Microchimica Acta最新文献

{"title":"A rapid and on-site visual sensor for tobacco mosaic virus detection based on photocatalytic molecularly imprinted ZnO nanorods","authors":"Yong Li,&nbsp;Lingyun Wang,&nbsp;Tao Pang,&nbsp;Ning Jiang,&nbsp;Changqun Cai,&nbsp;Hang Gong","doi":"10.1007/s00604-026-07971-2","DOIUrl":"10.1007/s00604-026-07971-2","url":null,"abstract":"<div>\u0000 \u0000 <p>A photocatalytic molecularly imprinted sensor based on zinc oxide nanorods (ZnO NRs) for the visual detection of tobacco mosaic virus (TMV)TVM is reported. The sensor operates through virus-selective binding within molecularly imprinted cavities, which suppresses the photocatalytic degradation of Brilliant Green (BG) under visible light, enabling semi-quantitative visual readout within 5 min. The ZnO NRs serve a dual role as the photoactive transducer and structural scaffold, facilitating selective TMV recognition without requiring any biological reagents (e.g., antibodies or enzymes) or RNA extraction, aligning with the principles of reagent minimization and waste prevention in Green Analytical Chemistry (GAC). The entire analytical process is designed to be environmentally benign. For on-site application, a rapid screening protocol enables visual readout within 5 min without any instrumentation. This system achieves a detection limit of 0.96 pM, with recoveries of 93.7-106.4%. With a cost of only RBM 0.07 per test, the rapid visual protocol offers a scalable, farmer-friendly solution for rapid field detection of TMV, exemplifying a sustainable and green analytical workflow for enhancing crop protection and sustainable agriculture.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical Abstract\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fe/Co-MOF-based cascade biocatalytic platform for ultrasensitive detection of α-amylase","authors":"Huan Liu,&nbsp;Yanlin Wang,&nbsp;Chaoqian Wu,&nbsp;Wanqiu Huang,&nbsp;Yin Han,&nbsp;Shaoning Yu","doi":"10.1007/s00604-026-07993-w","DOIUrl":"10.1007/s00604-026-07993-w","url":null,"abstract":"<div>\u0000 \u0000 <p>A novel biosensor for detection of α-amylase, a key functional enzyme in <i>Daqu</i> fermentation, has been developed addressing the challenges of interference and inefficiency associated with conventional methods. In the multi-enzymes cascade system (Glu-GOx@MOF), the enzymes were immobilized on metal–organic frameworks (MOF) with excellent peroxidase-like activity through a covalent bonding method, enabling efficient and sensitive detection of α-amylase activity. Combining theoretical calculations with experiments, we have demonstrated that the Fe/Co-MOF possesses remarkable peroxidase-mimicking properties. Therefore, Fe/Co-MOF not only serves as a reliable carrier for multiple enzymes but also functions as a high-performance nanozyme in cascade reactions. Compared with natural enzymes, this biocatalytic platform exhibits excellent cascade catalytic activity and stability in various harsh environments. On this basis, a cascade biocatalytic platform for α-amylase detection was developed, demonstrating a wide linear range from 25 to 18,000 U L⁻¹ and a low detection limit of 10.8 U L⁻¹. This work not only provides a robust tool for α-amylase monitoring in food quality control but also establishes a novel cascade amplification strategy utilizing enzyme-MOF hybrid systems for biosensing applications.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical Abstract\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147588552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of a magnetic covalent organic framework for the extraction and detection of benzimidazole residues in food matrices by UPLC-MS/MS","authors":"Lian Xu,&nbsp;Muyi He,&nbsp;Xiujuan Wang,&nbsp;Xuesong Feng,&nbsp;Minli Yang,&nbsp;Wei Guo","doi":"10.1007/s00604-026-07981-0","DOIUrl":"10.1007/s00604-026-07981-0","url":null,"abstract":"<div>\u0000 \u0000 <p>A novel magnetic covalent organic framework was innovatively developed as a high-performance adsorbent for magnetic solid-phase extraction (MSPE) of benzimidazole veterinary drug residues in food matrices. The synthesized nanocomposite features a well-ordered core-shell architecture with a notable specific surface area and remarkable superparamagnetic behavior, facilitating rapid phase separation within 3 min under a magnetic field. Seven representative benzimidazoles (albendazole sulfoxide, fenbendazole sulfoxide, flubendazole, fenbendazole, cambendazole, cyclobendazole, albendazole sulfone) were selected to systematically evaluate the extraction efficiency and method performance. The material exhibited superior adsorption capacities (46.2–62.0 mg/g) through synergistic π-π conjugation, hydrogen-bonding, and hydrophobic interactions with benzimidazole moieties. Notably, the adsorbent maintained 90% of its initial capacity after six regeneration cycles, demonstrating excellent reusability. An innovative MSPE-UPLC-MS/MS methodology was established for detecting trace-level residual compounds in food matrices (milk and honey), with determination coefficient R² ≥ 0.991. The method achieved unprecedented sensitivity with detection limits of 0.015–0.131 µg/kg and quantification limits of 0.050–0.436 µg/kg. Validation studies showed satisfactory recoveries (83.67-102.96%) and good precision (RSD &lt; 8.63%) across four spiking levels.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical abstract\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147588553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Label matters: comparing gold nanoparticles and nanoshells with upconversion nanoparticles for quantitative lateral flow immunoassays","authors":"Eliška Macháčová,&nbsp;Jakub Máčala,&nbsp;Martin Kopecký,&nbsp;Saara Kuusinen,&nbsp;Tero Soukka,&nbsp;Zdeněk Farka","doi":"10.1007/s00604-026-08015-5","DOIUrl":"10.1007/s00604-026-08015-5","url":null,"abstract":"<div>\u0000 \u0000 <p>Lateral flow immunoassay (LFIA) is a widely used point-of-care method for both qualitative and semi- or fully quantitative detection of clinical biomarkers. There has, however, been limited data available on direct comparison of different types of labels in the LFIA for quantitative analysis using the same non-competitive assay setup. In this study, two groups of antibody-conjugated nanoparticle labels are compared: conventional gold nanostructures with densitometry readout and upconversion nanoparticles (UCNPs) suitable for sensitive luminescence readout. First, the LFIA procedure was optimized using human serum albumin (HSA) as an analyte. In the group of gold-based labels, standard gold nanoparticles were compared with gold nanoshells (AuNSs). In the case of UCNP labels, doping with Er³⁺ and Tm³⁺ and surface modifications based on poly(ethylene glycol) and poly(acrylic acid) (PAA) were compared. The best representatives—AuNSs and PAA-Tm UCNPs—were successfully used to detect human serum albumin (HSA) in spiked urine samples. To assess assay versatility, prostate-specific antigen (PSA) was detected in serum. While AuNSs tended to aggregate in serum, the PAA-Tm UCNPs maintained their stability and achieved the limit of detection of 34 pg/mL. Finally, spiked serum samples were analyzed to evaluate detection trueness, achieving a strong correlation with the reference concentrations (recoveries ranging from 82 to 118%). We showed that both label choice and sample matrix are critical: while AuNSs and PAA-Tm UCNPs performed well in urine, PAA-Tm UCNPs excelled in the more complex serum matrix. Thus, PAA-Tm UCNPs were found to be the most suitable labels for biomarker quantitation, highlighting the strong potential of UCNPs for sensitive LFIA applications.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical abstract\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 4","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00604-026-08015-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A low-background, high-output electrochemiluminescence aptasensor for ultrasensitive detection of small biomolecules","authors":"Jiaxuan Li,&nbsp;Hongjie Lin,&nbsp;Fei Yan,&nbsp;Liang Cui","doi":"10.1007/s00604-026-07914-x","DOIUrl":"10.1007/s00604-026-07914-x","url":null,"abstract":"<div>\u0000 \u0000 <p> Leveraging the specific recognition capability of aptamers and the robust signal output of the Ru(bpy)₃²⁺/TPrA ECL system, a series of ECL-based aptasensors ha been developed for the detection of crucial small biomolecules. However, limitations such as low quenching efficiency and consequently limited sensitivity persist in current methods. To address these challenges, we have developed a low-background, high-output ECL signaling strategy and applied it to constructing a highly sensitive ECL aptasensor. Using ATP as a model target, the Fc-labeled aptamer effectively quenches the ECL signal, achieving a low background in the absence of ATP. Upon ATP binding, a conformational change in the aptamer restores and significantly enhances the ECL signal from the Ru(bpy)₃²⁺ luminophores. In this way, we have effectively integrated the aptamer, which serves as a specific recognition unit for the target, with a low-background, high-output ECL signaling system. The proposed sensor exhibited a linear response for ATP detection in the concentration range 10 pM to 1 µM, with a detection limit of 3.5 pM, along with excellent selectivity. The practical applicability and accuracy of the sensor were further demonstrated in real sample analyses. This method shows great promise for a wide range of applications in fields such as disease diagnosis and medical research.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical abstract\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 4","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding chemical composition of urinary crystals from ultrasonic echo signals via deep learning","authors":"Badrinathan Sridharan,&nbsp;Maaz Salman,&nbsp;Yeong Seo Park,&nbsp;Eun Ju Lee,&nbsp;Soonhyuk Tak,&nbsp;Jegyeong Ryu,&nbsp;Junghwan Oh,&nbsp;Deukhee Lee,&nbsp;Hae Gyun Lim","doi":"10.1007/s00604-026-08019-1","DOIUrl":"10.1007/s00604-026-08019-1","url":null,"abstract":"<div>\u0000 \u0000 <p>Conventional analyses of urinary stones like estimation of urinary markers provide ambiguous predictions on the type of stone while XRD, and FT-IR can only be performed on surgically removed samples. Hence, current clinical practice lacks non-invasive methods for early and accurate classification of stones based on their composition. This study presents an ultrasound-based non-invasive system integrated with a machine-learning algorithm for analyzing acoustic signals to classify in vitro fabricated urinary crystals. Calcium oxalate, calcium phosphate, and uric acid crystals were synthesized, characterized, and embedded in gelatin-based gel phantoms. Following morphological characterization of the crystal-infused phantoms, ultrasonic echo signals were acquired and processed using machine learning-based analytical models. The results demonstrated that the ultrasound-based system effectively enables non-invasive analysis of urinary stones and can provide information on their location and structural characteristics. In parallel, the machine-learning component enhances diagnostic accuracy by classifying the stone composition from the analyzed acoustic signals, facilitating early and precise diagnosis. This approach highlights the potential of ultrasound and AI integration as a reliable diagnostic tool for personalized stone-management strategies.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical abstract\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 4","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulfur-doped iron-based nanoenzymes as excellent peroxidase mimics for norfloxacin detection and array-based recognition of quinolone antibiotics","authors":"Yanbin Wang,&nbsp;Liling Wang","doi":"10.1007/s00604-026-07999-4","DOIUrl":"10.1007/s00604-026-07999-4","url":null,"abstract":"<div><p>Nanoenzymes have emerged as a powerful alternative to natural enzymes due to their excellent chemical stability and simple synthesis process. In this study, sulfur-doped iron-based nanostructures (FeS₄-T) were synthesized through a one-step hydrothermal method under mild conditions. FeS₄-T exhibited strong peroxidase-like activity, and the addition of norfloxacin significantly enhanced the color response of TMB/H₂O₂/FeS₄-T. Thus, a rapid and sensitive method for detecting norfloxacin was developed with a linear range of 0.05–10 μmol·L⁻¹ and a detection limit of 2 nM. Moreover, various quinolones produced different absorbance changes at 652 nm and 370 nm, forming a unique dual-wavelength signal. Based on these patterns, a colorimetric array was developed to identify seven quinolones and their mixtures. The sulfur-doping strategy proposed provides a novel approach for the rational design of iron-based nanoenzymes and highlights its significant potential in the environmental monitoring of emerging pollutants.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 4","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual colorimetric-photothermal lateral flow immunoassay based on Au@Pt nanozymes for sensitive detection of cardiac troponin I","authors":"Haoyuan Tan,&nbsp;Xuefeng Cao,&nbsp;Chenchen Xu,&nbsp;Yufan Zhang,&nbsp;Haiyin Li,&nbsp;Hongyuan Yan,&nbsp;Ming Su","doi":"10.1007/s00604-026-08012-8","DOIUrl":"10.1007/s00604-026-08012-8","url":null,"abstract":"<div><p> A dual-signal lateral flow immunoassay (LFIA) was developed utilizing gold–platinum core–shell nanoparticles (Au@Pt NPs) for ultrasensitive cardiac troponin I (cTnI) detection. Owing to the synergistic electronic effects between the Au core and dendritic Pt shell, the Au@Pt NPs exhibit both high peroxidase-mimetic activity and a strong near-infrared photothermal effect. This allows for integrated colorimetric amplification and photothermal signal transduction within a single strip format. Under optimized conditions, the assay achieved a visual detection limit of 0.1 ng·mL⁻¹. Quantitative colorimetric determination yield limits of detection (LOD) of 0.044 ng·mL⁻¹ in PBS and 0.051 ng·mL⁻¹ in serum. Notably, the photothermal mode demonstrated exceptional matrix resilience, maintaining nearly identical LODs in PBS (0.036 ng·mL⁻¹) and serum (0.037 ng·mL⁻¹) over a linear range of 0.1–10 ng·mL⁻¹. This matrix-resilient performance is attributed to the thermophysical confinement effect of the biological matrix, which enhances the sensitivity slope in complex media. Overall, the proposed dual-mode LFIA provides a robust, pretreatment-free diagnostic tool that combines rapid visual screening with precise quantitative analysis, supporting early, point-of-care assessment of myocardial injury.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 4","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A quinolinium-based fluorescent probe with high quantum yield for bisulfite detection and its applications in food testing, solid-phase immobilization, smartphone-assisted portable detection, and cell imaging","authors":"Ruiqi Ren,&nbsp;Long Wang,&nbsp;Ziqi Ma,&nbsp;Mingyu Tian,&nbsp;Tianyu Liang,&nbsp;Chengyan Wu,&nbsp;Lijun Tang,&nbsp;Yang Li,&nbsp;Keli Zhong,&nbsp;Xiaomei Yan","doi":"10.1007/s00604-026-08006-6","DOIUrl":"10.1007/s00604-026-08006-6","url":null,"abstract":"<div>\u0000 \u0000 <p>To achieve rapid and accurate detection of bisulfite (HSO₃⁻), we developed two novel fluorescent probes, <b>PTQ</b> and <b>PSQ</b>, featuring large Stokes shifts, a broad detection range, and high fluorescence quantum yields, based on intramolecular charge transfer mechanism. Among them, <b>PTQ</b> exhibits superior selectivity and sensitivity, accompanied by a distinct color change and a strong turn-on fluorescence response upon recognition of HSO₃⁻. Leveraging these properties, <b>PTQ</b> enables the effective detection of HSO₃⁻ in food samples. Furthermore, we constructed test strips, agarose gels, and a smartphone-assisted detection platform for the on-site monitoring of SO₂ gas and HSO₃⁻ in aqueous solutions, and preliminarily explored the potential application of <b>PTQ</b> as an anti-counterfeiting ink. Notably, <b>PTQ</b> also possesses mitochondria-targeting ability, enabling the visualization and imaging of exogenous and endogenous bisulfite in live cells and zebrafish. This work highlights the versatile potential of <b>PTQ</b> in environmental monitoring, food safety inspection, and bioimaging, providing a powerful tool for detecting SO₂ derivatives from abiotic samples to living organisms.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical Abstract\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 4","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel low-cost periodic and flexible SERS substrate fabrication via soft lithography and glancing angle deposition technique","authors":"Nidhi Mehta,&nbsp;Kanchan Saxena,&nbsp;Gourav Debnath,&nbsp;Lalit Mohan Kandpal,&nbsp;Dalip Singh Mehta","doi":"10.1007/s00604-026-07995-8","DOIUrl":"10.1007/s00604-026-07995-8","url":null,"abstract":"<div>\u0000 \u0000 <p>A highly periodic, low cost, scalable and flexible SERS substrate fabricated via soft lithography and glancing angle deposition (GLAD) technique is reported. The present approach relies on utilizing periodic data writing tracks of a used Blu-ray disk as a template to replicate intrinsic periodic pattern over polydimethylsiloxane (PDMS) films followed by the growth of ordered arrays of silver (Ag) nanostructures via GLAD technique. The resulting periodic array of Ag nanostructures with ~ 270 nm spacing, generates dense electromagnetic (EM) hotspots resulting in EM field enhancement thereby surface-enhanced Raman scattering (SERS) through localized surface plasmon resonance (LSPR) effect. Thiram was used as an analyte to determine the sensitivity of the fabricated SERS substrate. The statistically calculated value of limit of detection (LOD) for thiram is 1.99 × 10^–17 M. The analytical enhancement factor for the most intense Raman band of thiram is 1.2 × 10⁹. The number of molecules based enhancement factor for the prominent vibrational band (1513 cm^-1) of rhodamine 6G (R6G) is 1.054 × 10⁷. These substrates exhibited excellent reproducibility (RSD ~ 7.26%), repeatability (RSD ~ 5.85%) and long-term stability (90% signal retention under 30 days vacuum storage). The good mechanical strength of the substrate is supported by the signal retention of 90.31% under tensile strain of 26% and 58.7% of signal retention after one complete cycle of bending and releasing to original state. Thus, the fabricated substrate demonstrates a strong potential as an efficient ‘<i>paste-and-peel’</i> SERS platform for analyte detection on topologically curved surfaces.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical Abstract\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 4","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}