Dual-signal colorimetric sensor based on Fe,Ce-CDs for ultra-sensitive detection of nitrite in tobacco

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2025-09-10 DOI:10.1007/s00604-025-07500-7

Dongling Meng, Zhiyan Chen, Zhibin Chen, Junrao Cen, Jitao Li, Yaling Yang

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Abstract

Iron-cerium co-doped carbon dots (Fe,Ce-CDs) were synthesized by one-step hydrothermal method using tartaric acid and L-tryptophan as ligands. Fe,Ce-CDs shows excellent peroxidase-like (POD) activity and nitrite (NO₂⁻) can promote the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to its blue oxidation product (oxTMB) due to the formation of ∙NO₂ free radical. NO₂⁻ further react with oxTMB to form a yellow color via diazotization resulting in the absorbance Change at 450 nm. By Fe,Ce-CDs + NO₂⁻ + TMB + H₂O₂ and oxTMB + NO₂⁻ systems, a dual-signal colorimetric nanosensor for NO₂⁻ detection is developed with lower detection limits (LODs) of 0.272 μg/L and 0.019 mg/L, respectively. The proposed methods were applied to the detection of NO₂⁻ in tobacco samples with good recovery from 91.20 to 110.61%, achieving similar results and indicating their high accuracy and feasibility.

Graphical Abstract

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基于Fe、Ce-CDs的双信号比色传感器超灵敏检测烟草中亚硝酸盐

以酒石酸和l -色氨酸为配体，采用一步水热法制备了铁铈共掺杂碳点（Fe,Ce-CDs）。Fe，Ce-CDs表现出优异的过氧化物酶样（POD）活性，亚硝酸盐（NO2−）可通过∙NO2自由基的形成促进3,3 ',5,5 ' -四甲基苄基苯胺（TMB）氧化为其蓝色氧化产物（oxTMB）。NO2−进一步与oxTMB反应，通过重氮作用形成黄色，导致吸光度在450 nm处发生变化。采用Fe、Ce-CDs + NO2−+ TMB + H2O2和oxTMB + NO2−体系，构建了NO2−双信号比色纳米传感器，检测限分别为0.272 μg/L和0.019 mg/L。将该方法应用于烟草样品中NO2−的检测，回收率为91.20% ~ 110.61%，结果相似，表明该方法具有较高的准确性和可行性。图形抽象

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.