{"title":"2D Nb2C MXene/COF Composite as Electrochemical Platform for the Stress Marker Epinephrine Detection","authors":"Murali Punniyamoorthy, , , Charlin Soosaimanickam, , , Murugavel Kathiresan*, , and , Subbiah Alwarappan*, ","doi":"10.1021/acsanm.5c03086","DOIUrl":null,"url":null,"abstract":"<p >Epinephrine (or adrenaline) is a common stress marker secreted by the adrenal glands in response to stress. Monitoring epinephrine levels in real samples is therefore clinically relevant, as it provides information on the magnitude of stress experienced by an individual. Herein, we present the rational design of a covalently linked 2D Nb<sub>2</sub>C MXene/COF hybrid electrode as an electrochemical platform for the detection of epinephrine. The electrochemical oxidation of epinephrine to epinephrine quinone at the 2D Nb<sub>2</sub>C MXene/COF hybrid electrode was observed at +0.23 V vs Ag/AgCl. The proposed sensing platform exhibits a limit of detection of 1.09 μM (<i>N</i> = 3) and a sensitivity of 0.215 μA μM<sup>–1</sup> cm<sup>–2</sup>, with excellent selectivity and repeatability. Furthermore, this electrode was employed for the real-time analysis of spiked epinephrine in serum and urine samples.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19771–19778"},"PeriodicalIF":5.5000,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Nano Materials","FirstCategoryId":"88","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsanm.5c03086","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Epinephrine (or adrenaline) is a common stress marker secreted by the adrenal glands in response to stress. Monitoring epinephrine levels in real samples is therefore clinically relevant, as it provides information on the magnitude of stress experienced by an individual. Herein, we present the rational design of a covalently linked 2D Nb2C MXene/COF hybrid electrode as an electrochemical platform for the detection of epinephrine. The electrochemical oxidation of epinephrine to epinephrine quinone at the 2D Nb2C MXene/COF hybrid electrode was observed at +0.23 V vs Ag/AgCl. The proposed sensing platform exhibits a limit of detection of 1.09 μM (N = 3) and a sensitivity of 0.215 μA μM–1 cm–2, with excellent selectivity and repeatability. Furthermore, this electrode was employed for the real-time analysis of spiked epinephrine in serum and urine samples.
期刊介绍：
ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
