A novel dual-ligand luminescent Eu-based metal-organic framework for ratiometric fluorescence sensing and visual detection of tetracycline

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2025-09-04 DOI:10.1007/s00604-025-07401-9

Qi Cao, Songrui Li, Jiutong Ma, Qiong Jia

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Abstract

Tetracycline (TC) residues in animal-derived food pose a significant threat to human health, necessitating the development of straightforward and user-friendly methods for TC detection to safeguard food safety. Here, a series of novel Eu-based metal-organic frameworks (Eu-MOFs) were prepared using a dual-ligand strategy. In the midst of these Eu-MOFs, Eu-ABPDC_0.6/BPDC_0.4 exhibits the dual emission at 472 and 619 nm under single-wavelength excitation, enabling highly effective ratiometric fluorescence sensing of TC. Notably, the sensor presents favorable performance characteristics, including rapid response (90 s), high specificity, broad linear range (0.1–200 μM), and low detection limit (0.081 μM). Furthermore, based on the attractive performance of Eu-ABPDC_0.6/BPDC_0.4, it was further combined with carrageenan to prepare a hydrogel assay kit for onsite, smartphone-assisted visualization and quantitative detection of TC.

Graphical Abstract

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一种用于四环素比例荧光传感和视觉检测的新型双配体发光铕金属有机骨架

动物源性食品中的四环素残留对人类健康构成重大威胁，因此有必要开发简单易用的四环素检测方法，以保障食品安全。本文采用双配体策略制备了一系列新型铕基金属有机骨架（Eu-MOFs）。在这些eu - mof中，Eu-ABPDC0.6/BPDC0.4在单波长激发下表现出472和619 nm的双发射，实现了高效的TC比例荧光传感。该传感器具有响应速度快（90 s）、特异度高、线性范围宽（0.1 ~ 200 μM）、检出限低（0.081 μM）等特点。此外，基于Eu-ABPDC0.6/BPDC0.4的优异性能，我们进一步将其与卡拉胶结合，制备了一种用于现场、智能手机辅助可视化和定量检测TC的水凝胶检测试剂盒。图形抽象

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.