Construction of closed bipolar electrochemiluminescence sensor based on Co-MOF-derived Au/CoO-modified carbon cloth for uric acid detection

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2025-09-26 DOI:10.1007/s00604-025-07549-4

Huahua Dong, Kaige Qv, Qunyan Zhu, Jinshuo Li, Chang Liu, Lin Zhang, Wensheng Yang

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引用次数: 0

Abstract

A closed bipolar electrode-based electrochemiluminescence (cBPE-ECL) sensor was developed for wireless uric acid (UA) detection. In the cBPE-ECL sensor design, a cobalt-based metal–organic framework (Co-MOF)-derived Au/CoO-modified carbon cloth (Au/CoO-C/CC) electrode served as a polarized anode for UA oxidation, where the generated faradaic current triggered the cathodic ECL of [Ru(bpy)₃]²⁺-[S₂O₈]²⁻ at the polarized cathode electrode, enabling both quantitative and visual UA detection. The polarized anode was fabricated by incorporating Au nanoparticles into a Co-MOF structure on carbon cloth (CC), yielding an open architecture with enhanced charge transfer capabilities that significantly improved electrocatalytic activity toward UA. The as-prepared cBPE-ECL sensor exhibited excellent analytical performance, featuring a wide linear range (10–1000 µM), low detection limit (6 µM), high stability, good reproducibility, and strong anti-interference capabilities. The practical utility of this cBPE-ECL sensing platform was validated through successful UA detection in fetal bovine serum and artificial serum samples, achieving recoveries between 96.4 and 103.4%, demonstrating its potential for UA detection in clinical and biomedical applications.

Graphical abstract

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基于co - mof衍生Au/ co -改性碳布的封闭双极电化学发光尿酸检测传感器的构建。

研制了一种基于封闭双极电极的电化学发光（cBPE-ECL）传感器，用于无线尿酸（UA）检测。在cBPE-ECL传感器设计中，钴基金属有机框架（Co-MOF）衍生的Au/ cooc修饰碳布（Au/ cooc /CC）电极作为UA氧化的极化阳极，在极化阴极电极处产生法拉第电流触发[Ru(bpy)3]2+-[S2O8]2-的阴极ECL，从而实现定量和可视化的UA检测。通过将Au纳米颗粒加入到碳布（CC）上的Co-MOF结构中制备极化阳极，得到具有增强电荷转移能力的开放式结构，显著提高了对UA的电催化活性。所制备的cBPE-ECL传感器具有线性范围宽（10-1000µM）、检出限低（6µM）、稳定性高、重现性好、抗干扰能力强等特点。通过对胎牛血清和人工血清样品的UA检测，验证了该cBPE-ECL检测平台的实用性，回收率在96.4 ~ 103.4%之间，显示了其在临床和生物医学领域的应用潜力。

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.