Microchimica ActaPub Date : 2025-03-03DOI: 10.1007/s00604-025-07057-5
Emmanuel Chigozie Aham, A. Ravikumar, Kun Zeng, A. Arunjegan, G. Tamilselvan, Zhang Hu, Zhen Zhang, Hongjun Zhao
{"title":"Intelligent hydrogel and smartphone-assisted colorimetric sensor based on Bi-metallic organic frameworks for effective detection of kanamycin and oxytetracycline","authors":"Emmanuel Chigozie Aham, A. Ravikumar, Kun Zeng, A. Arunjegan, G. Tamilselvan, Zhang Hu, Zhen Zhang, Hongjun Zhao","doi":"10.1007/s00604-025-07057-5","DOIUrl":"10.1007/s00604-025-07057-5","url":null,"abstract":"<div><p> A smartphone-integrated colorimetric sensor is introduced for the rapid and simultaneous detection of kanamycin (KAN) and oxytetracycline (OTC). This sensor relies on the peroxidase-mimicking activity of Fe/Zr Bi-metallic organic frameworks (UIO-66(Fe/Zr)-NH<sub>2</sub>). This Bi-metallic MOF can facilitate the oxidation of a colorless substrate, 3,3′,5,5′-tetramethylbenzidine (TMB), by reactive oxygen species (ROS) derived from hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), resulting in the formation of blue-colored oxidized TMB (ox-TMB). Consequently, Fe/Zr MOF was utilized for the detection of KAN and OTC under optimized conditions. In the presence of KAN and OTC, the interaction between TMB and H<sub>2</sub>O<sub>2</sub> is inhibited, resulting in varying colorimetric responses. The approach accurately measured KAN and OTC, with detection limits as low as 0.44 and 6.86 nM, respectively. To achieve real-time and portable analysis even in harsh conditions, the proposed sensor was integrated with hydrogel-assisted smartphone technology thereby eliminating the need for expensive and cumbersome laboratory-based testing apparatus. Furthermore, the sensor was successfully used for real water sample analysis, with good recovery results. The proposed sensor provides a quick, visual, and highly sensitive approach for the simultaneous and accurate determination of KAN and OTC residues in polluted water, even at trace quantities. This study advances the application of MOF-based nanozymes in environmental monitoring, while also offering extensive opportunities for use in other fields.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 3","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metal–organic framework-based SERS probes with enrichment capability for trace detection: applications in biomarkers and pollutants","authors":"Yanxiao Quan, Guojun Weng, Jian Zhu, Jianjun Li, Junwu Zhao","doi":"10.1007/s00604-025-07055-7","DOIUrl":"10.1007/s00604-025-07055-7","url":null,"abstract":"<div><p>Surface-enhanced Raman scattering (SERS) has emerged as a powerful tool for trace substances detection due to its exceptional sensitivity, high anti-interference capability, and ease of operation, enabling detection at the single-molecule level. This makes SERS particularly promising for applications such as environmental monitoring, biomedical diagnostics, and food safety. Despite these advantages, SERS faces limitations due to the difficulty of enriching trace substances and the small Raman scattering cross sections of certain molecules. Metal–organic frameworks (MOFs), characterized by their high surface areas and porosity, tunable structures, and diverse functionalities, offer a promising solution to these challenges. By integrating MOFs with SERS technology, we explore how MOF-based SERS probes can enhance the sensitivity, selectivity, and efficiency of trace substance detection through mechanisms such as analyte enrichment, selective molecular capture, and electromagnetic field manipulation. In this paper, a comprehensive review of the structure and synthesis of MOF-SERS composites is presented, with an emphasis on their application in the detection of trace substances. The paper also discusses key challenges in the design and optimization of MOF-based SERS probes, particularly in terms of stability, reproducibility, and integration with existing detection platforms, aiming to broaden their practical applications and improve their detection efficiency.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 3","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Microchimica ActaPub Date : 2025-03-03DOI: 10.1007/s00604-025-06955-y
Samaneh Mirsian, Wolfgang Hilber, Ehsan Khodadadian, Maryam Parvizi, Amirreza Khodadadian, Seyyed Mehdi Khoshfetrat, Clemens Heitzinger, Bernhard Jakoby
{"title":"Graphene-based FETs for advanced biocatalytic profiling: investigating heme peroxidase activity with machine learning insights","authors":"Samaneh Mirsian, Wolfgang Hilber, Ehsan Khodadadian, Maryam Parvizi, Amirreza Khodadadian, Seyyed Mehdi Khoshfetrat, Clemens Heitzinger, Bernhard Jakoby","doi":"10.1007/s00604-025-06955-y","DOIUrl":"10.1007/s00604-025-06955-y","url":null,"abstract":"<p>Graphene-based field-effect transistors (GFETs) are rapidly gaining recognition as powerful tools for biochemical analysis due to their exceptional sensitivity and specificity. In this study, we utilize a GFET system to explore the peroxidase-based biocatalytic behavior of horseradish peroxidase (HRP) and the heme molecule, the latter serving as the core component responsible for HRP’s enzymatic activity. Our primary objective is to evaluate the effectiveness of GFETs in analyzing the peroxidase activity of these compounds. We highlight the superior sensitivity of graphene-based FETs in detecting subtle variations in enzyme activity, which is critical for accurate biochemical analysis. Using the transconductance measurement system of GFETs, we investigate the mechanisms of enzymatic reactions, focusing on suicide inactivation in HRP and heme bleaching under two distinct scenarios. In the first scenario, we investigate the inactivation of HRP in the presence of hydrogen peroxide and ascorbic acid as cosubstrate. In the second scenario, we explore the bleaching of the heme molecule under conditions of hydrogen peroxide exposure, without the addition of any cosubstrate. Our findings demonstrate that this advanced technique enables precise monitoring and comprehensive analysis of these enzymatic processes. Additionally, we employed a machine learning algorithm based on a multilayer perceptron deep learning architecture to detect the enzyme parameters under various chemical and environmental conditions. Integrating machine learning and probabilistic methods significantly enhances the accuracy of enzyme behavior predictions.</p>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 3","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00604-025-06955-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Microchimica ActaPub Date : 2025-03-03DOI: 10.1007/s00604-024-06867-3
Tanjib Ahmed, Md. Kamal Hosain, Abbas Z. Kouzani
{"title":"Highly sensitive SPR sensor employing zinc selenide, silver nanocomposite, and lead titanate for the detection of cancer cells","authors":"Tanjib Ahmed, Md. Kamal Hosain, Abbas Z. Kouzani","doi":"10.1007/s00604-024-06867-3","DOIUrl":"10.1007/s00604-024-06867-3","url":null,"abstract":"<p>This paper presents the design and evaluation of an optimized prism-based surface plasmon resonance (SPR) biosensor for the early detection of various cancer types. The Kretschmann configuration–based SPR sensor integrates multiple novel layers, including silver (Ag), zinc selenide (ZnSe), lead telluride (PbTiO<span>(_3)</span>), and silver nanocomposite layers. The SPR sensor is analyzed with angular interrogation analysis, which utilizes the attenuated total reflection (ATR) approach for investigating the refractive index component and detecting different forms of cancer cells. The design and performance evaluation are realized using the finite element method (FEM). The sensor can identify skin, cervical, blood, adrenal gland, breast (type I), and breast (type II) cancer with a sensitivity of 200.54°/RIU, 262.61°/RIU, 286.48°/RIU, 327.41°/RIU, 409.26°/RIU, and 427.72°/RIU, respectively. It exhibits a detection accuracy of 2 and a maximum quality factor of 107.14 RIU<span>(^{-1})</span>. In comparison with earlier research studies, a notable improvement in performance is demonstrated through the numerical analysis of the sensor properties.</p><p>Graphical abstract of the proposed sensor structure</p>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 3","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Microchimica ActaPub Date : 2025-03-03DOI: 10.1007/s00604-025-07071-7
A. Joel Amalan, S. Gopika Devi, M. Kanagalakshmi, Anitha Pius
{"title":"Role of π-π stacking and synergistic interactions in the colorimetric detection of Malachite Green using Zeolitic Imidazolate Framework incorporated with silver-doped Graphitic Carbon Nitride (ZIF-67@Ag-g-C3N4) based composite","authors":"A. Joel Amalan, S. Gopika Devi, M. Kanagalakshmi, Anitha Pius","doi":"10.1007/s00604-025-07071-7","DOIUrl":"10.1007/s00604-025-07071-7","url":null,"abstract":"<div><p> The facile synthesis is demonstrated of a composite consisting of Zeolitic Imidazolate Framework incorporated with Silver-doped Graphitic Carbon Nitride (ZIF-67@Ag-g-C<sub>3</sub>N<sub>4</sub>) for the sensitive and selective detection of Malachite Green (MG) through spectrophotometry and colorimetry. The composite was prepared through hydrothermal treatment of ZIF-67 and Ag-g-C<sub>3</sub>N<sub>4</sub>, with the latter two being prepared via mechanical stirring and calcination, respectively. Various techniques were used to examine the structural and morphological characteristics of ZIF-67@Ag-g-C<sub>3</sub>N<sub>4</sub>. The average particle size of the composite material was found to be 0.488 µm. ZIF-67@Ag-g-C<sub>3</sub>N<sub>4</sub> demonstrated enhanced colorimetric sensing of MG, attributed to the π-π stacking and synergistic interactions between ZIF-67 and Ag-g-C<sub>3</sub>N<sub>4</sub>, revealing a detection limit of MG as low as 12.72 µM. With its versatile and efficient approach to detect MG contamination from several kinds of water sources, the developed composite material represented an exciting breakthrough in environmental monitoring.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 3","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Microchimica ActaPub Date : 2025-03-01DOI: 10.1007/s00604-025-07061-9
Jiahao Yang, Lan Xu
{"title":"NiCu-layered double hydroxide–modified CuO nanorods for enhanced non-enzymatic glucose sensing","authors":"Jiahao Yang, Lan Xu","doi":"10.1007/s00604-025-07061-9","DOIUrl":"10.1007/s00604-025-07061-9","url":null,"abstract":"<div><p>A flexible non-enzymatic glucose sensor with high sensitivity (NiCu-LDH/CuO/NCC) was prepared by growing NiCu-layered double hydroxide (NiCu-LDH)–modified CuO nanorods on N-doped carbon cloth (NCC) using hydrothermal method and electrodeposition. The NCC provided abundant attachment sites and good electrical conductivity for CuO nanorods, and the hierarchical nanostructures (NiCu-LDH/CuO) had large specific surface area and highly catalytic active sites, which facilitated the electrooxidation of glucose. The effect of the ratio of Ni to Cu on the electrocatalytic performance of NiCu-LDH/CuO/NCC was evaluated. The results indicated that the optimized NiCu-LDH/CuO/NCC (Ni/Cu molar ratio of 2:1) had good electrocatalytic oxidation toward glucose, and exhibited high sensitivity (11.545 mA cm<sup>−2</sup> mM<sup>−1</sup>), low detection limit (0.26 μM), large linear range (0.001–1.5 mM), and good stability (95% after 28 days). Therefore, the hierarchical nanostructure is suitable for the construction of flexible non-enzymatic glucose sensors with high sensitivity, indicating that the combination of transition metal oxides and LDH provides a unique opportunity for designing high-performance electrochemical non-enzymatic glucose sensors.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 3","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sensitive colorimetric sensing of dopamine and TYR based on enhanced HRP-like activity of CuNi/Fe LDHs nanozymes","authors":"Fenghua Geng, Min Huang, Xiaoli Zhang, Yongxiang Wang, Congying Shao, Maotian Xu","doi":"10.1007/s00604-025-07056-6","DOIUrl":"10.1007/s00604-025-07056-6","url":null,"abstract":"<div><p> CuNi/Fe LDHs with HRP-like activity (nanozyme) have been prepared. Contrary to the expected design, free dopamine (DA) was found to greatly enhance the catalytic performances of CuNi/Fe LDHs nanozyme. As far as we know, this is the first report that free DA boosts the catalytic performances of LDHs. Given the superior HRP-like enzyme activity of DA-CuNi/Fe LDHs, a colorimetric method for DA and tyrosinase (TYR) assay with high sensitivity and specificity was established, and it was successfully applied to quantify DA in artificial cerebrospinal fluid and TYR in newborn calf serum. The acquired insights in DA-CuNi/Fe LDHs will contribute to future rational design of other high-performance nanozymes. In addition, the novel DA and TYR assay pave a way for designing further nanozymes-based colorimetric chemo/biosensors.</p></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 3","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Microchimica ActaPub Date : 2025-03-01DOI: 10.1007/s00604-025-07059-3
Mohammad Shojaee, Maryam Tohidi, Sedigheh Zeinali, Elahe Haghighi
{"title":"Synthesis of hierarchical ZIF-8/carbon nanotube structure via zinc hydroxide nanostrands as a butanol QCM nanosensor","authors":"Mohammad Shojaee, Maryam Tohidi, Sedigheh Zeinali, Elahe Haghighi","doi":"10.1007/s00604-025-07059-3","DOIUrl":"10.1007/s00604-025-07059-3","url":null,"abstract":"<div><p> A composite of ZIF-8 metal organic framework/multi-walled carbon nanotube (MWCNT) was synthesized at room temperature using zinc hydroxide nanostrands (ZHNSs) as the metal source. ZHNS not only served as a metal source but also acted as a template, confining the nucleation and growth of ZIF-8 on the MWCNT. This led to the low linker/metal ion molar ratio necessary for ZIF-8 synthesis. The resulting composite was used in the fabrication of a quartz crystal microbalance (QCM) nanosensor for detecting volatile organic compounds (VOCs). The nanosensor was assessed in a N<sub>2</sub> atmosphere with various VOCs, including n-hexane, n-pentane, acetone, ethanol, methanol, methyl butanol, and butanol at different concentrations. Among these VOCs, the sensor displayed the most significant response to butanol, showing a sensitivity of 2.20 Hz ppm<sup>−1</sup>.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 3","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Microchimica ActaPub Date : 2025-02-28DOI: 10.1007/s00604-025-07052-w
Haojie Li, Jie Liu, Cuili Li, Runze Wang, Sapna Kannan, XiuJun Li, Guanglei Fu
{"title":"Development of a syringe-hosted load-and-read immunoassay device using autoinjected distance readout in paper inserts","authors":"Haojie Li, Jie Liu, Cuili Li, Runze Wang, Sapna Kannan, XiuJun Li, Guanglei Fu","doi":"10.1007/s00604-025-07052-w","DOIUrl":"10.1007/s00604-025-07052-w","url":null,"abstract":"<div><p>Pressure-based signal readout is promising for developing instrument-free immunoassays, but new detection methods are desirable to further advance the applicability of point-of-care testing (POCT). Herein, we developed a syringe-hosted load-and-read immunoassay device using autoinjected distance readout in paper inserts. The device was composed of multiple disposable syringes as the host for immuno-recognition, a three-dimensional (3D)-printed loading magazine of the syringes, and paper inserts to the magazine for distance signal readout. Using prostate-specific antigen (PSA) as a model target, the immuno-recognition system was constructed on the inner cylinder walls of the syringes. The immuno-captured platinum nanoparticles (Pt NPs) catalyzed the decomposition of H<sub>2</sub>O<sub>2</sub> to produce O<sub>2</sub> in the cylinders, driving the automatic quantitative injection behavior of the syringes. By loading the syringes into the magazine, the autoinjected liquids were received by the paper inserts to display the immunoassay signals as a visual traveling distance of liquids. PSA was determined with a low limit of detection (LOD) of 0.32 ng/mL and high accuracy in testing clinical serum specimens. Given the advantages of the simple syringe-hosted immuno-recognition method and the load-and-read signal readout in the paper inserts, the immunoassay device shows great potential in POCT.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 3","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Microchimica ActaPub Date : 2025-02-27DOI: 10.1007/s00604-025-07051-x
Yutong Wang, Yizhi Liu, Xiao Liang, Zhiyuan Liu, Yaling Yang
{"title":"A colorimetric/SERS dual-mode sensor based on ferric ion-dopamine@Au–Ag-Au Janus NPs for acrylamide determination in baked goods","authors":"Yutong Wang, Yizhi Liu, Xiao Liang, Zhiyuan Liu, Yaling Yang","doi":"10.1007/s00604-025-07051-x","DOIUrl":"10.1007/s00604-025-07051-x","url":null,"abstract":"<div><p>This study successfully developed a colorimetric/SERS dual-mode sensor for determining acrylamide in baked goods based on the excellent peroxidase-like activity and Raman activity of Fe-PHS@Au–Ag-Au Janus NPs. In colorimetric mode, the thiol-ene Michael addition between acrylamide (AA) and glutathione (GSH) efficiently eliminates GSH-induced peroxidase-like activity inhibition. The peroxidase-like activity of Fe-PHS@Au–Ag-Au Janus NPs gradually recovered, and the blue color of the solution gradually deepened with the increase in AA dosage. In surface-enhanced Raman spectroscopy (SERS), Apt-Fe-PHS@Au–Ag-Au Janus NPs can selectively capture AA and bind specifically, leading to the dissociation of Apt and Fe-PHS@Au–Ag-Au Janus NPs. The Raman activity of Apt-Fe-PHS@Au–Ag-Au Janus NPs decreases due to the dissociation of Apt. The dual-mode sensor was utilized for the determination of acrylamide in the concentrations range from 0.05 to 20 µg·L<sup>−1</sup> with detection limits of 0.06 µg·L<sup>−1</sup> (SERS) and 0.01 µg·L<sup>−1</sup> (colorimetric). The recovery in baked samples was between 91.0 and 108.0%.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 3","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}