ACS Applied Nano Materials最新文献

{"title":"Multifunctional Carbon Fiber Composites via Interface-Engineered MXene-Polyurethane Hybrids: Synergistically Enhanced Mechanical, In Situ Damage Sensing, and EMI Shielding Properties","authors":"Yi Hu*,&nbsp;Xinhui He,&nbsp;Ye Liu,&nbsp;Yan Yang,&nbsp;Chunhao Ma,&nbsp;Zhiwei Sun and Jianjun Jiang*,&nbsp;","doi":"10.1021/acsanm.5c0118010.1021/acsanm.5c01180","DOIUrl":"https://doi.org/10.1021/acsanm.5c01180https://doi.org/10.1021/acsanm.5c01180","url":null,"abstract":"<p >An organic–inorganic hybrid filler system comprising isocyanate-terminated polyurethane (PU) and hydroxyl-terminated MXene nanoplatelets was developed and incorporated into an epoxy (EP) matrix. The 0.1% MXene and 1% PU in the EP matrix resulted in a 25% and 60% increase in tensile and bending strength, respectively, compared to neat EP, attributed to the crack-pinning effect of MXene, shear yielding and plastic deformation of PU, and strong chemical bonding between PU and EP. Vacuum-assisted resin infusion (VARI) was used to infuse the modified EP into a carbon fiber (CF) preform, leading to a 104% and 79% improvement in bending strength and interlaminar shear strength (ILSS) for the 0.1%MXene-1%PU-EP/CF composite compared to the desized CF/EP. The uniform dispersion of conductive MXene nanosheets and the inherent conductivity of the CF skeleton resulted in a 123% and 25% increase in out-of-plane and in-plane electrical conductivity. The conductive MXene-PU hybrid network enabled highly sensitive and reliable in situ damage sensing capabilities. The 0.1%MXene-1%PU-EP/CF composite exhibited a maximum electromagnetic interference (EMI) shielding effectiveness (SE) of 27.8 dB, attributed to conductive loss, interfacial polarization, and dipole polarization mechanisms. This study demonstrates the effectiveness of hybridizing MXene and PU in simultaneously enhancing the mechanical, electrical, in situ damage sensing, and EMI shielding properties of carbon fiber reinforced polymer (CFRP) composites, providing valuable insights for future research in multifunctional composite materials.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"10985–11001 10985–11001"},"PeriodicalIF":5.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes Loaded with Gold Nanoparticles and Temozolomide for Targeted Therapy of Glioblastoma","authors":"Sana Shaikh,&nbsp;Muhammad Younis,&nbsp;Khawar Ali Shahzad,&nbsp;Gao Renjie,&nbsp;Zhao Na,&nbsp;Qin Bingyao and Liudi Yuan*,&nbsp;","doi":"10.1021/acsanm.5c0206910.1021/acsanm.5c02069","DOIUrl":"https://doi.org/10.1021/acsanm.5c02069https://doi.org/10.1021/acsanm.5c02069","url":null,"abstract":"<p >Glioblastoma (GBM) is the highly aggressive and lethal primary tumor characterized by rapid growth, heterogeneity, and infiltration into surrounding brain tissues. Temozolomide (TMZ) is a key chemotherapeutic drug that is effective in GBM therapy. However, the effectiveness of TMZ is hindered by the blood–brain barrier (BBB). The BBB consists of multiple layers surrounded by blood vessels essential for protecting the central nervous system (CNS) and also limits the drug penetration within the brain. Exosomes are a class of extracellular vesicles secreted by various cells and have emerged as a promising drug delivery platform for treating GBM. Exosomes penetrate the BBB by multiple mechanisms, including receptor-mediated transcytosis, adsorptive mediated transcytosis, and endocytosis. Here, we developed a specific M1 macrophage-derived exosome (Exo)-based drug delivery nanoplatform against GBM. The TMZ and gold nanoparticles (AuNPs) were loaded into isolated Exo with the incubation method, and Exo-Au-TMZ was prepared. Here, we evaluated the anticancer effect of Exo-Au-TMZ on GBM in vitro and in vivo. The in vivo results showed that Exo-Au-TMZ has excellent BBB penetration and superior tumor accumulation and effectively inhibits tumor growth. In addition, Exo-Au-TMZ proved to be an excellent contrast agent for in vivo computed tomography (CT) imaging. We further validated the targeted accumulation of Exo-Au-TMZ by CT imaging. Overall, this study shows that Exo carrying TMZ and AuNPs can serve as a potentially powerful therapeutic nanoplatform for GBM treatment and could have utility in other central nervous system (CNS) disorders.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"11192–11200 11192–11200"},"PeriodicalIF":5.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoactive Nanomaterials for Broad-Spectrum Antibacterial Action: A Review","authors":"Jinwen Jiao,&nbsp;Wenbo Wu,&nbsp;Yongjian Du,&nbsp;Di Cai,&nbsp;Houchao Shan* and Tifeng Jiao*,&nbsp;","doi":"10.1021/acsanm.5c0226110.1021/acsanm.5c02261","DOIUrl":"https://doi.org/10.1021/acsanm.5c02261https://doi.org/10.1021/acsanm.5c02261","url":null,"abstract":"<p >The rising threat of microbial contamination and antibiotic resistance has prompted the development of innovative antimicrobial approaches. This review discusses strategies to optimize the nanomaterials’ light absorption, reactive oxygen species (ROS) generation, and photothermal conversion efficiency and systematically explores the action of photoactive nanomaterials. These nanomaterials exhibit exceptional photodynamic or photothermal properties, making them promising candidates for broad-spectrum antibacterial agents. Advancements in heterojunction design, surface modification, and combination therapies have significantly improved their antibacterial performance and selectivity. Despite the progress, challenges persist in achieving a harmonious balance between broad-spectrum action and selectivity for diverse applications. Nonetheless, this review anticipates substantial advancements in both fundamental research and practical applications in the future. The interdisciplinary collaboration between microbiology, nanotechnology, and phototherapy could drive innovations in the design and utilization of highly effective, selective, and resilient antimicrobial agents.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"10798–10818 10798–10818"},"PeriodicalIF":5.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large-Area Electrodeposited WSe₂ over Graphene Electrodes for Optoelectronics.","authors":"Jiapei Zhang, Shibin Thomas, Ahmad Nizamuddin Muhammad Mustafa, Victoria Greenacre, Nikolay Zhelev, Syeda Ramsha Ali, Yisong Han, Shaokai Song, Hongwei Zhang, Aiden Graham, Nema M Abdelazim, Sami Ramadan, Richard Beanland, Gillian Reid, Philip N Bartlett, Kees de Groot, Yasir J Noori","doi":"10.1021/acsanm.4c07346","DOIUrl":"https://doi.org/10.1021/acsanm.4c07346","url":null,"abstract":"<p><p>Integrating graphene and transition metal dichalcogenides (TMDs) into layered material heterostructures brings together the exciting properties that each constituent 2D material offers. However, scaling the growth of graphene-TMD and related heterostructures remains a major challenge. In this work, we demonstrate the use of electrodeposition with a single source precursor (SSP), WSeCl₄, to grow few-layer WSe₂ using graphene as an electrode. Through characterization via photoluminescence, X-ray photoelectron, and Raman spectroscopy, we show that the electrodeposited WSe₂ is stoichiometric and exhibits semiconducting and light-emitting properties. TEM imaging was also performed to show the ordering of the stacked layers of WSe₂ over graphene, demonstrating the polycrystalline structure of WSe₂. This work paves the way toward utilizing electrodeposition to stack multiple TMDs, including MoS₂, WS₂, and WSe₂ over graphene for electronic and optoelectronic applications.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"10842-10850"},"PeriodicalIF":5.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"l-Tetramethylammonium-Derived Blue Fluorescent Carbon Dots for Tetracycline Sensing and Memristor Technology","authors":"Jing Hu,&nbsp; and ,&nbsp;Shaogui Wu*,&nbsp;","doi":"10.1021/acsanm.5c0191110.1021/acsanm.5c01911","DOIUrl":"https://doi.org/10.1021/acsanm.5c01911https://doi.org/10.1021/acsanm.5c01911","url":null,"abstract":"<p >A facile solvothermal strategy employing <span>l</span>-asparagine as the sole carbon–nitrogen precursor was developed for the synthesis of bright blue-emitting carbon dots (B-CDs) with remarkable optical properties. The as-prepared B-CDs exhibit optimal excitation/emission wavelengths at 378 and 466 nm, a notably high quantum yield (QY) of 19.2%, and superior aqueous dispersibility, salt tolerance, and photostability. Leveraging their ultrasensitive response toward tetracycline antibiotics (TET, CTC, and OTC), we engineered a fluorescent nanoprobe enabling quantitative detection with an impressive linear correlation coefficient (<i>R</i>²) of 0.999 and a detection limit down to 0.139 μmol/L. Furthermore, preliminary investigations revealed the exceptional potential of B-CDs as functional materials in memristive devices, demonstrating their unique advantages for advanced electronic applications. This study not only expands the multifunctionality of carbon-based nanomaterials but also provides innovative material platforms for antibiotic surveillance and neuromorphic computing technology.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"11166–11172 11166–11172"},"PeriodicalIF":5.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pt Nanoparticles on Mg(OH)2 for the Selective Hydrogenation of Furfural to Furfuryl Alcohol","authors":"Min Fu,&nbsp;Ziyang Shan,&nbsp;Mingtao Zhang,&nbsp;Jiawen Wang,&nbsp;Fanxi Jia,&nbsp;Meili Guan,&nbsp;Kunhua Wang,&nbsp;Wei Chen,&nbsp;Meng Gao,&nbsp;Hui Li,&nbsp;Liangmin Ning*,&nbsp;Xin Liu and Hao Yu,&nbsp;","doi":"10.1021/acsanm.5c0133410.1021/acsanm.5c01334","DOIUrl":"https://doi.org/10.1021/acsanm.5c01334https://doi.org/10.1021/acsanm.5c01334","url":null,"abstract":"<p >Manipulating the Electronic Metal–Support Interaction (EMSI) in metal catalysts supported on various substrates has proven to be the most efficient strategy for adjusting the electronic structure and enhancing the catalytic efficiency. However, a comprehensive understanding of the electronic charge transfer mechanism during the catalytic process has been challenging to grasp. Herein, Pt-PtO_<i>x</i>/Mg(OH)₂-F (where F denotes a flower-like structure) was synthesized through a combination of the gas–liquid interface method and the sol–gel method. The catalyst features a uniform three-dimensional flower-like morphology assembled from ultrathin nanosheets, forming a nanostructured architecture with high surface area and abundant exposed active sites, which significantly enhances mass transport and catalytic accessibility. This nanostructured catalyst enabled the efficient conversion of furfural (FF), a biomass platform compound, into furfuryl alcohol (FA), achieving a furfural conversion of 99.9% and a furfuryl alcohol selectivity of 98.4%, with a turnover frequency (TOF) value of 333.96 h^–1, which is higher than the performance of most catalysts. Evidence from EXAFS, XPS, CO pulse spectroscopy, and theoretical calculations indicated electronic disruptions between Pt species and the Mg(OH)₂ support, wherein charge redistribution has a direct impact on the adsorption behavior during the catalytic procedure. The Pt–O bonds formed through orbital hybridization altered the charge state of surface Pt sites, directing more electrons toward the furfural intermediate (C₄H₃O–CHO*), thereby facilitating adsorption. Ultimately, the active sites of the Pt-PtO_<i>x</i>/Mg(OH)₂-F catalyst were composed of Pt^δ+ Lewis acid sites and OH^δ− Lewis base sites, with the furfural carbonyl coordinating with the oxygen atoms of ethanol and Pt^δ+ sites, forming a six-membered ring transition state that eventually achieved the reduction of the furfural carbonyl.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"11002–11014 11002–11014"},"PeriodicalIF":5.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large-Area Electrodeposited WSe2 over Graphene Electrodes for Optoelectronics","authors":"Jiapei Zhang,&nbsp;Shibin Thomas,&nbsp;Ahmad Nizamuddin Muhammad Mustafa,&nbsp;Victoria Greenacre,&nbsp;Nikolay Zhelev,&nbsp;Syeda Ramsha Ali,&nbsp;Yisong Han,&nbsp;Shaokai Song,&nbsp;Hongwei Zhang,&nbsp;Aiden Graham,&nbsp;Nema M. Abdelazim,&nbsp;Sami Ramadan,&nbsp;Richard Beanland,&nbsp;Gillian Reid,&nbsp;Philip N. Bartlett,&nbsp;Kees de Groot and Yasir J. Noori*,&nbsp;","doi":"10.1021/acsanm.4c0734610.1021/acsanm.4c07346","DOIUrl":"https://doi.org/10.1021/acsanm.4c07346https://doi.org/10.1021/acsanm.4c07346","url":null,"abstract":"<p >Integrating graphene and transition metal dichalcogenides (TMDs) into layered material heterostructures brings together the exciting properties that each constituent 2D material offers. However, scaling the growth of graphene-TMD and related heterostructures remains a major challenge. In this work, we demonstrate the use of electrodeposition with a single source precursor (SSP), WSeCl₄, to grow few-layer WSe₂ using graphene as an electrode. Through characterization via photoluminescence, X-ray photoelectron, and Raman spectroscopy, we show that the electrodeposited WSe₂ is stoichiometric and exhibits semiconducting and light-emitting properties. TEM imaging was also performed to show the ordering of the stacked layers of WSe₂ over graphene, demonstrating the polycrystalline structure of WSe₂. This work paves the way toward utilizing electrodeposition to stack multiple TMDs, including MoS₂, WS₂, and WSe₂ over graphene for electronic and optoelectronic applications.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"10842–10850 10842–10850"},"PeriodicalIF":5.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsanm.4c07346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ag2Cu2O3 Nanorods as Electrocatalysts for Hydrogen Production and Overall Water Splitting","authors":"Arvind Kumar*,&nbsp;Akshay Prakash Hegde,&nbsp;Mukesh Puttur,&nbsp;Lakshmi Sagar Gangadharappa and Nagaraja Subraya Hosakoppa*,&nbsp;","doi":"10.1021/acsanm.5c0001010.1021/acsanm.5c00010","DOIUrl":"https://doi.org/10.1021/acsanm.5c00010https://doi.org/10.1021/acsanm.5c00010","url":null,"abstract":"<p >In this research, a series of Ag₂Cu₂O₃ nanorods as electrocatalysts were prepared with three different drying temperatures (namely, W – 50, W – 80, and W – 120), utilizing a regular coprecipitation approach. These nanorods’ surface morphology and structural attributes were thoroughly characterized using Field Emission Scanning Electron Microscopy and High-Resolution Transmission Electron Microscopy, while X-ray diffraction provided insight into their crystal structures. The compositional analysis was accomplished via X-ray photoelectron spectroscopy and Raman spectroscopy. The W – 50 catalyst exhibited the most promising electrochemical response among the synthesized samples. In the solution of 1 M KOH, at a current density of 10 mA cm^–2, it demonstrated modest overpotential values and Tafel slopes of 81 and 97 mV dec^–1 for the hydrogen evolution reaction (HER), whereas 409 and 140 mV dec^–1 for the oxygen evolution reaction (OER). When tested with a two-electrode electrolyzer, W – 50 serving as together the anode and cathode, a trivial cell voltage of 1.9842 V was required to accomplish a current density of 100 mA cm^–2, with surprising stability over 50 h of continuous operation at 200 mA cm^–2 for overall water splitting. Additionally, W – 50 displayed excellent performance for HER; it necessitated an overpotential of 337 mV to accomplish an extreme current density of 800 mA cm^–2. This inquiry provides precious perceptions into the importance of confined spaces within transition metal oxide-based catalysts, advancing their application in electrocatalysis.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"10851–10863 10851–10863"},"PeriodicalIF":5.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NiCoMn-Layered Double Hydroxide Porous Hollow Nanocages for High-Performance Asymmetric Supercapacitors","authors":"Zihan Hua,&nbsp;Xiaofeng Qiu,&nbsp;Kailei Xu,&nbsp;Jun Cao,&nbsp;Bowei Li,&nbsp;Chunmeng Huang,&nbsp;Feng Jiang,&nbsp;Huiyu Li,&nbsp;Yongsheng Liu,&nbsp;Haijing Cao,&nbsp;Dongsheng Chen*,&nbsp;Yan Xu* and Yanyan Zhu*,&nbsp;","doi":"10.1021/acsanm.5c0151110.1021/acsanm.5c01511","DOIUrl":"https://doi.org/10.1021/acsanm.5c01511https://doi.org/10.1021/acsanm.5c01511","url":null,"abstract":"<p >As a core component of energy storage devices, the performance breakthrough of supercapacitors is crucial for the development of renewable energy systems, yet the synergistic improvement of energy density and cycle life remains a long-standing technical challenge in this field. Although layered double hydroxides (LDHs) with adjustable interlayer structures have emerged as promising high-capacity electrode candidates, existing mono/bimetallic LDHs are generally limited by poor conductivity and structural collapse during cycling, resulting in practical capacities often below theoretical values. This study proposes an innovative bimetal-templated strategy to synthesize ternary NiCoMn-LDHC with unique porous hollow nanocage structures through the construction of CoMn-based zeolitic imidazolate framework (CoMn-ZIF) precursors followed by controlled annealing and carbonization. The synergistic effects of ternary metals combined with hierarchical porous architecture endow the material with exceptional electrochemical properties. The NiCoMn-LDHC electrode demonstrates a high specific capacity of 261.33 mAh g^–1 at 1 A g^–1 and maintains 92.85% capacity retention after 10,000 cycles at 5 A g^–1. Furthermore, the asymmetric supercapacitor NiCoMn-LDHC//AC assembled with activated carbon (AC) exhibits outstanding electrochemical characteristics, achieving an energy density of 30.22 Wh kg^–1 at a power density of 800 W kg^–1. Remarkably, it retains 91.09% capacity retention even after 10,000 cycles at 5 A g^–1.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 20","pages":"10675–10686 10675–10686"},"PeriodicalIF":5.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor Microenvironment-Responsive Proteolytic Nanodrug against Breast Cancer","authors":"Tingting Li,&nbsp;Wei Zhang,&nbsp;Cheng Li*,&nbsp;Xiaoping Qian* and Jianhua Zou*,&nbsp;","doi":"10.1021/acsanm.5c0184410.1021/acsanm.5c01844","DOIUrl":"https://doi.org/10.1021/acsanm.5c01844https://doi.org/10.1021/acsanm.5c01844","url":null,"abstract":"<p >Regulating the tumor microenvironment (TME) is essential not only for improving drug delivery but also for enhancing the efficacy of chemotherapy and immunotherapy. Proteolysis-Targeting Chimera (PROTAC) technology with durable and tunable therapeutic advantages offers possibilities for enhancing treatment efficacy. However, the strong biological activity of PROTACs may lead to uncontrolled degradation of proteins at off-target sites, thereby limiting their therapeutic efficacy in vivo. In this study, we introduce proteolytic nanodrugs specifically engineered to target and degrade the Smad3 protein, a key factor in fibroblast activation, through encapsulating small-molecule PROTACs in targeted nanocarriers. By targeting Smad3 in tumor tissues, proteolytic nanodrug effectively inhibits tumor-associated fibroblast activation, enhancing the penetration of chemotherapeutic agents within the tumor. When doxorubicin was combined with proteolytic nanodrug, exhibited a robust inhibitory effect on tumor growth. This approach offers a strategy for utilizing PROTACs to modulate the tumor microenvironment and optimize cancer treatment outcomes.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"11140–11149 11140–11149"},"PeriodicalIF":5.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}