Microchimica Acta最新文献

{"title":"Multifunctional double hairpin DNA polydopamine nano-system for “switch-on” detection and intervention of high-grade dysplastic nodules","authors":"Jie Zhou,&nbsp;Junfen Feng,&nbsp;Xiaomeng Dong,&nbsp;Tong Zhang,&nbsp;Yuxin Wei,&nbsp;Yanzi Wang,&nbsp;Chenyu Shi","doi":"10.1007/s00604-026-08070-y","DOIUrl":"10.1007/s00604-026-08070-y","url":null,"abstract":"<div><p>The 5-year survival rate of early-stage hepatocellular carcinoma (HCC) patients remains only 60%, largely due to the inability to achieve ultra-early detection and safe, minimally invasive intervention of its premalignant precursor—high-grade dysplastic nodules (HGDN). Current clinical practice faces an unresolved dilemma: conventional imaging has limited sensitivity for HGDN, no standardized minimally invasive intervention exists, and no integrated platform enables synchronous detection, boundary localization and on-demand intervention, despite HGDN 80.8% 5-year HCC progression rate. To address these core challenges, we developed a multifunctional dual-hairpin DNA polydopamine nano-system (H/R@PDA-GC) targeting miRNA-224, a biomarker consistently upregulated during HGDN malignant transformation.</p><p>This system enables specific detection of miRNA-224 with an ultra-low limit of detection (LOD) of 0.068 pM. Clinically, there is a 3-5-year natural history window from HGDN formation to clinically diagnosable early HCC; thus, this system provides a potential technical tool for the ultra-early warning of HCC at the precancerous stage. It simultaneously activates near-infrared fluorescence for targeted imaging of HGDN to precisely delineate lesion boundaries, and leverages its efficient photothermal conversion capability to achieve effective ablation of HGDN in validated murine models. Both cellular and animal studies confirmed its good in vitro and short-term in vivo biocompatibility, significant anti-inflammatory and antioxidant effects, and therapeutic efficacy, addressing the dual clinical needs of ultra-early detection and safe intervention of premalignant lesions. Consequently, H/R@PDA-GC provides an integrated theranostic strategy, which has potential clinical value for reducing the risk of HCC progression, and lays a foundation for ultra-early intervention of HCC precancerous lesions.</p><p>Clinical trial number. Not applicable. </p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A UV-vis-fluorescence-smartphone-assisted hydrogel “three-in-one” platform based on light-responsive carbon dots nanozyme for multimodal glyphosate detection","authors":"Wanqi Yang,&nbsp;Haodong Yang,&nbsp;Yaxin Ma,&nbsp;Ao Hou,&nbsp;Xiangyu Yang,&nbsp;Pengjuan Ni,&nbsp;Yizhong Lu","doi":"10.1007/s00604-026-08031-5","DOIUrl":"10.1007/s00604-026-08031-5","url":null,"abstract":"<div>\u0000 \u0000 <p>The establishment of a fast and precise method for glyphosate detection holds critical importance in ensuring food safety. Herein, a multimodal sensing platform that integrated UV-vis, fluorescence and smartphone-assisted portable hydrogel kit was applied to detect glyphosate relying on the light-responsive oxidase-mimicking activity and intrinsic fluorescence of carbon dots (C-dots). C-dots enable the oxidation of 3,3’,5,5’-tetramethylbenzidine (TMB), resulting in blue-colored oxidized TMB (oxTMB) along with enhanced absorbance at 652 nm. Simultaneously, the inner filter effect between oxTMB and C-dots induces the fluorescence quenching of C-dots. However, the introduction of copper ions can capture photogenerated electrons, thereby inhibiting the oxidase-mimicking catalytic activity of C-dots, leading to a decrease in absorbance and the restoration of fluorescence. Once glyphosate is present in the system, it can coordinate with copper ions to restore the catalytic activity of C-dots, thereby causing an increase in absorbance and a simultaneous decrease in fluorescence. Consequently, quantification detection of glyphosate can be realized via UV-vis and fluorescence modes. More importantly, in light of the changes in solution color, a smartphone-assisted portable hydrogel kit was also developed for glyphosate detection. Therefore, a UV-vis-fluorescence-smartphone-assisted hydrogel “three-in-one” platform was established for glyphosate determination with corresponding limits of detection of 0.31, 0.12 and 5.07 µg/mL, respectively. This platform can achieve glyphosate detection within just one minute. Notably, this work represents the first application of light-responsive C-dots oxidase mimetics for glyphosate detection. By utilizing visible light as a clean energy source to drive and regulate the catalytic reaction, the proposed strategy eliminates the dependence on hazardous H₂O₂, offering a green, accurate, and rapid sensing platform with broad application.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical Abstract\u0000 <div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical detection of miRNA-128 in Alzheimer’s disease using (3-aminopropyl) triethoxysilane and citrate-capped green-synthesized silver nanoparticles","authors":"Sonia Rani,&nbsp;Abhilasha Khatri,&nbsp;Sarita Devi,&nbsp;Karthik Vinay Mahesh,&nbsp;Rajat Sandhir,&nbsp;Nirmal Prabhakar","doi":"10.1007/s00604-026-08040-4","DOIUrl":"10.1007/s00604-026-08040-4","url":null,"abstract":"<div><p>The diagnostic method for Alzheimer’s disease (AD) is moving towards non-invasive approaches and miRNAs in biofluids are being considered as potential early biomarkers. Among all the miRNAs, the elevated levels of miRNA-128 in the serum may serve as potential diagnostic biomarker for AD. We report an electrochemical sensing platform based on a reusable fluorine-doped tin oxide (FTO) electrode, modified with citrate-capped silver nanoparticles (Ag-Cit NPs) synthesized using the <i>Bryophyllum pinnatum</i> leaf extract. Initially, the FTO were treated with (3-aminopropyl) triethoxysilane (APTES) to achieve the amine groups interaction with Ag-Cit NPs (Ag-Cit/APTES/FTO electrode). The biotinylated-cDNA (Btn-cDNA) was conjugated on Ag-Cit/APTES/FTO electrode with the help of streptavidin (SV) and the possible vacant electrode surface was blocked with the help of 6-mercapto-1-hexanol (MCH). The fabricated biosensing electrode (MCH/Btn-cDNA/SV/Ag-Cit/APTES/FTO) showed the low detection limit of 0.024 fM for miRNA-128 detection using electrochemical impedance spectroscopy. With the limit of quantification of 0.080 fM and a sensitivity of 402.48 Ω fM⁻¹cm^− 1, this nanoplatform achieved recoveries of 99% to 101.9%. The selective signal for miRNA-128 was obtained when compared with the mismatch and single mismatch miRNAs. Furthermore, the reliable performance in the real serum samples of AD patients, recommends this nano-sensor platform for future non-invasive detection tool in early diagnosis of AD.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near infrared light enhanced a green vitamin Cu/Co@MOF laccase-like nanozyme activity for estrogen colorimetric detection","authors":"Xiao Li,&nbsp;Junfeng Fang,&nbsp;Tao Yuan,&nbsp;Lingchuan Li,&nbsp;Yaling Yang,&nbsp;Xiaomei Wu","doi":"10.1007/s00604-026-08035-1","DOIUrl":"10.1007/s00604-026-08035-1","url":null,"abstract":"<div>\u0000 \u0000 <p>The development of a bimetallic metal-organic framework (Cu/Co@MOF) is presented using copper and cobalt as central ions and vitamin B₆ as the green ligand through a straightforward microwave digestion technique that act as potent laccase mimics, specifically designed for estrogen (including estriol, estradiol, and diethylstilbestrol) sensing. A newly designed Cu/Co@MOF nanozyme probe exhibits significantly improved laccase-mimicking activity and photothermal efficiency when exposed to near-infrared (NIR) light. Experimental investigations elucidated that NIR promoted the activation of molecular oxygen (O₂) for generation of producing superoxide radicals (∙O₂⁻) and electron transfer efficiency (Co³⁺/Co²⁺-Cu⁺/Cu²⁺), improving oxygen activation efficiency and catalytic cycling. Under NIR stimulation, the catalytic efficiency of the Cu/Co@MOF nanozyme increases markedly, achieving a four times improvement compared to non-stimulated conditions. Importantly, Cu/Co@MOF maintains impressive stability across a broad pH range and temperatures. The absorbance of estradiol shows a linear correlation with concentrations spanning from 0.02 to 25 µg/L, 0.012 to 36 µg/L, and 0.045 to 15 µg/L, with corresponding detection limits of 0.016 µg/L, 0.006 µg/L, and 0.038 µg/L, respectively. Furthermore, the colorimetric sensor based on Cu/Co@MOF demonstrates outstanding performance in detecting estrogens.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical Abstract\u0000 <div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A hierarchical dual-lock mechanism empowered epifluidic patch for rapid glucose feedback in exercise-induced sweating","authors":"Zhu Yang,&nbsp;Mohamed I. H. Gama,&nbsp;Saminu Abdullahi,&nbsp;Mubashir Ali,&nbsp;David Chieng,&nbsp;Chiew-Foong Kwong,&nbsp;Pushpendu Kar,&nbsp;Zedong Nie","doi":"10.1007/s00604-026-08080-w","DOIUrl":"10.1007/s00604-026-08080-w","url":null,"abstract":"<div><p> A wearable epifluidic patch featuring a hierarchical dual-lock mechanism is introduced. Tetrahedral DNA nanostructures co-localize enzymes at defined spacing to promote substrate channeling and accelerate kinetics, while a gelatin hydrogel stabilizes the enzymatic microenvironment during hydration cycles, ensuring uniform reaction conditions for homogeneous signal formation. This design produced a visible glucose-responsive signal within 30 s, with a linear range of 50–400 µM and a detection limit of 9.98 µM. Integrated with passive microfluidics and smartphone imaging, the patch enables sequential sampling in human trials conducted during physical exercise. The hierarchical immobilization method, device design, and system integration outlined demonstrate a platform for intuitive, electronics-free colorimetric sensing in dynamic environments.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chiral separation of typical binaphthyl atropisomers using binary systems of natural deep eutectic solvents and β-cyclodextrin derivatives by miniaturized capillary electrophoresis with amperometric detection","authors":"Wei Zhou,&nbsp;Jingjing Zhang,&nbsp;Yuxuan Ma,&nbsp;Ping Song,&nbsp;Xinyi Huang,&nbsp;Qingcui Chu","doi":"10.1007/s00604-026-08086-4","DOIUrl":"10.1007/s00604-026-08086-4","url":null,"abstract":"<div>\u0000 \u0000 <p>Natural deep eutectic solvents (NADESs) have attracted considerable attention in the realm of chiral separation. At present, there are few reports on the chiral selectivity differences of NADESs and cyclodextrins with different types in capillary electrophoresis. In this work, a series of choline chloride-based NADESs were coupled with β-cyclodextrin derivatives to construct the binary chiral separation systems. Three binaphthyl atropisomers were selected as the model molecules to investigate the differences in chiral selectivity of the developed separation systems by a self-assembled miniaturized capillary electrophoresis with amperometric detection device (mini-CE-AD) for the first time. An interesting discovery is that the types and stereo-configurations of the hydrogen bond donors in NADESs coupled with the types of cyclodextrins exhibited stereoselectivity differences for the model atropisomers. NADESs based on stereoisomeric organic acids and neutral hydroxypropyl-β-cyclodextrin have played an important synergistic role in improving the resolution of 1,1’-bi(2-naphthol) and 2’-amino-[1,1’-binaphthalen]-2-ol, while choline chloride-urea DES and anionic sulfobutyl-β-cyclodextrin have a better synergistic effect for the separation of 1,1’-binaphthyl-2,2’-diamine. The relative standard deviations of migration time, peak area, and resolution for 1,1’-binaphthol isomers were within 8.6%, and the limits of detection reached 0.060 µg·mL^− 1 (S/<i>N</i> = 3). The structure-performance-characteristic relationship of NADESs and cyclodextrins provides new insights for the efficient design and selection of chiral selectors, and the mini-CE-AD system offers a rapid, low-cost, and portable analytical platform for chiral separation. In addition, the greenness and ecological friendliness of this method were evaluated by the modified green analytical procedure index and analytical greenness metric tools.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical abstract\u0000 <div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of Mn2O3/CdS heterojunction nanocomposite for liquefied petroleum gas detection","authors":"Kuwar Ankur Singh,&nbsp;Bala Bhardwaj,&nbsp;Keval Bharati,&nbsp;Rahul Pratap Singh,&nbsp;Prabhat Ranjan Tiwari,&nbsp;Monu Gupta,&nbsp;Bal Chandra Yadav,&nbsp;Santosh Kumar","doi":"10.1007/s00604-026-08083-7","DOIUrl":"10.1007/s00604-026-08083-7","url":null,"abstract":"<div>\u0000 \u0000 <p>Liquefied petroleum gas (LPG) is a versatile fuel but is incredibly combustible. Thus, its leakage detection/sensing is of prime importance for the safety of living beings and the environment. This paper reports the synthesis of manganese (III) oxide (Mn₂O₃)/ cadmium sulphide (CdS) composite nanomaterial using p-type Mn₂O₃ and n-type CdS nanomaterials via the hydrothermal method. Characterization of prepared materials was done by powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FESEM), energy-dispersive X-ray (EDX) spectroscopy, high resolution-transmission electron microscopy (HR-TEM), X-ray photoelectron spectroscopy (XPS), ultraviolet-visible (UV-Vis) spectroscopy, Mott-Schottky (M-S), and Fourier-transform infrared (FTIR) spectroscopy. PXRD analysis confirmed a cubic crystal structure with a crystallite size of 24.18 nm. The surface morphology and elemental composition were revealed by FESEM and EDX, respectively. HR-TEM and M-S analysis confirm the formation of a heterojunction in the nanocomposite phase. XPS spectroscopy revealed the chemical composition of the surface element of Mn₂O₃/CdS nanomaterial. UV-Vis spectroscopy determined that the nanocomposite’s optical band gap is 2.02 eV, which lies between 1.9 eV (Mn₂O₃) and 2.25 eV (CdS). FTIR analysis confirmed that the constituents Mn₂O₃ and CdS are successfully integrated in the composite Mn₂O₃/CdS nanomaterial, which has a hygroscopic character. The optimized Mn₂O₃/CdS was explored for the first time in the designing of a thin-film LPG sensor. The evaluated sensing parameters revealed that the designed sensor using Mn₂O₃/CdS exhibited the highest sensor response (1.6) and the lowest response time (7.79 s) and recovery time (10.84 s) as compared to constituent nanomaterials (Mn₂O₃ and CdS) at 5000 ppm. The developed sensor exhibits strong selectivity toward LPG, promising repeatability, and long-term stability. The effect of humidity on the designed sensor was also studied. The designed sensor outperforms in terms of material, recovery, and response times.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical abstract\u0000 <div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrovoltaic-photoelectric effect driven self-powered electrochemical aptasensor with engineered built-in electric field for on-site microcystin-RR detection in aquatic products","authors":"Yan Chen,&nbsp;Ding Jiang,&nbsp;Xiaojiao Du,&nbsp;Xue Wang,&nbsp;Xueling Shan,&nbsp;Wenchang Wang,&nbsp;Zhidong Chen","doi":"10.1007/s00604-026-08091-7","DOIUrl":"10.1007/s00604-026-08091-7","url":null,"abstract":"<div>\u0000 \u0000 <p>The bioaccumulation of hepatotoxic Microcystin-RR (MC-RR) in aquatic products poses a severe threat to human health via the food chain, underscoring the urgent need for sensitive detection methods. Herein, a self-powered electrochemical aptasensor was developed for on-site MC-RR monitoring based on ZIF-67/g-C₃N₄ heterojunctions. By coupling hydrovoltaic and photoelectric effects, the engineered built-in electric field significantly enhanced charge separation and water evaporation, amplifying the electrical signal by 11-fold under illumination. The aptamer-functionalized platform enabled specific MC-RR detection via modulating the interfacial charge transfer, achieving a wide linear range from 1 × 10^− 14 M to 1 × 10^− 10 M and an ultra-low detection limit of 2.36 × 10^− 15 M. Furthermore, the sensor demonstrated excellent selectivity against interfering substances and was successfully applied to the analysis of aquaculture water and crucian carp samples. This work presents a sustainable, high-performance self-powered sensing platform for early cyanotoxin screening to safeguard aquatic food safety. Its advantages of simple operation and high sensitivity make it a promising tool for on-site food safety monitoring.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical Abstract\u0000 <div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon-based field-effect transistor gas sensor modulated by gate electric field for trace-level hydrogen sulfide detection","authors":"Hongtao Kuang,&nbsp;Bohao Liu,&nbsp;Yuqing Li,&nbsp;Jinyong Hu,&nbsp;Bolang Cheng,&nbsp;Jun Hong,&nbsp;Yong Zhang","doi":"10.1007/s00604-026-08081-9","DOIUrl":"10.1007/s00604-026-08081-9","url":null,"abstract":"<div><p>Inspired by the signal amplification property of the field-effect transistor (FET) enabled by electric field modulation across the conducting channel, a carbon-based FET hydrogen sulfide (H₂S) sensor with ionogel sensing material was fabricated, providing trace-level detection without the need of thermal or optical fields. Under an applied back-gate voltage, the working state of the FET sensor could be regulated to the linear region, significantly boosting the sensor’s sensitivity toward low-concentration analytes. The proposed sensor exhibited a room-temperature detection ability toward 0.1-1 ppm of H₂S. Leveraging the hydrophobic nature of the ionogel, the sensor showed a slight response variation (6.8%) toward 1 ppm of H₂S in the range 10–90% relative humidity (RH). This work provides an electric field modulation strategy for trace-level gas detection, offering a feasible solution for the chip-integrated development of gas sensors.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A near-infrared excited Förster resonance energy transfer-based fluorescent sensor using core–shell upconversion nanoparticles functionalized with rhodamine B derivative for highly selective detection of Hg2+","authors":"Yanmei Zhang,&nbsp;Rui Jiang,&nbsp;Hongze Yang,&nbsp;Cheng Zhou,&nbsp;Mengxi Sun,&nbsp;Hong Chen,&nbsp;Donghai Lin,&nbsp;Liming Huang,&nbsp;Guosong Chen","doi":"10.1007/s00604-026-08050-2","DOIUrl":"10.1007/s00604-026-08050-2","url":null,"abstract":"<div>\u0000 \u0000 <p>A near-infrared (NIR)-excitable ratiometric fluorescent nanosensor, CS-UCNP@mSiO₂–RBPA, was developed for the selective and sensitive detection of Hg²⁺. The nanosensor is constructed by grafting a rhodamine B-derived probe (RBPA) onto mesoporous silica-coated core–shell NaYF₄:Yb,Er upconversion nanoparticles (UCNPs). Upon 980 nm excitation, the UCNPs exhibit characteristic green emission at ~ 543 nm and red emission at ~ 655 nm. In the presence of Hg²⁺, the spirolactam ring of RBPA opens specifically, producing a yellow-emitting species that enables efficient Förster resonance energy transfer (FRET) from the UCNP donor. This leads to a Hg²⁺ concentration-dependent quenching of green emission and a synchronous enhancement of yellow fluorescence at ~ 584 nm, with the red emission acting as a stable internal reference. The nanosensor shows outstanding selectivity toward Hg²⁺ against other competing metal ions and performs optimally at neutral pH. It presents a good linear response in the Hg²⁺ concentration range 0–70 µM via UV–vis absorption, and achieves an ultra-low detection limit of 14 nM based on the ratiometric fluorescence signal (I₅₈₄/I₆₅₅). Benefiting from NIR excitation, ratiometric self-calibration and excellent specificity, this fluorescent nanoplatform holds great potential for practical applications in environmental monitoring and biological analysis.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical Abstract\u0000 <div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"193 5","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}