Microchimica Acta最新文献_第9页

Sorbent magnetic levitation in the 3D printed platform 吸附剂悬浮在3D打印平台上

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-04-08 DOI: 10.1007/s00604-025-07116-x

Olga Mokhodoeva, Valeriia Maksimova, Tatiana Danilova, Denis Trofimov, Artem Krivenko, Valery Shkinev

{"title":"Sorbent magnetic levitation in the 3D printed platform","authors":"Olga Mokhodoeva, Valeriia Maksimova, Tatiana Danilova, Denis Trofimov, Artem Krivenko, Valery Shkinev","doi":"10.1007/s00604-025-07116-x","DOIUrl":"10.1007/s00604-025-07116-x","url":null,"abstract":"<div><p>The emerging technologies based on magnetic levitation and 3D printing manufacturing were utilized to create a sorbent retention platform as an alternative to traditional packed columns. The magnetic nanoscale sorbent was suspended in the aqueous solution in a 3D printed sorption cell placed between two permanent magnets. Simulations of hydrodynamic fluid and magnetic field were carried out to optimize the configuration and positioning of the sorption cell. The developed platform ensures uniform distribution of the sorbent in the cell’s volume and retention under dynamic conditions. The efficiency of palladium solid-phase extraction in a flow mode was demonstrated using modified magnetite nanoparticles. A high concentration factor can be achieved using the spiral shape of the cell with 50–100 mg of the suspended sorbent. The results of the spectrometric determination of trace amounts of palladium in natural water are given. An automated system for environmental analysis based on the proposed platform is promising. </p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transfer learning and data augmentation for glucose concentration prediction from colorimetric biosensor images 从比色生物传感器图像中预测葡萄糖浓度的迁移学习和数据增强

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-04-08 DOI: 10.1007/s00604-025-07136-7

Ga-Young Choi, Na-Ri Kim, Da-Young Yu, Taeha Lee, Gyudo Lee, Han-Jeong Hwang

{"title":"Transfer learning and data augmentation for glucose concentration prediction from colorimetric biosensor images","authors":"Ga-Young Choi, Na-Ri Kim, Da-Young Yu, Taeha Lee, Gyudo Lee, Han-Jeong Hwang","doi":"10.1007/s00604-025-07136-7","DOIUrl":"10.1007/s00604-025-07136-7","url":null,"abstract":"<div><p> A deep learning algorithm is introduced to accurately predict glucose concentrations using colorimetric paper sensor (CPS) images. We used an image dataset from CPS treated with five different glucose concentrations as input for deep learning models. Transfer learning was performed by modifying four established deep learning models—ResNet50, ResNet101, GoogLeNet, and VGG-19—to predict glucose concentrations. Additionally, we attempted to alleviate the challenge of requiring the large amount of training data by applying data augmentation techniques. Prediction performance was evaluated using coefficients of determination (<i>R</i><sup>2</sup>), root mean squared error (RMSE), and relative-RMSE (rRMSE). GoogLeNet showed the highest coefficient of determination (<i>R</i><sup>2</sup> = 0.994) and significantly lower prediction errors across all concentration levels compared with a traditional machine learning approach (two-sample <i>t</i>-test, <i>p</i> < 0.001). When data augmentation was performed using 20% of the entire training dataset, the mean prediction error was comparable to that of the original entire training dataset. We presented a novel approach for glucose concentration prediction using deep learning techniques based on transfer learning and data augmentation with image data. Our method uses images from CPS as input and eliminates the need for separate feature extraction, simplifying the prediction process.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porous GNPs assisted LAMP-CRISPR/Cas12a amperometric biosensor as a potential point of care testing system for SARS-CoV-2 多孔GNPs辅助LAMP-CRISPR/Cas12a安培生物传感器作为潜在的SARS-CoV-2护理点检测系统

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-04-07 DOI: 10.1007/s00604-025-07094-0

Mohammad Behnam Rad, Seyed Reza Mohebbi, Abbas Yadegar, Hedayatollah Ghourchian

{"title":"Porous GNPs assisted LAMP-CRISPR/Cas12a amperometric biosensor as a potential point of care testing system for SARS-CoV-2","authors":"Mohammad Behnam Rad, Seyed Reza Mohebbi, Abbas Yadegar, Hedayatollah Ghourchian","doi":"10.1007/s00604-025-07094-0","DOIUrl":"10.1007/s00604-025-07094-0","url":null,"abstract":"<div><p>A simple and ultrasensitive amperometric biosensor is introduced which has the potential to be applied as a point of care test for SARS-CoV-2 monitoring. It was prepared by integrating the reverse transcription loop-mediated isothermal amplification (RT‑LAMP) and CRISPR/Cas12a nuclease activity on a modified gold screen-printed electrode (GSPE). The GSPE is modified with double-end thiolated oligonucleotide reporters conjugated to porous gold nanoparticles (PGNPs) and inserted into a homemade poly-methyl methacrylate cartridge. This biosensor was integrated with a low-cost electronic kit to make a platform with the potential to be applied as a point-of-care testing system. The PGNPs on the reporters create a dense, negatively charged barrier that repels the redox couple of [Fe(CN)<sub>6</sub>]<sup>3−/4−</sup> from the GSPE surface. Upon the addition of a real sample, followed by LAMP amplification and Cas12a nuclease activity on disposable GSPE, in the presence of SARS-CoV-2, the single-guide RNA binds to the target sequence and activates Cas12a. The activated Cas12a then cleaves the reporters, releasing the PGNPs. This removal of electrostatic hindrance allows the redox couple of [Fe(CN)<sub>6</sub>]<sup>3−/4−</sup> to approach the positively charged GSPE, enhancing the amperometric signal. This biosensor offers an outstanding detection limit of 143 zM (~ 86 copies/mL) and a linear response from 4.7 to 7062 aM for SARS-CoV-2 real samples. By using double-end thiolated reporters and porous GNPs, this novel testing system makes it possible to minimize the required sample volume and reagent costs.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical luminescence sensor for the detection of Allure Red: double luminescence cooperative amplification strategy of self-supporting material Zn3Cu2O2 and CdTe@MWNTs 用于检测诱惑红的电化学发光传感器：自支撑材料 Zn3Cu2O2 和 CdTe@MWNTs 的双发光协同放大策略

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-04-07 DOI: 10.1007/s00604-025-07137-6

Ruidan Li, Li Tian, Yujia Song, Yanjia Guo, Guangping Ma, Pengfei Han, Hanyue Jiang, Wenzhuo Wang, Juan Lu

引用次数: 0

Adjustable crystallinity of covalent organic frameworks for electrochemical aptasensing of penicillin 用于青霉素电化学适配的共价有机框架的可调结晶度

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-04-07 DOI: 10.1007/s00604-025-07133-w

Haimei Qin, Huaqing Liang, Siyu Liao, Youjiang Tan, Yuehua Huang, Ziao Zong, Rong Wang, Jing Wang

引用次数: 0

Simultaneous enrichment and ultra-high sensitivity detection of multi-structural synthetic cannabinoids in large-volume wastewater 大容量废水中多结构合成大麻素的同时富集及超高灵敏度检测

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-04-07 DOI: 10.1007/s00604-025-07128-7

Rui Cao, Jiawei Chen, Ningjia Pang, Siyu Li, Mengyi Chen, Bin Di, Deli Xiao

{"title":"Simultaneous enrichment and ultra-high sensitivity detection of multi-structural synthetic cannabinoids in large-volume wastewater","authors":"Rui Cao, Jiawei Chen, Ningjia Pang, Siyu Li, Mengyi Chen, Bin Di, Deli Xiao","doi":"10.1007/s00604-025-07128-7","DOIUrl":"10.1007/s00604-025-07128-7","url":null,"abstract":"<div><p>Nowadays, the abuse of synthetic cannabinoids has aroused the world’s great attention. However, the determination of synthetic cannabinoids in wastewater faces the bottleneck of complex species and very low content. Therefore, this work integrated GO-Fe<sub>3</sub>O<sub>4</sub> with an ionic liquid (ILs-GO-Fe<sub>3</sub>O<sub>4</sub>) to create a mixed hemimicelles magnetic solid-phase extraction (MHMSPE) system for the detection of synthetic cannabinoids (SCs) in wastewater samples using ultrahigh-performance liquid chromatography—tandem mass spectrometry (UHPLC-MS/MS). Because of the multiple interaction sites of mixed hemimicelles’ magnetic solid-phase extraction materials, multi-structural synthetic cannabinoids can be enriched simultaneously. Under the optimized conditions, the limits of quantitation (LOQ) of the method were as low as 10–50 pg/L, lower than other methods. The average recoveries of 18 analytes were in the range 71.23–96.08% with relative standard deviations (RSD) lower than 15% (<i>n</i> = 6). To our knowledge, this is the first development of magnetic solid-phase extraction for large-volume samples pretreatment (1 L) and ultra-high sensitive detection of synthetic cannabinoids (10 pg/L), due to the high enrichment factor (10,000-fold). The extraction process was convenient, accurate, and rapid, and offers significant potential for ultra-high sensitivity detection in large-volume samples, providing a valuable tool for simultaneous broad-spectrum extraction and drug abuse monitoring.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-driven in situ deposited Au nanoparticles on ZnO substrate with ultrasensitive SERS enhancement for molecular detection 用超灵敏SERS增强技术在ZnO衬底上原位沉积Au纳米颗粒，用于分子检测

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-04-06 DOI: 10.1007/s00604-025-07118-9

Apichaya Chantaraklud, Chanoknan Rattanabut, Suwussa Bamrungsap, Tanujjal Bora

{"title":"Light-driven in situ deposited Au nanoparticles on ZnO substrate with ultrasensitive SERS enhancement for molecular detection","authors":"Apichaya Chantaraklud, Chanoknan Rattanabut, Suwussa Bamrungsap, Tanujjal Bora","doi":"10.1007/s00604-025-07118-9","DOIUrl":"10.1007/s00604-025-07118-9","url":null,"abstract":"<div><p>Uniform, reproducible and stable SERS substrates with high detection sensitivity are crucial for their successful commercial applications. Here, we introduce a plasmonic SERS substrate based on gold nanoparticles (AuNPs) fabricated by using a straightforward light-driven in-situ method for highly sensitive molecular detection. A dense array of zinc oxide nanorods (ZnO NRs) was used as a support surface for the in-situ growth of Au nanoparticles (AuNPs). The SERS performance of the fabricated Au-ZnO substrates was evaluated by using rhodamine 6G (R6G) dye as a model Raman probe, where the distribution of the AuNPs on the substrate was found to play an important role defining the SERS activities The Au-ZnO substrates exhibited exceptional homogeneity (RSD = 3.95%), a detection limit (LOD) of 9 × 10<sup>–11</sup> M, and signal enhancement in the order of 10<sup>6</sup>. Additionally, these substrates demonstrated good stability over a period of 4 weeks when stored under standard room conditions, maintaining more than 80% of the initial Raman signal intensity. When tested for antibiotic residue detection in water using amoxicillin as a model antibiotic, the Au-ZnO substrates revealed LOD in the order of 10<sup>–9</sup> M with linear detection over a wide concentration range of amoxicillin in water. The present work offers a straightforward and inexpensive solution-processed fabrication approach for SERS substrates that holds great potential for the development of extremely sensitive and reliable SERS-based detection and sensor systems.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterials functionalized signal-ON/OFF electrogenerated chemiluminescence biosensor for quantization of trypsin based on target-induced cleavage of peptide 纳米功能化信号-开关电致发光生物传感器用于胰蛋白酶的靶诱导裂解

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-04-04 DOI: 10.1007/s00604-025-07131-y

Shuo Kang, Ronghan Qu, Yuhong Duan, Jiale Yang, Fen Ma

{"title":"Nanomaterials functionalized signal-ON/OFF electrogenerated chemiluminescence biosensor for quantization of trypsin based on target-induced cleavage of peptide","authors":"Shuo Kang, Ronghan Qu, Yuhong Duan, Jiale Yang, Fen Ma","doi":"10.1007/s00604-025-07131-y","DOIUrl":"10.1007/s00604-025-07131-y","url":null,"abstract":"<div><p>Trypsin (TPN) is an important proteolytic enzyme in the digestive system and its abnormal levels are indicative of some pancreatic diseases. As an endopeptidase, TPN can cleave substrate peptide mainly by catalyzing the hydrolysis of the carboxyl side peptide bond of lysine (K) or arginine (R) residues. Based on this hydrolysis cleavage effect, two kinds of nanomaterials functionalized electrogenerated chemiluminescence (ECL) biosensors for the determination of TPN were designed as follows: A signal-ON ECL biosensor was fabricated by attaching substrate peptide (HWR*GWVC, “*” representing the cleavage site, abbreviated as HGC) labeled with ferrocene carboxylic acid (as quencher) onto the surface of NH<sub>2</sub>-MIL-53(Al) film which was incorporated with ECL emitting species (bis (2,2′-bipyridine)-4′-methyl-4-carboxybipyridine-ruthenium (N-succinimidylester)-bis (hexafluorophosphate) (Ru complex)). The presence of tryptic cleavage event can eventually lead the Fc complex to leave the electrode and results in the increase of the ECL intensity. HGC labeled with Ru-Ti<sub>3</sub>C<sub>2</sub>T<sub><i>x</i></sub>-AuNP complex was used as capture probe and signal probe, which was attached onto NH<sub>2</sub>-MIL-53(Al) film modified glassy carbon electrode. A signal-OFF ECL biosensor was built as described above. The presence of TPN lead the Ru-Ti<sub>3</sub>C<sub>2</sub>T<sub><i>x</i></sub>-AuNPs to leave the electrode, which resulted in the decreasing ECL intensity. As expected, the fabricated ECL biosensing methods provide excellent sensitivity and selectivity toward the TPN activity. Thus, this strategy shows great potential application in the clinic for diagnosis of TPN-indicating diseases as well as the screening of TPN inhibitor-based anti-cancer drugs.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143769687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A highly selective electrochemical aptasensor for Pb2+ based on molecular imprinting technology and tetrahedral DNA nanostructure 基于分子印迹技术和四面体DNA纳米结构的Pb2+高选择性电化学配体传感器

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-04-02 DOI: 10.1007/s00604-025-07101-4

Jiaqi Han, Nianxin Zhu, Jiahao Sha, Jinyan Cai, Hui Cao, Tai Ye, Liling Hao, Fei Xu

{"title":"A highly selective electrochemical aptasensor for Pb2+ based on molecular imprinting technology and tetrahedral DNA nanostructure","authors":"Jiaqi Han, Nianxin Zhu, Jiahao Sha, Jinyan Cai, Hui Cao, Tai Ye, Liling Hao, Fei Xu","doi":"10.1007/s00604-025-07101-4","DOIUrl":"10.1007/s00604-025-07101-4","url":null,"abstract":"<div><p> A novel electrochemical biosensor for the detection of lead ions (Pb<sup>2+</sup>) with improved specificity and sensitivity was developed. The sensor design incorporated molecular imprinting technology, where chitosan was polymerized on the electrode surface to form a lead-specific cavity structure, thereby enhancing selectivity in complex sample matrices. Meanwhile, the tetrahedral DNA nanostructure was employed as the recognition probe to mitigate the entanglement issues commonly associated with single-stranded DNA, thus improving the sensitivity of the detection. The developed sensor exhibited a linear dynamic range from 0.050 to 2.000 μg/mL, with a limit of detection (LOD) of 0.0034 μg/mL. The aptasensor’s efficacy was verified through the analysis of aquatic samples, demonstrating a high degree of reliability comparable to that of inductively coupled plasma mass spectrometry (ICP-MS).</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silica-based optical chemosensors for rapid and reliable on-site detection of gamma-hydroxybutyrate in beverages and oral fluids 用于快速可靠现场检测饮料和口服液中γ -羟基丁酸的硅基光学化学传感器

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-04-02 DOI: 10.1007/s00604-025-07134-9

Jordi Hernández-Contreras, Jordi Roig-Rubio, Margarita Parra, Salvador Gil, Pau Arroyo, José A. Sáez, Carlos Lodeiro, Pablo Gaviña

{"title":"Silica-based optical chemosensors for rapid and reliable on-site detection of gamma-hydroxybutyrate in beverages and oral fluids","authors":"Jordi Hernández-Contreras, Jordi Roig-Rubio, Margarita Parra, Salvador Gil, Pau Arroyo, José A. Sáez, Carlos Lodeiro, Pablo Gaviña","doi":"10.1007/s00604-025-07134-9","DOIUrl":"10.1007/s00604-025-07134-9","url":null,"abstract":"<div><p>The illicit use of gamma-hydroxybutyrate (GHB) in drug-facilitated crimes underscores the urgent need for rapid and reliable detection technologies. This study introduces two innovative silica-based nanosensors that offer real-time, on-site detection of GHB in spiked beverages at concentrations typical of chemical submission cases. Both chemosensors are based on silica nanoparticles functionalized with 2-aminonaphtoxazole derivatives. The first nanosensor, modified with a <i>p</i>-nitroaniline chromogenic unit, enables a visible color change for immediate visual identification, while the second incorporates a fluorescein derivative for high-sensitivity detection via fluorescence. Both nanosystems demonstrate exceptional specificity to GHB, with minimal interference from other substances. Moreover, the solid-phase integration of these nanosensors onto hydrophobic cellulose-based substrates enhances their portability and user-friendliness, making them suitable for nightlife venues and forensic applications. Finally, chromogenic precursor <b>1</b> has proven to be an excellent chemosensor for the visual detection of GHB in oral fluid, with a calculated LOD of 19.2 μM, and a linear response in the 32–132 μM range.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00604-025-07134-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0