ACS Applied Nano Materials最新文献

{"title":"Elucidating the Photoluminescence Origin of Silver Nanoclusters in Amorphous Matrices through Heavy-Atom Engineering","authors":"Wenyan Zheng,&nbsp;, ,&nbsp;Shugang Li,&nbsp;, ,&nbsp;Qunhuo Liu,&nbsp;, ,&nbsp;Muzhi Cai,&nbsp;, ,&nbsp;Feifei Huang,&nbsp;, ,&nbsp;Ying Tian,&nbsp;, ,&nbsp;Xvsheng Qiao*,&nbsp;, ,&nbsp;Junjie Zhang,&nbsp;, ,&nbsp;Shiqing Xu,&nbsp;, and ,&nbsp;Xianping Fan,&nbsp;","doi":"10.1021/acsanm.5c03705","DOIUrl":"https://doi.org/10.1021/acsanm.5c03705","url":null,"abstract":"<p >Silver (Ag) nanoclusters exhibit tunable dual emission integrating fluorescence and phosphorescence, yet in amorphous matrices blue fluorescence dominates, limiting phosphorescence and obscuring mechanisms of photoluminescence (PL). Here, halogen incorporation (Cl, Br, I) enhances heavy-atom effect, significantly increasing phosphorescence with a quantum yield of 27.54% through strengthened spin–orbit coupling and accelerated intersystem crossing. Iodide-modified glass achieves ultra-broadband emission (full width at half-maximum, fwhm = 223 nm), enabling its use as a single-component material for white-light-emitting diodes (WLEDs). The devices show stable chromaticity (CIE: 0.309, 0.352), high color rendering (Ra = 91.4), and correlated color temperature (CCT = 6552 K).</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19712–19717"},"PeriodicalIF":5.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guided Growth of Conductive MoO2@MoS2 Core–Shell Nanowires with Broad Photoluminescence for Improved Device Contacts","authors":"Yarden Danieli,&nbsp;, ,&nbsp;Rotem Zattelman,&nbsp;, ,&nbsp;Olga Brontvein,&nbsp;, ,&nbsp;Katya Rechav,&nbsp;, and ,&nbsp;Ernesto Joselevich*,&nbsp;","doi":"10.1021/acsanm.5c03264","DOIUrl":"https://doi.org/10.1021/acsanm.5c03264","url":null,"abstract":"<p >Mixed-dimensional heterostructures (MDHs) of layered materials, such as transition-metal dichalcogenides (TMDs), have gained extensive interest, owing to their remarkable optical and electronic properties. Achieving controlled growth of such MDHs is critical for advancing their integration into efficient electronic and optoelectronic devices as well as catalytic systems. However, precise control over the growth direction and orientation of bottom-up TMD-based MDHs remains a challenge. Here, we report on the synthesis of horizontally oriented MoO₂@MoS₂ core–shell nanowires on atomically flat R-, A-, M-plane sapphire and on faceted annealed miscut C-plane 1 ° toward-A sapphire surfaces. The process was generalized and expanded to MoO₂@MoSe₂ MDHs grown epitaxially on C-plane sapphire. Optical microscopy, scanning electron microscopy (SEM), and atomic-force microscopy (AFM) reveal that the nanowires achieve heights of hundreds of nanometers and align along a different set of preferred crystallographic orientations on each surface, indicating epitaxial and graphoepitaxial-guided growth. The optical properties of these core–shell nanowires are primarily determined by the MoS₂ shell, showing varied intensity around the MoS₂ band-edge emission at 1.8 eV and its characteristic A_1g and E_2g Raman modes. Thanks to the highly symmetrical growth and their high crystallinity, the MoO₂@MoS₂ nanowires grown on M-plane sapphire were analyzed using a scanning transmission electron microscope (STEM), confirming a continuous shell of MoS₂ with varying thickness, wrapping a crystalline MoO₂ core. The variation in shell thickness contributes to changes in the band structure along the wire, resulting in a broad-range photoluminescence. While optical behavior is dominated by the MoS₂ shell, the electrical properties are predominantly governed by the MoO₂ core, which demonstrates high conductivity reaching approximately 5 × 10⁴ S·cm^–1. The high conductivity of the horizontally oriented nanowires, coupled with their strong luminescence, makes each component (core and shell) contribute distinct functionalities and opens many opportunities for efficient electronic and optoelectronic devices.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19818–19829"},"PeriodicalIF":5.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsanm.5c03264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scattering-Dominant Contrast Agents for Optical Coherence Tomography","authors":"Yongping Chen*,&nbsp;, ,&nbsp;Jiefeng Xi,&nbsp;, ,&nbsp;V. N. Du Le,&nbsp;, ,&nbsp;Jessica Ramella-Roman,&nbsp;, and ,&nbsp;Xingde Li*,&nbsp;","doi":"10.1021/acsanm.5c03173","DOIUrl":"https://doi.org/10.1021/acsanm.5c03173","url":null,"abstract":"<p >We report a scattering-dominant agent that significantly enhances optical coherence tomography (OCT) imaging contrast. Unlike most other gold nanoparticle-based OCT agents, which are absorption-dominant and reduce imaging depth, our agent is based on gold nanocages, which exhibit a surface plasmon resonance (SPR) peak around 780 nm and a scattering cross-section that exceeds the absorption cross-section. The scattering-dominant gold nanocages act as nanosized mirrors that enhance backscattered OCT signals. The synthesis protocol for these nanocages is provided in detail. The optical properties of the gold nanocages were characterized using OCT imaging and further validated with integrating sphere measurements. OCT contrast enhancement was demonstrated through imaging of tissue phantoms containing embedded nanocages, as well as ex vivo imaging of mouse tissues and in vivo imaging of a mouse tumor following intravenous administration of PEGylated gold nanocages. To the best of our knowledge, this is the first demonstration of scattering-dominant OCT contrast agents utilizing structured gold nanocages.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19779–19785"},"PeriodicalIF":5.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binary PdCu Nanoparticles for Electrocatalytic Ethanol Oxidation","authors":"Xiaoling Zhang,&nbsp;, ,&nbsp;Jiasheng Wang,&nbsp;, ,&nbsp;Yidian Wang,&nbsp;, ,&nbsp;Yu Zhao,&nbsp;, ,&nbsp;Zhiying Liu,&nbsp;, and ,&nbsp;Peizhi Guo*,&nbsp;","doi":"10.1021/acsanm.5c03315","DOIUrl":"https://doi.org/10.1021/acsanm.5c03315","url":null,"abstract":"<p >In electrochemical reactions, the development of high-performance catalytic materials has always been the focus of research, among which regulating the morphology and structure of catalysts is the key strategy to improving the catalytic activity and durability. In this study, binary PdCu particles were prepared by a hydrothermal method under the synergistic action of poly(vinylpyrrolidone) (PVP) and formic acid. By tuning of the percentage of Cu in the metal precursor, alloy particles with irregular polyhedral structure were obtained. Experimental data show that the prepared PdCu nanoparticles exhibit good catalytic activity, which is attributed to their optimized morphological characteristics and electronic structure. In the ethanol oxidation reaction (EOR), the current densities of PdCu@NP#1, PdCu@NP#2, and PdCu@NP#3 reached 2519, 3312, and 2855 mA mg^–1, respectively. This study further discussed the improvement in the catalytic activity of alcohol oxidation from the viewpoint of the electronic structure and morphological characteristics of PdCu nanoparticles. By manipulation of the electronic structure to optimize the d-band center, the adsorption–desorption equilibrium between reactants and intermediates in EOR was adjusted. These results can help in the design and construction of high-performance metal-based alloy electrocatalysts.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19866–19874"},"PeriodicalIF":5.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical Fiber-Based Nanoporous Molecularly Imprinted Polymer Sensors for the Detection of Acute Kidney Injury Biomarkers Quinolinic Acid and Tryptophan","authors":"Noel Angelo Kalacas,&nbsp;, ,&nbsp;Bernadette Tse Sum Bui*,&nbsp;, ,&nbsp;Gerhard J. Mohr,&nbsp;, ,&nbsp;Pierre Galichon*,&nbsp;, and ,&nbsp;Karsten Haupt*,&nbsp;","doi":"10.1021/acsanm.5c03277","DOIUrl":"https://doi.org/10.1021/acsanm.5c03277","url":null,"abstract":"<p >The urinary quinolinic acid (QA)/<span>l</span>-tryptophan (T) ratio is a noninvasive prognostic biomarker for the early detection of acute kidney injury (AKI). We describe a rapid, sensitive, robust, and cost-effective detection tool in the form of a disposable optical fiber sensor for potential AKI testing based on molecularly imprinted polymers (MIPs). AKI is a sudden and life-threatening deterioration of kidney function. It occurs in &gt;50% of intensive care patients and is associated with multiple organ damage. Thus, AKI is a sign of severity, requiring urgent care. AKI is often rapidly reversible at its early stage; however, the current markers for AKI provide late diagnosis, and they are not suitable for continuous monitoring. Therefore, the implementation of point-of-care tests in clinical settings would foster early assessment so as to trigger a rapid treatment and save numerous lives. Herein, nanoporous MIP layers, endowed with a fluorescent naphthalimide reporter monomer, were synthesized on the surface of optical fiber waveguides via in situ evanescent wave photopolymerization, initiated by a visible-light-sensitive photoiniferter. The photoiniferter allowed for further coating of the MIP with polyethylene glycol brushes, which served as an antifouling polymer layer for enhanced sensing performance of the waveguide in urine samples. The MIP-coated optical fibers exhibited specific fluorescence enhancement when binding QA and T in spiked urine. MIP binding was also selective, as no recognition was observed with dipicolinic acid and <span>d</span>-tryptophan, which are very close structural analogues of QA and T, as well as with urea and creatinine, the major constituents of urine.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19830–19839"},"PeriodicalIF":5.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controllable Hydrothermal Synthesis of Core–Shell-Type BaFe12O19@Fe3O4/MWCNT Layered Composites with Enhanced Polarization Interfaces for Electromagnetic Energy Conversion","authors":"Zhuolun Li,&nbsp;, ,&nbsp;Haozhe Qi,&nbsp;, ,&nbsp;Xiaoxia Tian*,&nbsp;, ,&nbsp;Jiafu Wang,&nbsp;, ,&nbsp;Yuchuan Ma,&nbsp;, ,&nbsp;Jincai Wang,&nbsp;, ,&nbsp;Guodong Han,&nbsp;, and ,&nbsp;Shaobo Qu,&nbsp;","doi":"10.1021/acsanm.5c03727","DOIUrl":"https://doi.org/10.1021/acsanm.5c03727","url":null,"abstract":"<p >A ternary BaFe₁₂O₁₉/MWCNT/Fe₃O₄ composite was synthesized through sequential hydrothermal processing. This architecture leverages dimensional complementarity: interfacial polarization intensifies via synergistic contact between two-dimensional hexaferrite platelets and one-dimensional conductive carbon networks. Simultaneously, magnetic coupling is enhanced through Fe₃O₄ nanoclusters anchored onto ferrite surfaces, establishing exchange-biased magnetization dynamics. Comprehensive electromagnetic characterization revealed exceptional absorption performance, achieving −55.67 dB reflection loss at 15.62 GHz with a 4.03 GHz effective bandwidth (13.92–17.95 GHz) at 1.29 mm thickness. Performance enhancement stems from synergistic dielectric–magnetic interactions, including heterojunction polarization, exchange-coupled resonance, and multicomponent-enabled impedance matching. This structurally optimized system demonstrates substantial application potential for advanced broadband electromagnetic wave attenuation solutions.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"20042–20053"},"PeriodicalIF":5.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accurate Nondestructive Determination of Interfacial Oxide Layer Thickness on Si Wafers Using THz Inductive-Capacitive Resonant Metamaterial Spectroscopy","authors":"Heena Khand,&nbsp;, ,&nbsp;Rudrarup Sengupta*,&nbsp;, and ,&nbsp;Gabby Sarusi,&nbsp;","doi":"10.1021/acsanm.5c03806","DOIUrl":"https://doi.org/10.1021/acsanm.5c03806","url":null,"abstract":"<p >We present a nondestructive technique to accurately measure interfacial oxide layer thickness using inductive-capacitive (LC) resonant metamaterial terahertz (THz) impedance spectroscopy. THz LC resonant metamaterials demonstrate high sensitivity to changes of the substrate’s effective relative permittivity/refractive index. This sensitivity is manifested by a change in the metamaterial’s natural resonating frequency. Utilizing this property, we built an analytical model and experimental tool to determine the interfacial oxide layer thickness. It is supported by 3D electromagnetic simulations and terahertz spectroscopic results, utilizing our highly sensitive arrowhead LC resonant metamaterial sensor. This method can detect changes in interfacial oxide layer thickness with an accuracy of 2 nm and sensitivity of 1200 GHz/RIU, which is one of the highest sensitivities to date for determining the interfacial dielectrics. We also demonstrate a complete correlation of the simulations with spectroscopic experiments, verified by measuring the real oxide thickness using a focused-ion beam. This nondestructive method enables accurate profiling of the interfacial oxide across the wafer.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19724–19730"},"PeriodicalIF":5.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strain-Modulated Conductivity and Work Function on Thin Crystals of Mo2C","authors":"Gokay Adabasi,&nbsp;, ,&nbsp;Sourabh Kumar,&nbsp;, ,&nbsp;Elif Okay,&nbsp;, ,&nbsp;Joshua R. Evans,&nbsp;, ,&nbsp;Eren Atli,&nbsp;, ,&nbsp;Joshua Ancheta,&nbsp;, ,&nbsp;Goknur Cambaz Buke*,&nbsp;, ,&nbsp;Ashlie Martini*,&nbsp;, and ,&nbsp;Mehmet Z. Baykara*,&nbsp;","doi":"10.1021/acsanm.5c03237","DOIUrl":"https://doi.org/10.1021/acsanm.5c03237","url":null,"abstract":"<p >Thin transition metal carbides (TMCs) exhibit a favorable combination of electronic and mechanical properties that makes them attractive for applications ranging from flexible energy storage to electromagnetic shielding. However, the influence of strain on key electronic characteristics such as conductivity and work function has not yet been elucidated. Here, we present a combined experimental and computational study of surface electronics on thin crystals of molybdenum carbide (Mo₂C). Conductive atomic force microscopy (C-AFM) and Kelvin probe force microscopy (KPFM) performed on rippled regions of crystal surfaces reveal a significant increase in electrical conductivity and a notable reduction in work function under tensile strains of 1% and below. <i>Ab initio</i> calculations confirm the trends observed in the experiments, pointing toward increased density of states (DOS), enhanced mobility, and reduced work function under tensile strain. Our work highlights the potential of strain engineering for tuning the electronic characteristics of thin TMCs.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19810–19817"},"PeriodicalIF":5.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Potential and Selectivity of MoS2 Quantum Dots for Enzyme-Based Electrochemical Detection of Urea†","authors":"Iqra Sadia,&nbsp;, ,&nbsp;Khezina Rafiq*,&nbsp;, ,&nbsp;Muhammad Zeeshan Abid,&nbsp;, ,&nbsp;Muhammad Jalil,&nbsp;, ,&nbsp;Rabia Javed,&nbsp;, ,&nbsp;Abdul Rauf,&nbsp;, and ,&nbsp;Ejaz Hussain*,&nbsp;","doi":"10.1021/acsanm.5c03505","DOIUrl":"https://doi.org/10.1021/acsanm.5c03505","url":null,"abstract":"<p >In recent years, use of quantum dots (QDs) for sensing urea and glucose has gained significant attention and considerable interest. QDs have great potential for applications in portable kidney devices, water treatment, and food industry. Meanwhile, portable urea sensing devices can be the game changer not only for environmental surveillance but also for improving the life span of kidney patients. There are numerous materials that have been reported for urea sensing, but they are rejected due to various limitations. For example, they are often costly, less durable, toxic, and generally exhibit nonbiocompatibility. Current project has been designed to develop relatively cheaper and more effective material for the urea sensing application. As per purpose, molybdenum disulfide QDs (MoS₂ QDs) and bulk (MoS₂ bulk) have been synthesized via hydrothermal approach followed by their immobilization along with urease in silk fibroin (SF) discs. Aminated glassy carbon electrode (GCE), i.e., NH₂–GCE was used for electrochemical sensing of the urea analyte precursors. By the electrooxidation of carbamic acid, the GCE was tuned with amine groups (−NH₂). SF discs were used to ensure the interaction of urease with MoS₂ QDs and MoS₂ bulk with the surface of NH₂–GCE. Chemical characteristics and structural sensitivity of MoS₂ QDs were assessed via XRD, scanning electron microscopy, transmission electron microscopy, FT–IR, Raman, UV–Vis/DRS, photoluminescence, electron dispersive X-ray, XPS, electrochemical impedance spectroscopy, and AFM approaches and compared with those of bulk MoS₂. Cyclic voltammetry was used to anticipate urea detection of the as-fabricated electrode, i.e., MoS₂ QDs/Urs/SF/NH₂–GCE and MoS₂ bulk/Urs/SF/NH₂–GCE. The MoS₂ QDs-based detection platform exhibited a high sensitivity and detection response of 16.443 μA mM^–1 cm^–2 with a linear correlation among urea concentration and current in range of 0.1−1.9 mM. Limit of quantification and limit of detection were calculated to be 0.831 and 0.274 mM, respectively. Using replaceable SF discs embedded with urease, sensing responses were recorded. As a small volume of electrolyte is employed, MoS₂ QDs are integrated into the miniaturized urea sensing devices. Electrochemical sensing performances of MoS₂ QDs were compared with bulk MOS₂ that is comparatively less sensitive. Based on the sensing performances, it has been concluded that as-prepared MoS₂ QDs hold the potential to be effectively utilized for real-time urea detection.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19929–19942"},"PeriodicalIF":5.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2D Nb2C MXene/COF Composite as Electrochemical Platform for the Stress Marker Epinephrine Detection","authors":"Murali Punniyamoorthy,&nbsp;, ,&nbsp;Charlin Soosaimanickam,&nbsp;, ,&nbsp;Murugavel Kathiresan*,&nbsp;, and ,&nbsp;Subbiah Alwarappan*,&nbsp;","doi":"10.1021/acsanm.5c03086","DOIUrl":"https://doi.org/10.1021/acsanm.5c03086","url":null,"abstract":"<p >Epinephrine (or adrenaline) is a common stress marker secreted by the adrenal glands in response to stress. Monitoring epinephrine levels in real samples is therefore clinically relevant, as it provides information on the magnitude of stress experienced by an individual. Herein, we present the rational design of a covalently linked 2D Nb₂C MXene/COF hybrid electrode as an electrochemical platform for the detection of epinephrine. The electrochemical oxidation of epinephrine to epinephrine quinone at the 2D Nb₂C MXene/COF hybrid electrode was observed at +0.23 V vs Ag/AgCl. The proposed sensing platform exhibits a limit of detection of 1.09 μM (<i>N</i> = 3) and a sensitivity of 0.215 μA μM^–1 cm^–2, with excellent selectivity and repeatability. Furthermore, this electrode was employed for the real-time analysis of spiked epinephrine in serum and urine samples.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19771–19778"},"PeriodicalIF":5.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}