Microchimica Acta最新文献_第2页

Hairpin aptamer and ROS-sensitive microcapsule-mediated glycoprotein determination for the prognosis of colorectal cancer 发夹型适配体和对 ROS 敏感的微胶囊介导的糖蛋白测定用于结直肠癌的预后分析

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-12-21 DOI: 10.1007/s00604-024-06885-1

Xingjie Wu, Shasha Xiong, Ling Tao, Jian Huang, Xiangchun Shen

{"title":"Hairpin aptamer and ROS-sensitive microcapsule-mediated glycoprotein determination for the prognosis of colorectal cancer","authors":"Xingjie Wu, Shasha Xiong, Ling Tao, Jian Huang, Xiangchun Shen","doi":"10.1007/s00604-024-06885-1","DOIUrl":"10.1007/s00604-024-06885-1","url":null,"abstract":"<div><p>A novel glycoprotein assay was developed by integrating the hairpin aptamer (H-APT)–mediated glycoprotein recognition and the reactive oxygen species–sensitive microcapsule (ROS-MC)–induced signal amplification. The analyzing process begins with the transfer of the target glycoprotein to a chlorin e6 (Ce6)–labeled DNA sequence via H-APT-mediated DNA displacement. Subsequently, the Ce6-labeled DNA was used to induce the disassembly of fluorophore-loaded ROS-MC under 650-nm light irradiation. Leveraging the rapid release of the fluorophore and the high loading capacity of the MC, this glycoprotein assay is capable of quantifying glycoprotein content in native biofluids within 2.5 h, achieving a detection limit of 0.034 ng/mL. We applied this assay to determine the glycoprotein composition in plasma samples of colorectal cancer patients, revealing a significant increase in glycoprotein content for those with a poor prognosis. In summary, we have developed an innovative method for glycoprotein determination that shows potential for clinical translation.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142859490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Portable microfluidic devices for monitoring antibiotic resistance genes in wastewater

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-12-21 DOI: 10.1007/s00604-024-06898-w

Rida Feng, Kang Mao, Hua Zhang, Hongxiang Zhu, Wei Du, Zhugen Yang, Shuangfei Wang

{"title":"Portable microfluidic devices for monitoring antibiotic resistance genes in wastewater","authors":"Rida Feng, Kang Mao, Hua Zhang, Hongxiang Zhu, Wei Du, Zhugen Yang, Shuangfei Wang","doi":"10.1007/s00604-024-06898-w","DOIUrl":"10.1007/s00604-024-06898-w","url":null,"abstract":"<div><p>Antibiotic resistance genes (ARGs) pose serious threats to environmental and public health, and monitoring ARGs in wastewater is a growing need because wastewater is an important source. Microfluidic devices can integrate basic functional units involved in sample assays on a small chip, through the precise control and manipulation of micro/nanofluids in micro/nanoscale spaces, demonstrating the great potential of ARGs detection in wastewater. Here, we (1) summarize the state of the art in microfluidics for recognizing ARGs, (2) determine the strengths and weaknesses of portable microfluidic chips, and (3) assess the potential of portable microfluidic chips to detect ARGs in wastewater. Isothermal nucleic acid amplification and CRISPR/Cas are two commonly used identification elements for the microfluidic detection of ARGs. The former has better sensitivity due to amplification, but false positives due to inappropriate primer design and contamination; the latter has better specificity. The combination of the two can achieve complementarity to a certain extent. Compared with traditional microfluidic chips, low-cost and biocompatible paper-based microfluidics is a very attractive test for ARGs, whose fluid flow in paper does not require external force, but it is weaker in terms of repeatability and high-throughput detection. Due to that only a handful of portable microfluidics detect ARGs in wastewater, fabricating high-throughput microfluidic chips, developing and optimizing recognition techniques for the highly selective and sensitive identification and quantification of a wide range of ARGs in complex wastewater matrices are needed.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142859493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A ratiometric fluorescent probe based on water-soluble CsPbX3 (Br/I) perovskite nanocrystals for sensitive detection of tetracycline

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-12-21 DOI: 10.1007/s00604-024-06893-1

Renhao Ma, Jinyu Mei, Jiquan Gan, Fangkai Du, Chuanbin Qiu

{"title":"A ratiometric fluorescent probe based on water-soluble CsPbX3 (Br/I) perovskite nanocrystals for sensitive detection of tetracycline","authors":"Renhao Ma, Jinyu Mei, Jiquan Gan, Fangkai Du, Chuanbin Qiu","doi":"10.1007/s00604-024-06893-1","DOIUrl":"10.1007/s00604-024-06893-1","url":null,"abstract":"<div><p>A dual supersaturation recrystallization method was employed to synthesize water-stable, highly sensitive cesium-lead halide perovskite nanocrystals (CsPbBr<sub>3</sub> PNCs). The PNCs exhibited excellent water stability, a significant photoluminescence quantum efficiency of 83.03%, along with a narrow full width at half maximum (FWHM) of 20 nm. Following iodide ion treatment, the fluorescence emission peak of CsPbBr<sub>3</sub> PNCs can be tuned from 520 to 681 nm, causing a color transition from green to red. Within the 0–300 μM range, the red shift showed a linear correlation with I<sup>−</sup> concentration, achieving a detection limit as low as 0.40 μM. It is worth noting that excessive iodide ions could have allowed PNCs to exhibit dual emission with maximum wavelengths of 520 and 681 nm. A ratiometric perovskite nanoprobe was constructed with the green emission peak as an internal standard and the red emission peak as the response signal. The probe demonstrated a strong linear correlation with tetracycline concentrations ranging from 0 to 8 μM, with a detection limit of 88.60 nM (S/N = 3). This research offers valuable insights into the design and development of ratiometric perovskite sensors capable of detecting in aqueous solutions, while also emphasizing the importance of rapidly establishing hydrogen-bonding networks when analyzing such detection systems.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lanthanide and functionalization-free dual-state emitting zinc-based MOFs followed by dual-state detection: ratiometric and color-tonality visual detection of tetracycline in solution and on paper in food and environmental samples

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-12-21 DOI: 10.1007/s00604-024-06896-y

Sameera Sh. Mohammed Ameen, Khalid M. Omer

{"title":"Lanthanide and functionalization-free dual-state emitting zinc-based MOFs followed by dual-state detection: ratiometric and color-tonality visual detection of tetracycline in solution and on paper in food and environmental samples","authors":"Sameera Sh. Mohammed Ameen, Khalid M. Omer","doi":"10.1007/s00604-024-06896-y","DOIUrl":"10.1007/s00604-024-06896-y","url":null,"abstract":"<div><p>An efficient dual-state blue-emitting zinc-based metal–organic frameworks (MOFs), designated as UoZ-8 has been developed. Coordination-induced emission causes the UoZ-8 to give the blue emission in both solid and dispersed form in liquid. Upon the addition of tetracycline (TC), a noticeable shift from blue emission to greenish-yellow emission occurred, with a marked increase in intensity, which was attributed to the inner filter effect accompanied by aggregation-induced emission (IFE-AIE). Consequently, ratiometric-based fluorometry (in solution) and color tonality visual detection platform (on paper) were developed, exploiting the dual-state property of UoZ-8 alone and UoZ-8:TC. The detection limit using the ratiometric-based fluorescence method was 3.8 nM, while on paper it was 3.5 µM. Paper-based visual mode was used for the detection of TC in tap and river water samples showing satisfactory accuracy and precision.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142859491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress, challenges, and future perspectives of electrochemical biosensing of aflatoxins 黄曲霉毒素电化学生物传感技术的最新进展、挑战和未来展望

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-12-18 DOI: 10.1007/s00604-024-06857-5

Doddanagowada S, Venkata Narayana Palakollu, S. V. Prabhakar Vattikuti, Jaesool Shim, Naresh Mameda

{"title":"Recent progress, challenges, and future perspectives of electrochemical biosensing of aflatoxins","authors":"Doddanagowada S, Venkata Narayana Palakollu, S. V. Prabhakar Vattikuti, Jaesool Shim, Naresh Mameda","doi":"10.1007/s00604-024-06857-5","DOIUrl":"10.1007/s00604-024-06857-5","url":null,"abstract":"<div><p>Aflatoxins (AFs), produced by fungi, are highly hazardous and classified as mycotoxins. Controlling their levels is of significant concern. This group consists of 20 fungal metabolites, all structurally derived from difuranocoumarin. Exposure to AFs through food can cause critical health issues, such as cancers, deformities, and mutations, posing a significant global public health issue. The inherent dangers of AF exposure necessitate swift and reliable detection techniques to identify its presence in food products. The rise of nanotechnology has opened doors to innovative electrochemical biosensors, offering a promising solution to this pressing issue. This review delves into nanomaterial-based aptasensors, immunosensors, and molecularly imprinted polymers, the predominant electrochemical biosensors developed for AF detection. This paper offers a broad summary of recent advancements in biosensor technology in electrochemical sensing of AFs, alongside challenges to overcome limitations, and future perspectives.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142844930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical biosensor for detection of ampicillin in milk based on Au5Pt and DNA cycle dual-signal amplification strategy 基于 Au5Pt 和 DNA 循环双信号放大策略的检测牛奶中氨苄西林的电化学生物传感器

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-12-16 DOI: 10.1007/s00604-024-06817-z

Li Mingyao, Li Ruiyi, Li Zaijun

{"title":"Electrochemical biosensor for detection of ampicillin in milk based on Au5Pt and DNA cycle dual-signal amplification strategy","authors":"Li Mingyao, Li Ruiyi, Li Zaijun","doi":"10.1007/s00604-024-06817-z","DOIUrl":"10.1007/s00604-024-06817-z","url":null,"abstract":"<div><p>A biosensor is reported for electrochemical detection of ampicillin based on Au<sub>5</sub>Pt and DNA cycle dual-signal amplification strategy. Firstly, Au<sub>5</sub>Pt is prepared by reduction of chloroauric acid and chloroplatinic acid with serine-functionalized graphene quantum dot (SGQD). The resulting Au<sub>5</sub>Pt shows an excellent catalytic activity because of the synergy of Au and Pt. Then, Au<sub>5</sub>Pt is covalently combined with hairpin DNA and thionine molecule to form a redox probe. The probe was used for construction of the ampicillin biosensor coupling with DNA cycling. In the presence of ampicillin, the DNA cycle was triggered and leads to many redox probes being carried to the biosensor. This produces a significant signal amplification by oxidation and reduction of thionine molecules in these probes. The combination of Au<sub>5</sub>Pt catalysis with DNA cycle achieve ultrahigh sensitivity, selectivity, and stability for the electrochemical detection of ampicillin. Differential pulse voltammetry current linearly increases with the increase of ampicillin concentration in the range 1 × 10<sup>−18</sup>–1 × 10<sup>−12</sup> M with a detection limit of 3.2 × 10<sup>−19</sup> M (<i>S</i>/<i>N</i> = 3). The proposed analytical method has been satisfactorily used for electrochemical detection of ampicillin in milk.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-chromatic and multi-component lateral flow immunoassay for simultaneous detection of CP4 EPSPS, Bt-Cry1Ab, Bt-Cry1Ac, and PAT/bar proteins in genetically modified crops

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-12-16 DOI: 10.1007/s00604-024-06853-9

Yao Yang, Zini Zhang, Zhi Wang, Ruxin Pan, Huimin Wu, Shanshan Zhai, Gang Wu, Wei Fu, Hongfei Gao

{"title":"Multi-chromatic and multi-component lateral flow immunoassay for simultaneous detection of CP4 EPSPS, Bt-Cry1Ab, Bt-Cry1Ac, and PAT/bar proteins in genetically modified crops","authors":"Yao Yang, Zini Zhang, Zhi Wang, Ruxin Pan, Huimin Wu, Shanshan Zhai, Gang Wu, Wei Fu, Hongfei Gao","doi":"10.1007/s00604-024-06853-9","DOIUrl":"10.1007/s00604-024-06853-9","url":null,"abstract":"<div><p>A multi-chromatic and multi-component lateral flow immunoassay (MCMC-LFIA) was developed for simultaneous detection of CP4 EPSPS, Bt-Cry1Ab, Bt-Cry1Ac, and PAT/<i>bar</i> proteins in genetically modified (GM) crops. Captured antibodies specific to these exogenous proteins were separately immobilized on a nitrocellulose membrane as test zones. Multi-colored microspheres, used as visible multi-probes, were conjugated with corresponding antibodies and sprayed on the conjugate pad. The assay results can be visually interpreted within 10 min by observing the appearance of colored bands. The MCMC-LFIA demonstrated high sensitivity, with detection of limits of 7.8 ng/mL for CP4 EPSPS and 2.5 ng/mL for Bt-Cry1Ab, Bt-Cry1Ac, and PAT/<i>bar</i> proteins, significantly improving the performance of previously reported LFIAs. The MCMC-LFIA exhibited excellent specificity and was validated for practical use in field-based applications. The proposed MCMC-LFIA offers a rapid, sensitive, and user-friendly tool for the on-site large-scale screening of GM materials.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of an electrochemical sensor based on magnetic molecularly imprinted polymer-zeolite imidazole framework-8 for detection of 3,4-benzopyrene

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-12-13 DOI: 10.1007/s00604-024-06858-4

Binbin Zhou, Xinyi Li, Hao Xie, Xingxin Sheng, Lijun Huang, Yongbo Zhu, Meng Liang, Ming Zhong

{"title":"Construction of an electrochemical sensor based on magnetic molecularly imprinted polymer-zeolite imidazole framework-8 for detection of 3,4-benzopyrene","authors":"Binbin Zhou, Xinyi Li, Hao Xie, Xingxin Sheng, Lijun Huang, Yongbo Zhu, Meng Liang, Ming Zhong","doi":"10.1007/s00604-024-06858-4","DOIUrl":"10.1007/s00604-024-06858-4","url":null,"abstract":"<div><p> A novel molecular-imprinted electrochemical sensor for 3,4-benzopyrene (3, 4-BaP) in food samples, with high sensitivity and selective detection, is introduced. Firstly, graphene oxide was modified onto a glassy carbon electrode (GCE) by electroreduction deposition to form an RGO/GCE sensing platform, thereby enhancing the sensitivity and stability of the sensor. Then, magnetic molecularly imprinted polymer-zeolite imidazole framework-8 (MMIP-ZIF-8) was synthesized in one step using the crystal growth method and modified onto RGO/GCE, endowing the sensor with good adsorption capacity and selectivity. The performance of the sensor for 3, 4-BaP was studied using differential pulse voltammetry (DPV), and the detection conditions of the constructed sensor were optimized. The results showed that under the optimal conditions, the constructed sensor exhibited a wide linear range (0.5 ~ 1000 nmol L<sup>−1</sup>), a low limit of detection (0.16 nmol L<sup>−1</sup>), and good selectivity and stability for the detection of 3, 4-BaP. It also showed a good recovery (99.74 ~ 102.58%) for the detection of 3, 4-BaP in actual corn meal samples. The MMIP-ZIF-8/RGO/GCE sensor developed has potential application prospects in the precise detection of 3, 4-BaP in food.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mn, N co-doped CDs as a fluorescent nanosensing platform for the detection of tannic acid and hafnium ion and in vitro fluorescence imaging of U2OS osteosarcoma cells

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-12-11 DOI: 10.1007/s00604-024-06848-6

Xue-Lin Zhao, Sen-Zhen Wang, Lihua Zhang, Zhen Wang, Jin-Yan Huang, Song Liao, Min Lu, Zhi Yang, Xing-Jun Zhao, Zi-Yi Zhao, Zi-Xuan Guo, Lu-Nan Zhang, Pei-De Zhu, Meng Xu

{"title":"Mn, N co-doped CDs as a fluorescent nanosensing platform for the detection of tannic acid and hafnium ion and in vitro fluorescence imaging of U2OS osteosarcoma cells","authors":"Xue-Lin Zhao, Sen-Zhen Wang, Lihua Zhang, Zhen Wang, Jin-Yan Huang, Song Liao, Min Lu, Zhi Yang, Xing-Jun Zhao, Zi-Yi Zhao, Zi-Xuan Guo, Lu-Nan Zhang, Pei-De Zhu, Meng Xu","doi":"10.1007/s00604-024-06848-6","DOIUrl":"10.1007/s00604-024-06848-6","url":null,"abstract":"<div><p>Multi-wavelength emission fluorescent manganese-nitrogen co-doped carbon dots (Mn, N co-doped CDs) were synthesized by solvothermal method using <i>β</i>-cyclodextrin, O-phenylenediamine, and manganese chloride as raw materials. The prepared Mn, N co-doped CDs were used as fluorescent nanosensing platforms for the detection of metal ions and biomolecules and were found to be capable of fluorescence detection of tannic acid (TA) and hafnium (Hf) ion at 320, 380, and 480 nm excitation wavelengths with multi-response linear ranges of 0.7 ~ 1.2 µM and 6.35 ~ 13 µM and detection limits of 0.45 µM and 6.3 µM, respectively. The wide linear ranges and low detection limits may be due to the fluorescence resonance energy transfer effect between the platform and TA and Hf ions. In addition, it was found that Mn, N co-doped CDs had good photostability, biocompatibility, and low cytotoxicity, which could be used for in vitro fluorescence imaging of exogenous TA and Hf ion imaging in U2OS osteosarcoma cells. Thus, the probe has a promising application in biomedical fields as a new multi-responsive fluorescence nanosensing platform member.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00604-024-06848-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MnO2 nanoparticles enhance the activity of the Zr-MOF matrix electrochemical sensor for efficiently identifying ultra-trace tetracycline residues in food

IF 5.3 2区化学

Microchimica Acta Pub Date : 2024-12-08 DOI: 10.1007/s00604-024-06854-8

Siyu Tian, Jiahui Wang, Yu Jie, Zhu Ding, Xiao Wang, Jijiang Wang, Xiangyang Hou

{"title":"MnO2 nanoparticles enhance the activity of the Zr-MOF matrix electrochemical sensor for efficiently identifying ultra-trace tetracycline residues in food","authors":"Siyu Tian, Jiahui Wang, Yu Jie, Zhu Ding, Xiao Wang, Jijiang Wang, Xiangyang Hou","doi":"10.1007/s00604-024-06854-8","DOIUrl":"10.1007/s00604-024-06854-8","url":null,"abstract":"<div><p> A novel nanobiosensor was constructed by in situ locating nanometer MnO<sub>2</sub> particles with controllable size and morphology in a Zr-MOF substrate to serve as an electrochemical probe. The synergistic effect of the two components, Zr-MOFs with high specific surface area and compatibility as a carrier for MnO<sub>2</sub>, resulted in improved electrochemical activity and excellent electrochemical identification performance for the MnO<sub>2</sub>@Zr-MOF/GCE biosensor. Under optimized experimental conditions and using CV and DPV technology, the biosensor showed a wide linear detection range (2–200 μM), a low detection limit (2.577 × 10<sup>−8</sup> M), a recovery range (106.26–115.01%), and maximum relative standard deviation (5.155) for tetracycline (TC) identification. The recognition mechanism of the sensor was investigated adopting Laviron adsorption theory. The applicability of the sensor was verified through practical measurements. Overall, the MnO<sub>2</sub> @Zr-MOF/GCE sensor possesses the advantages of fast analysis speed, high sensitivity, high selectivity, and simple operation, making it suitable for detecting trace amounts of TC in food.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0