ACS Applied Nano Materials最新文献

{"title":"Superhydrophobic Polydimethylsiloxane/CNT/Spandex Composites as Flexible Multifunctional Strain Sensors","authors":"Xuemei Zhang,&nbsp;Hongwei Li,&nbsp;Zhao Yang,&nbsp;Guang Wang,&nbsp;Guixian Li*,&nbsp;Yunyan Gao,&nbsp;Fengxing Niu and Jie Liu,&nbsp;","doi":"10.1021/acsanm.4c0528710.1021/acsanm.4c05287","DOIUrl":"https://doi.org/10.1021/acsanm.4c05287https://doi.org/10.1021/acsanm.4c05287","url":null,"abstract":"<p >Recently, the field of intelligent wearable electronics regarding conductive elastomer composites has garnered considerable research interest. However, achieving a wide strain response range, high sensitivity, and superhydrophobicity simultaneously remains a challenge. Herein, 250-denier Spandex fibers were used as a flexible matrix, whereas low-cost carbon nanotubes (CNTs) served as a conductive filler. The CNTs were uniformly, rapidly, and spontaneously anchored the surface of the Spandex fibers through a method combining ultrasound and swelling. Subsequently, polydimethylsiloxane (PDMS) was employed for modification, resulting in a PDMS/CNT/Spandex composite material with a uniformly hierarchical micro–nanostructure. The composite material exhibited high sensitivity (with a maximum gauge factor of 417.92 within a strain range of 495%–525%), fast response/recovery times (100 ms/300 ms), and exceptional reliability over an ultra–wide strain range spanning from 0.1% to 525% and maintains good repeatability and stable response even after undergoing 2000 stretch–release cycles. Moreover, it possesses outstanding water-repellent and corrosion–resistant properties, enabling effective performance under harsh environmental conditions. This material is compact and portable, allowing for its seamless integration into textiles without compromising comfort. It can help detect several human activities, including subtle actions (e.g., vocal cord vibrations) and large-scale movements (e.g., joint bending), wirelessly transmit real-time signals of finger movements to mobile phones through Bluetooth technology, and enable real-time monitoring of airflow rate (ranging from 8 to 36 m³/h) by facilitating the construction of a simple gas flow testing system. Furthermore, weaving composite materials into tactile electronic networks could influence the mapping of 2D resistance changes to determine the weight and shape of objects. Therefore, this study provides a simple and versatile method to prepare high-performance strain sensors with considerable application potential in human movement monitoring, electronic skin, and human–computer interaction.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 3","pages":"1352–1365 1352–1365"},"PeriodicalIF":5.3,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143088181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing Oxygen Vacancies by Incorporating Co into Nano ZnO for Selective Hydrogenation of CO2 into Methanol","authors":"Juanjuan Yang*,&nbsp; and ,&nbsp;Dandan Shao*,&nbsp;","doi":"10.1021/acsanm.4c0724310.1021/acsanm.4c07243","DOIUrl":"https://doi.org/10.1021/acsanm.4c07243https://doi.org/10.1021/acsanm.4c07243","url":null,"abstract":"<p >CO₂ to methanol is considered a promising method for CO₂ conversion and utilization, yet achieving desirable selectivity remains a significant challenge. Herein, efficient CO₂ hydrogenation to methanol is achieved by synthesizing Co_0.7ZnO with abundant oxygen vacancies (O_v) through the incorporation of a portion of Co into nanoscale ZnO. By tuning the molar ratio of Co/(Co+Zn) in Co_<i>x</i>ZnO to increase the O_v content to 71%, CO₂ adsorption and activation to form formate (COOH*) are enhanced, thereby reducing the CO selectivity. The efficiency of the hydrogenation of CO₂ to methanol was optimized with Co_0.7ZnO, which exhibited an impressive methanol formation rate of 2.1 mmol/(g h) and a selectivity of up to 96.7%. The unique structure of incorporating partial Co into nanoscale ZnO to increase the level of O_v not only reduces the level of CO selectivity but also inhibits methane formation, thereby contributing to the high methanol selectivity. This study presents an innovative strategic design through partial doping, which is essential for controlling the selectivity of target products in the CO₂ hydrogenation.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 3","pages":"1673–1679 1673–1679"},"PeriodicalIF":5.3,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143087825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Enhancement of PEDOT on Nanocrystal-in-Glass Ti-Doped WO3 Thin Films for Applications in Electrochromic Smart Windows","authors":"Haopeng Jing,&nbsp;Kun Li,&nbsp;Shuling Xiang,&nbsp;Ran Jiang,&nbsp;Jumei Zhou and Hongliang Zhang*,&nbsp;","doi":"10.1021/acsanm.4c0647110.1021/acsanm.4c06471","DOIUrl":"https://doi.org/10.1021/acsanm.4c06471https://doi.org/10.1021/acsanm.4c06471","url":null,"abstract":"<p >WO₃ with nanocrystal-in-glass (nanocrystal-embedded amorphous matrix) characteristics is recognized as a highly promising electrochromic material. The demand for flexible and large-area electrochromic technologies is pushing the advancement of low-temperature and large-scale processes for WO₃ thin films. This study presents a functional ink designed for the low-temperature preparation of WO₃ thin films using blade-coating technology, enabling scalable and cost-effective production. The optimized WO₃:Ti-PEDOT hybrid electrochromic thin film demonstrates a high light modulation rate of 86.05% (@ 633 nm), a coloration efficiency of 54.1 cm² C^–1, an outstanding cycle stability exceeding 1000 cycles, and an ionic diffusion coefficient of 3.69 × 10^–8 cm² s^–1. One reason for the remarkably improved electrochromic performance is the synergistic effect of the nanostructured WO₃ glass-nanocrystal composites induced by Ti doping and the enhanced electrochemical reaction kinetics facilitated by the use of poly(3,4-ethylenedioxythiophene) (PEDOT), a conductive polymer, as a binder. This work demonstrates a feasible and cost-effective method for producing WO₃-based films for electrochromic smart windows, serving as an alternative to the existing vacuum-based WO₃ thin film production methods.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 3","pages":"1577–1585 1577–1585"},"PeriodicalIF":5.3,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143087964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metallic TiN Nanoparticle Cocatalyst with Hydrogen-Induced Nitrogen Vacancies for Plasmon-Enhanced Full Solar-Spectrum-Driven H2 Production","authors":"Yadong Wu,&nbsp;Lijuan Sun,&nbsp;Shahid Khan,&nbsp;Haopeng Jiang,&nbsp;Muhammad Adnan Qaiser,&nbsp;Han Li,&nbsp;Weikang Wang*,&nbsp;Lele Wang and Qinqin Liu*,&nbsp;","doi":"10.1021/acsanm.4c0592210.1021/acsanm.4c05922","DOIUrl":"https://doi.org/10.1021/acsanm.4c05922https://doi.org/10.1021/acsanm.4c05922","url":null,"abstract":"<p >Solar-driven hydrogen (H₂) production from water-splitting reactions has aroused intensive attention but is still challenging. Here, we report a hydrogen (H₂)-induced nitrogen-defective metallic titanium nitride (TiN) cocatalyst-decorated zinc indium sulfide (ZnIn₂S₄) nanoflower sphere for enhanced full solar-spectrum-driven H₂ production. The defective TiN cocatalysts with localized surface plasmon resonance (LSPR) effect obtained by thermal treatment in the H₂ atmosphere indicate reduced electrochemical resistance, rich surface active sites, and metallic features, and they were then decorated onto the ZnIn₂S₄ nanoflower through a one-pot solvothermal process. The resultant hydrogenated TiN nanoparticle-decorated ZnIn₂S₄ (TiN/ZnIn₂S₄, TZ) composite reveals an extended light absorption range, resisted photocorrosion, and accelerated charge separation, demonstrating a highest H₂ yield rate of 2.4 mmol·g^–1·h^–1 irradiated by visible light (λ ≥ 420 nm). Meaningfully, the optimal TZ-150 composite could even produce H₂, excited by NIR light (1050 nm), realizing a full solar-spectrum-induced H₂ production. This work would offer an interesting avenue to employ plasmon transition metal nitrides in full solar-spectrum photocatalytic reactions.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 3","pages":"1445–1453 1445–1453"},"PeriodicalIF":5.3,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143088137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Operation Speed and Thermal Stability of a 150 nm-Thick SbTe Film by Y Doping for Optoelectronic Hybrid Phase-Change Memory","authors":"Lihao Sun,&nbsp;Tao Wei*,&nbsp;Chuantao Xuan,&nbsp;Qianchen Liu,&nbsp;Jing Hu,&nbsp;Qianqian Liu,&nbsp;Miao Cheng,&nbsp;Ruirui Wang,&nbsp;Wanfei Li and Bo Liu*,&nbsp;","doi":"10.1021/acsanm.4c0561010.1021/acsanm.4c05610","DOIUrl":"https://doi.org/10.1021/acsanm.4c05610https://doi.org/10.1021/acsanm.4c05610","url":null,"abstract":"<p >Optoelectronic hybrid phase-change memory, as a kind of nonvolatile storage with ultrafast speed, has the potential to facilitate the integration of storage and computing and is regarded as a promising candidate for overcoming the “memory bottleneck”. However, the contradiction between thermal stability and operation speed in phase-change memory presents a challenge for the demands of in-memory computing. In this work, optoelectronic hybrid phase-change memory based on the Y-doped SbTe film is proposed to achieve ultrafast operation speed and high thermal stability. Results indicate that when the Y doping content is 27.4 at. %, the film exhibits good thermal stability with the crystallization temperature of 197 °C and a 10-year data retention of 121 °C. A low volume-change rate (0.5%) and resistance drift coefficient (0.006 at 85 °C for the film) are also obtained. Moreover, the operation speed reaches 26 ps for SET and 13 ps for RESET. Microstructural analysis reveals that the improved thermal stability is mainly due to the formation of Y–Te and Y–Sb bonds, enhancing the interaction between Y and Te atoms and the inhibition of grain growth. The ultrafast operation speed is primarily attributable to the structural similarity between amorphous and crystalline phases and the existence of the Sb–Sb vibrational mode. Consequently, the Y-doped SbTe film is promising for optoelectronic hybrid phase-change memory and has potential application in storage-computing integration.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 3","pages":"1377–1385 1377–1385"},"PeriodicalIF":5.3,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143088043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covalent Organic Frameworks with Fe/Co Single-Atom Nanozyme for Alendronate Sodium Detection","authors":"Jingcheng Cao,&nbsp;Jie Lv,&nbsp;Yingchao Yin,&nbsp;Qingqing Bai,&nbsp;Meng Li* and Zhiyong Hou*,&nbsp;","doi":"10.1021/acsanm.4c0611610.1021/acsanm.4c06116","DOIUrl":"https://doi.org/10.1021/acsanm.4c06116https://doi.org/10.1021/acsanm.4c06116","url":null,"abstract":"<p >Constructing nanozyme-based single atoms with exposed metal-Nx catalytic sites for alendronate sodium (ALDS) tablet quality control is a complex and uncommon task. Herein, we presented an innovative colorimetric assay to detect ALDS utilizing carbon-supported Fe/Co dual-atom nanozymes (Fe/Co_SA-NCs) derived from a precursor of porphyrin covalent organic frameworks (COFs). The Fe/Co_SA-NC nanozymes, featuring an Fe–N₅ active site and electronic interactions between Fe and Co, exhibited enhanced peroxidase-like activity. Experimental findings and theoretical calculations elucidated that the superior activity of Fe/Co_SA-NCs stemmed from the synergistic effect of the dual atoms, which boosted substrate adsorption and reduced the reaction barrier. When integrated with ALDS and Fe/Co_SA-NCs, the peroxidase-like activity of Fe/Co_SA-NCs could be inhibited due to ALDS-Fe³⁺ coordination. Leveraging this mechanism, a rapid and selective colorimetric method was developed for detecting ALDS. The Fe/Co_SA-NC sensor showed a detection limit of 0.96 μM for ALDS in phosphate buffer, surpassing traditional techniques in terms of efficiency, accuracy, and simplicity. Moreover, the system was successfully utilized to control the pharmaceutical quality of ALDS and to determine ALDS in urine samples. This work opens a powerful avenue for developing efficient dual-atom nanozymes from COFs and expands the potential applications of nanozyme clinical pharmacy.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 3","pages":"1490–1498 1490–1498"},"PeriodicalIF":5.3,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143087641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of Cu2NiSnS4 Nanoparticles on CdS with a Computationally Predicted Low Lattice Mismatch for Photoelectrochemical Hydrogen Evolution","authors":"Dhanaraj S. Nilegave,&nbsp;Arijeet Sarangi,&nbsp;Sachin R. Rondiya,&nbsp;Gulistan Y. Shaikh,&nbsp;Mamta P. Nasane,&nbsp;Sagar B. Jathar,&nbsp;Sunil V. Barma,&nbsp;Kiran B. Kore,&nbsp;S. V. Ghaisas,&nbsp;Sudip Chakraborty* and Adinath M. Funde*,&nbsp;","doi":"10.1021/acsanm.4c0665410.1021/acsanm.4c06654","DOIUrl":"https://doi.org/10.1021/acsanm.4c06654https://doi.org/10.1021/acsanm.4c06654","url":null,"abstract":"<p >The quaternary chalcogenide Cu₂NiSnS₄ (CNTS) nanoparticles, made up of earth-abundant elements, are one of the most favorable in the family of CM_<i>x</i>TS (M_<i>x</i> = Ni, Co, Cd, Fe, Mg, Mn, and Zn) for photoelectrochemical (PEC) hydrogen production due to the lowest resistivity, high absorption coefficient, and tunable band gap for sunlight absorption with suitable band edges. A p-type semiconductor, CNTS, is one of the stable photocathodes in the category of efficient ones. In this theoretical-aided experimental work, we illustrate the photoelectrochemical credibility of CNTS nanomaterials synthesized by a facile hot-injection method with CdS as a photoanode for hydrogen evolution with the interface of an alkaline electrolyte. Using density functional theory simulations, charge density difference, work function, and structural properties were evaluated, suggesting better lattice matching at the CNTS/CdS supercell interface with a lattice mismatch less than 3% along with better charge transfer. An optical band gap of 1.40 eV and a crystallite size of 48 nm were observed for CNTS evaluated. A high short-circuit current density of 6.656 mA cm^–2 IPCE for the CNTS/CdS heterojunction was observed to be 14.87% at 505 nm. This promotes the heterojunction to possess minimal chances of material’s phase change and hence stability.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 3","pages":"1628–1639 1628–1639"},"PeriodicalIF":5.3,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143087735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heat Treatment of Fe-doped Zr-MOF Catalysts for Dual Lewis Acid Sites Promoted CO2 Cycloaddition","authors":"Sheng-Nan Zhang,&nbsp;Yi-Ming Lin,&nbsp;Qing-Jing Wang,&nbsp;Jia Yang*,&nbsp;Zhengkun Yang,&nbsp;Xifan Chen,&nbsp;Junzhong Wang* and Juan-Ding Xiao*,&nbsp;","doi":"10.1021/acsanm.4c0651810.1021/acsanm.4c06518","DOIUrl":"https://doi.org/10.1021/acsanm.4c06518https://doi.org/10.1021/acsanm.4c06518","url":null,"abstract":"<p >The activation and transformation of CO₂ into high value-added chemicals are very promising for meeting the carbon neutrality. Lewis acids are attractive in CO₂ catalytic activation due to the fact that the O atom of CO₂ can be attacked by the electrophilic centers. Here, a series of single-atom Fe-doped Zr-MOF nanocatalysts, denoted as Fe-ZrMOF-T, are prepared. The coordination environment for Fe single atoms can be modulated by heat treatment, which shows influence on the expression of Lewis acidity and affects the catalytic ability toward the CO₂ cycloaddition. It was found that Fe-ZrMOF-5 obtained by heat treatment at 500 °C possesses the highest activity. Results show the synergistic effect between the dual Lewis acid sites of Fe³⁺ and Zr⁴⁺ on this Lewis acid catalysis, in which Fe³⁺ is prone to activate epoxides while Zr⁴⁺ prefers to react with CO₂. The corresponding reaction mechanism was proposed based on these findings.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 3","pages":"1596–1604 1596–1604"},"PeriodicalIF":5.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143087877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vertical β-MnO2@δ-MnO2 Core–Shell Heterostructures with Superior Cycling Stability for All-in-One Flexible Supercapacitors","authors":"Can Tang,&nbsp;Yi Zhang,&nbsp;Shun Lu*,&nbsp;Yi Zeng,&nbsp;Qingsong Hua* and Yongxing Zhang*,&nbsp;","doi":"10.1021/acsanm.4c0637310.1021/acsanm.4c06373","DOIUrl":"https://doi.org/10.1021/acsanm.4c06373https://doi.org/10.1021/acsanm.4c06373","url":null,"abstract":"<p >β-MnO₂, as the most stable phase of polycrystalline MnO₂, has a narrow tunnel structure that limits ion diffusion and electron transfer, restricting its application in supercapacitors. In this work, we present a novel all-in-one MnO₂-based material, β-MnO₂@δ-MnO₂, featuring a unique three-dimensional architecture with ultrathin δ-MnO₂ nanostructures vertically grown on the β-MnO₂ network. This innovative design leverages the structural support of β-MnO₂ to enhance the electrode material’s specific surface area and effectively mitigate volume changes during ion adsorption/desorption, a key factor for improving cycling stability. As a result, the β-MnO₂@δ-MnO₂ composite demonstrates exceptional electrochemical performance, with a remarkable cycling stability of 98% capacitance retention after 10,000 cycles. Additionally, it maintains 74.2% of its capacitance when the current density increases from 1.0 to 20 A g^–1, showcasing an outstanding rate capability. When assembled into an asymmetric supercapacitor device, the β-MnO₂@δ-MnO₂ electrodes deliver a high surface capacitance of 287.3 mF cm^–2 and a significant area energy density of 159.3 μWh cm^–2. This work represents a significant advancement in the optimization of β-MnO₂ for supercapacitor applications, demonstrating the practical benefits of rational nanostructure design. The β-MnO₂@δ-MnO₂ composite not only enhances performance in energy storage devices but also holds potential for other applications, offering new opportunities for the development of flexible, high-performance energy storage systems.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 3","pages":"1568–1576 1568–1576"},"PeriodicalIF":5.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143087865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoporous Graphene Integrated onto Bimodal Waveguide Biosensors for Detection of C-Reactive Protein.","authors":"Bárbara Lisboa, Maria Soler, Rukmani Singh, Jesús Castro-Esteban, Diego Peña, Aitor Mugarza, Laura M Lechuga, César Moreno","doi":"10.1021/acsanm.4c06716","DOIUrl":"https://doi.org/10.1021/acsanm.4c06716","url":null,"abstract":"<p><p>Despite the outstanding progress in photonic sensor devices, a major limitation for its application as label-free biosensors for biomedical analysis lies in the surface biofunctionalization step, that is, the reliable immobilization of the biorecognition element onto the sensor surface. Here, we report the integration of bottom-up synthesized nanoporous graphene onto bimodal waveguide interferometric biosensors as an atomically precise biofunctionalization scaffold. This combination leverages the high sensitivity of bimodal waveguide interferometers and the large functional surface area of nanoporous graphene to create highly sensitive, selective, and robust biosensors for the direct immunoassay detection of C-reactive protein (CRP), an inflammatory biomarker widely used in the clinical diagnosis of infections and sepsis. The limit of detection was determined at 3 ng/mL, which is well below the clinical cutoff levels required for the diagnostic detection of CRP in patient samples. This innovative approach holds promise for transforming diagnostics, environmental monitoring, and various fields requiring precise biomolecular detection.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 3","pages":"1640-1648"},"PeriodicalIF":5.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}