Microchimica Acta最新文献

{"title":"Isothermal nucleic acid amplification for monitoring hand-foot-and-mouth disease: current status and future implications.","authors":"Zhen Chen, Kang Mao, Zhuo Chen, Rida Feng, Wei Du, Hua Zhang, Chenglong Tu","doi":"10.1007/s00604-024-06899-9","DOIUrl":"https://doi.org/10.1007/s00604-024-06899-9","url":null,"abstract":"<p><p>With the global prevalence of the hand-foot-and-mouth disease (HFMD) epidemic, the development of reliable point-of-care testing (POCT) is crucial for the timely identification and prevention of outbreaks. Isothermal nucleic acid amplification techniques (INAATs) have attracted much attention because of their high efficiency for rapid diagnosis. In this work, we systematically summarize the current status of INAATs for HFMD and discuss advantages and drawbacks of various INAATs for HFMD. The INAATs for HFMD detection mainly include loop-mediated isothermal amplification (LAMP), simultaneous amplification and testing (SAT), and recombinase polymerase amplification (RPA). Among them, LAMP has excelled in several diagnostic metrics and has made significant progress in the field of POCT. SAT has been effective in overcoming the problem of RNA degradation. RPA is suited for on-site testing due to its rapid amplification rate and low reaction temperature. In addition, this study explores the potential of INAATs in lateral flow strips (LFS) test and microfluidic devices for HFMD. LFS is typically used for qualitative analysis and supports multiple detection. Microfluidics can integrate necessary processes of sample pre-processing, amplification, and signal output, enabling high-throughput qualitative or quantitative detection and demonstrating the potential of monitoring HFMD. We hope the current work will provide insights into INAATs for monitoring HFMD and serve as a reference for the implementation of on-site EV detection for public health.</p>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":"31"},"PeriodicalIF":5.3,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-sensitive detection of 4-chloro-2-methylphenoxyacetic acid herbicide using a porous Co-1,4-benzenedicarboxylate /montmorillonite nanocomposite sensor","authors":"Mona Elfiky,&nbsp;Moa’mena Abdo,&nbsp;Mona Darwesh,&nbsp;Nehal Salahuddin","doi":"10.1007/s00604-024-06765-8","DOIUrl":"10.1007/s00604-024-06765-8","url":null,"abstract":"<div><p>The detection of 4-chloro-2-methylphenoxyacetic acid (CMPA) herbicide is crucial due to the potential health risks linked to exposure through drinking water, air, and food, which may adversely affect liver and kidney functions. To address this environmental concern and promote sustainable agriculture, a sensitive carbon paste sensor incorporating a composite material was developed. The composite sensor is based on porous cobalt-1,4-benzenedicarboxylate metal–organic framework and exfoliated montmorillonite nanolayers (Co-OF/MMt). This sensor enables the voltammetric detection of CMPA in real soil samples using linear sweep adsorptive anodic stripping voltammetry (LS-AdASV), facilitating early and accurate monitoring of herbicide levels. The Co-OF/MMt nanocomposite was synthesized via a hydrothermal method involving the precipitation of Co-OF in the presence of MMt. Comprehensive characterization of the synthesized materials was carried out using Fourier transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM), SEM-Energy dispersive X-ray spectroscopy (SEM–EDX) and surface area analysis (BET). The resulting modified carbon paste sensor, utilizing 1.0% Co-OF/MMt nanocomposite, exhibited superior electrochemical properties compared with the bare carbon paste sensor, possessing an electroactive surface area of 1004.1 m²/g with a minimal resistivity (R_ct) of 330 Ω. Under standard operating conditions, the developed sensor demonstrated detection limits of 0.03 nM and 0.1 nM across two broad linear ranges (0.03 to 0.10 nM – 0.10 to 1.0 nM) and (0.1 to 1.0 nM – 1.0 to 7.0 nM), respectively, for CMPA determination in both bulk and soil samples. These results pointed out the promising electrochemical modified sensor for the direct and simple detection of certain herbicides in environmental matrices, without the need for sample pretreatment steps. This capability supports sustainable development goals by enhancing effective environmental monitoring.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00604-024-06765-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An aptamer sensor based on AgNPs@MOF for surface-enhanced Raman spectroscopy detection of sulfadimethoxine in food","authors":"Zhanye Yang,&nbsp;Nan Zhang,&nbsp;Haiyang Lv,&nbsp;Xinge Ju,&nbsp;Yanhua Chen,&nbsp;Ziwei Zhang,&nbsp;Yuan Tian,&nbsp;Bing Zhao","doi":"10.1007/s00604-024-06897-x","DOIUrl":"10.1007/s00604-024-06897-x","url":null,"abstract":"<div><p>A highly sensitive aptamer sensor (aptasensor) is proposed based on metal–organic frameworks-silver nanoparticles (AgNPs@MOF) to detect sulfadimethoxine (SDM) by surface-enhanced Raman spectroscopy (SERS). AgNPs@MOF with SERS activity was successfully fabricated by synthesizing AgNPs in situ on the surface of MIL-101(Fe), and SDM aptamer and Raman reporter 4-aminophenthiophenol (4-ATP) were selected as specific recognition elements and signal probes, respectively. When SDM was absent, the SDM aptamers were effectively adsorbed on the surface of AgNPs@MOF, thus keeping AgNPs@MOF in a dispersed state, resulting in a weakened SERS signal of 4-ATP. In the presence of SDM, the combination of SDM and aptamer formed a rigid hairpin SDM-aptamer complex, which bound less to AgNPs@MOF. Therefore, fewer aptamers were adsorbed on AgNPs@MOF, which exposed more hot spots, resulting in an enhanced SERS signal of 4-ATP. The aptasensor had good selectivity and sensitivity towards SDM and a good linear relationship between SERS intensity and SDM concentration in the range 6.00–150.00 ng/mL, with the limit of detection as low as 2.73 ng/mL. Further application to honey and chicken samples spiked with SDM resulted in satisfactory recoveries, and the aptasensor showed good stability and reproducibility in real samples. The aptasensor based on AgNPs@MOF was proposed for the first time to detect trace SDM by SERS, which provided a favorable way to develop various sensing platforms for antibiotic detection in food safety.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of ochratoxin A in a coffee sample utilizing an electrochemical aptasensor fabricated through encapsulation of toluidine blue within a Zn-based metal–organic framework","authors":"Elaheh Amini–Nogorani,&nbsp;Hamid R. Zare,&nbsp;Fahime Jahangiri–Dehaghani,&nbsp;Ali Benvidi","doi":"10.1007/s00604-024-06863-7","DOIUrl":"10.1007/s00604-024-06863-7","url":null,"abstract":"<div><p>An electrochemical aptasensor has been developed specifically for the sensitive and selective determination of ochratoxin A (OTA), one of the most important mycotoxins. The aptasensor utilizes a glassy carbon electrode that has been modified with toluidine blue (TB) encapsulated in a Zn-based metal–organic framework (TB@Zn-MOF). The results demonstrate that in the presence of OTA, the peak current of the differential pulse voltammogram (DPV) related to TB oxidation is notably decreased. The changes in the oxidation peak current of TB encapsulated in Zn-MOF, both in the absence and presence of OTA, serve as an analytical signal for accurately measuring its concentration. With the proposed aptasensor, OTA can be determined within a linear concentration range 1.0 × 10⁻⁴ – 200.0 ng mL⁻¹, with a detection limit of 2.1 × 10⁻⁵ ng mL⁻¹. The aptasensor design is suitable for measuring OTA concentration in coffee powder samples. This represents the first report to utilize TB@Zn-MOF in designing an applicable aptasensor to OTA measurement. The high porosity of the Zn-MOF allows for a large number of TB molecules to be encapsulated in its cavities, while its large surface area enables more OTA aptamers to be immobilized on the electrode surface. These two key features significantly enhance the sensitivity of the aptasensor in measuring OTA concentration.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of size and particle number concentration of metallic nanoparticles using isotope dilution analysis combined with single particle ICP-MS to minimise matrix effects","authors":"Marta Hernández-Postigo,&nbsp;Armando Sánchez-Cachero,&nbsp;María Jiménez-Moreno,&nbsp;Rosa Carmen Rodríguez Martín-Doimeadios","doi":"10.1007/s00604-024-06894-0","DOIUrl":"10.1007/s00604-024-06894-0","url":null,"abstract":"<div><p>Single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) is a powerful tool for metallic nanoparticle (NP) characterisation in terms of concentration and, taking into account several assumptions, also size. However, this technique faces challenges, such as the intrinsic matrix effect, which significantly impact the results when analysing real complex samples. This issue is critical for the calculations of key SP-ICP-MS parameters ultimately altering the final outcomes. Novel analytical approaches with high metrological quality such as isotope dilution analysis (IDA) can overcome these limitations by improving signal discrimination in challenging SP-ICP-MS scenarios. This alternative has mainly been applied for NP size characterisation but remains underexplored in modern ICP-MS and SP set-ups. Thus, the implementation of a revised version of IDA-SP-ICP-MS, including recent advances in quadrupole ICP-MS and SP data processing, which enables reliable NP sizing and counting, would be of utmost interest. In this work, this combination using the species-unspecific IDA mode has been investigated as an alternative to tackle matrix effect caused by complex matrices with platinum NPs as a case study. The optimum ionic tracer concentration has been evaluated for different PtNP sizes, resulting in a range of 500 to 1000 ng L⁻¹ due to differences in the mean NP signal. A valuable in-house spreadsheet for the data treatment has also been developed. The successful applicability of the methodology for determining the size and particle number concentration of 30 and 50 nm PtNPs has been demonstrated not only in environmental samples (synthetic and natural seawater), but also, for the first time, in biological matrices such as cell culture media and human urine.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A sandwich-type electrochemiluminescence biosensor based on Ni3(HAB)2/Au@ZnNiAl-LDH/Ru@MIL-53(Al)-NH2 for ultra-sensitive detection of microRNA-155","authors":"Zekai Wang,&nbsp;Lingli Qu,&nbsp;Yu’e Yang,&nbsp;Weikang Cui,&nbsp;Yangyang Gu,&nbsp;Haibo Wang,&nbsp;Hongzhi Pan","doi":"10.1007/s00604-024-06870-8","DOIUrl":"10.1007/s00604-024-06870-8","url":null,"abstract":"<div><p>A novel electrochemiluminescence (ECL) biosensor was developed for the ultrasensitive detection of miRNA-155, based on the synergistic combination of multifunctional nanomaterials. The biosensor employed a conductive metal–organic framework (MOF), Ni₃(HAB)₂ (HAB = hexaaminobenzene), as the substrate material. The unique π-electron conjugated structure of Ni₃(HAB)₂ endowed the biosensor with excellent electron transport properties, significantly enhancing its sensitivity. Furthermore, the innovative preparation of Au@ZnNiAl-LDH nanocomposites, characterized by a high specific surface area was employed to synergistically enhance the catalytic performance of the biosensor in conjunction with Ni₃(HAB)₂. The Au@ZnNiAl-LDH also provided stable anchoring sites for the capture unit, comprised of a DNA tetrahedron hairpin composite structure (DT-HP). Additionally, a porous aluminum-based metal–organic framework (MIL-53(Al)-NH₂) was utilized to encapsulate Ru(bpy)₃²⁺, constructing a Ru@MIL-53(Al)-NH₂ signal unit that effectively improved the stability of the ECL signal. Under optimal conditions, the ECL intensity of the biosensor exhibited a robust linear relationship with the logarithm of miRNA-155 concentration over a range 3 fM to 1 nM, achieving a detection limit as low as 0.9 fM. Moreover, the biosensor demonstrated exceptional specificity, selectivity, and stability, highlighting its significant potential for applications in bioanalysis and clinical diagnosis, particularly for the early diagnosis of tumor.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An electrochemical aptasensor for the detection of bisphenol A based on triple signal amplification assisted by gold nanoparticles, hemin/G-quadruplex DNAzyme, and exonuclease I","authors":"Yanhong Liu,&nbsp;Xueqin Xu","doi":"10.1007/s00604-024-06882-4","DOIUrl":"10.1007/s00604-024-06882-4","url":null,"abstract":"<div><p>A triple signal amplified electrochemical aptasensor for the detection of bisphenol A (BPA) was developed for the first time based on gold nanoparticles (AuNPs), hemin/G-quadruplex DNAzyme, and exonuclease I (Exo I) assisted amplification strategies. The BPA aptamer (Apt) hybridized with the capture probe (CP) was fixed on the gold electrode (GE) to form the double-stranded DNA (dsDNA) structure. When BPA was present, the Apt was detached from the GE surface by specific recognition between the BPA and Apt, forming BPA-Apt complexes in solution. The complexes could be selectively digested by Exo I, releasing BPA to participate in the cycle for binding to other Apt in dsDNA. The hybridization of the CP and auxiliary DNA (aDNA) within the detect probe DNA (dpDNA)-AuNP-aDNA nanocomplex allowed the nanocomplex to connect to the GE surface. The dpDNA interacted with K⁺ and hemin to produce hemin/G-quadruplex DNAzyme, which catalyzed H₂O₂ reduction, accelerated methylene blue (MB) oxidization, and further amplified the electrochemical signal. The integration of triple signal amplification strategies with aptamer-specific recognition enabled sensitive and specific detection of BPA. Under optimized conditions, the aptasensor exhibited a linear range of 0.1 pM–10 nM, with a low detection limit of 76 fM. Moreover, the designed aptasensor was successfully applied to detect BPA in lake water, fruit juice, and honey samples.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fe/Pt-doped carbon nanoparticles with peroxidase-like activity for point-of-care determination of uric acid","authors":"Xia Tong,&nbsp;Guozhu Li,&nbsp;Qianyu Guo,&nbsp;Jie Hu,&nbsp;Baiyan Zhang,&nbsp;Sumiao Liu,&nbsp;Jing Guo,&nbsp;Liyun Zhang","doi":"10.1007/s00604-024-06861-9","DOIUrl":"10.1007/s00604-024-06861-9","url":null,"abstract":"<div><p> A pasting-3D microfluidic paper-based analytical device (P-3D μPAD) was developed. It enabled an efficient cascade reaction between urate oxidase (UOX) and Fe/Pt-doped carbon nanoparticles (Fe/Pt-CNPs) for visual colorimetric detection of uric acid (UA). The novel Fe/Pt-CNP nanozyme performed high peroxidase-like activity toward 3,3′,5,5′-tetramethylbenzidine (TMB) and H₂O₂ with Michaelis − Menten constants (K_m) of 0.97 and 2.30 mM, respectively. The UOX-Fe/Pt-CNP system was incorporated into P-3D μPAD: the 1st layer was UOX hydrolysis reaction under alkaline pH, and the 2nd layer was Fe/Pt-CNPs catalyzing H₂O₂ to oxidize TMB at acidic pH. The separated two layers allowed cascade reaction under different working pH without sacrificing the activity of UOX or Fe/Pt-CNPs. The images were captured and analyzed by the camera and “Color Recognition” application using a  smartphone. The linear range of P-3D μPAD for UA was 25–1000 μM with a limit of detection of 10 μM which met the requirements for clinical applications. The high accuracy of P-3D μPAD for UA detection in invasive (blood) and noninvasive (saliva) samples has been confirmed by the biochemical analyzer. This work offers a sensitive, flexible, affordable, and disposable tool for on-site UA level monitoring and provides new insight into natural enzyme and nanozyme tandem systems for biosensing.</p></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142859492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publisher Correction: Establishment of a visual assessment platform for total antioxidant capacity of Ganoderma sichuanense based on Arg-CeO2 hydrogel nanozyme utilizing a self-programmed smartphone app and a self-designed 3D-printed device","authors":"Suhui Tan,&nbsp;Mengyuan Tan,&nbsp;Tao Zhang,&nbsp;Lu Gao,&nbsp;Yi Li,&nbsp;Xuechao Xu,&nbsp;Zhen-quan Yang","doi":"10.1007/s00604-024-06888-y","DOIUrl":"10.1007/s00604-024-06888-y","url":null,"abstract":"","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142859769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gold nanoclusters decorated hollow ZIF-8 encapsulating iron-catecholates as oxidase mimetics for ratiometric colorimetric detection of nitrite","authors":"Cunhui Wu,&nbsp;Mengzhen Dai,&nbsp;Xinguang Qin,&nbsp;Gang Liu,&nbsp;Haizhi Zhang","doi":"10.1007/s00604-024-06879-z","DOIUrl":"10.1007/s00604-024-06879-z","url":null,"abstract":"<div><p> Gold nanoclusters decorated hollow ZIF-8 encapsulating iron-catecholates (Fe-HHTP@HZIF-8@ AuNCs) was formed through self-assembly of Fe³⁺ and 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP), in situ embedding of ZIF-8, and Au³⁺-Zn²⁺ exchange reaction. Its morphology and structure were fully characterized by high-resolution transmission electron microscopy, X-ray diffraction, transmission electron microscopy element mapping, and X-ray photoelectron spectroscopy. Additionally, its oxidase-like activity was explored with <i>K</i>_<i>m</i> of 0.21 mM and <i>V</i>_max of 1.74 × 10⁻⁶ M·s⁻¹ toward 3,3′,5,5′-tetramethylbenzidine (TMB). Due to its excellent catalytic activity and nitrite mediated diazotization of oxTMB, a ratiometric colorimetric method for nitrite detection was established and validated with wide linear range (2.0–400.0 μM), low LOD (0.12 μM), high accuracy (recovery of 95.11–102.14%), and good selectivity. This method was then utilized to determine the nitrite content in sausages and tap water. This study provided a new idea for developing efficient nanozymes and offered an accurate approach for nitrite determination.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}