Sandip Gangadhar Balwe, Dohyeon Moon, Minki Hong, Joon Myong Song
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引用次数: 0
摘要
肿瘤精准医疗的出现强调了对创新治疗策略的迫切需求，这种策略既能有效整合诊断和治疗，又能最大限度地降低侵入性。氧化锰纳米材料（MONs）已成为生物医学中一类前景广阔的纳米载体，尤其适用于靶向给药和肿瘤治疗管理。这些纳米材料的特点是对肿瘤微环境（TME）反应灵敏、催化效率高、生物降解性好以及磁共振成像功能先进。这些特性大大提高了给药效果，促进了实时生物成像，实现了早期肿瘤检测，从而提高了癌症疗法的精确性和有效性。本综述重点介绍 MONs 在合成和治疗应用方面取得的重大进展，首先全面概述关键合成方法，包括热分解、高锰酸钾还原、剥离、吸附-氧化和水热/溶热技术。我们深入探讨了以 MONs 和 H-MnO₂ 为基础的纳米材料的制备，强调了它们的化学性质、表面改性和毒性特征，这对它们的临床应用至关重要。此外，我们还讨论了 H-MnO₂ 基纳米材料在 pH 值响应型药物释放、克服多药耐药性 (MDR)、免疫疗法以及开发用于协同治疗癌症的纳米疫苗等方面的显著应用。通过探讨 MONs 目前在临床转化中面临的挑战，我们提出了克服这些障碍的未来研究方向。通过强调 MONs 在改变癌症治疗模式方面的潜力，本综述旨在激发人们进一步研究 MONs 在肿瘤学中的多功能应用，从而最终为制定更有效的个性化治疗策略做出贡献。
Manganese oxide nanomaterials: bridging synthesis and therapeutic innovations for cancer treatment
The advent of precision medicine in oncology emphasizes the urgent need for innovative therapeutic strategies that effectively integrate diagnosis and treatment while minimizing invasiveness. Manganese oxide nanomaterials (MONs) have emerged as a promising class of nanocarriers in biomedicine, particularly for targeted drug delivery and the therapeutic management of tumors. These nanomaterials are characterized by exceptional responsiveness to the tumor microenvironment (TME), high catalytic efficiency, favorable biodegradability, and advanced capabilities in magnetic resonance imaging. These attributes significantly enhance drug delivery, facilitate real-time bioimaging, and enable early tumor detection, thereby improving the precision and effectiveness of cancer therapies. This review highlights the significant advancements in the synthesis and therapeutic applications of MONs, beginning with a comprehensive overview of key synthetic methods, including thermal decomposition, potassium permanganate reduction, exfoliation, adsorption–oxidation, and hydro/solvothermal techniques. We delve into the preparation of MONs and H–MnO₂-based nanomaterials, emphasizing their chemical properties, surface modifications, and toxicity profiles, which are critical for their clinical application. Moreover, we discuss the notable applications of H–MnO₂-based nanomaterials in pH-responsive drug release, overcoming multidrug resistance (MDR), immunotherapy, and the development of nanovaccines for synergistic cancer treatments. By addressing the current challenges in the clinical translation of MONs, we propose future research directions for overcoming these obstacles. By underscoring the potential of MONs to transform cancer treatment paradigms, this review aims to inspire further investigations into their multifunctional applications in oncology, thus ultimately contributing to more effective and personalized therapeutic strategies.
期刊介绍：
Nano Convergence is an internationally recognized, peer-reviewed, and interdisciplinary journal designed to foster effective communication among scientists spanning diverse research areas closely aligned with nanoscience and nanotechnology. Dedicated to encouraging the convergence of technologies across the nano- to microscopic scale, the journal aims to unveil novel scientific domains and cultivate fresh research prospects.
Operating on a single-blind peer-review system, Nano Convergence ensures transparency in the review process, with reviewers cognizant of authors' names and affiliations while maintaining anonymity in the feedback provided to authors.
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