ACS Applied Nano Materials最新文献

{"title":"Spatial Confinement Mechanism for Developing Versatile Nonionic Guest-in-CD-MOF-1 Complexes to Generate Transparent Nonionic Guest in Aqueous Dispersion","authors":"Danyu Lv,&nbsp;, ,&nbsp;Huanyu Xu,&nbsp;, ,&nbsp;Ji Ma,&nbsp;, ,&nbsp;Zhong Han*,&nbsp;, and ,&nbsp;Yongguang Guan*,&nbsp;","doi":"10.1021/acsanm.5c03482","DOIUrl":"https://doi.org/10.1021/acsanm.5c03482","url":null,"abstract":"<p >Understanding the universal encapsulation mechanism of nonionic guests in CD-MOF-1 is important to develop various stable nanosized nonionic guest-in-CD-MOF-1 complexes for improving the aqueous dispersity of hydrophobic nonionic guests. Herein, typal nonionic guests with different sizes and van der Waals volumes were encapsulated into CD-MOF-1. We found that urolithin A (Uro-A) could be effectively encapsulated into CD-MOF-1 compared to other guests. The long edge size of Uro-A (1.06 nm) exceeds the aperture size of CD-MOF-1 (0.78 nm), while its short edge size (0.62 nm) is slightly smaller than the aperture size. The van der Waals volume of Uro-A is 193.07 ų, smaller than the A and B pore volumes of CD-MOF-1 (i.e., 2571.14 ų and 381.51 ų). Consequently, Uro-A can easily enter into the pores of CD-MOF-1 via free diffusion, while the noncovalent spatial confinement prevents the encapsulated Uro-A against escaping. Ellagic acid (EA) and caffeic acid phenethyl ester (CAPE) share similar molecular dimensions and van der Waals volumes compared to Uro-A, resulting in a reasonable loading capacity and are effectively difficult to escape from CD-MOF-1. However, the van der Waals volumes of Vitamin K1 (VK1) and coenzyme Q₁₀ (CoQ₁₀) are significantly larger than the B pore volume of CD-MOF-1, stopping them from diffusing into CD-MOF-1. Alternatively, carvacrol, geranyl acetate, and nerol have excessively small dimensions and van der Waals volumes and thus are prone to escape from CD-MOF-1 during the washing process. Furthermore, the developed Uro-A-in-CD-MOF-1 presented desirable hydrolysis characteristics without significant residual nanostructures. This work provides a universal mechanism for developing nonionic guest-in-CD-MOF-1 to improve aqueous dispersibility of hydrophobic guests, providing potential applications in food, cosmetics, and pharmaceutical development.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19910–19918"},"PeriodicalIF":5.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Transcriptomic and Metabolomic Profiling of Cobalt Nanoparticle-Induced Cytotoxicity in THP-1 Macrophages: Implications for Prosthetic Implants","authors":"Zhao Liu*,&nbsp;, ,&nbsp;Wancong Zhang,&nbsp;, ,&nbsp;Zhidao Xia,&nbsp;, ,&nbsp;Zhengdou Li,&nbsp;, ,&nbsp;Shunbin Zhang,&nbsp;, ,&nbsp;Xiaoxiao Liu,&nbsp;, ,&nbsp;Xu Li,&nbsp;, ,&nbsp;Ling Ding,&nbsp;, ,&nbsp;Shijie Tang*,&nbsp;, and ,&nbsp;Xinliang Zhu*,&nbsp;","doi":"10.1021/acsanm.5c04298","DOIUrl":"https://doi.org/10.1021/acsanm.5c04298","url":null,"abstract":"<p >Cobalt, a high-grade metallic substance, is utilized across a wide variety of applications, ranging from joint prostheses to dental fillings. This has increased the level of human exposure to cobalt nanoparticles (CoNPs), potentially causing adverse local tissue reactions and implantation failure. The mechanisms are not fully understood. In this study, a macrophage model of cell exposure to CoNPs was employed to investigate the potential effects of CoNPs on cellular metabolic pathways and gene regulatory networks based on previous explorations on the complications of artificial joint implants. Results showed that CoNPs significantly affected cell membrane components and the expression of genes encoding extracellular matrix proteins. In addition, CoNPs downregulated amino acid metabolism and inhibited pentose metabolism. Based on the observed metabolome and transcriptome alterations, we concluded that the regulatory networks involving pentose and drug metabolism pathways may mediate CoNP-induced toxicity in macrophages. Therefore, beyond inflammatory responses, the combinatorial effects of numerous metabolic regulatory networks may also contribute to CoNP-induced cell damage, particularly in macrophages. These findings provide a deeper insight into the health concerns related to metal nanoparticles of implant materials and emphasize the necessity for safer applications of metal-containing implantable products.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"20115–20127"},"PeriodicalIF":5.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategic Design of a Single-Source Precursor for in Situ Generation and Integration of Adherent Species on Ni3S4 Entangled-Nanosheets for Energy Storage Applications","authors":"Rahul Singh,&nbsp;, ,&nbsp;Rohit Thakur,&nbsp;, ,&nbsp;Umasharan Sahu,&nbsp;, ,&nbsp;Ramesh Chandra Sahoo,&nbsp;, ,&nbsp;Bhagavatula L.V. Prasad*,&nbsp;, and ,&nbsp;H.S.S. Ramakrishna Matte*,&nbsp;","doi":"10.1021/acsanm.5c03542","DOIUrl":"https://doi.org/10.1021/acsanm.5c03542","url":null,"abstract":"<p >Synthesizing transition-metal chalcogenides (TMC) via a single-source precursor (SSP) route has shown great potential due to better reproducibility and control over stoichiometry, phase, and morphology. While the SSP converts into TMC, surfactants or coordinating species are essential to ensure dispersibility for further solution-based processing protocols. These additional species are typically highly toxic, difficult to remove, and adversely affect device performance. Here, as a proof of concept, design-induced <i>in situ</i> stabilized Ni₃S₄ (D<i>i</i>SNi) protocol demonstrates that strategic SSP design and optimized reaction conditions can facilitate directed chemical reactivity, gradually generating adhering species, which seamlessly integrate onto the metal chalcogenides, aiding the formation of stable dispersions without utilizing additional stabilizers. The proposed mechanism is validated by detailed strategic experiments and analysis, like X-ray photoelectron spectroscopy (XPS), accelerated dispersion stability measurements, and postsynthesis base treatment, which confirm the presence of <i>in situ</i> generated diethylammonium ion (DEA⁺) as the adherent and corroborate its role in dispersibility. The obtained Ni₃S₄ entangled-nanosheets are utilized to fabricate additive-free symmetric supercapacitors with organic electrolyte for charge storage over an extended potential window of 2.8 V and an energy density of 12.44 μW h cm^–2 at a power density of 0.42 mW cm^–2. The devised D<i>i</i>SNi protocol showcases the importance of the SSP design for achieving multifunctionality. It is anticipated to have a broader impact on the role of careful design of SSP, making it an ideal contender for synthesizing transition-metal chalcogenides.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 41","pages":"19943–19951"},"PeriodicalIF":5.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"pH and Glutathione-Responsive Sequentially Releasing Hydroxyl Radical and Hydrogen Sulfide Nanozyme for Effective Wound Infection Treatment via Bimodal Chemodynamic-Gas Therapy","authors":"Jun Zhao,&nbsp;, ,&nbsp;Yangfeng Du,&nbsp;, ,&nbsp;Wanqin Cai,&nbsp;, ,&nbsp;Pei Zhang,&nbsp;, ,&nbsp;Xiling Song,&nbsp;, ,&nbsp;Wenxuan Ye,&nbsp;, ,&nbsp;Yunping Peng*,&nbsp;, ,&nbsp;Jianfu Zhao*,&nbsp;, and ,&nbsp;Siming Yu*,&nbsp;","doi":"10.1021/acsanm.5c03513","DOIUrl":"https://doi.org/10.1021/acsanm.5c03513","url":null,"abstract":"<p >Nowadays, bacterial infection-associated diseases pose significant threats to human public health. Developing alternative strategies for the highly efficient treatment of bacterial infections is in urgent demand. It is well-known that hydroxyl radical (^•OH) exhibits strong antibacterial activity and is widely used for chemodynamic therapy (CDT), while hydrogen sulfide (H₂S) displays the ability to promote wound healing for gas therapy (GT). In the present work, a multifunctional nanozyme with pH and GSH dual-responsive sequentially releasing ^•OH and H₂S properties was rationally designed for high-efficiency wound infection treatment via bimodal CDT and GT therapy. Herein, dendritic mesoporous organic silica (DMOS) nanoparticles were prepared and used as the carrier for in situ copper peroxide (CP) nanodots growth, obtaining nanozyme of DMOS@CP. In the acidic condition, CP decorated on DMOS was first decomposed by generating ^•OH via the Fenton-like reaction, which was able to effectively inhibit bacterial growth, as well as eradicate bacterial biofilms, by disrupting the bacterial cell membrane, increasing intracellular ROS generation, and damaging bacterial DNA. Subsequently, DMOS can be further dissociated by GSH to release a substantial amount of H₂S to promote bacterial wound healing. The mechanism study revealed that H₂S was capable of first reversing the inflammatory microenvironment of the wound by reprogramming M2-type macrophage polarization, followed by upregulating expressions of hypoxia-inducible factor-1α, vascular endothelial growth factor, and CD31 to promote cell migration and angiogenesis.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 40","pages":"19518–19534"},"PeriodicalIF":5.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoscale GO–AgNPs/CMC Films for Food Safety Monitoring: Dual-Mode Optical Sensors for Brilliant Blue Detection","authors":"A. Joel Amalan,&nbsp;, ,&nbsp;S. Gopika Devi,&nbsp;, and ,&nbsp;Anitha Pius*,&nbsp;","doi":"10.1021/acsanm.5c03379","DOIUrl":"https://doi.org/10.1021/acsanm.5c03379","url":null,"abstract":"<p >The development of nanoscale multifunctional sensing platforms for food safety monitoring has gained much interest in recent years. Here, we present a dual-mode optical sensor based on a graphene oxide–silver nanoparticle (GO–AgNP) nanocomposite dispersed in a biodegradable carboxymethyl cellulose (CMC) film for selective detection of Brilliant Blue FCF (BB) dye. The nanoscale dispersion of GO sheets and AgNPs in the polymer matrix introduces high surface area, intense π–π stacking, and surface plasmon-coupled fluorescence quenching that synergistically enhance the sensing properties. The nanocomposite showed cyan fluorescence emission under UV irradiation with bands at 469 and 546 nm that were progressively quenched by BB through static interactions and inner filter effects (IFE), giving a “turn-off” fluorometric response. Concurrently, a characteristic colorimetric shift from pale brown to bluish-green supported naked-eye identification. The sensor exhibited an extensive linear range (1 nM to 25 μM) and low detection thresholds of 0.321 μM (fluorescence) and 1.886 μM (colorimetry), along with excellent selectivity against structurally related dyes and ionic interferents. Smartphone-based HSV (Hue, Saturation, Value) analysis also facilitated portable and semiquantitative confirmation. Excellent recoveries (97.2–104.3% recovery, relative standard deviation (RSD) &lt; 3.6%) were obtained from real sample recovery studies in drinks and candies. These results highlight the viability of the GO–AgNP/CMC nanocomposite film as a cost-effective, disposable, and environmentally friendly nanoscale platform for applicable food safety screening of artificial coloring agents.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 40","pages":"19384–19399"},"PeriodicalIF":5.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoporous Fluorine-Containing Polynaphthoylenebenzimidazole Films: Implications for High-Temperature Hydrogen Recovery","authors":"Alexandr Y. Alentiev,&nbsp;, ,&nbsp;Daria A. Syrtsova,&nbsp;, ,&nbsp;Roman Y. Nikiforov,&nbsp;, ,&nbsp;Victoria E. Ryzhikh,&nbsp;, ,&nbsp;Sergey O. Ilyin,&nbsp;, ,&nbsp;Ivan S. Levin,&nbsp;, ,&nbsp;Yulia A. Volkova,&nbsp;, ,&nbsp;Igor I. Ponomarev,&nbsp;, and ,&nbsp;Kirill M. Skupov*,&nbsp;","doi":"10.1021/acsanm.5c03696","DOIUrl":"https://doi.org/10.1021/acsanm.5c03696","url":null,"abstract":"<p >Developing effective approaches for the synthesis of nanomaterials with enhanced properties for applications in high-temperature hydrogen recovery and gas separation technology is a challenging task. Nanoporous polymer films hold significant potential for a diverse range of applications owing to their distinctive characteristics, such as high surface area, adjustable pore size, and selectivity for chemical interactions. The study presents a two-stage method (enabling less toxic solvents) for the production of nanoporous films of heat-resistant and highly permeable fluorine-containing polynaphthoylenebenzimidazole (or polybenzimidazobenzophenanthroline) (PNBI-6F), produced from polymer solutions in DMSO and N-MP. Nanoporosity of the samples is revealed by the CO₂ adsorption method. It has been determined that the selection of the solvent can influence the characteristics and structure of the nanoporous polymer matrix. The gas transport properties of the films in the temperature range 20–250 °C have also been examined. All of the obtained nanoporous PNBI-6F films retain their mechanical properties at the maximum temperature for an extended period of time. The XRD and DMA methods and gas transport properties unexpectedly reveal a unique two-state behavior with distinct activation energies for gas permeability for each state. The initial state is characterized by lower gas permeability and free volume upon initial heating below 150 °C. A second state, which is metastable and characterized by an increase in gas permeability and free volume, occurs above 150 °C and persists in the sample over a prolonged period of time after cooling. Overcoming high-temperature gas separation challenges for H₂–CO₂ mixtures is essential for improving current hydrogen recovery processes and for better purification of reformed hydrogen. Therefore, it is important that the obtained gas transport characteristics significantly exceed the upper bound of the 2008 H₂–CO₂ Robeson diagram. The obtained results suggest the application of the nanoporous material in high-temperature hydrogen recovery technology.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 40","pages":"19598–19608"},"PeriodicalIF":5.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Z-Scheme Heterojunction of Nanomaterials for the Simultaneous Electrochemical Detection of Chloramphenicol and Furazolidone in Food Samples","authors":"Santhosh Arehalli Shivamurthy*,&nbsp;, ,&nbsp;Sirisha Subbareddy,&nbsp;, ,&nbsp;Srujan Basavapura Ravikumar,&nbsp;, ,&nbsp;Sahana Kamanna Metry,&nbsp;, and ,&nbsp;Sandeep Shadakshari*,&nbsp;","doi":"10.1021/acsanm.5c03561","DOIUrl":"https://doi.org/10.1021/acsanm.5c03561","url":null,"abstract":"<p >Advanced nanomaterials offer transformative potential in addressing food safety challenges, particularly in the detection of antibiotic residues. This study reports the synthesis of a dual Z-scheme heterojunction nanocomposite BWS/PGCN/EBS via ultrasonication for electrochemical sensing applications. The heterojunction integrates bismuth tungsten selenide (BWS) with porous graphitic carbon nitride (PGCN) as a highly conductive matrix, followed by europium bismuth selenide (EBS), with both semiconductors doped to enhance their electronic properties. This configuration facilitates efficient charge separation and favorable band alignment, significantly improving electrochemical performance. Morphological characterizations confirm the structural integrity and atomic arrangement of the composite. Electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and linear sweep voltammetry (LSV) reveal high sensitivity in detecting chloramphenicol (CAP) and furazolidone (FZ), both individually and simultaneously. The sensor demonstrates low detection limits of 18.91 nM for CAP and 6.49 nM for FZ when measured individually. Under simultaneous detection conditions, the limits of detection are 11.31 nM for CAP and 11.75 nM for FZ, with corresponding quantification limits of 34.29 and 35.63 nM. A linear current response is observed across analyte concentrations ranging from 10 nM to 50 nM, with calculated sensitivities of 2.66 × 10^–5 A.nM^–1.cm^–2 for CAP and 3.035 × 10^–5 A.nM^–1.cm^–2 for FZ, further validating the sensor’s quantitative performance. The sensor maintains high selectivity in the presence of common interferents and demonstrates excellent recovery rates in real food matrices, such as milk and honey. Density functional theory (DFT) studies are conducted to support the proposed redox mechanism, and the computational results correlate well with the experimental findings, confirming the sensor’s enhanced performance for FZ over CAP. This work underscores the critical role of advanced nanomaterials in developing sensitive, selective, and reliable electrochemical sensors, contributing to public health protection and the advancement of sustainable analytical technologies.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 40","pages":"19568–19579"},"PeriodicalIF":5.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Point-of-Care Tests via Pollen-Based Nanoplasmonic Chips Combined with a Synthetic Receptor for FKBP12 Biomarker Detection at a Single-Molecule Level","authors":"Chiara Marzano,&nbsp;, ,&nbsp;Rosalba Pitruzzella,&nbsp;, ,&nbsp;Cosimo Bartolini,&nbsp;, ,&nbsp;Laura Pasquardini,&nbsp;, ,&nbsp;Annabella la Grasta,&nbsp;, ,&nbsp;Martina Tozzetti,&nbsp;, ,&nbsp;Raffaella Germinario,&nbsp;, ,&nbsp;Teresa Natale,&nbsp;, ,&nbsp;Ahtsham Ishaq,&nbsp;, ,&nbsp;Stefano Menichetti,&nbsp;, ,&nbsp;Francesco Arcadio,&nbsp;, ,&nbsp;Luigi Zeni,&nbsp;, ,&nbsp;Francesco Dell’Olio,&nbsp;, ,&nbsp;Gabriella Caminati*,&nbsp;, and ,&nbsp;Nunzio Cennamo*,&nbsp;","doi":"10.1021/acsanm.5c02895","DOIUrl":"https://doi.org/10.1021/acsanm.5c02895","url":null,"abstract":"<p >The selective and rapid detection of FKBP12 is crucial due to its involvement in immunosuppression, neurodegenerative and oncological diseases, and some fundamental cellular processes. A low-cost point-of-care test (POCT) based on a simple setup, combined with plasmonic sensor chips for ultrasensitive detection of FKBP12, is developed. The sensing principle exploits pollen-based natural nanostructures covered by gold nanofilms and functionalized with synthetic GPS-SH1 receptors. The experimental results demonstrated ultrahigh performance due to the hybrid plasmonic phenomena, with a detection limit of 0.17 aM for FKBP12. This label-free optical-chemical sensor is based on portable and simple equipment, operates in 10 min, requires a small volume of the sample, and only requires a dilution step to perform the measurement on real samples. The high selectivity of the developed sensor chip for FKBP12 is demonstrated, and its applicability in complex matrices such as serum and plasma is validated. Furthermore, two surface functionalization strategies with different receptor-to-spacer ratios, 1:6 and 1:3, are investigated, identifying the optimal ratio to achieve better binding sensitivity. This work highlights the potential of plasmonic nanostructured pollen-based chips functionalized with GPS-SH1 receptors for the detection of FKBP12 at the single-molecule level, paving the way for advances in diagnostics and therapeutic monitoring via low-cost POCT with cheaper and disposable chips.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 40","pages":"19154–19166"},"PeriodicalIF":5.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsanm.5c02895","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delivering Drugs to Cancer Cells and inside the Mitochondria Using a Dual-Ligand Installed Targeted Drug Delivery System","authors":"Purvi Kishore,&nbsp;, ,&nbsp;Sourav Barman,&nbsp;, ,&nbsp;Rimpa Dey,&nbsp;, ,&nbsp;Ankita Jana,&nbsp;, ,&nbsp;Malabika Ghosh,&nbsp;, ,&nbsp;Pousali Bag,&nbsp;, ,&nbsp;Tapas Ghatak,&nbsp;, ,&nbsp;Partha Sona Maji,&nbsp;, ,&nbsp;Chitrita Ghosh,&nbsp;, ,&nbsp;Nayana Mukherjee,&nbsp;, ,&nbsp;Ankan Dutta Chowdhury,&nbsp;, ,&nbsp;Souvik Ghatak,&nbsp;, ,&nbsp;Rupam Mukherjee,&nbsp;, ,&nbsp;Arnab Basu,&nbsp;, ,&nbsp;Ali Hossain Khan,&nbsp;, ,&nbsp;Surya K. Ghosh,&nbsp;, ,&nbsp;Sadananda Mandal,&nbsp;, and ,&nbsp;Amit Ranjan Maity*,&nbsp;","doi":"10.1021/acsanm.5c04231","DOIUrl":"https://doi.org/10.1021/acsanm.5c04231","url":null,"abstract":"<p >Traditional anticancer therapy faces major limitations due to the off-target toxicity of drugs. A specialized drug delivery system (DDS) has proven to be a potential approach for overcoming this barrier. Targeted delivery to cancer cells not only enhances the precision of drug localization but also minimizes adverse effects of the drug by further directing therapeutic agents selectively to their site of action inside specific intracellular organelles. Among various targets, folate receptors show a significantly higher level of expression in many cancer types, making them suitable for preclinical developments. Moreover, after this selective delivery of anticancer drugs to cancer cells, regulation of the intracellular trafficking process could also impact the efficacy of drug actions. This selective targeting of cancer cells and delivery of drugs to their sites of action could be achieved by using two different types of targeting ligands on the same DDS surface. Herein, we used a chitosan-based biopolymer, modified by cholesterol molecules using a simple chemical approach and installed dual ligands, folic acid (FA) and triphenylphosphine (TPP) for selective cancer cell targeting and further mitochondrial delivery of curcumin. Cellular uptake studies in KB cells, which overexpress folate receptors, using fluorescence microscopy and flow cytometry analysis confirmed that the targeted DDS has many-fold higher cellular uptake than the nontargeted DDS (without decoration of TPP) and the null DDS (without FA and TPP on its surface), respectively, which induced more cytotoxic effects on cancer cells. The developed chemical approach employed for polymer synthesis and ligand decoration is a simple, straightforward, and one-step process that generates a versatile and multifaceted DDS with the possibility to encapsulate a wide variety of drugs (hydrophobic, charged, small molecule, biomolecule drugs, etc.) and ligands for enhanced precision therapy.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 40","pages":"19668–19678"},"PeriodicalIF":5.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemistry, Chirality, and Complexity as Concepts in Single-Walled Carbon Nanotube Research","authors":"David M. Jiménez,&nbsp;, ,&nbsp;Ion Isasti,&nbsp;, ,&nbsp;Alejandro López-Moreno,&nbsp;, and ,&nbsp;Emilio M. Pérez*,&nbsp;","doi":"10.1021/acsanm.5c02709","DOIUrl":"https://doi.org/10.1021/acsanm.5c02709","url":null,"abstract":"<p >More than 30 years have elapsed since the description of single-walled carbon nanotubes (SWCNTs). Thirty years of intense research effort initially focused on elucidating the outstanding physical properties of SWCNTs, which gave rise to hopes for an immediate technological revolution. In parallel, advancements in synthesis and purification procedures afforded ever better samples of SWCNTs. A deeper understanding of the difficulties in exploiting the extraordinary intrinsic properties of SWCNTs and the advent of graphene marked the end of the hype. SWCNTs have now stepped out of the valley of disillusionment and are firmly climbing the slope of enlightenment. In this review, we highlight three broad concepts that we believe will permeate research in SWCNTs for the next few years: chemistry, chirality, and complexity. The quality of commercially available SWCNT samples, coupled with advances in characterization techniques, particularly microscopy, facilitates complex chemical derivatization of SWCNTs with reliable structural characterization. The endohedral modification of SWCNTs, inclusion of quantum defects, and synthesis of mechanically interlocked derivatives are illustrative examples. We also overview how enantiomeric resolution of SWCNTs enables new fields of research such as chiral sensing, catalysis, and spin filtering. Complexity, once seen as an enemy, now shows promise in several fields, as exemplified by physically unclonable functions and neuromorphic computing. These three axes, controlled chemical modification, chiral discrimination, and system-level complexity, are increasingly interwoven, defining an emerging research landscape for SWCNTs. Taken together, they offer a framework for reimagining the roles of SWCNTs in both fundamental science and technology. We hope this review inspires innovative research lines and encourages young scientists to focus on SWCNTs.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 40","pages":"19085–19107"},"PeriodicalIF":5.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}