Microchimica Acta最新文献_第3页

Magnetic nanoparticle SERS sensor for rapid and selective detection of ClO− in drinking water 用于饮用水中氯离子快速选择性检测的磁性纳米粒子SERS传感器。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-10-01 DOI: 10.1007/s00604-025-07586-z

Liu Wang, Mingli Wang

引用次数: 0

Correction: Non-invasive detection of VEGF secretion from small clusters of mesenchymal stem cells using VEGF-SSSA integrated into the CellStudio platform 更正：使用整合到CellStudio平台的VEGF- sssa，对间充质干细胞小簇的VEGF分泌进行无创检测。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-10-01 DOI: 10.1007/s00604-025-07581-4

Enrique Azuaje-Hualde, Naiara Lartitegui-Meneses, Fernando Benito-Lopez, Lourdes Basabe-Desmonts

引用次数: 0

Ultra-convenient and rapid synthesis of FeAg MOGs for sensitive test strips detection of dopamine in human serum 超方便快速合成用于人血清多巴胺敏感试纸的FeAg MOGs。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-30 DOI: 10.1007/s00604-025-07565-4

Kangyi Guo, Yipi Xiao, Yun He, Jie Liu, Liang Guo, Aiping Fan, Zheling Zeng, Xiangjuan Zheng, Xiluan Yan

{"title":"Ultra-convenient and rapid synthesis of FeAg MOGs for sensitive test strips detection of dopamine in human serum","authors":"Kangyi Guo, Yipi Xiao, Yun He, Jie Liu, Liang Guo, Aiping Fan, Zheling Zeng, Xiangjuan Zheng, Xiluan Yan","doi":"10.1007/s00604-025-07565-4","DOIUrl":"10.1007/s00604-025-07565-4","url":null,"abstract":"<div><p>Metal-organic gels (MOGs) represent the unique category of metal-organic materials, notably distinguished by their expansive specific surface area, highly porous structural frameworks, and readily accessible metallic active sites. This investigation involved the synthesis of FeAg MOGs at ambient temperature using 1,3,5-phenyltricarboxylic acid (H<sub>3</sub>BTC) as a ligand through a simple, one-step method. The resultant FeAg MOGs exhibit excellent oxidase activity, capable of oxidizing 3,3',5,5'-tetramethylbenzidine (TMB) into blue oxTMB. In experimental studies we have discovered that dopamine (DA) exhibits the specific inhibitory effect on the colorimetric response of the FeAg MOGs-TMB system. Based on this a simple, rapid, and sensitive colorimetric method for the selective detection of DA was developed. This methodology possesses a ultra-wide detection range (linear range: 2 μM to 5000 μM) with a detection limit (LOD, S/N = 3) of 1.324 μM. It has proven effective and has been utilized successfully for the quantitative testing of DA in samples of human serum. Furthermore, a test paper has been designed to visually determine DA concentration within a range 2 μM to 1000 μM. The study demonstrates the enormous potential of MOGs for application in the field of colorimetric analysis.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MOF-based ratiometric fluorescent biosensors for selective and sensitive detection of hydrogen sulfide in food products 基于mof的比例荧光生物传感器用于食品中硫化氢的选择性和灵敏检测。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-30 DOI: 10.1007/s00604-025-07564-5

Yang Shen, Rou Chen, Yun Wang, Yanjun Qiu, Yuting Zhang, Xiaoli Wang, Nandi Zhou

{"title":"MOF-based ratiometric fluorescent biosensors for selective and sensitive detection of hydrogen sulfide in food products","authors":"Yang Shen, Rou Chen, Yun Wang, Yanjun Qiu, Yuting Zhang, Xiaoli Wang, Nandi Zhou","doi":"10.1007/s00604-025-07564-5","DOIUrl":"10.1007/s00604-025-07564-5","url":null,"abstract":"<div><p>Hydrogen a metal–organic framework (MOF)-based ratiometric fluorescent biosensor (Uio-66-N<sub>3</sub>@Cy3) was developed for the determination of hydrogen sulfide (H<sub>2</sub>S). The sensor combines the high specificity of the H<sub>2</sub>S-azide reaction with the inherent self-calibration capability of MOF-based dual-emission signals for efficient detection. The biosensor operates via H<sub>2</sub>S-selective azide-to-amine conversion, which suppresses photoinduced electron transfer to simultaneously restore the MOF's intrinsic fluorescence while maintaining Cy3's stable fluorescence, enabling ratiometric detection. The biosensor exhibits a dual-linear response across 0.5–100 nM and 0.5–4.0 μM, with detection limits as low as 36 pM and 27 nM, respectively. Furthermore, the biosensor shows exceptional selectivity against 18 potential interferents and long-term stability (RSD < 3.5% over 14 days). Importantly, the ratiometric mechanism enables robust performance in complex food samples (beer and milk), yielding 99.74–103.00% recoveries with minimal variance. Unlike intensity-based probes, this system provides intrinsic calibration through simultaneous dual-channel detection, making it ideal for real-world applications. Our work not only delivers a superior H<sub>2</sub>S sensor but also establishes a generalizable platform for ratiometric detection of diverse contaminants in food systems.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced cyclohexane resistive gas sensing using Mg-doped Bi2WO6 hollow microtubes derived from selective etching of MOF 利用MOF选择性蚀刻制备的掺镁Bi2WO6空心微管增强环己烷电阻气敏。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-30 DOI: 10.1007/s00604-025-07437-x

Wenjing Wei, Jingwei Liu, Zhijie Duan, Xuezhi Bao, Feng Zhang, Jingxiang Zhao

{"title":"Enhanced cyclohexane resistive gas sensing using Mg-doped Bi2WO6 hollow microtubes derived from selective etching of MOF","authors":"Wenjing Wei, Jingwei Liu, Zhijie Duan, Xuezhi Bao, Feng Zhang, Jingxiang Zhao","doi":"10.1007/s00604-025-07437-x","DOIUrl":"10.1007/s00604-025-07437-x","url":null,"abstract":"<div><p>The design of composition and morphology is a highly effective strategy for transforming solid metal–organic frameworks (MOFs) into hollow structures. In this study, we synthesized Mg-doped Bi<sub>2</sub>WO<sub>6</sub> hollow tubes using bismuth metal–organic frameworks (CAU-17) as templates. This process involves the synthesis of solid CAU-17 microtubes, the etching of hollow tubes using Mg<sup>2+</sup>/WO<sub>4</sub><sup>2−</sup> ions, and the formation of Mg/Bi<sub>2</sub>WO<sub>6</sub> hollow microtubes through air annealing. The unique hollow structure and complex composition of Mg/Bi<sub>2</sub>WO<sub>6</sub> contribute to its exceptional resistive gas sensing performance for detecting cyclohexane. The excellent cyclohexane sensing capabilities of Mg/Bi<sub>2</sub>WO<sub>6</sub> are a result of the cooperative enhancement from its hollow structure (high utility factor) and Mg doping (optimized receptor and transducer functions), with its high selectivity being fundamentally governed by the favorable adsorption thermodynamics and kinetics of cyclohexane on its surface. The Mg/Bi<sub>2</sub>WO<sub>6</sub> (ω<sub>Mg</sub> = 0.2 wt.%) sensor exhibits remarkable sensitivity (50 ppm, R<sub>a</sub>/R<sub>g</sub> = 67), detecting cyclohexane as low as 0.1 ppm at 275 °C (R<sub>a</sub>/R<sub>g</sub> = 1.2). Additionally, it demonstrates excellent selectivity and outstanding stability for cyclohexane, underscoring its potential for practical applications in the clinical diagnosis of tuberculosis patients. This work presents a novel strategy for the rational design of hollow tube metal oxides with superior resistive gas sensing capabilities, paving the way for future advancements in multifunctional materials.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enzyme-free quantification of breast cancer–derived exosomes via cubic DNA nanostructure-enhanced hybridization chain reaction 通过立方DNA纳米结构增强的杂交链式反应对乳腺癌来源的外泌体进行无酶定量。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-30 DOI: 10.1007/s00604-025-07545-8

Wenting Cheng, Jinhua Chen, Han Pan, Miao He, Yongliang Cai, Zhongyun Wang, Yang Xiang

{"title":"Enzyme-free quantification of breast cancer–derived exosomes via cubic DNA nanostructure-enhanced hybridization chain reaction","authors":"Wenting Cheng, Jinhua Chen, Han Pan, Miao He, Yongliang Cai, Zhongyun Wang, Yang Xiang","doi":"10.1007/s00604-025-07545-8","DOIUrl":"10.1007/s00604-025-07545-8","url":null,"abstract":"<div><p>Breast tumor–derived exosomes promise to guide diagnosis and therapy. But the small size and low mass of exosomes have higher requirements for target binding and signal amplification. Although hybridization chain reaction (HCR) has been extensively utilized for the sensitive detection of an enormous range of biomolecules, including the exosomes, achieving sufficient amplification efficiency remains challenging. To address this limitation, more and more researchers integrate the reaction system with functional materials of DNA. Inspired by this, we herein report for the first time the cubic DNA nanostructure enhanced hybridization chain reaction (CDN-HCR) to detect breast tumor–derived exosomes. Unlike other nanostructure-assisted HCR approaches, the four cholesterol anchors on the CDN enhance the binding affinity of signal probes for exosomes, while the four triggers combined with the supporting CDN further improve the reaction efficiency of HCR. Furthermore, incorporating an electrochemical detection system, the assay platform enables enzyme-free and label-free detection of exosomes. The quantitative detection of exosomes is easily achieved with a linear range of 5.5 × 10<sup>2</sup> to 5.5 × 10<sup>7</sup> particles/μL and a minimal detectable concentration of 51 particles/μL. Finally, the human serum study proves the feasibility of this technique in clinic applications.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacteriophages combined with hybridized nanoflower-based electrochemical biosensor for the specific and rapid detection of live Acinetobacter baumannii in real samples 噬菌体结合杂交纳米花电化学生物传感器特异性快速检测真实样品中的活鲍曼不动杆菌。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-30 DOI: 10.1007/s00604-025-07562-7

Huan Wang, Wajid Hussain, Xiaohan Yang, Yanming Chen, Tong Hu, Wei Chen, Shenqi Wang

{"title":"Bacteriophages combined with hybridized nanoflower-based electrochemical biosensor for the specific and rapid detection of live Acinetobacter baumannii in real samples","authors":"Huan Wang, Wajid Hussain, Xiaohan Yang, Yanming Chen, Tong Hu, Wei Chen, Shenqi Wang","doi":"10.1007/s00604-025-07562-7","DOIUrl":"10.1007/s00604-025-07562-7","url":null,"abstract":"<div><p><i>Acinetobacter</i> <i>baumannii</i> is an opportunistic nosocomial bacterial pathogen that causes significant global morbidity and mortality. A rapid and accurate detection platform is essential to minimize the risk of nosocomial infections and drug resistance. We developed an innovative electrochemical biosensor for the rapid detection of <i>A. baumannii</i> in real samples, using a unique enzyme immobilization method. The biosensor is capable of identifying <i>A. baumannii</i> through the specific phages attached to HRP@Cu<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> hybrid nanoflower with the help of AuNPs, creating a bifunctional complex that offers both biomolecular recognition and signal amplification. The developed phage-based electrochemical biosensor was efficient in detecting live <i>A. baumannii</i> across a range of 5.77 × 10<sup>2</sup>–5.77 × 10<sup>7</sup> CFU/mL, up to 3 CFU/mL, within 30 min in serum and plasma samples. The biosensor employs a straightforward design, offering more simple operation and higher specificity than traditional methods, such as culturing. Furthermore, the immobilization of HRP on the hybrid nanoflowers improved its stability against environmental conditions and affinity for the substrate. The findings of this study demonstrate that electrochemical biosensors based on HRP-hybrid nanoflowers and phages can be effectively utilized for the rapid detection of <i>A. baumannii</i> while also laying the groundwork for stable HRP immobilization.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile one-pot preparation of chiral metal–organic framework L-His-ZIF-67@SiO2 composite for HPLC enantioseparation 高效液相色谱拆分手性金属-有机骨架L-His-ZIF-67@SiO2复合材料的简易一锅制备。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-28 DOI: 10.1007/s00604-025-07558-3

Ren-Xiu He, Hao Wang, Tian-Jian Xiong, Yun-Qiao Zhao, Yun-Jie Li, Bang-Jin Wang, Jun-Hui Zhang, Sheng-Ming Xie, Jia-Ni Yang, Li-Ming Yuan

{"title":"Facile one-pot preparation of chiral metal–organic framework L-His-ZIF-67@SiO2 composite for HPLC enantioseparation","authors":"Ren-Xiu He, Hao Wang, Tian-Jian Xiong, Yun-Qiao Zhao, Yun-Jie Li, Bang-Jin Wang, Jun-Hui Zhang, Sheng-Ming Xie, Jia-Ni Yang, Li-Ming Yuan","doi":"10.1007/s00604-025-07558-3","DOIUrl":"10.1007/s00604-025-07558-3","url":null,"abstract":"<div><p>A chiral core–shell microsphere composite, L-His-ZIF-67@SiO<sub>2</sub>, was constructed by a one-pot method using SiO<sub>2</sub>-COOH as the carrier. The density of the MOF shell was regulated by altering the reaction time and the mixing ratio of the precursor to SiO<sub>2</sub>-COOH. As a new chiral stationary phase (CSP), the core–shell composite was applied to the enantiomeric separation in HPLC. With n-hexane/isopropanol as the mobile phase, a great variety of positional isomers and racemates were separated on the L-His-ZIF-67@SiO<sub>2</sub> packed column. There are 6 positional isomers and 12 chiral compounds including alcohols, ketones, epoxides, and esters that can be separated on this chiral column with good separation efficiency. The separation performance of the chiral column was examined in relation to injection masses, temperature, and mobile phase composition. Its application in the determination of enantiomeric excess and isomeric impurities in actual samples demonstrated its feasibility for practical HPLC analysis. Additionally, the chiral resolution capabilities of the L-His-ZIF-67@SiO<sub>2</sub> packed column were compared with those of two commercial chiral columns, indicating that the L-His-ZIF-67@SiO<sub>2</sub> packed column can serve as a complementary alternative. The results demonstrate that optimizing reaction conditions to construct uniform chiral MOFs@SiO<sub>2</sub> composites for HPLC enantioseparation offers novel insights into the development of MOF materials in chromatography.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bientropy-powered catalysis crosslinked ultrasensitive nanobiosensor for precise NIR light-regulated imaging of tumor biomarkers 生物熵驱动的催化交联超灵敏纳米生物传感器，用于肿瘤生物标志物的精确近红外光调节成像。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-26 DOI: 10.1007/s00604-025-07554-7

Lejing Yao, Xiaoming Sun, Qing Tang, Jingwei Qiu, Da Liu, Cheng-Yu Li

{"title":"Bientropy-powered catalysis crosslinked ultrasensitive nanobiosensor for precise NIR light-regulated imaging of tumor biomarkers","authors":"Lejing Yao, Xiaoming Sun, Qing Tang, Jingwei Qiu, Da Liu, Cheng-Yu Li","doi":"10.1007/s00604-025-07554-7","DOIUrl":"10.1007/s00604-025-07554-7","url":null,"abstract":"<div><p>Owing to the protease-free and hairpin DNA primers-free design of entropy-powered catalysis (EPC), nanobiosensors constructed from this amplification protocol show promising potential for detecting tumor biomarkers in live biosystems. Nevertheless, EPC’s single-round signal enhancement and perpetual activation during bio-delivery severally restrict its sensitivity and precision in responding to low-concentration analytes. To overcome these restrictions, this study first links together fuel strands produced by two separate EPC modules, thus establishing an ultrasensitive nanobiosensor that implements an exceptional crosslinked bientropy-powered catalysis with more powerful two-round amplification capacity. Following that, one DNA segment is embedded with a photocleavable bond to block the analyte’s recognition site, whereby a near-infrared light (NIR)-regulated strategy facilitated by upconversion luminescence is utilized to precisely activate the biosensing operation. Our conceptual proof is validated by determining microRNA-21, a low-abundance biomarker inclined to be overexpressed in various malignant tumors. In addition to ultra-high sensitivity (with a remarkably low limit of detection of 32.44 fM) and satisfactory specificity (discriminating even single-nucleotide mutations) in buffered environments, this bientropy-powered catalysis crosslinked nanobiosensor enables reliable imaging assays in both live cells and animals, offering a potent toolbox for cancer diagnostics.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of closed bipolar electrochemiluminescence sensor based on Co-MOF-derived Au/CoO-modified carbon cloth for uric acid detection 基于co - mof衍生Au/ co -改性碳布的封闭双极电化学发光尿酸检测传感器的构建。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-26 DOI: 10.1007/s00604-025-07549-4

Huahua Dong, Kaige Qv, Qunyan Zhu, Jinshuo Li, Chang Liu, Lin Zhang, Wensheng Yang

{"title":"Construction of closed bipolar electrochemiluminescence sensor based on Co-MOF-derived Au/CoO-modified carbon cloth for uric acid detection","authors":"Huahua Dong, Kaige Qv, Qunyan Zhu, Jinshuo Li, Chang Liu, Lin Zhang, Wensheng Yang","doi":"10.1007/s00604-025-07549-4","DOIUrl":"10.1007/s00604-025-07549-4","url":null,"abstract":"<div><p>A closed bipolar electrode-based electrochemiluminescence (cBPE-ECL) sensor was developed for wireless uric acid (UA) detection. In the cBPE-ECL sensor design, a cobalt-based metal–organic framework (Co-MOF)-derived Au/CoO-modified carbon cloth (Au/CoO-C/CC) electrode served as a polarized anode for UA oxidation, where the generated faradaic current triggered the cathodic ECL of [Ru(bpy)<sub>3</sub>]<sup>2+</sup>-[S<sub>2</sub>O<sub>8</sub>]<sup>2−</sup> at the polarized cathode electrode, enabling both quantitative and visual UA detection. The polarized anode was fabricated by incorporating Au nanoparticles into a Co-MOF structure on carbon cloth (CC), yielding an open architecture with enhanced charge transfer capabilities that significantly improved electrocatalytic activity toward UA. The as-prepared cBPE-ECL sensor exhibited excellent analytical performance, featuring a wide linear range (10–1000 µM), low detection limit (6 µM), high stability, good reproducibility, and strong anti-interference capabilities. The practical utility of this cBPE-ECL sensing platform was validated through successful UA detection in fetal bovine serum and artificial serum samples, achieving recoveries between 96.4 and 103.4%, demonstrating its potential for UA detection in clinical and biomedical applications.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0