Nano ConvergencePub Date : 2024-12-13DOI: 10.1186/s40580-024-00466-x
Yeochan Yun, Seewoo Kim, Sang-Nam Lee, Hyeon-Yeol Cho, Jeong-Woo Choi
{"title":"Nanomaterial-based detection of circulating tumor cells and circulating cancer stem cells for cancer immunotherapy","authors":"Yeochan Yun, Seewoo Kim, Sang-Nam Lee, Hyeon-Yeol Cho, Jeong-Woo Choi","doi":"10.1186/s40580-024-00466-x","DOIUrl":"10.1186/s40580-024-00466-x","url":null,"abstract":"<div><p>Nanomaterials have emerged as transformative tools for detecting circulating tumor cells (CTCs) and circulating cancer stem cells (CCSCs), significantly enhancing cancer diagnostics and immunotherapy. Nanomaterials, including those composed of gold, magnetic materials, and silica, have enhanced the sensitivity, specificity, and efficiency of isolating these rare cells from blood. These developments are of paramount importance for the early detection of cancer and for providing real-time insights into metastasis and treatment resistance, which are essential for the development of personalized immunotherapies. The combination of nanomaterial-based platforms with phenotyping techniques, such as Raman spectroscopy and microfluidics, enables researchers to enhance immunotherapy protocols targeting specific CTC and CCSC markers. Nanomaterials also facilitate the targeted delivery of immunotherapeutic agents, including immune checkpoint inhibitors and therapeutic antibodies, directly to tumor cells. This synergistic approach has the potential to enhance therapeutic efficacy and mitigate the risk of metastasis and relapse. In conclusion, this review critically examines the use of nanomaterial-driven detection systems for detecting CTCs and CCSCs, their application in immunotherapy, and suggests future directions, highlighting their potential to transform the integration of diagnostics and treatment, thereby paving the way for more precise and personalized cancer therapies.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00466-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano ConvergencePub Date : 2024-12-12DOI: 10.1186/s40580-024-00458-x
Ki-Hoon Son, Sehoon Oh, Junho Lee, Sobin Yun, Yunseo Shin, Shaohua Yan, Chaun Jang, Hong-Sub Lee, Hechang Lei, Se Young Park, Hyejin Ryu
{"title":"Persistent ferromagnetic ground state in pristine and Ni-doped Fe3GaTe2 flakes","authors":"Ki-Hoon Son, Sehoon Oh, Junho Lee, Sobin Yun, Yunseo Shin, Shaohua Yan, Chaun Jang, Hong-Sub Lee, Hechang Lei, Se Young Park, Hyejin Ryu","doi":"10.1186/s40580-024-00458-x","DOIUrl":"10.1186/s40580-024-00458-x","url":null,"abstract":"<div><p>Room-temperature magnetism and its stability upon miniaturization are essential characteristics required for materials for spintronic devices and information storage. Among various candidates, Fe<sub>3</sub>GaTe<sub>2</sub> stands out due to its high Curie temperature and strong perpendicular magnetic anisotropy (PMA), recently gaining large attention as one of the promising candidate materials for spintronics applications. In this study, we measured the thickness-dependent ferromagnetic properties of Fe<sub>3</sub>GaTe<sub>2</sub> and (Fe<sub>1 − x</sub>Ni<sub>x</sub>)<sub>3</sub>GaTe<sub>2</sub> (with x = 0.1) flakes. We observed that both pristine and Ni-doped Fe<sub>3</sub>GaTe<sub>2</sub> exhibit persistent ferromagnetism, with only a minor decrease in T<sub>C</sub> as the thickness is reduced to a few tens of nanometers. This capacity to retain robust ferromagnetic properties at reduced dimensions is highly advantageous for thin-film applications, which is crucial for the scaling of spintronic devices. Understanding and controlling thickness-dependent magnetic properties is fundamental to harnessing the full potential of Fe<sub>3</sub>GaTe<sub>2</sub> in van der Waals magnetic heterostructures and advanced spintronic technologies.</p></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00458-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano ConvergencePub Date : 2024-12-12DOI: 10.1186/s40580-024-00465-y
Gyu Won Kim, Minwoo Lee, Jihong Bae, Jihoon Han, Seokmin Park, Wooyoung Shim
{"title":"Li-ion transport in two-dimensional nanofluidic membranes","authors":"Gyu Won Kim, Minwoo Lee, Jihong Bae, Jihoon Han, Seokmin Park, Wooyoung Shim","doi":"10.1186/s40580-024-00465-y","DOIUrl":"10.1186/s40580-024-00465-y","url":null,"abstract":"<div><p>The growing demand for lithium, driven by its critical role in lithium-ion batteries (LIBs) and other applications, has intensified the need for efficient extraction methods from aqua-based resources such as seawater. Among various approaches, 2D channel membranes have emerged as promising candidates due to their tunable ion selectivity and scalability. While significant progress has been made in achieving high Li<sup>+</sup>/Mg<sup>2+</sup> selectivity, enhancing Li<sup>+</sup> ion selectivity over Na<sup>+</sup> ion, the dominant monovalent cation in seawater, remains a challenge due to their similar properties. This review provides a comprehensive analysis of the fundamental mechanisms underlying Li<sup>+</sup> selectivity in 2D channel membranes, focusing on the dehydration and diffusion processes that dictate ion transport. Inspired by the principles of biological ion channels, we identify key factors—channel size, surface charge, and binding sites—that influence energy barriers and shape the interplay between dehydration and diffusion. We highlight recent progress in leveraging these factors to enhance Li<sup>+</sup>/Na<sup>+</sup> selectivity and address the challenges posed by counteracting effects in ion transport. While substantial advancements have been made, the lack of comprehensive principles guiding the interplay of these variables across permeation steps represents a key obstacle to optimizing Li<sup>+</sup>/Na<sup>+</sup> selectivity. Nonetheless, with their inherent chemical stability and fabrication scalability, 2D channel membranes offer significant potential for lithium extraction if these challenges can be addressed. This review provides insights into the current state of 2D channel membrane technologies and outlines future directions for achieving enhanced Li<sup>+</sup> ion selectivity, particularly in seawater applications.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00465-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano ConvergencePub Date : 2024-12-11DOI: 10.1186/s40580-024-00462-1
Chae Yeon Han, Sang-Hun Choi, Soo-Hyang Chi, Ji Hyun Hong, Young-Eun Cho, Jihoon Kim
{"title":"Nano-fluorescence imaging: advancing lymphatic disease diagnosis and monitoring","authors":"Chae Yeon Han, Sang-Hun Choi, Soo-Hyang Chi, Ji Hyun Hong, Young-Eun Cho, Jihoon Kim","doi":"10.1186/s40580-024-00462-1","DOIUrl":"10.1186/s40580-024-00462-1","url":null,"abstract":"<div><p>The lymphatic system plays a crucial role in maintaining physiological homeostasis and regulating immune responses. Traditional imaging modalities such as magnetic resonance imaging, computerized tomography, and positron emission tomography have been widely used to diagnose disorders in the lymphatic system, including lymphedema, lymphangioma, lymphatic metastasis, and Castleman disease. Nano-fluorescence technology has distinct advantages—including naked-eye visibility, operational simplicity, portability of the laser, and real-time visibility—and serves as an innovative alternative to traditional imaging techniques. This review explores recent advancements in nano-fluorescence imaging aimed at enhancing the resolution of lymphatic structure, function, and immunity. After delineating the fundamental characteristics of lymphatic systems, it elaborates on the development of various nano-fluorescence systems (including nanoparticles incorporating fluorescent dyes and those with intrinsic fluorescence) while addressing key challenges such as photobleaching, limited tissue penetration, biocompatibility, and signal interference from biomolecules. Furthermore, this review highlights the clinical applications of nano-fluorescence and its potential integration into standard diagnostic protocols. Ongoing advancements in nanoparticle technology underscore the potential of nano-fluorescence to revolutionize the diagnosis and treatment of lymphatic disease.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00462-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano ConvergencePub Date : 2024-12-04DOI: 10.1186/s40580-024-00460-3
Yangjin Lee, Uje Choi, Kwanpyo Kim, Alex Zettl
{"title":"Recent progress in realizing novel one-dimensional polymorphs via nanotube encapsulation","authors":"Yangjin Lee, Uje Choi, Kwanpyo Kim, Alex Zettl","doi":"10.1186/s40580-024-00460-3","DOIUrl":"10.1186/s40580-024-00460-3","url":null,"abstract":"<div><p>Encapsulation of various materials inside nanotubes has emerged as an effective method in nanotechnology that facilitates the formation of novel one-dimensional (1D) structures and enhances their functionality. Because of the effects of geometrical confinement and electronic interactions with host nanotubes, encapsulated materials often exhibit low-dimensional polymorphic structures that differ from their bulk forms. These polymorphs exhibit unique properties, including altered electrical, optical, and magnetic behaviors, making them promising candidates for applications in electronics, energy storage, spintronics, and quantum devices. This review explores recent advancements in the encapsulation of a wide range of materials such as organic molecules, elemental substances, metal halides, metal chalcogenides, and other complex compounds. In particular, we focus on novel polymorphs formed through the geometrical confinement effect within the nanotubes. The atomic structure, other key properties, and potential applications of these encapsulated materials are discussed, highlighting the impact of nanotube encapsulation on their functionalities.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00460-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano ConvergencePub Date : 2024-12-02DOI: 10.1186/s40580-024-00454-1
Kugalur Shanmugam Ranjith, Ali Mohammadi, Ganji Seeta Rama Raju, Yun Suk Huh, Young-Kyu Han
{"title":"Interfacial charge transfer on hierarchical synergistic shell wall of MXene/MoS2 on CdS nanospheres: heterostructure integrity for visible light responsive photocatalytic H2 evolution","authors":"Kugalur Shanmugam Ranjith, Ali Mohammadi, Ganji Seeta Rama Raju, Yun Suk Huh, Young-Kyu Han","doi":"10.1186/s40580-024-00454-1","DOIUrl":"10.1186/s40580-024-00454-1","url":null,"abstract":"<div><p>Energy scarcity and environmental pollution have prompted research in hydrogen generation from solar to develop clean energy through highly efficient, effective, and long-lasting photocatalytic systems. Designing a catalyst with robust stability and an effective carrier separation rate was achieved through heterostructure assembly, but certain functionalities must be explored. In this paper we designed a ternary heterostructure assembly of CdS nanospheres wrapped with hierarchical shell walls of layered MXene-tagged MoS<sub>2</sub> nanoflakes, forming intimate interfaces through an in-situ growth process. An in-layered shell wall of MXene with surface-wrapped MoS<sub>2</sub> nanoflakes as a core–shell assembly improved the photo-corrosion resistance and accelerated the production of photocatalytic H<sub>2</sub> (38.5 mmol g<sup>−1</sup> h<sup>−1</sup>), which is 10.7, 3.1, and 1.9 times faster than that of CdS, CdS–MXe, and CdS–MoS<sub>2</sub> nanostructures, respectively. The apparent quantum efficiency of the CdS–MXe<sub>2.4</sub>/MoS<sub>2</sub> heterostructure was calculated to be 34.6% at λ = 420 nm. X-ray and ultraviolet photoelectron spectroscopies validated the electronic states, energy band alignment, and work function of the heterostructures, whilst time-resolved photoluminescence measured the carrier lifespan to evaluate the effective charge migration in the CdS-MXe/MoS<sub>2</sub> heterostructure. The dual surface wrapping of MXe/MoS<sub>2</sub> over CdS nanospheres confirmed the structural durability that remained intact throughout the photocatalytic reaction, promoting approximately 93.1% of its catalytic property even after five repeatable cycles. This study examined how the MXene heterostructure template improves the catalytic efficiency and opens a new way to design MXene-based durable heterostructure catalysts for solar-energy conversion.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00454-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano ConvergencePub Date : 2024-12-02DOI: 10.1186/s40580-024-00457-y
Ji-Eun Lee, Yu Liu, Jinwoong Hwang, Choongyu Hwang, Cedomir Petrovic, Se Young Park, Hyejin Ryu, Sung-Kwan Mo
{"title":"Topological surface states of semimetal TaSb2","authors":"Ji-Eun Lee, Yu Liu, Jinwoong Hwang, Choongyu Hwang, Cedomir Petrovic, Se Young Park, Hyejin Ryu, Sung-Kwan Mo","doi":"10.1186/s40580-024-00457-y","DOIUrl":"10.1186/s40580-024-00457-y","url":null,"abstract":"<div><p>Topological surface states, protected by the global symmetry of the materials, are the keys to understanding various novel electrical, magnetic, and optical properties. TaSb<sub>2</sub> is a newly discovered topological material with unique transport phenomena, including negative magnetoresistance and resistivity plateau, whose microscopic understanding is yet to be reached. In this study, we investigate the electronic band structure of TaSb<sub>2</sub> using angle-resolved photoemission spectroscopy and density functional theory. Our analyses reveal distinct bulk and surface states in TaSb<sub>2</sub>, providing direct evidence of its topological nature. Notably, surface states predominate the electronic contribution near the Fermi level, while bulk bands are mostly located at higher binding energies. Our study underlines the importance of systematic investigations into the electronic structures of topological materials, offering insights into their fundamental properties and potential applications in future technologies.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00457-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano ConvergencePub Date : 2024-11-30DOI: 10.1186/s40580-024-00459-w
Seonhong Min, Minwook Jeon, Junsang Cho, Jin Ho Bang, Prashant V. Kamat
{"title":"Spectroelectrochemical insights into the intrinsic nature of lead halide perovskites","authors":"Seonhong Min, Minwook Jeon, Junsang Cho, Jin Ho Bang, Prashant V. Kamat","doi":"10.1186/s40580-024-00459-w","DOIUrl":"10.1186/s40580-024-00459-w","url":null,"abstract":"<div><p>Lead halide perovskites have emerged as a new class of semiconductor materials with exceptional optoelectronic properties, sparking significant research interest in photovoltaics and light-emitting diodes. However, achieving long-term operational stability remains a critical hurdle. The soft, ionic nature of the halide perovskite lattice renders them vulnerable to various instabilities. These instabilities can be triggered by factors such as photoexcitation, electrical bias, and the surrounding electrolyte/solvent or atmosphere under operating conditions. Spectroelectrochemistry offers a powerful approach to bridge the gap between electrochemistry and photochemistry (or spectroscopy), by providing a comprehensive understanding of the band structure and excited-state dynamics of halide perovskites. This review summarizes recent advances that highlight the fundamental principles, the electronic band structure of halide perovskite materials, and the photoelectrochemical phenomena observed upon photo- and electro-chemical charge injections. Further, we discuss halide instability, encompassing halide oxidation, vacancy formation, ion migration, degradation, and sequential expulsion under electrical bias. Spectroelectrochemical studies that provide a deeper understanding of interfacial processes and halide mobility can pave the way for the design of more robust perovskites, accelerating future research and development efforts.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00459-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142753961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano ConvergencePub Date : 2024-11-27DOI: 10.1186/s40580-024-00456-z
Sandip Gangadhar Balwe, Dohyeon Moon, Minki Hong, Joon Myong Song
{"title":"Manganese oxide nanomaterials: bridging synthesis and therapeutic innovations for cancer treatment","authors":"Sandip Gangadhar Balwe, Dohyeon Moon, Minki Hong, Joon Myong Song","doi":"10.1186/s40580-024-00456-z","DOIUrl":"10.1186/s40580-024-00456-z","url":null,"abstract":"<div><p>The advent of precision medicine in oncology emphasizes the urgent need for innovative therapeutic strategies that effectively integrate diagnosis and treatment while minimizing invasiveness. Manganese oxide nanomaterials (MONs) have emerged as a promising class of nanocarriers in biomedicine, particularly for targeted drug delivery and the therapeutic management of tumors. These nanomaterials are characterized by exceptional responsiveness to the tumor microenvironment (TME), high catalytic efficiency, favorable biodegradability, and advanced capabilities in magnetic resonance imaging. These attributes significantly enhance drug delivery, facilitate real-time bioimaging, and enable early tumor detection, thereby improving the precision and effectiveness of cancer therapies. This review highlights the significant advancements in the synthesis and therapeutic applications of MONs, beginning with a comprehensive overview of key synthetic methods, including thermal decomposition, potassium permanganate reduction, exfoliation, adsorption–oxidation, and hydro/solvothermal techniques. We delve into the preparation of MONs and H–MnO₂-based nanomaterials, emphasizing their chemical properties, surface modifications, and toxicity profiles, which are critical for their clinical application. Moreover, we discuss the notable applications of H–MnO₂-based nanomaterials in pH-responsive drug release, overcoming multidrug resistance (MDR), immunotherapy, and the development of nanovaccines for synergistic cancer treatments. By addressing the current challenges in the clinical translation of MONs, we propose future research directions for overcoming these obstacles. By underscoring the potential of MONs to transform cancer treatment paradigms, this review aims to inspire further investigations into their multifunctional applications in oncology, thus ultimately contributing to more effective and personalized therapeutic strategies.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00456-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano ConvergencePub Date : 2024-11-26DOI: 10.1186/s40580-024-00455-0
Jiande Zhang, Min-Hyeok Kim, Seulgi Lee, Sungsu Park
{"title":"Integration of nanobiosensors into organ-on-chip systems for monitoring viral infections","authors":"Jiande Zhang, Min-Hyeok Kim, Seulgi Lee, Sungsu Park","doi":"10.1186/s40580-024-00455-0","DOIUrl":"10.1186/s40580-024-00455-0","url":null,"abstract":"<div><p>The integration of nanobiosensors into organ-on-chip (OoC) models offers a promising advancement in the study of viral infections and therapeutic development. Conventional research methods for studying viral infection, such as two-dimensional cell cultures and animal models, face challenges in replicating the complex and dynamic nature of human tissues. In contrast, OoC systems provide more accurate, physiologically relevant models for investigating viral infections, disease mechanisms, and host responses. Nanobiosensors, with their miniaturized designs and enhanced sensitivity, enable real-time, continuous, in situ monitoring of key biomarkers, such as cytokines and proteins within these systems. This review highlights the need for integrating nanobiosensors into OoC systems to advance virological research and improve therapeutic outcomes. Although there is extensive literature on biosensors for viral infection detection and OoC models for replicating infections, real integration of biosensors into OoCs for continuous monitoring remains unachieved. We discuss the advantages of nanobiosensor integration for real-time tracking of critical biomarkers within OoC models, key biosensor technologies, and current OoC systems relevant to viral infection studies. Additionally, we address the main technical challenges and propose solutions for successful integration. This review aims to guide the development of biosensor-integrated OoCs, paving the way for precise diagnostics and personalized treatments in virological research.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00455-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}