Microchimica Acta最新文献

{"title":"Development of a green-synthesized molecularly imprinted polymer-based electrochemical nanosensor for the determination of N-nitrosodimethylamine (NDMA) in serum and tap water","authors":"Nimisha Jadon,&nbsp;Ahmet Cetinkaya,&nbsp;Goksu Ozcelikay-Akyildiz,&nbsp;S. Irem Kaya,&nbsp;Esen Bellur Atici,&nbsp;Lokman Uzun,&nbsp;Sibel A. Ozkan","doi":"10.1007/s00604-024-06850-y","DOIUrl":"10.1007/s00604-024-06850-y","url":null,"abstract":"<div><p>N-nitrosodimethylamine (NDMA) was determined using a molecularly imprinted polymer (MIP)-based electrochemical sensor. Green-synthesized silver nanoparticles were functionalized with cysteamine to enhance their integration into the electrode surface, which was used to modify a glassy carbon electrode (GCE). Furthermore, a MIP-based electrochemical sensor was constructed via electropolymerization of 3-aminophenyl boronic acid (3-APBA) as a conjugated functional monomer in the presence of lithium perchlorate (LiClO₄) solution as a dopant, chitosan as a carrier natural polymer, and NDMA as a template/target molecule. The polymer film was characterized by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). The analytical performance of the silver nanomaterial-based MIP-based electrochemical (AgNPs@Chitosan/3-APBA@MIP-GCE) sensor was evaluated under optimized conditions. The linear range of NDMA was 1.0 × 10^–13–1.0 × 10^–12 M (0.1–1.0 pM), with a limit of detection (LOD) of 3.63 × 10^–15 M (3.63 fM) using differential pulse voltammetry (DPV). Method validation figured out that the developed MIP-based electrochemical nanosensor exhibited excellent selectivity, accuracy, and precision, which was shown by the analysis of synthetic serum samples and tap water. The LOD and LOQ in serum samples were 17.8 fM and 59.5 fM, respectively, which were in agreement with the developed method. Good recovery results confirm the successful application of the method in serum and tap water samples. The selectivity of the developed AgNPs@Chitosan/3-APBA@MIP-GCE sensor for NDMA was demonstrated in the presence of NDEA, sartans (valsartan, losartan, irbesartan, candesartan, telmisartan), and potential interferents that are possibly present in biological fluids (dopamine, ascorbic acid, uric acid) besides ionic species (sodium, chloride, potassium, nitrate, magnesium, sulfate) and common analgesic paracetamol.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 12","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142736937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temperature-dependent luminescent copper nanoclusters with noncovalent interactions for determination of β-galactosidase activity","authors":"Yanping Chang,&nbsp;Jingyi Wang,&nbsp;Hongwei Guo,&nbsp;Wanqing Yao,&nbsp;Haijiao Xie,&nbsp;Long Li,&nbsp;Xianhu Liu","doi":"10.1007/s00604-024-06844-w","DOIUrl":"10.1007/s00604-024-06844-w","url":null,"abstract":"<div><p>The synthesis of a novel bidentate ligand-protected copper nanocluster via a solid-state strategy is reported. Single-crystal X-ray diffraction analysis result reveals that the copper nanocluster features an octahedral core (Cu₆) coordinated by six ligands. Noncovalent interactions (C-H^<b>…</b>π and π^<b>…</b>π) exist between the copper nanoclusters. The copper nanocluster displays luminescence even at 250 °C. The luminescence intensity is linearly correlated with temperature changes. The copper nanocluster can assemble into luminescent nanosheets whose emission is quenched by 4-nitrophenol. Spectroscopic analysis and theoretical calculations results demonstrate that the inner filter effect and electron transfer cause the above quenching effect. A probe based on luminescent nanosheets was constructed for β-galactosidase activity determination. The linearity range is 3.3–91.8 U·L⁻¹, and the limit of detection is 0.45 U·L⁻¹. This probe was also evaluated for determination of the β-galactosidase activity in human serum via spiking experiments. The recoveries ranged from 96.2% to 101.8%.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 12","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142736816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic poly(phages) encoded probes–based dual-mode assay for rapid determination of live Escherichia coli and Hafnia paralvei based on microfluidic chip and ATP bioluminescence meter","authors":"Ye Wang,&nbsp;Ming Wang,&nbsp;Hang You,&nbsp;Chao Chen,&nbsp;Jing Zhang,&nbsp;Tianhua Li,&nbsp;Ning Gan","doi":"10.1007/s00604-024-06809-z","DOIUrl":"10.1007/s00604-024-06809-z","url":null,"abstract":"<div><p> A dual-mode assay was developed for screening and detecting live <i>Escherichia coli</i> (<i>E. coli</i>) and <i>Hafnia paralvei</i> (<i>H. paralvei</i>) (as two typical pathogens in aquatic environments) based on magnetic poly(phages) encoded probes (MPEP). The probes were prepared by grafting a large number of phages targeting different target bacteria on a long-chain DNA structure, respectively. They could specifically capture and enrich <i>E. coli</i> and <i>H. paralvei</i> by magnetic separation. Then, different DNA signal tags with different lengths conjugate with the corresponding MPEP-bacteria complex and form two kinds of sandwich structures, respectively. After that, the captured <i>E. coli</i> and <i>H. paralvei</i> were lysed to release both adenosine triphosphate (ATP) and DNA signal tags. The measurement includes two steps. Firstly, a portable ATP bioluminescence meter was employed to rapidly screen the positive samples that contain either of the two target bacteria. Secondly, only positive samples were injected into the microfluidic chip which could detect various DNA signal tags for accurate quantification of the target bacteria. The assay demonstrated high sensitivity (3 CFU/mL for <i>E. coli</i> and 5 CFU/mL for <i>H. paralvei</i>), high specificity (strain identification), signal amplification (20-fold), and short time (≤ 35 min). It can be applied to detect other pathogens solely by changing the relative phage in MPEP. Furthermore, the proposed dual-mode assay provides a wide prospect for rapid screening and accurate determination of live foodborne pathogens. Clinical Trial Number: nbdxms-20240322.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 12","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00604-024-06809-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoelectrochemical immunosensor for chloramphenicol detection based on cation exchange reaction-mediacted photocurrent enhancement of ZnIn2S4/TiO2/Ti3C2 MXene coupled with controlled-release strategy","authors":"Mengqin Zheng,&nbsp;Huizi Lin,&nbsp;Suhua Li,&nbsp;Shuoying Huang,&nbsp;Jiangwei Huang,&nbsp;Wenqiang Lai,&nbsp;Dianping Tang,&nbsp;Youxiu Lin","doi":"10.1007/s00604-024-06847-7","DOIUrl":"10.1007/s00604-024-06847-7","url":null,"abstract":"<div><p> A photocurrent enhancing photoelectrochemical (PEC) immunosensor was developed for chloramphenicol (CAP) detection based on cation exchange reaction. The efficient split-type PEC immunosensor combined with controlled-release strategy was established using the ZnIn₂S₄/TiO₂<b>/</b>Ti₃C₂ MXene (ZIS/T/M) composite as the photoactive material and CuO as the signal response probe. In the presence of target CAP, CuO-labeled CAP antibody (CuO-mAb) was introduced onto the microplate via a competitive-type immunoassay. Under acidic conditions, a large amount of Cu²⁺ released from CuO-mAb, which triggered a cation exchange reaction with the Zn²⁺ in ZIS/T/M-modified photoelectrode to generate Cu_xS, resulting in enhancing the photocurrent. As a result, the quantitative detection of CAP was achieved by detecting the photocurrent change. Under optimized conditions, the linear range of the sensor was 1 pg/mL to 50 ng/mL, and the detection limit was 0.24 pg/mL. The excellent PEC behavior of ZIS/T/M composite could be attributed to the fact that heterojunction formation improved the migration and separation of the photocarrier. Additionally, by virtue of the photocurrent-enhancing strategy via cation exchange reaction and the controlled releasing signal amplification method of ion, the PEC immunosensor has high sensitivity and satisfactory accuracy, offering great potential applications in the determination of CAP.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 12","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated tetrahydroxyphthalocyanine-coated graphene decorated with ionic liquid-functionalized gold nanoparticles for highly sensitive and selective electrochemical determination of ascorbic acid in fruit juices","authors":"Lin Mei,&nbsp;Yanmei Shi,&nbsp;Xueke Ding,&nbsp;Jing Li","doi":"10.1007/s00604-024-06852-w","DOIUrl":"10.1007/s00604-024-06852-w","url":null,"abstract":"<div><p>Surface functionalization and the combined utilization of zero‐dimensional and two‐dimensional nanomaterials is an effective method to achieve highly sensitive detection for electrochemical analysis. Using an all-in-one strategy, phthalocyanine, gold nanoparticles, and ionic liquid were successively modified on the graphene surface as a highly integrated electrode modification material. Phthalocyanine can repair the defects of reduced graphene oxide by binding to the graphene structure surface through non-covalent functionalization. The combination of ionic liquid on the surface of gold nanoparticles can enhance their physical and chemical activity while preserving their stability. The obtained phthalocyanine-coated graphene nanosheets decorated with ionic liquid-functionalized gold nanoparticles nanocomposites had enhanced electrocatalysis and conductivity ability, and were used for highly sensitive electrochemical detection of ascorbic acid in fruit juices. Excellent results were obtained for the detection of ascorbic acid in the linear range 0.05 to 50 µmol/L with a detection limit of 6.80 nmol/L (<i>S/N</i> = 3) and a sensitivity of 2.68 μA μM⁻¹cm⁻², indicated that the proposed sensor strategy with multiple signal amplification can achieve higher detection sensitivity. Furthermore, the sensor was used to quantify ascorbic acid content in grapefruit and orange juice with good selectivity and accuracy. The highly integrated electroactive nanocomposites construction method described may also be used with other electrode modification materials and is anticipated to yield fresh perspectives on the advancement of ultrasensitive detection.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 12","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A portable colorimetric immunosensor for highly sensitive point-of-care testing of leather artifacts","authors":"Chao Zhang,&nbsp;Yichang Li,&nbsp;Hui Si,&nbsp;Hao Du,&nbsp;Lianpeng Lv,&nbsp;Bing Xu,&nbsp;Yefeng Deng,&nbsp;Junting Li,&nbsp;Hailiang Yang,&nbsp;Yang Zhou,&nbsp;Bing Wang","doi":"10.1007/s00604-024-06842-y","DOIUrl":"10.1007/s00604-024-06842-y","url":null,"abstract":"<div><p> A point-of-care testing (POCT) platform, i.e., a portable colorimetric immunosensor based on iron oxide magnetic beads and AuNPs, has been developed for detecting leather residues. The immunosensor demonstrates a linear detection range from 1 ng/mL to 10 µg/mL, with a limit of detection (LOD) of 0.985 ng/mL. The sensor exhibits high specificity and repeatability and performs effectively in detecting leather artifacts excavated from Inner Mongolia. Thus, the proposed colorimetric immunosensor not only enables the micro-detection of leather artifacts but also shows significant potential for on-site leather detection at archaeological sites.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 12","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasensitive electrochemiluminescencent multivalent aptamer sensor based on energy and electron transfer dual quenching tactics","authors":"Yuan Ni,&nbsp;Ding Jiang,&nbsp;Xiaomei An,&nbsp;Wenchang Wang,&nbsp;Zheng Sun,&nbsp;Haibo Li,&nbsp;Hiroshi Shiigi,&nbsp;Zhidong Chen","doi":"10.1007/s00604-024-06833-z","DOIUrl":"10.1007/s00604-024-06833-z","url":null,"abstract":"<div><p> An efficient “on-off-on” electrochemiluminescence (ECL) aptasensor utilizing dual-mechanism quenching was constructed for detecting furanyl fentanyl (FuF). The first signal “on” state was achieved by novel dual-ligand zinc metal-organic frameworks (Zn-MOFs), which were synthesized by self-assembly reaction using zinc atom clusters as metal nodes, achieving strong and stable ECL emission. The “off” state was realized by the energy and electron quenching effect of copper-doped WO₃. Specifically, in addition to the overlap of the UV-Vis spectrum, energy transfer existed between the acceptor and donor after doping copper. Therefore, copper created a “highway” for electron transfer between the donor and acceptor, which greatly improved the quenching efficiency. Simultaneously, employing multivalent aptamers as capture probes augmented the binding affinity and probability of association between aptamer and target through a synergistic multivalent effect. Consequently, the second “on” state was the ECL signal restored by introducing FuF. Benefiting from the combination of the multivalent aptamers strategy with the “on-off-on” design, the developed aptasensor showed excellent linearity (1.0 × 10⁻¹³ to 1.0 × 10⁻⁶ g/L) with a low limit of detection of 5.5 × 10⁻¹⁴ g/L (<i>S</i>/<i>N</i> = 3). Additionally, it demonstrates a relative standard deviation (RSD) of less than 5% and good recovery ranging from 97.6 to 102%. The proposed aptasensor presents considerable potential for rapid, sensitive, and accurate determination of FuF.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 12","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-situ oxidative polymerization of dopamine triggered by CuO2 in acidic condition and application in “turn-off” sensing","authors":"Yang Huang,&nbsp;Shangming Wu,&nbsp;Siyi Yang,&nbsp;Miao He,&nbsp;Wenhao Ma,&nbsp;Huanbao Fa,&nbsp;Yongzhong Wang,&nbsp;Changjun Hou,&nbsp;Mei Yang","doi":"10.1007/s00604-024-06791-6","DOIUrl":"10.1007/s00604-024-06791-6","url":null,"abstract":"<div><p>Dopamine (DA) is a key neurotransmitter whose concentration affects various neurological disorders. Unlike previous methods that synthesize non-fluorescent polydopamine (NFL-PDA) under alkaline conditions, this study introduces a novel “turn-off” sensing method for DA using NFL-PDA synthesized through a unique reaction pathway. In our approach, CuO₂ nanodots, created via a simple reduction method, catalyze the formation of hydroxyl radicals (•OH) in acidic conditions, triggering the oxidative polymerization of DA into NFL-PDA. The reaction between DA and CuO₂ nanodots in acidic solution was examined to understand the process. UiO-66-NH₂ was then used to test NFL-PDA’s fluorescence quenching ability and to further investigate the DA determination mechanism. Results showed that fluorescence quenching was due to enhanced non-radiative energy transfer and Förster resonance energy transfer (FRET) between NFL-PDA and UiO-66-NH₂. This led to the development of a simple “turn-off” fluorometric DA determination method with a linear range of 0.1–200 μmol/L and a limit of detection (LOD) of 0.0575 μmol/L. Although this method does not outperform existing NFL-PDA synthesis methods under alkaline conditions, it provides a new synthesis approach and application for sensing DA, contributing to the basic theory of chemical sensing. Additionally, DA determination in human serum samples was successfully achieved, with results consistent with high-performance liquid chromatography (HPLC).</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 12","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bi2S3/BiOCl heterojunction-based photoelectrochemical aptasensor for ultrasensitive assay of fumonisin B1 via signal amplification with in situ grown Ag2S quantum dots","authors":"Pengfei Yu,&nbsp;Meixin Li,&nbsp;Shun Wang,&nbsp;Shanshan Li,&nbsp;Jiaqi Cui,&nbsp;Jun Yang,&nbsp;Shuang Liu,&nbsp;Ling Kong,&nbsp;Zhiwei Chen","doi":"10.1007/s00604-024-06846-8","DOIUrl":"10.1007/s00604-024-06846-8","url":null,"abstract":"<div><p>Fumonisin B₁ (FB₁) is a mycotoxin mainly found in corn, peanuts, and wheat crops, which affects human health. Based on bismuth sulfide/bismuth oxychloride (Bi₂S₃/BiOCl) composite material, silver sulfide (Ag₂S) was grown in situ as a quantum dot sensitization signal, and a photoelectrochemical (PEC) aptasensor was designed by layer upon layer modification to detect FB₁. Bi₂S₃/BiOCl has a wide range of visible light absorption, stable chemical properties, and a simple synthesis method. In the construction process, L-ascorbic acid (AA) is selected to provide electrons and inhibit photogenerated electron-hole (e^-/h⁺) recombination. Under the optimal experimental conditions, the detection range of the fabricated PEC aptasensor was 0.001 ~ 100 ng/mL, and the detection limit was 0.016 pg/mL. The prepared PEC aptasensor has high sensitivity, stability, and reproducibility. The combination of aptamer and PEC sensor provides a novel method for the application of PEC sensor in mycotoxin detection.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 12","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ampicillin-derived carbon dots as the sensitive probe for the detection of Fe3+ and Cu2+ in living cells and water samples","authors":"Hongjie Dong,&nbsp;Huanhuan Xie,&nbsp;Xiaoman Xie,&nbsp;Qi Wang,&nbsp;Hang Sun,&nbsp;Wenju Zhu,&nbsp;Guihua Zhao,&nbsp;Chao Xu,&nbsp;Kun Yin,&nbsp;Junmei Zhang","doi":"10.1007/s00604-024-06849-5","DOIUrl":"10.1007/s00604-024-06849-5","url":null,"abstract":"<div><p> Water-soluble N-doped fluorescent (FL) carbon dots (ACDs) were successfully fabricated hydrothermally using ampicillin sodium as sole precursor. The produced ACDs exhibit satisfactory optical behavior, favorable photostability, and acceptable water solubility. With bright blue emission at 450 nm, the ACDs were utilized for multivariate sensing Fe³⁺ and Cu²⁺ based on the synergistic effect of the inner filter effect (IFE) and static quenching with detection limits of 0.31 μM and 0.26 μM, respectively. The practicality of ACDs has been verified by the successful determination  of Fe³⁺ and Cu²⁺ in real water and living cells. These findings confirm the feasibility of the proposed ACDs as FL sensors for efficient and selective detection of Fe³⁺ and Cu²⁺, which present promising prospects for real-time monitoring these two metal ions  in environmental and biological systems.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 12","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}