is inserted between the transparent conductive oxide recombination layer and the hole transport layer (HTL) of a methylammonium lead iodide (MAPbI<sub>3</sub>)-based perovskite top cell. This layer restores junction functionality and enables charge transfer between sub-cells via efficient carrier recombination at the RJ, which electrically connects the two cells. Acting as a sacrificial layer, PEDOT:PSS temporarily prevents resistive SiO<sub><i>x</i></sub> formation and improves interface quality. High-resolution transmission electron microscopy and X-ray photoelectron spectroscopy confirm suppression of SiO<sub><i>x</i></sub> growth during HTL annealing. Moreover, the Cu-doped NiO<sub><i>x</i></sub> HTL fabrication method proves critical, where process optimization improves electrical contact. Combined with PEDOT:PSS interface engineering, these enhancements promote efficient recombination by tuning interfacial energy levels and increasing band bending at the RJ. As a result, tandem devices comprising an aluminum back-surface field <i>p</i>-type homojunction Si bottom cell and a <i>p-i-n</i> perovskite top cell achieve 21.95% power conversion efficiency and an 81.3% fill factor —among the highest reported for monolithic perovskite/Si tandem solar cells.</p></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"12 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-025-00492-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photocatalytic effect of gold-zinc oxide composite nanostructures for the selective and controlled killing of antibiotic-resistant bacteria and the removal of resistant bacterial biofilms from the body 金-氧化锌复合纳米结构在选择性可控杀灭耐药细菌和去除体内耐药细菌生物膜中的光催化作用
IF 13.4 2区 材料科学
Nano Convergence Pub Date : 2025-05-14 DOI: 10.1186/s40580-025-00488-z
Jongjun Park, Tae Hui Bae, Su Yong Kim, Seongeun Park, Yonghyun Choi, Masayoshi Tanaka, Jiwon Kim, Jaehee Jang, Jihyuk Yang, Hee-Young Lee, Tagbo H. R. Niepa, Shin Hyuk Kang, Jonghoon Choi
{"title":"Photocatalytic effect of gold-zinc oxide composite nanostructures for the selective and controlled killing of antibiotic-resistant bacteria and the removal of resistant bacterial biofilms from the body","authors":"Jongjun Park,&nbsp;Tae Hui Bae,&nbsp;Su Yong Kim,&nbsp;Seongeun Park,&nbsp;Yonghyun Choi,&nbsp;Masayoshi Tanaka,&nbsp;Jiwon Kim,&nbsp;Jaehee Jang,&nbsp;Jihyuk Yang,&nbsp;Hee-Young Lee,&nbsp;Tagbo H. R. Niepa,&nbsp;Shin Hyuk Kang,&nbsp;Jonghoon Choi","doi":"10.1186/s40580-025-00488-z","DOIUrl":"10.1186/s40580-025-00488-z","url":null,"abstract":"<div><p>Infections involving antibiotic-resistant bacteria have become a major problem. Pathogenic bacteria use mechanisms such as drug target bypass, target modification, and biofilm formation to evade treatment. To respond to these problems, antibacterial research using metal and metal oxide nanoparticles is currently active. Nanoparticles treat bacterial infections through reactive oxygen species generation or antibacterial ion release. However, their application has faced problems related to human compatibility, as they react non-specifically, targeting both mammalian and bacterial cells. In addition, ZnO nanoparticles show low antibacterial activity against Gram-negative bacteria. Thus, the demand for antibacterial substances with enhanced specificity and improved efficacy is increasing. We bound gold to the surface of ZnO nanoparticles, enabling photocatalytic and photothermal actions through visible light irradiation. To improve bacterial specificity, Concanavalin A (Con A), a lectin that can specifically target bacterial membrane lipopolysaccharides, was conjugated with the nanoparticles. We showed that Con A-conjugated Au/ZnO nanoparticles (Au/ZnO-Con A) exhibit photocatalytic and photothermal effects under white light, enhancing their antibacterial ability, and through enhanced specificity, increased antibacterial and anti-biofilm abilities were confirmed. The developed particles showed the potential to alleviate antibiotic resistance in a bacterial skin infection model, presenting a new platform for treating bacterial infections.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"12 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-025-00488-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amorphous boron nitride: synthesis, properties and device application 非晶态氮化硼:合成、性能及器件应用
IF 13.4 2区 材料科学
Nano Convergence Pub Date : 2025-05-02 DOI: 10.1186/s40580-025-00486-1
Seyed Mehdi Sattari-Esfahlan, Saeed Mirzaei, Mukkath Joseph Josline, Ji-Yun Moon, Sang-Hwa Hyun, Houk Jang, Jae-Hyun Lee
{"title":"Amorphous boron nitride: synthesis, properties and device application","authors":"Seyed Mehdi Sattari-Esfahlan,&nbsp;Saeed Mirzaei,&nbsp;Mukkath Joseph Josline,&nbsp;Ji-Yun Moon,&nbsp;Sang-Hwa Hyun,&nbsp;Houk Jang,&nbsp;Jae-Hyun Lee","doi":"10.1186/s40580-025-00486-1","DOIUrl":"10.1186/s40580-025-00486-1","url":null,"abstract":"<div><p>Amorphous boron nitride (a-BN) exhibits remarkable electrical, optical, and chemical properties, alongside robust mechanical stability, making it a compelling material for advanced applications in nanoelectronics and photonics. This review comprehensively examines the unique characteristics of a-BN, emphasizing its electrical and optical attributes, state-of-the-art synthesis techniques, and device applications. Key advancements in low-temperature growth methods for a-BN are highlighted, offering insights into their potential for integration into scalable, CMOS-compatible platforms. Additionally, the review discusses the emerging role of a-BN as a dielectric material in electronic and photonic devices, serving as substrates, encapsulation layers, and gate insulators. Finally, perspectives on future challenges, including defect control, interface engineering, and scalability, are presented, providing a roadmap for realizing the full potential of a-BN in next-generation device technologies.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"12 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-025-00486-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced voltage and capacitance in flexible supercapacitors using electrospun nanofiber electrolytes and CuNi2O3@N-Doped omnichannel carbon electrodes 利用静电纺纳米纤维电解质和CuNi2O3@N-Doped全通道碳电极提高柔性超级电容器的电压和电容
IF 13.4 2区 材料科学
Nano Convergence Pub Date : 2025-04-29 DOI: 10.1186/s40580-025-00485-2
Ponnaiah Sathish Kumar, Jihoon Bae, Jong Wook Roh, Yuho Min, Sungwon Lee
{"title":"Enhanced voltage and capacitance in flexible supercapacitors using electrospun nanofiber electrolytes and CuNi2O3@N-Doped omnichannel carbon electrodes","authors":"Ponnaiah Sathish Kumar,&nbsp;Jihoon Bae,&nbsp;Jong Wook Roh,&nbsp;Yuho Min,&nbsp;Sungwon Lee","doi":"10.1186/s40580-025-00485-2","DOIUrl":"10.1186/s40580-025-00485-2","url":null,"abstract":"<div><p>Developing functional solid polymer electrolytes (SPEs) is crucial for flexible, lightweight, and portable supercapacitors. This work presents an electrospinning approach to fabricate SPEs using poly(vinyl alcohol)-sodium chloride (PVA-NaCl) nanofibers (PNNF). CuNi<sub>2</sub>O<sub>3</sub> nanoparticles deposited on nitrogen-doped omnichannel carbon nanofibers (CuNi<sub>2</sub>O<sub>3</sub>@N-OCCFs), coated onto a carbon cloth (CC), serve as the positive electrode, enhancing faradaic capacitance. Meanwhile, the rationally designed N-OCCFs, also coated onto CC, function as the negative electrode, providing a high-surface-area, and facilitating rapid electron transport. Comprehensive characterization revealed insights into the morphology and chemical composition of both electrodes and the PNNF electrolyte. An all-solid-state asymmetric flexible supercapacitor (AFSC) device, CuNi<sub>2</sub>O<sub>3</sub>@N-OCCFs-1.5//N-OCCFs-1.5, was assembled using PNNF as both the electrolyte and separator and evaluated against devices employing gel and aqueous electrolytes. The PNNF electrolyte enabled a wider potential window (2.2 V) compared to gel (2.0 V) and liquid (1.8 V) electrolytes. The AFSC achieved an impressive energy density of 63.6 Wh kg<sup>−1</sup> at a power density of 1100 W kg<sup>−1</sup>, with 96.2% capacitance retention after 6000 charge/discharge cycles at 10 A g⁻<sup>1</sup>. When two devices were connected in series, they powered a red LED for 5.33 min and a blue LED for 1.43 min, demonstrating practical applicability. This study provides a simple and effective strategy for fabricating high-energy–density AFSCs with excellent cycling stability and broad potential for flexible electronics.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"12 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-025-00485-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor-specific biochemical nanoconversion of self-assembled peptide-conjugated paclitaxel-docetaxel-based nanoparticles 自组装肽偶联紫杉醇-多西他赛纳米颗粒的肿瘤特异性生化纳米转化
IF 13.4 2区 材料科学
Nano Convergence Pub Date : 2025-04-26 DOI: 10.1186/s40580-025-00487-0
Hansol Lim, Jae-Hyeon Lee, So-Hyeon Park, Jun-Hyuck Lee, Hyesu Jang, Seong-Bin Yang, Minho Seo, Seokwoo Lee, Jooho Park
{"title":"Tumor-specific biochemical nanoconversion of self-assembled peptide-conjugated paclitaxel-docetaxel-based nanoparticles","authors":"Hansol Lim,&nbsp;Jae-Hyeon Lee,&nbsp;So-Hyeon Park,&nbsp;Jun-Hyuck Lee,&nbsp;Hyesu Jang,&nbsp;Seong-Bin Yang,&nbsp;Minho Seo,&nbsp;Seokwoo Lee,&nbsp;Jooho Park","doi":"10.1186/s40580-025-00487-0","DOIUrl":"10.1186/s40580-025-00487-0","url":null,"abstract":"<div><p>Docetaxel (DTX, <b>1</b>) and paclitaxel (PTX, <b>2</b>) are famous cytotoxic agents widely used in cancer therapy, however, their low specificity for tumor cells often results in severe systemic toxicity. Beyond conventional prodrug strategies, this study introduces a novel nanoconversion technology that chemically modifies DTX to form self-assembled nanoparticles (NPs), which subsequently convert into a paclitaxel-mimicking molecule (PTXm, <b>3</b>). Hydrophilic acetylated Phe-Arg-Arg-Phe peptide ((Ac)FRRF, <b>4</b>) and hydrophobic docetaxel were conjugated to prepare self-assembled (Ac)FRRF-DTX NPs. The selective cleavage of the Arg-Phe bond by cathepsin B, which is abundant in cancer cells, facilitated the nanoconversion of PTXm (<b>3</b>) from (Ac)FRRF-DTX NPs, demonstrating effective cytotoxic effects. Utilizing the cleavage site of peptide and specific sequences (ex. Arg-Arg-Phe), this approach does not simply act as a prodrug but allows the nanomaterial to transform into another cytotoxic biomolecule within tumors. (Ac)FRRF-DTX NPs exhibited remarkable physicochemical properties, superior anti-cancer efficacy, and low toxicity, showcasing an innovative conversion in peptide-conjugated nanomedicine. Unlike traditional prodrug chemistry, this tumor-specific nanoconversion process involves the biochemical transformation of DTX (<b>1</b>) into PTXm (<b>3</b>) via enzymatic action. Overall, this study provides an outstanding example of chemical drug molecular modification through the concept of nanoconversion.</p></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"12 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-025-00487-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guided electrocatalyst design through in-situ techniques and data mining approaches 通过原位技术和数据挖掘方法指导电催化剂设计
IF 13.4 2区 材料科学
Nano Convergence Pub Date : 2025-04-18 DOI: 10.1186/s40580-025-00484-3
Mingyu Ma, Yuqing Wang, Yanting Liu, Shasha Guo, Zheng Liu
{"title":"Guided electrocatalyst design through in-situ techniques and data mining approaches","authors":"Mingyu Ma,&nbsp;Yuqing Wang,&nbsp;Yanting Liu,&nbsp;Shasha Guo,&nbsp;Zheng Liu","doi":"10.1186/s40580-025-00484-3","DOIUrl":"10.1186/s40580-025-00484-3","url":null,"abstract":"<div><p>Intuitive design strategies, primarily based on literature research and trial-and-error efforts, have significantly contributed to advancements in the electrocatalyst field. However, the inherently time-consuming and inconsistent nature of these methods presents substantial challenges in accelerating the discovery of high-performance electrocatalysts. To this end, guided design approaches, including in-situ experimental techniques and data mining, have emerged as powerful catalyst design and optimization tools. The former offers valuable insights into the reaction mechanisms, while the latter identifies patterns within large catalyst databases. In this review, we first present the examples using in-situ experimental techniques, emphasizing a detailed analysis of their strengths and limitations. Then, we explore advancements in data-mining-driven catalyst development, highlighting how data-driven approaches complement experimental methods to accelerate the discovery and optimization of high-performance catalysts. Finally, we discuss the current challenges and possible solutions for guided catalyst design. This review aims to provide a comprehensive understanding of current methodologies and inspire future innovations in electrocatalytic research.</p></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"12 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-025-00484-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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