Microchimica Acta最新文献_第4页

Bientropy-powered catalysis crosslinked ultrasensitive nanobiosensor for precise NIR light-regulated imaging of tumor biomarkers 生物熵驱动的催化交联超灵敏纳米生物传感器，用于肿瘤生物标志物的精确近红外光调节成像。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-26 DOI: 10.1007/s00604-025-07554-7

Lejing Yao, Xiaoming Sun, Qing Tang, Jingwei Qiu, Da Liu, Cheng-Yu Li

{"title":"Bientropy-powered catalysis crosslinked ultrasensitive nanobiosensor for precise NIR light-regulated imaging of tumor biomarkers","authors":"Lejing Yao, Xiaoming Sun, Qing Tang, Jingwei Qiu, Da Liu, Cheng-Yu Li","doi":"10.1007/s00604-025-07554-7","DOIUrl":"10.1007/s00604-025-07554-7","url":null,"abstract":"<div><p>Owing to the protease-free and hairpin DNA primers-free design of entropy-powered catalysis (EPC), nanobiosensors constructed from this amplification protocol show promising potential for detecting tumor biomarkers in live biosystems. Nevertheless, EPC’s single-round signal enhancement and perpetual activation during bio-delivery severally restrict its sensitivity and precision in responding to low-concentration analytes. To overcome these restrictions, this study first links together fuel strands produced by two separate EPC modules, thus establishing an ultrasensitive nanobiosensor that implements an exceptional crosslinked bientropy-powered catalysis with more powerful two-round amplification capacity. Following that, one DNA segment is embedded with a photocleavable bond to block the analyte’s recognition site, whereby a near-infrared light (NIR)-regulated strategy facilitated by upconversion luminescence is utilized to precisely activate the biosensing operation. Our conceptual proof is validated by determining microRNA-21, a low-abundance biomarker inclined to be overexpressed in various malignant tumors. In addition to ultra-high sensitivity (with a remarkably low limit of detection of 32.44 fM) and satisfactory specificity (discriminating even single-nucleotide mutations) in buffered environments, this bientropy-powered catalysis crosslinked nanobiosensor enables reliable imaging assays in both live cells and animals, offering a potent toolbox for cancer diagnostics.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of closed bipolar electrochemiluminescence sensor based on Co-MOF-derived Au/CoO-modified carbon cloth for uric acid detection 基于co - mof衍生Au/ co -改性碳布的封闭双极电化学发光尿酸检测传感器的构建。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-26 DOI: 10.1007/s00604-025-07549-4

Huahua Dong, Kaige Qv, Qunyan Zhu, Jinshuo Li, Chang Liu, Lin Zhang, Wensheng Yang

{"title":"Construction of closed bipolar electrochemiluminescence sensor based on Co-MOF-derived Au/CoO-modified carbon cloth for uric acid detection","authors":"Huahua Dong, Kaige Qv, Qunyan Zhu, Jinshuo Li, Chang Liu, Lin Zhang, Wensheng Yang","doi":"10.1007/s00604-025-07549-4","DOIUrl":"10.1007/s00604-025-07549-4","url":null,"abstract":"<div><p>A closed bipolar electrode-based electrochemiluminescence (cBPE-ECL) sensor was developed for wireless uric acid (UA) detection. In the cBPE-ECL sensor design, a cobalt-based metal–organic framework (Co-MOF)-derived Au/CoO-modified carbon cloth (Au/CoO-C/CC) electrode served as a polarized anode for UA oxidation, where the generated faradaic current triggered the cathodic ECL of [Ru(bpy)<sub>3</sub>]<sup>2+</sup>-[S<sub>2</sub>O<sub>8</sub>]<sup>2−</sup> at the polarized cathode electrode, enabling both quantitative and visual UA detection. The polarized anode was fabricated by incorporating Au nanoparticles into a Co-MOF structure on carbon cloth (CC), yielding an open architecture with enhanced charge transfer capabilities that significantly improved electrocatalytic activity toward UA. The as-prepared cBPE-ECL sensor exhibited excellent analytical performance, featuring a wide linear range (10–1000 µM), low detection limit (6 µM), high stability, good reproducibility, and strong anti-interference capabilities. The practical utility of this cBPE-ECL sensing platform was validated through successful UA detection in fetal bovine serum and artificial serum samples, achieving recoveries between 96.4 and 103.4%, demonstrating its potential for UA detection in clinical and biomedical applications.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A simple and rapid colorimetric sensor for uric acid detection based on ligand-modified silver nanoparticles with oxidase activity 一种基于氧化酶活性配体修饰银纳米粒子的尿酸检测比色传感器。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-25 DOI: 10.1007/s00604-025-07566-3

DongboYang, Guangda Xu, Jinkun Yan, Lefa Zhao

{"title":"A simple and rapid colorimetric sensor for uric acid detection based on ligand-modified silver nanoparticles with oxidase activity","authors":"DongboYang, Guangda Xu, Jinkun Yan, Lefa Zhao","doi":"10.1007/s00604-025-07566-3","DOIUrl":"10.1007/s00604-025-07566-3","url":null,"abstract":"<div><p> Novel silver nanoparticles modified with 1-methyl-1H-imidazole-2-carbaldehyde (AgNPs@MCA) with superior oxidase-like activity are reported for the first time. AgNPs@MCA directly utilized dissolved oxygen to catalyze the oxidation of the chromogenic substrate 3,3',5,5'-tetramethylbenzidine (TMB), generating blue oxidized TMB (oxTMB). Density functional theory (DFT) calculations were employed to elucidate the role of MCA in the catalytic process. Furthermore, leveraging the ability of uric acid (UA) to scavenge reactive oxygen species (ROS) in the system, a simple and rapid colorimetric method for UA detection was established. Under optimal conditions, the proposed method exhibited a linear range of 20–100 μM and a detection limit (LOD) of 1 μM. The assay demonstrated good selectivity, stability, and reproducibility. Detection results in actual human urine samples aligned with normal physiological levels, validating the potential of this colorimetric sensing approach for biomedical applications.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An automated portable LAMP-based centrifugal microfluidic system for nucleic acid detection of multiple pathogens in feline upper respiratory disease 基于lamp的自动便携式离心微流控系统用于猫上呼吸道疾病多种病原体的核酸检测。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-25 DOI: 10.1007/s00604-025-07540-z

Wangyu Bi, Fei Wen, Shanglin Cai, Yucui Li, Lei Zhang, Liang Bai, Jie Wang, Cencan Xing, Lei Zhang, Hongwu Du, Lei Wang

{"title":"An automated portable LAMP-based centrifugal microfluidic system for nucleic acid detection of multiple pathogens in feline upper respiratory disease","authors":"Wangyu Bi, Fei Wen, Shanglin Cai, Yucui Li, Lei Zhang, Liang Bai, Jie Wang, Cencan Xing, Lei Zhang, Hongwu Du, Lei Wang","doi":"10.1007/s00604-025-07540-z","DOIUrl":"10.1007/s00604-025-07540-z","url":null,"abstract":"<div><p> A portable centrifugal microfluidic nucleic acid analyzer tailored for point-of-care diagnostics was developed. The system consists of a main unit and a sector-shaped microfluidic chip driven by centrifugal force. By incorporating branched microchannels into the chip design, the system enables simultaneous detection of multiple targets from a single sample. The sample flows sequentially through the sample reservoir, dissolution chamber, and metering structure before reaching the reaction chamber. Under the presence of specific primers, the analyzer performs loop-mediated isothermal amplification (LAMP) by heating the chip. Fluorescence signals are captured by the optical detection module and displayed in real-time. We designed highly specific primers targeting six common feline upper respiratory disease (FURD) pathogens and extensively validated the device’s specificity and sensitivity. The system demonstrated a low detection limit (10–100 copies/μL) and successfully identified 72 clinically positive samples, achieving 100% agreement with conventional PCR. Weighing only 5 kg, the analyzer can accurately detect and identify six FURD-related pathogens from a single sample within 30 min. This method enables a shift from single-target to multitarget detection and promotes the broader adoption of decentralized testing. It offers an efficient and convenient solution for rapid and accurate pathogen detection, particularly in pet hospitals and veterinary clinical diagnostics.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile sulfur-doping by self-photosensitization of graphene quantum dots in DMSO for improved sensing 利用自光敏石墨烯量子点在DMSO中掺杂硫以改善传感性能。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-25 DOI: 10.1007/s00604-025-07512-3

Dongping Cai, Kai Shi, Zhengxing Gong, Xinfeng Zhang

{"title":"Facile sulfur-doping by self-photosensitization of graphene quantum dots in DMSO for improved sensing","authors":"Dongping Cai, Kai Shi, Zhengxing Gong, Xinfeng Zhang","doi":"10.1007/s00604-025-07512-3","DOIUrl":"10.1007/s00604-025-07512-3","url":null,"abstract":"<div><p>A photosensitization-based synthesis strategy is established enabling the room-temperature preparation of sulfur-doped graphene quantum dots (S-GQDs). Under 365-nm UV irradiation, GQDs produce singlet oxygen (<sup>1</sup>O<sub>2</sub>), catalyzing the oxidation of dimethyl sulfoxide (DMSO) into sulfur-containing intermediates, which subsequently react with surface functional groups on GQDs to achieve precise sulfur doping. The introduced defect states significantly enhanced radiative recombination, raising the quantum yield to 29.5%. The S-GQDs showed outstanding stability, including superior photobleaching resistance (minimal fluorescence change after 3.5 h UV exposure), high thermal stability (minimal variation from 20 to 80 °C), excellent pH tolerance (< 10% fluctuation within pH 3–12), and stable fluorescence in high-salinity and long-term storage conditions. Utilizing photoinduced electron transfer (PET) and fluorescence resonance energy transfer (FRET) mechanisms, the S-GQDs exhibited sensitivity and selectivity toward picric acid (PA), with a linear response between 1 and 60 μM and a detection limit of 0.56 μM. Practical tests confirmed reliable detection of PA on human finger surfaces, and the results were in good agreement with those obtained by high-performance liquid chromatography (HPLC). This photosensitization-based oxidation strategy provides a green, scalable route for preparation of high-performance S-GQDs that have broad potential applications in environmental monitoring, bioanalysis, etc.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CeO2/g-C3N4 photoactive nanozyme-based colorimetric immunoassay for carcinoembryonic antigen detection 基于CeO2/g-C3N4光活性纳米酶的比色免疫法检测癌胚抗原。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-25 DOI: 10.1007/s00604-025-07524-z

Yan Cheng, Yunzhi Wang, Pengcheng Zhang, Xing Hu, Xiaolin Hou, Bing Zhang

{"title":"CeO2/g-C3N4 photoactive nanozyme-based colorimetric immunoassay for carcinoembryonic antigen detection","authors":"Yan Cheng, Yunzhi Wang, Pengcheng Zhang, Xing Hu, Xiaolin Hou, Bing Zhang","doi":"10.1007/s00604-025-07524-z","DOIUrl":"10.1007/s00604-025-07524-z","url":null,"abstract":"<div><p>Enzyme-mimicking nanomaterials have gained significant attention for use in colorimetric immunoassays. However, further enhancing their mimetic enzyme activity remains crucial for improving assay sensitivity. In this study, CeO<sub>2</sub>/g-C<sub>3</sub>N<sub>4</sub> nanozymes were synthesized with enhanced catalytic activity when exposed to visible light. The irradiation facilitates electron transfer within the CeO<sub>2</sub>/g-C<sub>3</sub>N<sub>4</sub> nanomaterials, leading to the generation of reactive oxygen species (ROS). These ROS then promote the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB), causing a distinct color change. Based on this, a novel colorimetric immunoassay platform was developed, using the CeO<sub>2</sub>/g-C<sub>3</sub>N<sub>4</sub> nanomaterials as labels. Under visible light, the color development signal was significant amplified, resulting in improved sensitivity. This approach showed a linear response for the detection of carcinoembryonic antigen (CEA) in the range 0.5–30 ng/mL, with a limit of detection (LOD) of 0.13 ng/mL. The assay also demonstrated high specificity and excellent reproducibility. Consequently, this method offers a promising strategy for early cancer diagnosis and holds considerable potential for wider clinical applications.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micro- and nanoscale biosensing technologies for early diagnosis of Parkinson’s disease 用于帕金森病早期诊断的微纳米级生物传感技术。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-24 DOI: 10.1007/s00604-025-07505-2

Tejas Nikam, Anika Rana, Shubhini A. Saraf, Saurabh Awasthi

{"title":"Micro- and nanoscale biosensing technologies for early diagnosis of Parkinson’s disease","authors":"Tejas Nikam, Anika Rana, Shubhini A. Saraf, Saurabh Awasthi","doi":"10.1007/s00604-025-07505-2","DOIUrl":"10.1007/s00604-025-07505-2","url":null,"abstract":"<div><p>Parkinson’s disease (PD), the second most prevalent neurodegenerative disorder, remains challenging to diagnose at its earliest stages due to the absence of definitive biomarkers and overlapping clinical features with other synucleinopathies, thereby delaying therapeutic intervention and effective disease management. This review provides an integrative evaluation of established and emerging approaches for detecting PD-specific biomarkers in biofluids and tissues with high sensitivity and specificity. Conventional assays such as seed amplification techniques, proximity ligation and extension methods, bead-based microarrays, and immunoassays including ELISA, electrochemiluminescence, and SIMOA are examined alongside their performance metrics and inherent limitations. We then highlight next-generation micro- and nanoscale biosensing platforms, including nanopore-based resistive pulse sensing, surface plasmon resonance (SPR), surface-enhanced Raman spectroscopy (SERS), field-effect transistors (FETs), electrochemical sensors, and lateral flow assays (LFAs), which are capable of ultrasensitive detection at nano- to attomolar concentrations. Particular emphasis is given to nucleic acid-based technologies such as aptasensors, genosensors, and CRISPR/Cas systems for their exceptional molecular recognition, programmable signal outputs, and portability. The potential of artificial intelligence and machine learning tools (e.g., SVM, RF, DNN) to improve biomarker interpretation, enable multiplexed analysis, and facilitate real-time monitoring is also discussed. Finally, we outline key translational challenges, including assay standardization, clinical validation, scalability, integration into wearable and point-of-care devices, and regulatory hurdles towards the development of robust, clinically deployable diagnostic platforms for early PD detection and monitoring.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual enzyme-mimetic activity of graphene oxide framework encapsulated copper-palladium bimetallic nanoparticles for uricase-free colorimetric detection of uric acid 氧化石墨烯框架包封铜钯双金属纳米颗粒用于无尿酸酶比色检测的双酶模拟活性研究。

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-24 DOI: 10.1007/s00604-025-07494-2

Diksha J. Baruah, Pulakesh Borah, Ashutosh Thakur, Manash R. Das

{"title":"Dual enzyme-mimetic activity of graphene oxide framework encapsulated copper-palladium bimetallic nanoparticles for uricase-free colorimetric detection of uric acid","authors":"Diksha J. Baruah, Pulakesh Borah, Ashutosh Thakur, Manash R. Das","doi":"10.1007/s00604-025-07494-2","DOIUrl":"10.1007/s00604-025-07494-2","url":null,"abstract":"<div><p> A novel CuPd@GOF nanocomposite is introduced, where copper and palladium nanoparticles (∼2 nm) are encapsulated within a three-dimensional graphene oxide framework (GOF), enabling superior catalytic performance. The rigid GOF structure ensures high nanoparticle dispersion, Maximizing atom utilization and catalytic efficiency. Additionally, Cu incorporation enhances activity through Fenton-like catalysis while reducing Material costs. The nanocomposite possesses a 2.72 eV bandgap, facilitating light harvesting ability for photocatalysis. CuPd@GOF exhibits dual enzyme-mimetic activities: a superior peroxidase-mimic activity, surpassing monometallic Cu@GOF and Pd@GOF, and an oxidase-mimic activity under external light irradiation. The peroxidase-mimic activity of this novel nanocomposite was exploited for uricase-free colorimetric detection of uric acid (UA), a key biomarker for gout and kidney disorders. The colorimetric assay utilizes Cu-mediated urate complexation and π–π interactions for enzyme-free detection, achieving a detection Limit of 12.62 µM with a broad linear range (5–100 µM) within 10 min. The method exhibits good selectivity against biological interferents and was successfully validated using fetal bovine serum, demonstrating its potential for biomedical applications.\u0000</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Multifunctional cerium nanolabels in electrochemical immunosensing with improved robustness and performance: determination of TIM-1 in colorectal cancer scenarios as a case study 更正：多功能铈纳米标签在电化学免疫传感中具有更好的鲁棒性和性能：以结肠直肠癌场景中TIM-1的测定为例研究

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-23 DOI: 10.1007/s00604-025-07561-8

Andrea Cabrero-Martín, Sara Santiago, Verónica Serafín, María Pedrero, Ana Montero-Calle, José M. Pingarrón, Rodrigo Barderas, Susana Campuzano

引用次数: 0

Correction: Biotechnology-enhanced immunoassay for accurate determination of HT-2 toxin in edible insect samples 校正：生物技术增强免疫分析法用于可食用昆虫样品中HT-2毒素的准确测定

IF 5.3 2区化学

Microchimica Acta Pub Date : 2025-09-23 DOI: 10.1007/s00604-025-07563-6

Raúl Sancho-García, Fernando Navarro-Villoslada, Fernando Pradanas-González, Henri O. Arola, Bettina Glahn-Martínez, Tarja K. Nevanen, Elena Benito-Peña

引用次数: 0