Microchimica Acta最新文献

{"title":"Recent advances in MXene, MOF, and COF based NH₃ gas sensors for environmental monitoring: sensing mechanisms, analytical performance, and future perspectives.","authors":"Khursheed Ahmad, Chellakannu Rajkumar, Tae Hwan Oh, Mohd Shabbir","doi":"10.1007/s00604-026-08447-z","DOIUrl":"https://doi.org/10.1007/s00604-026-08447-z","url":null,"abstract":"<p><p>The increasing use of ammonia (NH₃) in agriculture, refrigeration, chemical processing, and energy applications has increased concerns over its toxicity and corrosiveness. This suggest the need for sensitive NH₃ monitoring under practical conditions. This review critically evaluates recent advances in MXene, metal-organic framework (MOF), and covalent organic framework (COF) based NH₃ sensors. MXenes are promising for room-temperature sensing because of their high conductivity and efficient charge transport, but oxidation, restacking, and humidity interference continue to hinder stable and reproducible performance. In contrast, MOFs provide molecular-sieving capability, high porosity, and Lewis-acidic adsorption sites, but their poor conductivity and limited stability necessitate integrating it with semiconductors, polymers, or carbon-based materials. Similarly, COFs exhibit tunable pore structures, ordered transport pathways, and good chemical stability. Despite these advantages, their application in NH₃ sensing remains relatively limited. The analytical performance of MXene, MOF, and COF based NH₃ sensors has been critically discussed with the underlying sensing mechanisms. The key challenges, future perspectives, and emerging research directions are also discussed. Unlike earlier reviews that discuss these materials separately, this review compares MXene, MOF, and COF based NH₃ sensors using the same performance criteria, providing a clearer view of their strengths and remaining limitations. We believe that this review will provide a useful overview for researchers developing MXene, MOF, and COF based NH₃ sensors.</p>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-potential ratiometric electrochemiluminescence sensor based on ZnO@g-C₃N₄ and GO@luminol for metronidazole detection.","authors":"Pengfei Han, Li Tian, Guangping Ma, Wenzhuo Wang, Hanyue Jiang, Huiyuan Mao, Ruixin Li, Tengying Ma, Juan Lu, Jing Wang","doi":"10.1007/s00604-026-08454-0","DOIUrl":"https://doi.org/10.1007/s00604-026-08454-0","url":null,"abstract":"<p><p>A dual-potential ratiometric electrochemiluminescence (RECL) sensor for metronidazole (MNZ) detection has been developed. The sensor was constructed by sequentially depositing a ZnO@g-C₃N₄ cathodic layer serving as the response signal and a graphene oxide(GO)@luminol anodic layer serving as the reference signal. In the persulfate system, the maximum initial cathodic signal was obtained from ZnO@g-C₃N₄, with the addition of MNZ, the cathodic signal was selectively quenched whereas the anodic signal remained unchanged. The mechanism was verified by radical-scavenging experiments. Under optimal conditions, the ratiometric signal (I_a/I_c) exhibited a linear relationship with the logarithm of MNZ concentration (lgC_MNZ) over 1.0 × 10^- 10 to 1.0 × 10^- 6 mol L^- 1. The limit of detection was 3.3 × 10^- 11 mol L^- 1 (S/N = 3). The proposed RECL sensor was further applied to real samples, demonstrating its feasibility and potential for MNZ determination in complex matrices.</p>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interfacial engineering-tailored self-cascading nanozyme for sensitive and rapid detection of different amylases.","authors":"Hao Shen, Nana Li, Mengdi Hao, Fan Yang, Shaoning Yu","doi":"10.1007/s00604-026-08463-z","DOIUrl":"https://doi.org/10.1007/s00604-026-08463-z","url":null,"abstract":"<p><p>The precise quantification of amylases activities in complex environments is crucial in actual manufacturing. We synthesized a self-cascading nanozyme (Au@MOF-235) with glucose oxidase (GOx)-mimicking and peroxidase (POD)-mimicking ability. The stable electrostatic interaction guarantees the homogeneous immobilization of Au nanoparticles with a remarkable GOx-simulating property and thorough active site exposure of MOF-235. Moreover, the generated gluconic acid modulates the acidic level and boosts the POD-mimetic behavior of MOF-235. Consequently, we constructed a platform for sensitive determination of four amylases, demonstrating wide linear ranges (α-amylase: 4-400 U/L, β-amylase: 4-500 U/L, γ-amylase: 10-300 U/L, and pullulanase: 10-400 U/L) and low detection limits (α-amylase: 1.74 U/L, β-amylase: 1.85 U/L, γ-amylase: 5.76 U/L, and pullulanase: 3.68 U/L). This study offers a reliable approach for tracking amylases during food manufacturing with advanced self-cascading and self-activating nanozymes.</p>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A tumor microenvironment-activatable CuS@TF nanosystem with intrinsic multi-nanozyme properties for NIR-II photoacoustic imaging-guided synergistic PTT/CDT.","authors":"Zhixing Liang, Wenyi Wang, Yanfei Liu, Tao Yuan, Jinwei Sun, Xuliang Li, Yan-Cheng Liu, Xiaohuan Guo, Yuxuan Mo, Changchun Wen","doi":"10.1007/s00604-026-08462-0","DOIUrl":"https://doi.org/10.1007/s00604-026-08462-0","url":null,"abstract":"<p><p>The efficacy of single-modal chemodynamic therapy (CDT) is often restricted by the antioxidant scavenging of overexpressed glutathione (GSH) within the tumor microenvironment (TME) and insufficient catalytic kinetics. Meanwhile, traditional photothermal therapy (PTT) also faces bottlenecks of a single therapeutic mechanism and low photothermal conversion efficiency, leading to unsatisfactory overall anti-tumor outcomes. To address these challenges, we constructed a smart-responsive, core-shell multifunctional nanotheranostic platform for near-infrared-II (NIR-II) photoacoustic (PA) imaging-guided synergistic PTT/CDT. This platform utilizes copper sulfide nanoparticles (CuS) as the photothermal core, conformally coated in situ with an Fe-tannic acid (TF) metal-phenolic network (MPN) shell (CuS@TF). In the mildly acidic TME, the TF shell dissociates to expose Fe/Cu bimetallic catalytic centers possessing excellent intrinsic peroxidase-like and catalase-like activities. Driven by the synergistic reduction of endogenous GSH and tannic acid, CuS@TF not only effectively depletes antioxidant GSH but also efficiently modulates H₂O₂ metabolism, triggering a cascade burst of highly toxic hydroxyl radicals (·OH). Furthermore, under 1064 nm laser irradiation, the highly efficient localized hyperthermia generated by the CuS core not only directly ablates the tumor but also thermodynamically boosts the catalytic kinetics of the nanozymes, achieving profound PTT-sensitized CDT. Systematic in vitro and in vivo evaluations demonstrate that, under the precise navigation of PA imaging, CuS@TF exhibits remarkable tumor eradication efficacy (with a tumor inhibition rate of ~ 96.2%) and excellent in vivo biosafety. This work provides a novel design paradigm for the development of precise synergistic tumor theranostics based on multifunctional nanozymes.</p>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Engineering a Gd2(WO4)3-P@rGO heterostructure for enhanced electrochemical sensing and therapeutic drug monitoring of erdafitinib.","authors":"Rasha M K Mohamed, Rania H Taha, Ibrahim Hotan Alsohaimi, Khulaif Alshammari, Hassan M A Hassan, Hossieny Ibrahim, Mohamed M El-Wekil","doi":"10.1007/s00604-026-08455-z","DOIUrl":"https://doi.org/10.1007/s00604-026-08455-z","url":null,"abstract":"","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in MOF-based room-temperature gas sensors: dimensional nanostructure and advanced transduction mechanisms","authors":"Jency Rubia. J,&nbsp;Julaiba Tahsina Mazumder,&nbsp;Arindam Majhi,&nbsp;Ravindra Kumar Jha","doi":"10.1007/s00604-026-08416-6","DOIUrl":"10.1007/s00604-026-08416-6","url":null,"abstract":"<div><p>In the modern era, where ultra-low power gas sensing devices is in high demand due to government policies and people’s consciousness, room-temperature sensing devices becomes very relevant. The conventional sensing devices usually operate at higher temperatures, mostly in the temperature range of 100°C – 450°C as the conventional metal oxide receptors show activated surface behavior in this regime. Elevated temperature helps in overcoming reaction barriers, improves adsorption-desorption kinetics, which has a direct impact on reversability of the device, reduces gas and moisture poisoning, and helps in a significant improvement in signal-to-noise ratio (SNR). However, it has several drawbacks, including high power consumption, material degradation, poor selectivity, safety concerns, system integration issue with CMOS as well as flexible substrates. Therefore, there is a quest for advanced functional materials which can detect gases at low temperature, preferably at room temperature. Metal Organic frameworks (MOF) which has several favourable properties like their high tunable porosity, strong but reversible adsorption behaviour, and chemical flexibility. Not to mention, they have exceptionally high surface area, intrinsic porosity for better molecular sieving, rich chemical functionality, ability to host conductive guests. Over it, the intelligent selection of ligand and metal nodes can be really beneficial in designing room-temperature sensing receptors. In this review, we have discussed different electronic transduction techniques beyond chemiresistive devices like capacitive, transistors, diodes. used for gas detection based on MOFs. All these discussion is done keeping mechanistic insights in place. Since all these devices are based on different nanostructures of MOF, a more detailed view on the different nanostructures like 0D,1D,2D, and 3D MOFs, has been discussed with sensing using these materials. Further, strategies to improve the sensing performance of these MOFs are discussed which will help future researchers in developing tailor-made devices for targeted analytes. At last, the paper concluded with the future research directions and the feasibility for developing next-generation, highly sensitive for real-world applications.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Au nanoparticle-loaded mixed-valence MnOₓ nanosheets as an oxidase-like nanozyme for rapid colorimetric determination of leucomalachite green in fish and water","authors":"Huasheng Lai,&nbsp;Fangsi Fu,&nbsp;Siyu Zhu,&nbsp;Meng Xu","doi":"10.1007/s00604-026-08449-x","DOIUrl":"10.1007/s00604-026-08449-x","url":null,"abstract":"<div><p>Au nanoparticle-loaded mixed-valence MnOₓ nanosheets were prepared as an oxidase-like nanozyme for colorimetric determination of leucomalachite green (LMG). The nanozyme oxidized colorless LMG to the strongly absorbing malachite green (MG) chromophore using dissolved molecular oxygen without externally added H₂O₂. The resulting MG produced a characteristic absorption band at 620 nm. Electron microscopy, elemental mapping, X-ray diffraction, and X-ray photoelectron spectroscopy confirmed crystalline Au nanodomains dispersed on a low-crystallinity mixed-valence MnO_x matrix. The catalytic response was maximal at pH 3.0 and reached a stable value within approximately 60 s. Initial-rate measurements showed apparent Michaelis–Menten behavior, with an apparent K_m of 39.2 µM and V_max of 0.0345 µM s⁻¹. Radical-scavenging and electron paramagnetic resonance experiments supported a multistep reactive-oxygen-species pathway involving hydroxyl radicals and singlet oxygen. The analytical response was linear over 30–1000 µg L⁻¹, with a detection limit of 2.1 µg L⁻¹. This corresponds to a theoretical fish-sample equivalent of 0.42 µg kg⁻¹ after sample concentration. Recoveries of 81.6–110.2% were obtained for fish and water samples. A positive fish sample gave 25.4 µg kg⁻¹ by the Au–MnO_x assay, in reasonable agreement with the HPLC result of 23.4 µg kg⁻¹.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From biomolecular recognition to bioinspired smart materials: engineering selectivity for chemical analysis","authors":"Elena Benito-Peña,&nbsp;Karsten Haupt","doi":"10.1007/s00604-026-08445-1","DOIUrl":"10.1007/s00604-026-08445-1","url":null,"abstract":"","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of unamplified mycobacterium tuberculosis genomic DNA in sputum samples using a metal-enhanced fluorescence-based biosensor","authors":"Tooba Radaei,&nbsp;Marziyeh Mousazadeh,&nbsp;Gholamreza Hamzehloo,&nbsp;Bita Bakhshi,&nbsp;Maryam Nikkhah","doi":"10.1007/s00604-026-08461-1","DOIUrl":"10.1007/s00604-026-08461-1","url":null,"abstract":"<div><p><i>Mycobacterium tuberculosis </i>the development of a metal-enhanced fluorescence (MEF)-based biosensor in this study enabled the detection of <i>Mycobacterium</i><i> tuberculosis</i> DNA extracted from sputum samples with high sensitivity and without the need for DNA amplification. The detection process involved the utilization of silver dendritic nanostructures, which were grown on the surface of silicon wafers and subsequently modified with a probe that was designed to target the specific DNA Insertion Element 6110 (IS6110) gene of <i>M. tuberculosis</i>. A comparison was made between the performance of the developed nanobiosensor and that of other methods, including smear, culture, PCR, and real-time PCR. A total of 385 (including 50 confirmed positive) sputum samples were examined. Of these, 8.8%, 10%, 11.9%, 13%, and 12% cases were confirmed positive by smear, culture, PCR, real-time PCR, and the developed nanobiosensor, respectively. The limit of detection was established at 2.9 × 10² copies for PCR and 2.9 × 10 copies for both real-time PCR and the nanobiosensor. The sensitivities of smear, culture, PCR, and the nanobiosensor, in comparison to GeneXpert MTB/RIF assay, were determined to be 68%, 78%, 86%, and 92%, respectively. The specificity of each method was 100%. The findings suggest that the developed nanobiosensor is a low-cost, accurate, and rapid tool for the detection of tuberculosis.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytosine compounds-modulated fluorescent CuNCs for fingerprint discrimination of tetracyclines antibiotics based on host-guest pattern recognition","authors":"Jing Zhu,&nbsp;Peiming Yang,&nbsp;Qinghong Zhang,&nbsp;Wenwu Wang","doi":"10.1007/s00604-026-08429-1","DOIUrl":"10.1007/s00604-026-08429-1","url":null,"abstract":"<div><p>Multiple CuNCs with modulable spectra were obtained by selecting nucleoside molecules as ligands. C-series CuNCs showed strong and discrepant emission intensities which were selected as the recognition elements of a three-channel fluorescent sensor array after surface modification with SH-β-cyclodextrin. Leveraging differences in host-guest recognition between various tetracyclines and the β-cyclodextrin cavity, the array generated distinct fluorescence response fingerprint patterns, enabling high-throughput discrimination of six structurally similar tetracycline antibiotics at different concentrations. Linear discriminant analysis revealed a linear relationship between the most influential discrimination factor and the antibiotic concentrations, allowing for highly sensitive and specific detection. And we obtained the satisfactory detection limits for tetracycline, aureomycin, oxytetracycline, doxycycline hydrochloride, minocycline and methacycline and they were 0.61 µM, 0.48 µM, 0.53 µM, 0.51 µM, 1.2 µM and 1.4 µM, respectively. Furthermore, the sensor array successfully identified spiked six antibiotics at different concentrations in environmental water and commercial milk samples, and achieved 100% accuracy in double-blind screening of unknown samples. This work provides an efficient sensing strategy for detecting structural analogs in complex matrices, with promising potential in environmental monitoring and food safety.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}