{"title":"用于谷胱甘肽比色检测的Ag+功能化结构彩色水凝胶传感器的构建","authors":"Qianqian Feng, Jiang Zhou, Lingfeng Wang, Xiaojiao Gong, Qiang Xi, Shengyuan Yang, Wenfang Du, Fubing Xiao","doi":"10.1007/s00604-025-07442-0","DOIUrl":null,"url":null,"abstract":"<div><p>An Ag<sup>+</sup>-functionalized structural color hydrogel (Ag<sup>+</sup>-SCH) sensor is constructed for colorimetric detection of glutathione (GSH). The hydrogel is prepared by using the coordination of Ag<sup>+</sup> and 1-vinylimidazole (1-VI) as cross-linking network. GSH acts as a competitive ligand to break the coordination between Ag<sup>+</sup> and 1-VI, leading to the expansion and structural color change of the hydrogel. Quantification was achieved by measuring particle spacing changes, yielding a dynamic range of 0.1–200 μM with a limit of detection (LOD) of 0.04 μM. Alternatively, smartphone-based hue analysis enables sensitive GSH detection with a LOD of 0.79 μM. The sensor has proven to show high selectivity, excellent reusability, and long-term stability. In human serum tests, the Ag<sup>+</sup>-SCH performed comparably to commercial kits, while offering significantly lower cost. This portable, low-cost platform meets practical needs for GSH monitoring in diverse settings.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Construction of an Ag+-functionalized structural color hydrogel sensor for colorimetric detection of glutathione\",\"authors\":\"Qianqian Feng, Jiang Zhou, Lingfeng Wang, Xiaojiao Gong, Qiang Xi, Shengyuan Yang, Wenfang Du, Fubing Xiao\",\"doi\":\"10.1007/s00604-025-07442-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>An Ag<sup>+</sup>-functionalized structural color hydrogel (Ag<sup>+</sup>-SCH) sensor is constructed for colorimetric detection of glutathione (GSH). The hydrogel is prepared by using the coordination of Ag<sup>+</sup> and 1-vinylimidazole (1-VI) as cross-linking network. GSH acts as a competitive ligand to break the coordination between Ag<sup>+</sup> and 1-VI, leading to the expansion and structural color change of the hydrogel. Quantification was achieved by measuring particle spacing changes, yielding a dynamic range of 0.1–200 μM with a limit of detection (LOD) of 0.04 μM. Alternatively, smartphone-based hue analysis enables sensitive GSH detection with a LOD of 0.79 μM. The sensor has proven to show high selectivity, excellent reusability, and long-term stability. In human serum tests, the Ag<sup>+</sup>-SCH performed comparably to commercial kits, while offering significantly lower cost. This portable, low-cost platform meets practical needs for GSH monitoring in diverse settings.</p><h3>Graphical abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":705,\"journal\":{\"name\":\"Microchimica Acta\",\"volume\":\"192 10\",\"pages\":\"\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microchimica Acta\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00604-025-07442-0\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microchimica Acta","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s00604-025-07442-0","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Construction of an Ag+-functionalized structural color hydrogel sensor for colorimetric detection of glutathione
An Ag+-functionalized structural color hydrogel (Ag+-SCH) sensor is constructed for colorimetric detection of glutathione (GSH). The hydrogel is prepared by using the coordination of Ag+ and 1-vinylimidazole (1-VI) as cross-linking network. GSH acts as a competitive ligand to break the coordination between Ag+ and 1-VI, leading to the expansion and structural color change of the hydrogel. Quantification was achieved by measuring particle spacing changes, yielding a dynamic range of 0.1–200 μM with a limit of detection (LOD) of 0.04 μM. Alternatively, smartphone-based hue analysis enables sensitive GSH detection with a LOD of 0.79 μM. The sensor has proven to show high selectivity, excellent reusability, and long-term stability. In human serum tests, the Ag+-SCH performed comparably to commercial kits, while offering significantly lower cost. This portable, low-cost platform meets practical needs for GSH monitoring in diverse settings.
期刊介绍：
As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.
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