{"title":"2D Nb2C MXene/COF复合材料作为应力标记物检测肾上腺素的电化学平台","authors":"Murali Punniyamoorthy, , , Charlin Soosaimanickam, , , Murugavel Kathiresan*, , and , Subbiah Alwarappan*, ","doi":"10.1021/acsanm.5c03086","DOIUrl":null,"url":null,"abstract":"<p >Epinephrine (or adrenaline) is a common stress marker secreted by the adrenal glands in response to stress. Monitoring epinephrine levels in real samples is therefore clinically relevant, as it provides information on the magnitude of stress experienced by an individual. Herein, we present the rational design of a covalently linked 2D Nb<sub>2</sub>C MXene/COF hybrid electrode as an electrochemical platform for the detection of epinephrine. The electrochemical oxidation of epinephrine to epinephrine quinone at the 2D Nb<sub>2</sub>C MXene/COF hybrid electrode was observed at +0.23 V vs Ag/AgCl. The proposed sensing platform exhibits a limit of detection of 1.09 μM (<i>N</i> = 3) and a sensitivity of 0.215 μA μM<sup>–1</sup> cm<sup>–2</sup>, with excellent selectivity and repeatability. Furthermore, this electrode was employed for the real-time analysis of spiked epinephrine in serum and urine samples.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19771–19778"},"PeriodicalIF":5.5000,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"2D Nb2C MXene/COF Composite as Electrochemical Platform for the Stress Marker Epinephrine Detection\",\"authors\":\"Murali Punniyamoorthy, , , Charlin Soosaimanickam, , , Murugavel Kathiresan*, , and , Subbiah Alwarappan*, \",\"doi\":\"10.1021/acsanm.5c03086\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Epinephrine (or adrenaline) is a common stress marker secreted by the adrenal glands in response to stress. Monitoring epinephrine levels in real samples is therefore clinically relevant, as it provides information on the magnitude of stress experienced by an individual. Herein, we present the rational design of a covalently linked 2D Nb<sub>2</sub>C MXene/COF hybrid electrode as an electrochemical platform for the detection of epinephrine. The electrochemical oxidation of epinephrine to epinephrine quinone at the 2D Nb<sub>2</sub>C MXene/COF hybrid electrode was observed at +0.23 V vs Ag/AgCl. The proposed sensing platform exhibits a limit of detection of 1.09 μM (<i>N</i> = 3) and a sensitivity of 0.215 μA μM<sup>–1</sup> cm<sup>–2</sup>, with excellent selectivity and repeatability. Furthermore, this electrode was employed for the real-time analysis of spiked epinephrine in serum and urine samples.</p>\",\"PeriodicalId\":6,\"journal\":{\"name\":\"ACS Applied Nano Materials\",\"volume\":\"8 41\",\"pages\":\"19771–19778\"},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2025-10-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Nano Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsanm.5c03086\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Nano Materials","FirstCategoryId":"88","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsanm.5c03086","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
肾上腺素（或肾上腺素）是一种常见的应激标志物，由肾上腺分泌，以应对压力。因此，监测真实样本中的肾上腺素水平具有临床相关性，因为它提供了个体所经历的压力程度的信息。在此，我们提出了一个合理的设计共价连接的2D Nb2C MXene/COF混合电极作为检测肾上腺素的电化学平台。在+0.23 V vs Ag/AgCl条件下，在2D Nb2C MXene/COF杂化电极上，肾上腺素被电化学氧化为肾上腺素醌。该传感平台的检测限为1.09 μM (N = 3)，灵敏度为0.215 μA μM - 1 cm-2，具有良好的选择性和重复性。此外，该电极被用于实时分析在血清和尿液样品中添加肾上腺素。
2D Nb2C MXene/COF Composite as Electrochemical Platform for the Stress Marker Epinephrine Detection
Epinephrine (or adrenaline) is a common stress marker secreted by the adrenal glands in response to stress. Monitoring epinephrine levels in real samples is therefore clinically relevant, as it provides information on the magnitude of stress experienced by an individual. Herein, we present the rational design of a covalently linked 2D Nb2C MXene/COF hybrid electrode as an electrochemical platform for the detection of epinephrine. The electrochemical oxidation of epinephrine to epinephrine quinone at the 2D Nb2C MXene/COF hybrid electrode was observed at +0.23 V vs Ag/AgCl. The proposed sensing platform exhibits a limit of detection of 1.09 μM (N = 3) and a sensitivity of 0.215 μA μM–1 cm–2, with excellent selectivity and repeatability. Furthermore, this electrode was employed for the real-time analysis of spiked epinephrine in serum and urine samples.
期刊介绍：
ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.
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