ACS Applied Nano Materials最新文献

{"title":"Tunable Magnetic Remanence of Antiferromagnetically Coupled Fe3O4@SiO2 Nanoparticles for In Vivo Biomedical Applications","authors":"Patrick Steinkraus,&nbsp;, ,&nbsp;Ecem Tiryaki,&nbsp;, ,&nbsp;Inci N. Sahin,&nbsp;, ,&nbsp;Tatiana Smoliarova,&nbsp;, ,&nbsp;Marina Spasova,&nbsp;, ,&nbsp;Michael Farle*,&nbsp;, and ,&nbsp;Verónica Salgueiriño*,&nbsp;","doi":"10.1021/acsanm.5c02458","DOIUrl":"https://doi.org/10.1021/acsanm.5c02458","url":null,"abstract":"<p >Magnetic nanoparticles with zero magnetic remanence, which can be noninvasively switched to a high magnetization state, represent a promising route for biomedical applications. Here, we report on nanoparticles consisting of ferrimagnetic Fe₃O₄ half-ellipsoids in a shell of SiO₂ whose magnetization can be noninvasively set to an antiparallel-coupled (zero stray field) or ferromagnetically coupled state (maximum stray field). The hybrid particle is enclosed by a diamagnetic SiO₂ coating protecting it against the environment and allowing functionalization for specific drug targeting. Through micromagnetic simulations, we demonstrate the feasibility to noninvasively tune the magnetic remanence of these synthetic ellipsoidal magnetic particles from zero for the antiferromagnetic-coupled state to a maximum magnetization for the ferromagnetic-coupled state. This control renders the particles remarkable for in vivo biomedical applications requiring magnetomechanical or magnetothermal activation.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19731–19738"},"PeriodicalIF":5.5,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsanm.5c02458","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bifunctional Fluorescent AuNPs/g-C3N4 Nanomatrix for Sequential Detection of Cu2+ and Ciprofloxacin Assists the Construction of a Three-Way Molecular Logic Gate","authors":"Sowndarya Ayyavu,&nbsp;, ,&nbsp;Sivakumar Sengodan,&nbsp;, ,&nbsp;Daniel T. Thangadurai*,&nbsp;, ,&nbsp;Devaraj Nataraj,&nbsp;, ,&nbsp;Maheswar Rajagopal,&nbsp;, and ,&nbsp;Nicolas Gascoin,&nbsp;","doi":"10.1021/acsanm.5c03350","DOIUrl":"https://doi.org/10.1021/acsanm.5c03350","url":null,"abstract":"<p >An excitation-independent (λ_em = 434 nm; λ_ex = 370 nm) fluorescent AuNPs/g-C₃N₄ nanomatrix developed for the selective, sensitive, and sequential fluorescence <i>turn-off/on</i> detection of Cu²⁺ and ciprofloxacin (CIP) in water and urine, respectively, is presented here. The AuNPs/g-C₃N₄ was synthesized via an <i>in situ</i> self-deposition method, with comprehensive structural characterization confirming the successful deposition of AuNPs (∼22 nm) onto g-C₃N₄ sheets. The AuNPs/g-C₃N₄ exhibited highly sensitive fluorescence quenching in response to Cu²⁺, displaying a linear concentration range of 0 → 55 μM and LoD of 2.33 μM. Stern–Volmer analysis indicated a static quenching mechanism for Cu²⁺ binding, with a K_SV of 2.4 × 10^–2 LM^–1. Time-resolved fluorescence lifetime decay profiles revealed a slight decrease in the average lifetime of AuNPs/g-C₃N₄ (from 4.48 to 4.05 ns) upon successive additions of Cu²⁺ (0.5, 1.0, and 1.5 μM), further supporting a static quenching interaction. Furthermore, the AuNPs/g-C₃N₄ probe demonstrated good sensitivity toward CIP in the 0 → 100 μM concentration range, with an LoD of 4.65 μM. Notably, the addition of CIP to the AuNPs/g-C₃N₄·Cu²⁺ solution resulted in the reduction of Cu²⁺ to Cu⁺, leading to a near 100% recovery of the AuNPs/g-C₃N₄ fluorescence. In contrast, the average lifetime of AuNPs/g-C₃N₄ (4.48 ns) significantly changed to 1.22 × 10^–8, 4.91 × 10^–10, and 1.51 × 10^–10 s upon the addition of CIP (0.5, 1.0, and 1.5 μM, respectively). The practical utility of this fluorescence nanomatrix was validated by its accurate detection of Cu²⁺ in real-water samples and CIP in human urine samples, achieving high recovery rates (101–106%). These findings confirm the AuNPs/g-C₃N₄ probe as an effective and rapid <i>turn-off/on</i> fluorescence sensor for the concurrent detection of Cu²⁺ and CIP in aqueous and biological matrices. Moreover, the observed fluorescence turn-off/on switching behavior induced by Cu²⁺ and CIP enabled the construction of a three-input molecular logic gate keypad lock system for potential information storage applications.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19875–19891"},"PeriodicalIF":5.5,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-Pot Thermal Plasma Synthesis of Hybrid Nanostructures with Ni NPs on BNNT Surface for Stable and Efficient Catalytic Ammonia Decomposition","authors":"Hee Il Yoo,&nbsp;, ,&nbsp;Byongjoo Bark,&nbsp;, ,&nbsp;Sang-Woo Jeon,&nbsp;, ,&nbsp;Sung-Hwan Lim,&nbsp;, ,&nbsp;Shin-Hyun Kang,&nbsp;, ,&nbsp;Tae-Hwan Kim,&nbsp;, and ,&nbsp;Se Youn Moon*,&nbsp;","doi":"10.1021/acsanm.5c02904","DOIUrl":"https://doi.org/10.1021/acsanm.5c02904","url":null,"abstract":"<p >A hybrid nanomaterial comprising Ni nanoparticles (NPs) grown on the outer walls of boron nitride nanotubes (BNNTs) was synthesized using a one-pot, <i>in situ</i>, mass-production thermal plasma method. The Ni/BNNT nanomaterial, with Ni NPs separately distributed on BNNT surfaces, preserved the hollow tubular structure of BNNTs and the catalytic activity of Ni NPs. Morphological, structural, and compositional analyses revealed well-crystallized Ni NPs, averaging less than 6 nm in diameter and accounting for 30% of the volume concentration, on BNNT surface. At a gas hourly space velocity of NH₃ of 12,820 mL g^–1h^–1, Ni/BNNTs achieved 100% NH₃ conversion at 750 °C with an apparent activation energy of 71.4 kJ mol^–1. Additionally, a 100 h long-term NH₃ decomposition test demonstrated the excellent thermal stability of Ni/BNNTs, with no aggregation of Ni NPs or loss of catalytic performance. This study presents a promising synthesis pathway for metal NP/BNNT hybrids suitable for high-temperature catalytic applications, offering superior stability, sintering resistance, and enhanced dispersibility.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19748–19757"},"PeriodicalIF":5.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolizable Photosensitizers with Aggregation-Induced Emission for Photodynamic Cancer Therapy","authors":"Songlin Lu,&nbsp;, ,&nbsp;Defeng Yin,&nbsp;, ,&nbsp;Xijuan Wang,&nbsp;, ,&nbsp;Meng Han,&nbsp;, ,&nbsp;Zheng Wang,&nbsp;, ,&nbsp;Yuru Zhang,&nbsp;, ,&nbsp;Xiaosu Ma,&nbsp;, ,&nbsp;Yang Yang,&nbsp;, ,&nbsp;Daming Gao*,&nbsp;, and ,&nbsp;Zhanggui Wang*,&nbsp;","doi":"10.1021/acsanm.5c03305","DOIUrl":"https://doi.org/10.1021/acsanm.5c03305","url":null,"abstract":"<p >Photodynamic therapy (PDT) relies on photosensitizers to produce reactive oxygen species (ROS), particularly singlet oxygen (¹O₂), for tumor cell elimination. However, the slow metabolism of many photosensitizers in vivo often results in adverse effects. This study develops a metabolizable photosensitizer, 2-(4’-(10H-phenothiazin-10-yl)-[1,1’-biphenyl]-4-yl)-3-(4’-(1,2,2-triphenylvinyl)-[1,1’-biphenyl]-4-yl) fumaronitrile (TFP), with aggregation-induced emission (AIE) properties. TFP NPs, synthesized via a five-step process and formulated using DSPE-PEG2000, exhibited a maximum emission wavelength of 585 nm, an ¹O₂ yield of 28.5%, and selective oxidation by endogenous hypochlorite (ClO^–), which converts TFP into a nonemissive sulfoxide metabolite. This metabolic responsiveness, validated through HPLC and MS measurements in mouse plasma, ensures efficient clearance via hepatic cytochrome P450 enzymes, minimizing systemic toxicity. The in vitro study results indicated that the IC₅₀ values for TFP NPs against HeLa, H-22, and HepG2 cells were 21.8 μg/mL, 25.5 μg/mL, and 24.5 μg/mL, respectively, thereby confirming their efficacy across a range of cancer cell types. TFP NPs efficiently targeted HeLa cells in vitro, and in vivo studies in H22-tumor-bearing mice revealed a substantial reduction in tumor size with minimal side effects under 420 nm irradiation in a mouse model. These findings demonstrate that TFP NPs hold great potential as PDT agents, offering promising applications in cancer treatment with reduced systemic side effects compared to conventional agents.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19852–19865"},"PeriodicalIF":5.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Walled Carbon Nanotube Dispersant for the Controlled Assembly into Conductive Films, Aligned Films, and Fibers","authors":"Hirokuni Jintoku*,&nbsp;, ,&nbsp;Keiko Kojima,&nbsp;, ,&nbsp;Toshiya Okazaki,&nbsp;, and ,&nbsp;Don N. Futaba*,&nbsp;","doi":"10.1021/acsanm.5c03680","DOIUrl":"https://doi.org/10.1021/acsanm.5c03680","url":null,"abstract":"<p >The practical deployment of single-walled carbon nanotubes (SWCNTs) in advanced devices relies heavily on their solution processability. However, dispersion remains a significant challenge due to competing requirements: effective exfoliation demands strong energy input, which often leads to structural damage, and dispersant selection depends on solvent compatibility, target concentration, and intended application. Here, we report the design and synthesis of a highly versatile azobenzene-based dispersant (<b>AB</b>) that addresses these limitations by enabling the dispersion of SWCNTs with minimal damage in both aqueous and polar organic solvents. The <b>AB</b> dispersant promotes partial isolation of ultralong SWCNTs, up to tens of micrometers in length, while reducing the rest into small bundles of only a few tubes with well-preserved crystallinity. To demonstrate the broad utility of this dispersant, we applied <b>AB</b>-dispersed SWCNTs to three distinct device-relevant applications: transparent conductive films (TCFs), aligned coatings, and conductive fibers. The TCFs fabricated from aqueous <b>AB</b> dispersions exhibited high transmittance (88 and 76%) and low sheet resistance (86 and 67 Ω/sq) without postdeposition doping, surpassing most CNT–TCFs prepared by wet-coating methods. Aligned SWCNT films were formed via shear-assisted coating with a nematic order parameter of <i>S</i>_2D = 0.33. Fully aqueous wet spinning into calcium acetate solutions yielded dense (1.1 g/cm³), highly conductive (5932 S/cm) fibers. Our results demonstrate that the <b>AB</b> dispersant provides a unified and scalable strategy for producing high-performance CNT materials with minimal structural degradation. While further optimization of the processes for the individual application is necessary to improve alignment, density, and mechanical properties, these results represent a critical step toward application-flexible, sustainable, and industrially viable CNT processing.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"20017–20028"},"PeriodicalIF":5.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theranostic Applications of Tailored Lipid-based Nanoparticles as Drug Delivery Systems for Cancer Treatment","authors":"Chetna Gupta*,&nbsp;, ,&nbsp;Himanshu Yadav,&nbsp;, ,&nbsp;Ishika Dhanwani,&nbsp;, and ,&nbsp;Shikha Gulati*,&nbsp;","doi":"10.1021/acsanm.5c03503","DOIUrl":"https://doi.org/10.1021/acsanm.5c03503","url":null,"abstract":"<p >Cancer remains one of the leading causes of mortality worldwide, and researchers across the globe are striving to develop more effective and targeted treatment strategies. Conventional cancer therapies face major limitations, including poor tumor specificity, systemic toxicity, and limited therapeutic outcomes. Lipid-based nanoparticles (LNPs) have emerged as versatile carriers that address these challenges by improving drug solubility, stability, biodistribution, and tumor accumulation through both passive and active targeting mechanisms. Beyond drug delivery, LNPs are increasingly engineered as theranostic platforms, integrating therapeutic payloads with imaging agents for real-time monitoring, image-guided therapy, and improved treatment precision. This narrative review critically summarizes advances in liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and hybrid systems across diverse cancer types, highlighting key preclinical and clinical findings. We further discuss challenges such as stability, immunogenicity, large-scale manufacturing, and regulatory barriers. Finally, we outline future perspectives on LNPs, including their integration with immunotherapy, gene editing, and AI-assisted design, emphasizing their potential in advancing personalized nanomedicine.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19679–19711"},"PeriodicalIF":5.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Bilayer Nanoenvironment on the Catalytic Activity of Lipid–Pd–Nanoparticle Assemblies in Water","authors":"Nicholas Pavlakovich,&nbsp;, ,&nbsp;Saba Dalaub,&nbsp;, ,&nbsp;Patrick Nasser,&nbsp;, ,&nbsp;Maribelle Monroy,&nbsp;, ,&nbsp;Austin Nerhus,&nbsp;, ,&nbsp;Elisa Merced Olivas,&nbsp;, ,&nbsp;Justin Mulvey,&nbsp;, ,&nbsp;Giuseppe Di Palma,&nbsp;, ,&nbsp;Joseph P. Patterson*,&nbsp;, and ,&nbsp;Young-Seok Shon*,&nbsp;","doi":"10.1021/acsanm.5c04145","DOIUrl":"https://doi.org/10.1021/acsanm.5c04145","url":null,"abstract":"<p >Our previous work has shown that the bilayer characteristics of lipid–nanoparticle assemblies (LNAs) consisting of 1,2-distearoyl-<i>sn</i>-glycero-3-phosphocholine (DSPC) liposomes and hydrophobic Pd nanoparticles (PdNPs) allow the hydrophobic substrates to enter the hydrophobic region of the assemblies and promote hydrogenation in water. In this paper, to better understand the effects of the bilayer nanoenvironment within liposomes on the catalytic activity of LNAs, the structure/composition-property relationships of LNAs are investigated by manipulating the lipid and nanoparticle compositions. Specifically, lipids with different chain lengths, mixed lipids with varying mass ratios, and PdNPs with different surface ligand densities but similar core sizes were introduced into the bilayers of LNAs to control the immediate environments surrounding nanoparticle catalysts. Catalytic studies showed that the hydrogenation kinetic rate depends on the lipid composition of LNAs. LNAs composed of 1,2-dilouryl-<i>sn</i>-glycero-3-phosphocholine (DLPC) performed hydrogenation more quickly than LNAs of DSPC. Interestingly, binary LNAs with DSPC and DLPC mixed lipids were less catalytically active than monotonic LNAs with either type of lipids. Regarding the effect of the surface ligand density of PdNPs, the enhanced catalytic activities observed for PdNPs with a lower surface ligand density in organic solvents nearly disappeared for hydrophobic PdNPs when embedded into the liposome bilayer.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"20096–20104"},"PeriodicalIF":5.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Cost Multilayer MXene Doped Carbon Electrode for High-Performance Hole-Transport-Layer-Free Perovskite Solar Cells","authors":"Yating Du,&nbsp;, ,&nbsp;Wei Huang,&nbsp;, ,&nbsp;Siyuan Li,&nbsp;, ,&nbsp;Songwei Wang,&nbsp;, ,&nbsp;Huanzhi Zhang,&nbsp;, ,&nbsp;Lixian Sun,&nbsp;, ,&nbsp;Chengwen Huang*,&nbsp;, ,&nbsp;Jinxiang Chen*,&nbsp;, and ,&nbsp;Ping Cai*,&nbsp;","doi":"10.1021/acsanm.5c03359","DOIUrl":"https://doi.org/10.1021/acsanm.5c03359","url":null,"abstract":"<p >Hole-transport-layer (HTL)-free carbon-based PSCs (C-PSCs) show attractive commercial potential due to low production costs, simplifying manufacturing process, and relatively high stability. The defect passivation of perovskite and energy-level modification of the carbon electrode are crucial to further improve the PCE and stability of C-PSCs. Herein, a low-cost multilayer Ti₃C₂T_<i>x</i> MXene is doped into carbon paste to construct MXene@carbon electrode for C-PSCs. The preparation of multilayer MXene is simple and cost-effective due to only requiring the etching of the MAX phase. The incorporation of MXene appropriately increases the work function, providing a suitable energy level alignment between perovskite and MXene@carbon. The surface T_<i>x</i> groups of MXene can form favorable interaction with the oxygen-containing functional groups of graphite, facilitating the good dispersion of MXene in the carbon paste, which improve the interface contact between perovskite and MXene@carbon and the conductivity and morphology of MXene@carbon electrode. Therefore, the MXene@carbon C-PSCs show enhanced charge transport and extraction and reduced defects and charge recombination and thus achieve significantly improved photovoltaic performance and operational stability. Compared with the conrtol MAPbI₃ device with pristine carbon electrode (PCE of 12.69%), the MXene@carbon device exhibits obviously higher PCE of 16.00%, which is top-level for HTL-free MAPbI₃ C-PSCs without perovskite passivators. Moreover, the average PCE (14.68%) of the MXene@carbon devices was also significantly higher than that (12.37%) of the control devices. The impressive results indicate the great potential of the MXene doped carbon electrode for high-performance C-PSCs.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19892–19900"},"PeriodicalIF":5.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial Confinement Mechanism for Developing Versatile Nonionic Guest-in-CD-MOF-1 Complexes to Generate Transparent Nonionic Guest in Aqueous Dispersion","authors":"Danyu Lv,&nbsp;, ,&nbsp;Huanyu Xu,&nbsp;, ,&nbsp;Ji Ma,&nbsp;, ,&nbsp;Zhong Han*,&nbsp;, and ,&nbsp;Yongguang Guan*,&nbsp;","doi":"10.1021/acsanm.5c03482","DOIUrl":"https://doi.org/10.1021/acsanm.5c03482","url":null,"abstract":"<p >Understanding the universal encapsulation mechanism of nonionic guests in CD-MOF-1 is important to develop various stable nanosized nonionic guest-in-CD-MOF-1 complexes for improving the aqueous dispersity of hydrophobic nonionic guests. Herein, typal nonionic guests with different sizes and van der Waals volumes were encapsulated into CD-MOF-1. We found that urolithin A (Uro-A) could be effectively encapsulated into CD-MOF-1 compared to other guests. The long edge size of Uro-A (1.06 nm) exceeds the aperture size of CD-MOF-1 (0.78 nm), while its short edge size (0.62 nm) is slightly smaller than the aperture size. The van der Waals volume of Uro-A is 193.07 ų, smaller than the A and B pore volumes of CD-MOF-1 (i.e., 2571.14 ų and 381.51 ų). Consequently, Uro-A can easily enter into the pores of CD-MOF-1 via free diffusion, while the noncovalent spatial confinement prevents the encapsulated Uro-A against escaping. Ellagic acid (EA) and caffeic acid phenethyl ester (CAPE) share similar molecular dimensions and van der Waals volumes compared to Uro-A, resulting in a reasonable loading capacity and are effectively difficult to escape from CD-MOF-1. However, the van der Waals volumes of Vitamin K1 (VK1) and coenzyme Q₁₀ (CoQ₁₀) are significantly larger than the B pore volume of CD-MOF-1, stopping them from diffusing into CD-MOF-1. Alternatively, carvacrol, geranyl acetate, and nerol have excessively small dimensions and van der Waals volumes and thus are prone to escape from CD-MOF-1 during the washing process. Furthermore, the developed Uro-A-in-CD-MOF-1 presented desirable hydrolysis characteristics without significant residual nanostructures. This work provides a universal mechanism for developing nonionic guest-in-CD-MOF-1 to improve aqueous dispersibility of hydrophobic guests, providing potential applications in food, cosmetics, and pharmaceutical development.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19910–19918"},"PeriodicalIF":5.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Transcriptomic and Metabolomic Profiling of Cobalt Nanoparticle-Induced Cytotoxicity in THP-1 Macrophages: Implications for Prosthetic Implants","authors":"Zhao Liu*,&nbsp;, ,&nbsp;Wancong Zhang,&nbsp;, ,&nbsp;Zhidao Xia,&nbsp;, ,&nbsp;Zhengdou Li,&nbsp;, ,&nbsp;Shunbin Zhang,&nbsp;, ,&nbsp;Xiaoxiao Liu,&nbsp;, ,&nbsp;Xu Li,&nbsp;, ,&nbsp;Ling Ding,&nbsp;, ,&nbsp;Shijie Tang*,&nbsp;, and ,&nbsp;Xinliang Zhu*,&nbsp;","doi":"10.1021/acsanm.5c04298","DOIUrl":"https://doi.org/10.1021/acsanm.5c04298","url":null,"abstract":"<p >Cobalt, a high-grade metallic substance, is utilized across a wide variety of applications, ranging from joint prostheses to dental fillings. This has increased the level of human exposure to cobalt nanoparticles (CoNPs), potentially causing adverse local tissue reactions and implantation failure. The mechanisms are not fully understood. In this study, a macrophage model of cell exposure to CoNPs was employed to investigate the potential effects of CoNPs on cellular metabolic pathways and gene regulatory networks based on previous explorations on the complications of artificial joint implants. Results showed that CoNPs significantly affected cell membrane components and the expression of genes encoding extracellular matrix proteins. In addition, CoNPs downregulated amino acid metabolism and inhibited pentose metabolism. Based on the observed metabolome and transcriptome alterations, we concluded that the regulatory networks involving pentose and drug metabolism pathways may mediate CoNP-induced toxicity in macrophages. Therefore, beyond inflammatory responses, the combinatorial effects of numerous metabolic regulatory networks may also contribute to CoNP-induced cell damage, particularly in macrophages. These findings provide a deeper insight into the health concerns related to metal nanoparticles of implant materials and emphasize the necessity for safer applications of metal-containing implantable products.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"20115–20127"},"PeriodicalIF":5.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}