Microchimica Acta最新文献_第7页

N-doped silicon QDs: facile synthesis and application as sensor for discrimination and selective detection of oxytetracycline, tetracycline, and chlortetracycline in foods 掺氮硅 QDs：简易合成及作为传感器用于食品中土霉素、四环素和金霉素的鉴别和选择性检测。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-10-25 DOI: 10.1007/s00604-024-06786-3

Rui Zhou, Wenwen Guo, Jing Wang, Xiaoxiao Yu, Yiwei Wu

{"title":"N-doped silicon QDs: facile synthesis and application as sensor for discrimination and selective detection of oxytetracycline, tetracycline, and chlortetracycline in foods","authors":"Rui Zhou, Wenwen Guo, Jing Wang, Xiaoxiao Yu, Yiwei Wu","doi":"10.1007/s00604-024-06786-3","DOIUrl":"10.1007/s00604-024-06786-3","url":null,"abstract":"<div><p>Nitrogen-doped silicon quantum dots (N-SiQDs) with a quantum yield of up to 37.8% were simply synthesized using inexpensive and readily available silica as the silicon source. Based on the internal filter effect (IFE), both oxytetracycline (OTC) and tetracycline (TC) can effectively and rapidly quench the fluorescence of N-SiQDs at 380 nm. However, interestingly, the accompanied formation of a new complex of OTC with N-SiQDs could emit fluorescence at 505 nm, resulting in a gradual color change of the sensor from blue to yellow under the irradiation of 365 nm UV lamp. Thus, a visual semi-quantitative detection of OTC was realized. In contrast, based on the aggregation-induced luminescence (AIE) effect, chlortetracycline (CTC) linearly enhanced the fluorescence intensity of N-SiQDs, which can effectively reduce other interfering signals, and can significantly improve the sensitivity and selectivity. Hence, a low limit of detection of 47 nM for CTC was obtained. On account of the three distinctly different phenomena and mechanisms of N-SiQDs sensor exhibited towards OTC, TC, and CTC, a novel sensing method for discriminating and selectively measuring OTC, TC, and CTC in food was developed.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 11","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An innovative strategy for Gefitinib quantification in pharmaceutical and plasma samples using a graphene quantum dots-combined gold nanoparticles composite electrochemical sensor 利用石墨烯量子点-金纳米颗粒复合电化学传感器定量检测药物和血浆样品中吉非替尼的创新策略。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-10-24 DOI: 10.1007/s00604-024-06766-7

Jieping Cao, Yingmei Shi, Juntong Chen, Zhibin Yan, Minmin Zhang, Mingliang Jin, Lingling Shui, Zhenping Liu, Huiling Feng

{"title":"An innovative strategy for Gefitinib quantification in pharmaceutical and plasma samples using a graphene quantum dots-combined gold nanoparticles composite electrochemical sensor","authors":"Jieping Cao, Yingmei Shi, Juntong Chen, Zhibin Yan, Minmin Zhang, Mingliang Jin, Lingling Shui, Zhenping Liu, Huiling Feng","doi":"10.1007/s00604-024-06766-7","DOIUrl":"10.1007/s00604-024-06766-7","url":null,"abstract":"<div><p>An innovative methodology is proposed for quantifying Gefitinib (GFT) using an electrochemical sensor constructed from a composite of graphene quantum dots (GQDs) and gold nanoparticles (AuNPs). GQDs were synthesized from graphite, preserving graphene’s large surface area and excellent electron transfer capabilities while enhancing dispersibility. The combination of GQDs with AuNPs resulted in an AuNPs@GQDs composite, which was used to construct the sensor. The synthesized nanomaterials were characterized using scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and the electrochemical performance of the sensor was evaluated via cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Under optimized conditions, the sensor displayed a linear calibration curve for GFT detection within the range 0.01 to 10.0 µM, with a limit of detection (LOD) of 0.005 µM (S/<i>N</i> = 3). The sensor demonstrated excellent anti-interference properties and stability in tests using pharmaceutical formulations and plasma samples. Compared to chromatographic methods, the sensor exhibited similar accuracy and recovery. Its easy fabrication and high sensitivity make it a promising tool for pharmaceutical analysis and clinical therapeutic drug monitoring.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 11","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00604-024-06766-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red-emissive carbon dots from Hibiscus rosa-sinensis: a detailed appraisal of tartrazine dye sensing properties 来自木槿的红色发射性碳点：对酒石酸染料传感特性的详细评估。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-10-24 DOI: 10.1007/s00604-024-06789-0

Neha Garg, Navisha Sharma, Abhijit Dan, Savita Chaudhary

{"title":"Red-emissive carbon dots from Hibiscus rosa-sinensis: a detailed appraisal of tartrazine dye sensing properties","authors":"Neha Garg, Navisha Sharma, Abhijit Dan, Savita Chaudhary","doi":"10.1007/s00604-024-06789-0","DOIUrl":"10.1007/s00604-024-06789-0","url":null,"abstract":"<div><p>An economically viable and greener approach is introduced to fabricate red emissive carbon dots (R@CQDs) via employing hydrothermal means on <i>Hibiscus rosa-sinensis</i> leaves as precursor source. The obtained R@CQDs displayed excitation-dependent behavior, with high aqueous stability, quantum yield of 56%, and outstanding fluorescence aptitude under the conditions of varied range of ionic strength and pH (1–12). The fluorescence emission behavior of R@CQDs displayed selective turn off fluorescence response to tartrazine over other interfering species with a limit of detection of 0.09 µM and quantitation limit of 0.30 µM. Theoretical calculations employing density functional theory (DFT) were carried out to complement experimental findings and getting insights into the underlying mechanism governing the sensing of tartrazine. The developed sensor holds significant potential for tartrazine detection in real samples and offering wider prospective in the food safety assessment.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 11","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00604-024-06789-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Boron-doped carbon dots with time-resolved room temperature phosphorescence for detection of ciprofloxacin hydrochloride and information encryption applications 具有时间分辨室温磷光的掺硼碳点用于检测盐酸环丙沙星和信息加密应用。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-10-23 DOI: 10.1007/s00604-024-06767-6

Xueyu Wang, Xin Wei, Runze Tong, Chunhui Yi, Yidi Wang, Yang Fu, Fanyong Yan

{"title":"Boron-doped carbon dots with time-resolved room temperature phosphorescence for detection of ciprofloxacin hydrochloride and information encryption applications","authors":"Xueyu Wang, Xin Wei, Runze Tong, Chunhui Yi, Yidi Wang, Yang Fu, Fanyong Yan","doi":"10.1007/s00604-024-06767-6","DOIUrl":"10.1007/s00604-024-06767-6","url":null,"abstract":"<div><p>Novel boron-doped carbon dots (BCDs) with extended afterglow characteristics were synthesized via a one-step solvothermal method using acrylamide, sulfosalicylic acid, and sodium tetraborate as protective matrices. The presence of boron from sodium tetraborate introduced an empty orbital, allowing it to form a more extended conjugated system with adjacent oxygen atoms, thereby lowering the energy level of the lowest unoccupied molecular orbital in the system. The phosphorescence emission of these BCDs exhibits a red shift over time from 450 to 500 nm. These BCDs have been effectively utilized to produce anti-counterfeit phosphorescent powder. Additionally, the BCDs display optimal fluorescence excitation at 330 nm and optimal emission at 420 nm. They demonstrate a detection limit for ciprofloxacin hydrochloride of 37 nM in the 1-100 µM concentration range and 26 nM in the 100-210 µM range. This fluorescence detection is governed by an inner filter effect. Real sample testing further confirms that these BCDs serve as excellent sensors for ciprofloxacin hydrochloride.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 11","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An innovative homogeneous electrochemistry coupled with colorimetry dual-model sensing strategy for perfluorooctane sulfonate based on Cu@CuO aerogel nanozyme 基于 Cu@CuO 气凝胶纳米酶的创新型全氟辛烷磺酸均相电化学耦合比色法双模式传感策略。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-10-23 DOI: 10.1007/s00604-024-06751-0

Yuanyuan Xu, Qingqing Yin, Ningjing Du, Yinhui Yi, Gangbing Zhu

{"title":"An innovative homogeneous electrochemistry coupled with colorimetry dual-model sensing strategy for perfluorooctane sulfonate based on Cu@CuO aerogel nanozyme","authors":"Yuanyuan Xu, Qingqing Yin, Ningjing Du, Yinhui Yi, Gangbing Zhu","doi":"10.1007/s00604-024-06751-0","DOIUrl":"10.1007/s00604-024-06751-0","url":null,"abstract":"<div><p>By preparing Cu@CuO aerogel as a nanozyme which exhibits prominent peroxidase-like (POD) activity, an innovative homogeneous electrochemistry (HEC) coupled with the colorimetry dual-model sensing strategy is proposed to detect perfluorooctane sulfonate (PFOS) for the first time. Cu@CuO aerogel accelerates the oxidation process of colorless o-phenylenediamine to form yellow 2,3-diaminophenazinc (DAP), and meanwhile, DAP as an electroactive substance creates a reduction peak current upon the electrochemical measurements. Interestingly, in the presence of PFOS, the POD activity of Cu@CuO aerogel is inhibited since the specific coordination between PFOS and Cu(II) can cover the active sites, resulting in the color of the sensing system becoming light and the peak current of DAP decreasing. This innovative dual-mode detection method showed excellent electrochemical detection of PFOS in the concentration range 10.0 ~ 1125.0 nM with a limit of detection (LOD) as low as 3.3 nM and a LOD of 20.8 nM in the colorimetric detection in the range 62.3 ~ 875 nM. Furthermore, the sensor was successfully used for the analysis of real samples with an RSD value ≤ 6.5%. The successful application of this two-mode sensing method for the determination of PFOS holds promise for the detection of other contaminants in the future.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 11","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Willow catkin template synthesis of NiS@NSC hollow tubes for highly sensitive dual-function electrochemical detection of acetaminophen and Cu2+ 柳树柔荑模板合成用于高灵敏度对乙酰氨基酚和 Cu2 双功能电化学检测的 NiS@NSC 空心管。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-10-23 DOI: 10.1007/s00604-024-06731-4

Menghao Li, Yuying Xin, Xiaohan Sun, Xianfa Zhang, Yingming Xu, Xiaoli Cheng, Shan Gao, Lihua Huo

{"title":"Willow catkin template synthesis of NiS@NSC hollow tubes for highly sensitive dual-function electrochemical detection of acetaminophen and Cu2+","authors":"Menghao Li, Yuying Xin, Xiaohan Sun, Xianfa Zhang, Yingming Xu, Xiaoli Cheng, Shan Gao, Lihua Huo","doi":"10.1007/s00604-024-06731-4","DOIUrl":"10.1007/s00604-024-06731-4","url":null,"abstract":"<div><p>Public health and environmental well-being have become increasingly threatened by the contamination of pharmaceuticals and heavy metal ions. This study focuses on addressing this critical issue by developing a novel electrochemical sensor for the dual-functional detection of acetaminophen (AP) and Cu<sup>2+</sup>. Utilizing willow catkins as a biomass template, a hollow tubular NiS@NSC composite was prepared by simple nickel salt impregnation combined with calcination and sulfurization. A highly sensitive dual-functional electrochemical sensor was thus constructed that can detect both acetaminophen (AP) and Cu<sup>2+</sup>. By examining its electrochemical properties, the sensor achieves an impressive detection limit of 1.33 pM for AP, with a linear range of 4.00 pM ~ 0.15 mM. The sensor can also detect Cu<sup>2+</sup>, with a detection limit of 1.04 µM, and a linear range of 3.13 µM ~ 0.66 mM. The sensor also exhibits strong resistance to interference, and good repeatability and stability. In addition, the sensor has demonstrated good performance in actual sample analysis, including the detection of AP in serum and Cu<sup>2+</sup> in wastewater. This excellent electrochemical sensing performance is mainly attributed to the synergistic effect of its unique tubular structure and highly conductive N, S co-doped carbon. This results in the sensor exhibiting minimal charge transfer resistance, an extensive electrochemically active surface area, and a high density of active sites.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 11","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Portable alkaloid discrimination via nanozyme-mediated colorimetric paper-based sensor array integrated with smartphone detection 通过纳米酶介导的比色纸质传感器阵列与智能手机检测相结合实现便携式生物碱鉴别。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-10-23 DOI: 10.1007/s00604-024-06770-x

Xiaoxue Liu, Min Chen, Fangbin Wang, Liang Zhu

{"title":"Portable alkaloid discrimination via nanozyme-mediated colorimetric paper-based sensor array integrated with smartphone detection","authors":"Xiaoxue Liu, Min Chen, Fangbin Wang, Liang Zhu","doi":"10.1007/s00604-024-06770-x","DOIUrl":"10.1007/s00604-024-06770-x","url":null,"abstract":"<div><p>A paper-based colorimetric sensor array mediated by a novel nanozyme (CuCo<sub>2</sub>O<sub>4</sub>) was developed using a screen-printing technology. The aim was to facilitate the identification of different kinds of alkaloids. Typically, three chromogenic substrates (3,3′,5,5′-tetramethylbenzidine, 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid), and <i>o</i>-phenylenediamine) were selected as sensing elements, which can be catalyzed by a CuCo<sub>2</sub>O<sub>4</sub> nanozyme with peroxidase-like activity to yield corresponding oxidized products, thereby inducing color changes. Owing to the varying inhibitory ability of different alkaloids on acetylcholinesterase (AChE), a decrease in choline (Ch) concentration occurs and subsequently results in the restoration of color within the units of sensor array. Color data can be transformed into hue information with a smartphone. The above color variations generated a unique “fingerprint” pattern on five alkaloids (berberine, palmatine, jatrorrhizine, eserine, and harmane), which can be successfully discriminated through linear discriminant analysis in the range 0.2 to 20 µM. Furthermore, the sensor arrays allowed successful discrimination of the above five alkaloids in Chinese herbal medicine samples and recognition of 22 blind samples. This work presents a novel nanozyme-based paper sensor array, which is a user-friendly and reliable platform for probing different alkaloids. In addition, the developed sensing strategy enables the identification of AChE-related diseases, positively contributing to the screening available of AD-associated drugs.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 11","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Turn-off fluorescent nanoprobe based on carbon dots synthesised by UV/H2O2 advanced oxidation for the detection of bisphenol A in canned foods 基于 UV/H2O2 高级氧化法合成的碳点的熄灭荧光纳米探针，用于检测罐头食品中的双酚 A。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-10-23 DOI: 10.1007/s00604-024-06784-5

Alberto Abalde-Pujales, Isela Lavilla, Carlos Bendicho, Vanesa Romero

{"title":"Turn-off fluorescent nanoprobe based on carbon dots synthesised by UV/H2O2 advanced oxidation for the detection of bisphenol A in canned foods","authors":"Alberto Abalde-Pujales, Isela Lavilla, Carlos Bendicho, Vanesa Romero","doi":"10.1007/s00604-024-06784-5","DOIUrl":"10.1007/s00604-024-06784-5","url":null,"abstract":"<div><p> A novel assay was developed based on a turn-off fluorescent probe using the in situ generation of carbon dots (CDs) by means of UV/H<sub>2</sub>O<sub>2</sub> advanced oxidation of carbohydrates for the detection of bisphenol A (BPA) in food. Different parameters involved in the synthesis of CDs for the direct recognition of BPA have been optimised and a sensing mechanism is outlined. The presence of H<sub>2</sub>O<sub>2</sub> during CD synthesis causes a fluorescence enhancement due to the action of highly oxidant HO<sup>·</sup> radicals formed throughout the photochemical reaction. Phenolic compounds such as BPA can be easily degraded by the UV/H<sub>2</sub>O<sub>2</sub> oxidation process, acting as a HO<sup>·</sup> free radical scavengers. This results in a decrease in the fluorescence that can be related to the BPA concentration. Under optimal conditions, a detection limit of 15 µg/kg of BPA and a quantification limit of 46 µg/kg of BPA in food samples were obtained. The repeatability and reproducibility, expressed as relative standard deviation and obtained for two concentration levels (30 µg/kg and 200 µg/kg, <i>n</i> = 5), were less than 2.0% and 6.4%, respectively. The proposed procedure was applied to the analysis of five samples of canned foods (sweet corn, peas, mushrooms, cockles and natural tuna), obtaining concentrations in the range 29.8–49.9 µg/kg of sample. Recovery studies were conducted at two concentration levels (100 and 400 µg BPA/kg of sample), resulting in recoveries in the range 99–101%. Method validation against two certified reference materials was also successfully performed. The experimental results demonstrate that the novel approach is suitable for the detection and quantification of BPA in canned foods.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 11","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic enantioseparation system based on a novel nanomaterial synthesized by chiral metal–organic framework and chiral molecularly imprinted polymer in capillary electrochromatography 毛细管电色谱中基于手性金属有机框架和手性分子印迹聚合物合成的新型纳米材料的协同对映体分离系统

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-10-22 DOI: 10.1007/s00604-024-06773-8

Pandeng Miao, Dongyang Zhu, Shuaijing Du, Yingxiang Du

{"title":"Synergistic enantioseparation system based on a novel nanomaterial synthesized by chiral metal–organic framework and chiral molecularly imprinted polymer in capillary electrochromatography","authors":"Pandeng Miao, Dongyang Zhu, Shuaijing Du, Yingxiang Du","doi":"10.1007/s00604-024-06773-8","DOIUrl":"10.1007/s00604-024-06773-8","url":null,"abstract":"<div><p>A capillary electrochromatography (CEC) synergistic enantioseparation system based on a novel nanomaterial synthesized by chiral molecularly imprinted polymers (CMIPs) and chiral metal organic frameworks (CMOFs) was developed. Compared with CMIPs and CMOFs alone, the enantioseparation performance of ofloxacin (OFL) of the CEC with the novel nanomaterial as stationary phases was greatly improved. CMOFs with chiral recognition ability have synergize with CMIPs to greatly improve the chiral selectivity of the novel stationary phases in CEC. As a proof-of-concept demonstration, a coated capillary column was prepared by a sol–gel method using S-OFL (template), iron-based cyclodextrin MOF (Fe-CD-MOF, a CMOF), 3-aminopropyltriethoxysilane (functional monomer), and tetraethyl orthosilicate (cross-linking agent). Then, the newly constructed CEC system has excellent enantioseparation performance of OFL with a resolution of 3.92. Finally, computerized molecular docking revealed that the difference in the binding ability of Fe-CD-MOF to ofloxacin enantiomers was an important mechanism for CEC chiral separation. This innovative development of synergistic chiral stationary phases based on CMOFs and CMIPs creates a highly efficient potential direction for enantiomer separation.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 11","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00604-024-06773-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel approach of differentiation of adenoma and carcinoma in lung cancer based on biogenic in situ synthesis of gold nanostructures on various oligonucleotide motifs 基于在各种寡核苷酸图案上生物原位合成金纳米结构的肺癌腺瘤和癌分化新方法。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-10-22 DOI: 10.1007/s00604-024-06744-z

Seyedeh Saina Seifzadeh, Yasaman-Sadat Borghei, Nastaran Roknabadi, Seyed Javad Mowla

{"title":"A novel approach of differentiation of adenoma and carcinoma in lung cancer based on biogenic in situ synthesis of gold nanostructures on various oligonucleotide motifs","authors":"Seyedeh Saina Seifzadeh, Yasaman-Sadat Borghei, Nastaran Roknabadi, Seyed Javad Mowla","doi":"10.1007/s00604-024-06744-z","DOIUrl":"10.1007/s00604-024-06744-z","url":null,"abstract":"<div><p>A unique approach is introduced for constructing gold nanocrystals (AuNCs) with RNA motif–directed morphologies in a sequence-independent manner and its applications in the clinical area are described. By using this method, a label-free LSPR-based detection method for the SOX2OT transcript, long non-coding RNAs (lncRNAs), which is a prognostic indicator of poor survival in lung cancer patients is presented. For the first time, we examined how the structural changes of RNA after the heteroduplex formation with a specific DNA probe can change the morphology and LSPR band of AuNCs. Using this method, is was possible to differentiate lung squamous cell carcinoma from adenocarcinoma samples without a need for a prior amplification of the target lncRNA. The approach of using specific DNA probe enables the in situ synthesis of nanocrystals in a different way and expands this method for future translational medicine, particularly detection of specific RNA.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 11","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0