Microchimica Acta最新文献

{"title":"Raspberry-shaped H-COF-based dual-mode fluorescent sensing probe for tetracycline antibiotics: standalone and electrospun mat-based point-of-care applications","authors":"Rinkal Chopada,&nbsp;Nitin Kumar,&nbsp;Ashwani Singh,&nbsp;Vanish Kumar","doi":"10.1007/s00604-026-08453-1","DOIUrl":"10.1007/s00604-026-08453-1","url":null,"abstract":"<div><p>Two-dimensional fluorescent materials have emerged as promising candidates for applications in food safety, environmental monitoring, and disease diagnostics, particularly for point-of-care sensors. We report solvothermal development of an imine-linked 2D hydrogen-covalent hybridized organic framework (H-COF), DaTa-1, with novel raspberry-like morphology for the sensitive chemosensing of tetracyclines (TCs) in tap water and milk samples. The developed H-COF exhibited good thermal stability and strong fluorescence in aqueous suspension and in the solid state. DaTa-1 demonstrated excellent sensing performance for TCs (especially for 0.2–10 ppm and 12–60 ppm ranges), achieving low detection limits of 43.80, 46.42, 55.81, and 104.20 ppb for tetracycline, chlortetracycline, oxytetracycline, and doxycycline, respectively. Notably, the inner filter effect is primarily responsible for generating sensing signals. Furthermore, density functional theory (DFT) calculations suggested photoinduced electron transfer (PET) as an additional pathway contributing to dynamic quenching. To make the developed system more accessible, DaTa-1 was incorporated into polyacrylonitrile (PAN) nanofibers via electrospinning and used for the on-site and smartphone-assisted visual detection of TCs.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eu3+-doped CeO2 with regulated oxygen vacancies for highly sensitive organophosphorus detection","authors":"Huan Wang,&nbsp;Jinhua Huang,&nbsp;Jiayi Yan,&nbsp;Zhibo Xue,&nbsp;Jun Li,&nbsp;Xia Hong,&nbsp;Yichun Liu","doi":"10.1007/s00604-026-08460-2","DOIUrl":"10.1007/s00604-026-08460-2","url":null,"abstract":"<div><p>Eu³⁺-doped CeO₂ nanoparticles with regulated oxygen vacancies (V_o^••) have been developed as phosphatase-like nanozymes for highly sensitive colorimetric detection of p-nitrophenyl phosphate (p-NPP), a model phosphate ester substrate. Eu³⁺ serves simultaneously as a defect regulator that modulates V_o^•• formation and as a luminescent probe for tracking the local environment associated with V_o^••. Spectroscopic analyses revealed that moderate Eu³⁺ doping promotes the preferential formation of Ce-adjacent V_o^••, generating highly active Ce⁴⁺-V_o^••-Ce³⁺ configurations that enhance substrate adsorption and facilitate P–O bond cleavage. CeO₂: 2%Eu exhibits the highest hydrolysis activity, enabling highly sensitive detection of p-NPP with a detection limit of 54 nM over a linear range of 1.2–200 µM, approximately 12-fold lower than that of undoped CeO₂. Coupled with a smartphone-assisted paper-based platform, the nanozyme enables portable, visual and quantitative colorimetric detection. This work provides new insights into defect-engineered nanozyme design and offers a promising strategy for the development of highly sensitive OPC sensors.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic boronate–Ti(IV) dual-affinity nanoparticles for simultaneous enrichment and sequential elution of glycopeptides and phosphopeptides","authors":"Yanling Liu,&nbsp;Xiying Wang,&nbsp;Jing Yang,&nbsp;Xiucan Li,&nbsp;Zhian Sun","doi":"10.1007/s00604-026-08466-w","DOIUrl":"10.1007/s00604-026-08466-w","url":null,"abstract":"<div><p>The simultaneous enrichment of glycopeptides and phosphopeptides from complex peptide mixtures remains challenging because boronate affinity and immobilized metal ion affinity chromatography (IMAC) typically require different pH conditions for efficient binding. We evaluated the previously reported dual boronate–Ti(IV) magnetic nanomaterial, Mag@DBA-Ti(IV), as a sample-preparation platform for the single-sorbent, single-loading-condition enrichment and sequential elution of glycopeptides and phosphopeptides. The material, prepared by co-immobilizing a low-p<i>K</i>ₐ boronic acid ligand and alendronate on magnetic nanoparticles, followed by Ti(IV) chelation, was originally developed for small-molecule enrichment; its translation to peptide-level proteomics is established here. The integrated boronate and Ti(IV)-IMAC sites enabled concurrent binding of glycopeptides and phosphopeptides under neutral loading conditions, with selective release achieved using acidic and alkaline eluents, respectively. This translation required redesigning the elution chemistry for MS compatibility, replacing the high-pH sodium phosphate eluent used for small molecules with 0.4 mol L⁻¹ NH₃·H₂O, and establishing that the dual-affinity sites retain selectivity when glycopeptides and phosphopeptides are low-abundance species competing with a large excess of unmodified peptides. Mag@DBA-Ti(IV) exhibited high adsorption capacities toward model protein digests, reaching 71.4 mg g⁻¹ for IgG digest and 125 mg g⁻¹ for α-casein digest. The material also showed high selectivity for both glycopeptides and phosphopeptides in the presence of a 500-fold excess of bovine serum albumin digest, allowing detection at concentrations as low as 10⁻¹⁰ mol L⁻¹. When applied to U251 cell lysate digests, Mag@DBA-Ti(IV) enabled the identification of 1,945 glycopeptides from 752 glycoproteins and 7,498 phosphopeptides from 2,410 phosphoproteins in a single experiment. These results demonstrate that the dual boronate–Ti(IV) affinity concept, originally established for small molecules, can be translated to peptide-level bottom-up proteomics, providing a single-sorbent route to integrated glycoproteomic and phosphoproteomic determination.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cu-V-Ag tri-metal mesoporous nanozyme for high-efficiency UV-vis/RGB monitoring of CrO42− and amoxicillin residue","authors":"Huitian Zhi,&nbsp;Yingchao Yang,&nbsp;Juan Yu,&nbsp;Hanning Song,&nbsp;Chenxi Li,&nbsp;Jiachen Wang,&nbsp;Xianyu Wang,&nbsp;Zhengquan Yan,&nbsp;Lei Hu","doi":"10.1007/s00604-026-08458-w","DOIUrl":"10.1007/s00604-026-08458-w","url":null,"abstract":"<div><p>To monitor toxic CrO42− and amoxicillin residue efficiently, tri-metal Cu-V-Ag mesoporous nanospheres (Cu-V-Ag MNS) were identified in this work. Based on the synergistic effect among Ag⁰, V₂O₅, CuOx and bovine serum albumin (BSA), Cu-V-Ag MNS expressed outstanding oxidase-like activity to catalyze 3,3’,5,5’-tetramethylbenzidine (TMB) oxidization with Vmax/Km of 0.0326 mM/2.86×10⁻⁸ M·s⁻¹. Trace CrO₄²⁻ or amoxicillin could exclusively enhance or deteriorate its oxidase-like activity with clear hyperchromic or hypochromic effect. Under optimized conditions, Cu-V-Ag MNS was applied for dual-mode UV-vis/red-green-blue (RGB) monitoring of CrO₄²⁻ or amoxicillin with satisfactory relative standard deviations less than 3.78%/₄.01% or 3.58%/3.92% respectively. The dual-mode monitoring reliability and sensing mechanism to CrO₄²⁻ and amoxicillin were investigated in detail. This work will provide a potential to modify nature bio-macromolecules for dual-mode high-efficiency monitoring of environmental contaminations practically.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capillary-integrated chiral gold nanocrystals for label-free SERS detection of serum amyloid-β 1–42 in Alzheimer’s disease rats","authors":"Yangfan Zhou,&nbsp;Huaiwu Fu,&nbsp;Kaiyong Chen,&nbsp;Yixuan Jiang,&nbsp;Zixun Wang,&nbsp;Weixing Wu,&nbsp;Xiaowei Cao","doi":"10.1007/s00604-026-08457-x","DOIUrl":"10.1007/s00604-026-08457-x","url":null,"abstract":"<div><p>Chiral plasmonics was integrated with surface-enhanced Raman scattering (SERS) technology to develop a high-performance chiral SERS sensor with promising applications for the early identification and ultrasensitive detection of Alzheimer’s disease. The sensor utilizes the self-assembly of chiral gold nanocrystals (CG NCs) on the inner wall of a capillary, introducing a surface-enhanced Raman scattering chiral anisotropy (SERS-ChA) effect. Consequently, a label-free chiral SERS sensor ‌is‌ constructed. In the presence of the target analyte Amyloid-β 1–42 (Aβ₁₋₄₂, Aβ₄₂), CG NCs generate an electric-dipole-magnetic-dipole coupling effect within the chiral plasmonic field, resulting from selective resonance coupling between enantiomer-induced electric and magnetic dipole (MD) moments. This process significantly enhances the chiral asymmetric response and amplifies the SERS signal, allowing highly sensitive recognition and detection of Aβ₄₂. The sensor exhibits excellent analytical performance, achieving a limit of detection (LOD) as low as 0.0899 pg/mL. Furthermore, it demonstrates strong selectivity for Aβ₄₂ and robust resistance to interference from other substances commonly present in serum. By analyzing serum samples from rat models of Alzheimer’s disease and comparing the results with those from an Aβ1–42 ELISA kit, a high correlation (R² = 0.976) was demonstrated, validating the sensor’s practicality and accuracy and indicating its stable and reliable quantitative performance in complex biological matrices. This study provides new insights and theoretical foundations for the early screening and diagnosis of Alzheimer’s disease.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-emissive ratiometric probe integrating TP-BDB-COF and N-CDs@ZIF-8 for ultrasensitive hypochlorite detection in aqueous environments","authors":"Mengjun Wang,&nbsp;Rong Huang,&nbsp;Xinwen Yang,&nbsp;Minghao Zeng,&nbsp;Huizhen Wang,&nbsp;Xiaojun Luo","doi":"10.1007/s00604-026-08464-y","DOIUrl":"10.1007/s00604-026-08464-y","url":null,"abstract":"<div><p>A ratiometric fluorescence probe was developed by integrating a covalent organic framework (TP-BDB-COF) with N-doped quantum dots (N-CDs) encapsulated in zeolitic imidazolate framework-8 (N-CDs@ZIF-8), enabling highly sensitive and selective detection of hypochlorite (ClO⁻) in aqueous environments. The yellow-orange-emissive TP-BDB-COF, synthesized by the condensation of 2,4,6-triformylphloroglucinol (TP) and 3,3’-dimethyl-[1,1’-biphenyl]-4,4’-diamine (BDB), exhibited specific fluorescence quenching at 570 nm upon interaction with ClO⁻. The blue-emissive N-CDs@ZIF-8 served as a stable reference signal at 430 nm, enabling self-calibration via the ratiometric signal (F₄₃₀/F₅₇₀). This dual-signal strategy significantly improved detection accuracy and reliability. This sensor exhibited a broad linear fluorometric response range of 0.05 to 200 µM for ClO⁻, with an exceptionally low detection limit of 22 nM. Moreover, its practical applicability was validated through analysis of real water samples, yielding satisfactory spike recoveries between 98.53% and 101.30%. This approach not only offers a robust method for monitoring ClO⁻ in complex matrices but also provides a versatile framework for constructing high-performance ratiometric sensors.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confinement enhanced phosphorescent electrochemiluminescence of copper iodide cluster complex for imaging detection of organophosphorus pesticide","authors":"Mengjiao Li,&nbsp;Yanmei Liu,&nbsp;Yuan Li,&nbsp;Guijun Li,&nbsp;Si Zhang,&nbsp;Weiwei Chen,&nbsp;Huangxian Ju","doi":"10.1007/s00604-026-08456-y","DOIUrl":"10.1007/s00604-026-08456-y","url":null,"abstract":"<div><p>Owing to the spin statistics of electrogenerated excitons, conventional fluorescent ECL materials fail to utilize 75% of the triplet excitons. To improve the utilization efficiency of triplet excitons, this work proposed a strategy for the design of phosphorescent ECL material based on the synergistic effect of heavy-atom iodine enhanced spin-orbit coupling (SOC) and rigid molecular environment. A copper-iodide cluster complex Cu₄I₆(pr-ted)₂ was successfully synthesized using 1-propyl-1,4-diazabicyclo[2.2.2]octanium (pr-ted) as the organic cation and polyvinylpyrrolidone for chain entanglement. The enhanced SOC promoted efficient intersystem crossing, and thus rapidly populated long-lived triplet excited states, which lifted the spin-forbidden transition from the triplet state to the ground state for efficient radiative utilization of triplet excitons. The rigid network could effectively suppress non-radiative transitions and mitigate dynamic oxygen quenching. The ECL process of designed Cu₄I₆(pr-ted)₂ followed a new cluster-centered charge transfer mechanism with low non-radiative losses, exhibiting a long luminescence lifetime, high quantum yield, and an excellent ECL efficiency of 33.5%. Based on the strong ECL emission of Cu₄I₆(pr-ted)₂, an ECL imaging sensor was constructed for the quantitative detection of organophosphorus pesticides with malathion as a model analyte, which achieved a linear detection range of 10^− 3 − 10³ pg/mL and a detection limit as low as 7.68 × 10^− 4 pg/mL. This work provided a new approach for the development of efficient and low-cost phosphorescent ECL materials as well as their biosensing applications.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-functional Cu-doped carbon dots for antioxidant cytoprotection and fluorescent detection of tetracycline","authors":"Qian Lu,&nbsp;Yanxu Liu,&nbsp;Mengci Jin,&nbsp;Kai Xue,&nbsp;Shenna Chen,&nbsp;Lina Geng","doi":"10.1007/s00604-026-08467-9","DOIUrl":"10.1007/s00604-026-08467-9","url":null,"abstract":"<div><p>Dual‑functional copper‑doped carbon dots (Cu‑CDs) were prepared through a hydrothermal route using eco‑friendly copper citrate as the starting material. The resulting Cu‑CDs exhibited a uniform spherical morphology, stable excitation‑independent blue fluorescence, and reversible Cu⁺/Cu²⁺ redox couples, which collectively contributed to excellent antioxidant and fluorescent sensing performance. Owing to the synergistic effect of surface functional groups and Cu⁺/Cu²⁺ valence cycling, Cu‑CDs could efficiently scavenge ·OH radicals and exhibited much better retention of radical‑scavenging activity under high‑temperature conditions compared with natural ascorbic acid. Cellular experiments on MOVAS cells showed no significant reduction in cell viability under tested conditions (25‑100 µg/mL Cu‑CDs). Cu‑CDs could effectively eliminate intracellular reactive oxygen species and confer protective effects against H₂O₂‑ induced oxidative damage in MOVAS cells. In parallel, a sensitive fluorescent sensing platform for tetracycline detection was developed based on the inner filter effect. This constructed sensor offered dual linear detection ranges of 2–40 µM and 40–118 µM, a low limit of detection of 0.22 µM and exhibited outstanding anti-interference capacity against common metal ions, amino acids and coexisting organic substances. Satisfactory spike recoveries and low RSD values were obtained in pork and milk food matrices, demonstrating reliable practicability for food safety monitoring. Significantly, complementary experiments revealed that the electron‑transfer‑based antioxidant mechanism and the physical IFE‑dependent sensing mechanism operate independently without mutual interference, thereby effectively avoiding the functional crosstalk often seen in conventional dual‑functional carbon dot systems. Altogether, this study provides a simple and green approach to constructing high‑stability multifunctional carbon nanomaterials with promising applications in oxidative stress protection and food safety monitoring.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A self-cascade triple-functional AuNPs-modified FeCe-MOF-derived carbon material for enzyme-free colorimetric detection of glucose and cholesterol","authors":"Tong Wu,&nbsp;Si Wu,&nbsp;Tao Feng,&nbsp;Xiaolu Li,&nbsp;Tingpeng Chen,&nbsp;Xiangtai Zhang,&nbsp;Yuqi Tang","doi":"10.1007/s00604-026-08452-2","DOIUrl":"10.1007/s00604-026-08452-2","url":null,"abstract":"<div><p>A novel AuNPs-modified FeCe-MOF derived carbon material (FeCe@C-AuNPs) nanozyme was developed for the colorimetric detection of glucose and cholesterol. In the constructed system, AuNPs mainly exhibited oxidase-like activity toward glucose and cholesterol oxidation, generating H₂O₂, while FeCe@C served as a peroxidase mimic to activate H₂O₂ and produce hydroxyl radicals (•OH), which subsequently oxidized colorless 3,3′,5,5′-tetramethylbenzidine (TMB) into blue ox-TMB. The synergistic interaction among Fe, Ce, the carbon matrix, and AuNPs facilitated interfacial electron transfer, promoted H₂O₂ activation, and enhanced the overall cascade catalytic performance. The glucose assay exhibited two linear ranges of 0–2 and 2–10 mM, whereas cholesterol showed a linear range of 0–10 µM, with detection limits of 0.19 mM and 0.85 µM, respectively. Glucose and cholesterol can be determined under their respective optimized pH conditions using the same FeCe@C-AuNPs platform. The method was successfully applied to commercial beverage and milk samples, yielding recoveries of 94.02–106.93%. Moreover, FeCe@C-AuNPs-3 maintained stable catalytic activity and detection performance during storage for 60 days. This study provides a promising strategy for constructing efficient cascade nanozyme systems for biomolecule sensing.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Materials for liver-on-a-chip: modules, properties, and future directions","authors":"He-Ru Wang,&nbsp;Jia-Xu Li,&nbsp;Chun-Hua Wan,&nbsp;Jing Zhou,&nbsp;Ning Bao","doi":"10.1007/s00604-026-08448-y","DOIUrl":"10.1007/s00604-026-08448-y","url":null,"abstract":"<div><p>The liver is the primary hub of our body for metabolism, detoxification, and drug biotransformation. While conventional two-dimensional cell culture and animal models can only partly recapitulate the complex hepatic microenvironment for the study of the liver, Liver-on-a-chip (LiOC) systems can simulate livers by integrating microfluidics, cell biology and engineered microenvironments. It is crucial to apply materials with specific properties in appropriate places because no single material can meet all the requirements for fabrication of LiOC systems. Moreover, improper material selection may lead to abnormal cell phenotypes and generate false experimental data. By advancing the philosophy of “right material in right place”, in this review we systematically evaluated the structure of LiOC modules, including microfluidic, biological and sensing modules, followed by dissection of material-induced artifacts. We then discussed critical challenges including long-term material degradation, batch-to-batch variability, and the gap between laboratory prototypes and industrial production. We also summarize application-oriented material selection criteria and reporting needs for drug screening, hepatotoxicity testing, disease modeling, and personalized medicine. Finally, it outlined future perspectives on possible applications of smart biomimetic materials in LiOC systems, such as stimulus-responsive hydrogels, wood, and piezoelectric hydrogels, along with functionally integrated materials and AI-assisted material screening. This review may provide a framework for material selection and design toward standardized, high-fidelity LiOC platforms.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}