ACS Applied Nano Materials最新文献

{"title":"Review of TiO2-Based Nanocatalysts for Photocatalytic Nitrogen Reduction to Ammonia","authors":"Xiaolin Zheng,&nbsp;Yanchao Wang,&nbsp;Xunshang Shi,&nbsp;Qinghong Liu,&nbsp;Shuai Wu,&nbsp;Yan Ding,&nbsp;Zhiying Feng,&nbsp;Chenxi Zhang and Libin Yang*,&nbsp;","doi":"10.1021/acsanm.5c0239810.1021/acsanm.5c02398","DOIUrl":"https://doi.org/10.1021/acsanm.5c02398https://doi.org/10.1021/acsanm.5c02398","url":null,"abstract":"<p >The traditional ammonia synthesis process of the Haber–Bosch method must be carried out at high temperatures and high pressure with energy-intensive consumption and carbon emission. As a green and low-energy alternative technology, photocatalytic ammonia synthesis technology has received increasing attention. Recent advances in the fabrication of TiO₂-based nanocatalysts for the photocatalytic N₂ reduction reaction (NRR) under mild conditions are reviewed and summarized. In this paper, we compare and analyze various methods for detecting low ammonia concentrations with advanced detection techniques in the field. In order to enhance the activity of TiO₂-based nanocatalysts for photocatalytic NRR, various methods are summarized such as molecular structure engineering, interfacial modulation engineering, crystallographic engineering, surface modulation engineering, and morphology engineering. Besides, the mechanism of the photocatalytic ammonia synthesis was analytically proven. A comparison for the advantages of the TiO₂-based nanocatalyst synthesis process is presented and discussed, as well as its future potential applications in NRR.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"10819–10833 10819–10833"},"PeriodicalIF":5.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible Self-Powered Ti3C2Tx MXene Nanosheet/CdS Nanobelt Photodetector with Enhanced Responsivity and Photosensitivity","authors":"Muhammad Zubair Nawaz*,&nbsp;Asad Khaleeq,&nbsp;Waqar ul Hasan,&nbsp;Waqas Ahmad,&nbsp;Rana Zafar Abbas Manj,&nbsp;Muhammad Shahrukh Saleem,&nbsp;Inaam Ullah,&nbsp;Ayesha Irfan,&nbsp;Israr Masood ul Hasan,&nbsp;Muhammad Yaqub,&nbsp;HM Noor ul Huda Khan Asghar,&nbsp;Gul Naz,&nbsp;Mai Li,&nbsp;Chunrui Wang and Yury Yuryevich Illarionov*,&nbsp;","doi":"10.1021/acsanm.5c0137310.1021/acsanm.5c01373","DOIUrl":"https://doi.org/10.1021/acsanm.5c01373https://doi.org/10.1021/acsanm.5c01373","url":null,"abstract":"<p >Can the semimetallic 2D Ti₃C₂T_<i>x</i> MXene function as an active photosensitive material rather than merely an electrode? Can a flexible, self-powered photodetector based entirely on 2D and 1D photoactive materials overcome the persistent challenge of high dark current that often limits low-light detection? Addressing these questions, we report a flexible self-driven photodetector constructed from a 2D Ti₃C₂T_<i>x</i> MXene and a 1D CdS nanobelt heterojunction, where both constituents actively contribute to low-light detection. Unlike conventional approaches where MXene serves as a passive electrode, Ti₃C₂T_<i>x</i> here plays an active role in photogeneration and charge separation. The 2D-1D architecture facilitates the formation of a strong built-in electric field across the interface, promoting efficient photocarrier extraction while significantly suppressing dark current. The device achieves an exceptional light-to-dark current ratio exceeding ≈10⁵, a high responsivity of ≈34.42 A/W, and detectivity up to ≈5.68 × 10¹⁴ Jones, along with a rapid response time of ≈7.2/120 μs under zero bias. These results highlight the potential of MXene-based heterostructures in advancing high-performance, low-light, self-powered optoelectronic platforms.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"11015–11025 11015–11025"},"PeriodicalIF":5.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photothermal Properties of Size-Tunable Gold Nanotriangles with Matching near Infrared Plasmon Resonance Wavelengths","authors":"Camila M. Otero,&nbsp;Guillermina Boggan Simal,&nbsp;Christoph M. Maier,&nbsp;Gabriel Lavorato,&nbsp;Julián Gargiulo,&nbsp;Carolina Vericat* and M. Ana Huergo*,&nbsp;","doi":"10.1021/acsanm.5c0213210.1021/acsanm.5c02132","DOIUrl":"https://doi.org/10.1021/acsanm.5c02132https://doi.org/10.1021/acsanm.5c02132","url":null,"abstract":"<p >Metallic nanoparticles are among the preferred materials for nanoscale conversion of light into heat because of their localized plasmon resonances, which provide exceptionally high absorption cross sections. These materials are widely used in various fields such as biomedical applications, water desalinization, or solar energy harvesting. However, the absorption of light by plasmonic nanoparticles and their associated heat generation depends on multiple parameters such as composition, shape, size, wavelength, and concentration. This complexity makes their controlled design and optimization challenging and constitutes one of the bottlenecks in the field. Among the many available plasmonic nanoparticles, Au nanotriangles are particularly appealing due to their high photothermal stability and tunable resonances in the biological window. In this work, we study the influence of the dimensions on the light-to-heat conversion efficiency of Au nanotriangles. Isolating the role of geometry and size in the photothermal efficiency is challenging, as plasmon resonances are strongly size dependent. Here, we carefully synthesized two sets of Au nanotriangles with similar resonances but different dimensions. By evaluating and comparing multiple theoretical and experimental photothermal metrics, we provide insights on how nanoparticle size influences their efficiency at varying concentrations. It was found that smaller nanotriangles generate more heat per unit of Au mass if used at low concentrations, but these differences disappear at larger concentrations. On the other hand, larger nanotriangles generate more heat per nanoparticle, at all concentrations. These findings offer guidelines for designing and optimizing plasmonic nanoheaters according to their desired application.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"11209–11218 11209–11218"},"PeriodicalIF":5.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced SERS Detection Using TiO2 Photonic Crystals with In-Situ-Grown Au/Ag Nanoparticles","authors":"Zeyu Wang,&nbsp;Jake Wu,&nbsp;Xiangming Li,&nbsp;Xiaoliang Chen,&nbsp;Chunjie He,&nbsp;Jinyou Shao* and Rong-Fuh Louh*,&nbsp;","doi":"10.1021/acsanm.5c0022110.1021/acsanm.5c00221","DOIUrl":"https://doi.org/10.1021/acsanm.5c00221https://doi.org/10.1021/acsanm.5c00221","url":null,"abstract":"<p >Surface-enhanced Raman spectroscopy (SERS) has been widely utilized for the detection of disease biomarkers, pesticides, and environmental pollutants due to its exceptional sensitivity, real-time responsiveness, and unique interactions between adsorbates and substrates. Here, we present a composite metal/semiconductor material comprising TiO₂ nanosphere substrates integrated with in-situ-grown Au or Ag nanoparticles (NMNPs@TiO₂). These composite nanospheres are assembled by an electrophoretic self-assembly process to form a photonic crystal structure with three-dimensionally ordered periodic geometric features and show remarkable sensitivity and stability for SERS detection, achieving a detection limit as low as 10^–9 M for Rhodamine 6G. Beyond merely enhancing SERS signals by generating uniformly distributed metal plasmonic “hot spots” on TiO₂ substrates, similar to traditional semiconductor substrates, this photonic crystal substrate also exhibits advanced light absorption and localization capabilities. The absorbed light drives the defect excitation of TiO₂, facilitated by its multicrystalline structure. Excited electrons from the TiO₂ nanospheres contribute to the enhancement of localized surface plasmon resonance through charge transfer to noble-metal nanoparticles. Additionally, the synthesis of NMNPs@TiO₂ nanospheres avoids the use of toxic reagents, and substrate assembly is achieved through a simple electrodeposition process. This approach simplifies fabrication while enabling the production of SERS detectors with exceptional spatial and temporal signal stability. With increasing demands for higher detection sensitivity, signal uniformity, and detector durability for SERS detection applications, the NMNPs@TiO₂ nanosphere-based photonic crystal substrate underscores its potential to significantly improve the SERS detection efficiency, making it ideal for ultrasensitive chemical detection applications.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"10864–10873 10864–10873"},"PeriodicalIF":5.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pd Nanoclusters on TiO2 for Photocatalytic Conversion of Phenylacetylene to Styrene","authors":"Weijie Jia,&nbsp;Haifeng Wang,&nbsp;Chen Xue,&nbsp;Yaying Li and Qi Xiao*,&nbsp;","doi":"10.1021/acsanm.5c0172310.1021/acsanm.5c01723","DOIUrl":"https://doi.org/10.1021/acsanm.5c01723https://doi.org/10.1021/acsanm.5c01723","url":null,"abstract":"<p >Selective hydrogenation of phenylacetylene is a crucial industrial reaction, yet developing catalysts with both high selectivity and activity remains challenging. Conventional hydrogenation catalysts often exhibit unevenly dispersed active metals, leading to agglomeration and reduced catalytic performance. Herein, with the aid of the ice-templating (ICT) strategy, we present TiO₂-supported Pd nanocluster photocatalysts with ultralow Pd loading (0.1 wt %). The optimized Pd/TiO₂–ICT catalyst achieves exceptional catalytic performance under ambient conditions (room temperature and atmospheric pressure) with methanol solvent and light irradiation, delivering 99% phenylacetylene conversion alongside 98% styrene selectivity. Advanced characterization reveals the catalyst’s superior structural features, including ultrasmall Pd clusters (1.2 nm diameter) and reduced Pd–Pd coordination number (6.3), which are significantly better than conventional counterparts. Systematic investigations establish a clear positive correlation between catalytic efficiency and critical structural parameters: smaller cluster dimensions and lower metal coordination numbers at equivalent Pd loadings. Mechanistic studies through comprehensive characterization elucidate that the photogenerated hydrogen radicals (•H) from methanol splitting directly drive the selective hydrogenation process. This study offers insights into both the application and structure–activity relationship of the ICT-based catalysts.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"11095–11103 11095–11103"},"PeriodicalIF":5.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Performance ZnCo2O4/MnMoO4 Nanosheet Array Electrodes for Asymmetric Supercapacitors","authors":"Thirumoorthi Jothilakshmi,&nbsp;Nagarajan Sivakumar*,&nbsp;Balasankar Athinarayanan,&nbsp;Subramanian Tamil Selvan,&nbsp;Tae Hwan Oh and Subramaniyan Ramasundaram*,&nbsp;","doi":"10.1021/acsanm.5c0197710.1021/acsanm.5c01977","DOIUrl":"https://doi.org/10.1021/acsanm.5c01977https://doi.org/10.1021/acsanm.5c01977","url":null,"abstract":"<p >Metal molybdate compounds are highly promising supercapacitor electrode materials due to their excellent specific capacitance and mechanical stability. In this study, a ZnCo₂O₄/MnMoO₄ composite electrode featuring a porous, interconnected nanosheet array structure was synthesized using a two-step hydrothermal method. The nanocomposite showed a remarkable specific capacitance of 1988 F g^–1 at 1 A g^–1 and retained 95% capacitance after 5000 cycles. The highly permeable nanosheet structure, combined with the synergistic interaction between ZnCo₂O₄ and MnMoO₄, contributed to its high specific capacitance. An asymmetric supercapacitor (ASC) comprising the ZnCo₂O₄/MnMoO₄ electrode and activated carbon operating at a maximum voltage of 1.7 V delivered a notable energy density of 51 Wh kg^–1 at a power density of 842 W kg^–1. After 5000 cycles, the ASC retained 99% of its capacitance. The interconnected porous nanosheets enhanced the number of electroactive sites and facilitated the efficient electron flow. Two ASC devices connected in series continuously powered a light-emitting diode (LED) for over 15 min, demonstrating the practical applicability of the ZnCo₂O₄/MnMoO₄ electrode in high-performance supercapacitor applications requiring long lifespans.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"11173–11184 11173–11184"},"PeriodicalIF":5.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aluminum-Catalyzed Lateral Growth of Spherulite-like GeS Thin Films on Insulating Substrates Using Vapor Transport: Implications for Electro-optic Applications","authors":"Qinqiang Zhang*,&nbsp;Ryo Matsumura and Naoki Fukata*,&nbsp;","doi":"10.1021/acsanm.5c0155210.1021/acsanm.5c01552","DOIUrl":"https://doi.org/10.1021/acsanm.5c01552https://doi.org/10.1021/acsanm.5c01552","url":null,"abstract":"<p >Due to the presence of lone-pair electrons, it is challenging to attain lateral growth of thin films of Group IV monochalcogenides. In this study, lateral growth of germanium monosulfide (GeS) thin films with a minimum thickness of approximately 20 nm was attained on SiO₂/Si and quartz substrates at a growth temperature of 420 °C, employing a combined method that uses an aluminum (Al) catalyst and a predeposited amorphous GeS layer. Time-dependent changes in grown GeS thin films using a 5 nm-thick Al layer on SiO₂/Si and quartz substrates were shown to exhibit a lateral growth rate of 2–3 μm/s. The birefringent properties of grown GeS with a Maltese extinction cross pattern were confirmed by using cross-polarized optical microscopy, indicating the formation of a spherulite-like structure. It appears that Mullins–Sekerka instability dominates the growth front at the periphery of circular domains, causing a dendrite morphology. A transition region dominated by kinetic-limited diffusion occurs, forming the spherulite-like structure of GeS. X-ray diffraction and atomic force probe investigations reveal the grown spherulite-like GeS, on insulating substrates, to consist of a layered structure with a flat surface. The single-crystalline area of GeS appears to be larger than 200 nm in size, as evaluated by selected area electron diffraction via transmission electron microscopy. This study reveals a potential method of achieving the lateral growth of GeS on insulating substrates. This method may facilitate the use of GeS as functional semiconductors for developing next-generation electro-optic applications, such as in-memory sensing and computing devices, with potential for programming via electric and optical control.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"11046–11055 11046–11055"},"PeriodicalIF":5.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface-Controlled Modulation of Copper Nanocluster–DNA Interaction and Its Implication for Targeted Biological Applications","authors":"Joyoti Ghosh,&nbsp;Chinmayee Patra,&nbsp;Debabrata Chakraborty,&nbsp;Debraj Koiri,&nbsp;Sumit Kumar Pradhan and Moloy Sarkar*,&nbsp;","doi":"10.1021/acsanm.5c0187410.1021/acsanm.5c01874","DOIUrl":"https://doi.org/10.1021/acsanm.5c01874https://doi.org/10.1021/acsanm.5c01874","url":null,"abstract":"<p >The present study aims to investigate the role of surface ligands in governing the binding interaction between copper nanoclusters (CuNCs) and deoxyribonucleic acid (DNA) in order to assess their potential for biotherapeutic applications. For this purpose, CuNCs having three chemically different surface ligands, namely, tannic acid (TA), chitosan (Cht), and cysteine (Cys), are synthesized and characterized using various analytical methods. The binding interaction studies were performed at both ensemble average and single-molecule levels by exploiting several spectroscopic and microscopic techniques. Initial investigations have revealed that cysteine-capped copper nanoclusters (Cys-CuNCs) follow a one-step binding mechanism, whereas tannic acid-capped copper nanoclusters (TA-CuNCs) and chitosan-capped copper nanoclusters (Cht-CuNCs) exhibit a two-step binding process while interacting with DNA. Additionally, circular dichroism measurements have provided valuable information about the structural integrity of DNA when exposed to different CuNCs. Furthermore, fluorescence correlation spectroscopic measurement has depicted that the binding interaction events between CuNCs and DNA are different for the three different CuNCs, even at the single-molecule level. Notably, the outcome of the present investigations has suggested that the accumulation of DNA bases in the presence of Cht-CuNCs, along with their weak intermolecular interactions with DNA, can make Cht-CuNCs highly suitable for gene therapy. Conversely, TA-CuNCs and Cys-CuNCs may hold significant potential for bioimaging and biosensing applications due to their ability to maintain DNA’s structural integrity and their good biocompatibility. Overall, this study has effectively highlighted the crucial role of surface ligands in nanoscale materials for modulating DNA interactions and emphasized their potential in targeted biological applications.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"11150–11165 11150–11165"},"PeriodicalIF":5.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of Interstitial Buffering Space in Yolk–Shell Tin–Carbon Nanocomposites Used as Electrodes for Lithium-Ion Batteries","authors":"Haozhi Zhao,&nbsp;Congwei Wang*,&nbsp;Quanlong Wang,&nbsp;Chuanyi Chen,&nbsp;Longyu Wang,&nbsp;Rongyu Li,&nbsp;Yongyong Yu,&nbsp;Yuede Pan,&nbsp;Gang Li* and Kaiying Wang,&nbsp;","doi":"10.1021/acsanm.5c0097510.1021/acsanm.5c00975","DOIUrl":"https://doi.org/10.1021/acsanm.5c00975https://doi.org/10.1021/acsanm.5c00975","url":null,"abstract":"<p >Tin-based anodic materials, benefiting from their large theoretical specific capacity and minimal operating potential, are considered high-development potential alternative anodes for lithium-ion batteries (LIBs). Nevertheless, the alloying-dealloying processes between tin (Sn) and lithium ions result in severe volume expansion, which leads to a poorly stabilized solid-electrolyte interface (SEI) layer and resultant inferior cycling performance, posing major obstacles to their commercialization. Herein, a structural regulation strategy was proposed to optimize the interstitial void buffer layer within yolk–shell structures to mitigate the lithiation-associated volume expansion. The tetraethyl orthosilicate-hydrolyzed SiO₂ layer was located between Sn and the resin-derived carbon coating, whose thickness could be sophisticatedly optimized via regulating the hydrolysis durations. Following the carbonization and etching, an optimized buffer layer was encapsulated within a protective carbon shell (Sn@Void@C), which could effectively accommodate Sn’s volume expansion during the alloying period, significantly enhancing its performance in electrochemical processes and structural stability. Specifically, the Sn@Void@C anode retained a high specific capacity of 720 mAh g^–1 after 400 cycles at 0.2 C and demonstrated an outstanding capacity of 520 mAh g^–1 after 500 cycles at 0.5 C. This work provides a facile and effective strategy for rationally designing tin-based anodes for lithium-ion batteries.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"10932–10943 10932–10943"},"PeriodicalIF":5.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-ROS Nanoenzyme-Based Nerve Regeneration","authors":"Tianqi Su,&nbsp;Guoliang Shi,&nbsp;Nantian Chen,&nbsp;Jinpeng Wang,&nbsp;Yuhui Cui,&nbsp;Xingyu Zhou,&nbsp;Haofeng Cheng,&nbsp;Jun Bai,&nbsp;HengChao Ma,&nbsp;Jiang Peng*,&nbsp;Wenjing Xu* and Jun Zhang*,&nbsp;","doi":"10.1021/acsanm.5c0094010.1021/acsanm.5c00940","DOIUrl":"https://doi.org/10.1021/acsanm.5c00940https://doi.org/10.1021/acsanm.5c00940","url":null,"abstract":"<p >Peripheral nerve injury severely impairs motor and sensory function, and treatment options other than autologous nerve grafting are limited. Adipose-derived stem cells (ADSCs) have been widely used in the clinic and show promise for nerve regeneration; however, their therapeutic effects have not been optimized. This study describes a method of combining ADSCs with nanoscale Prussian blue nanoparticles (PBNPs) to overcome oxidative stress and enhance repair. In vitro, the combined treatment reduced reactive oxygen species levels and protected ADSC survival and mitochondrial function under oxidative stress. In vivo, allogeneic nerve grafts of ADSC with Prussian blue nanoparticles (ADSC-PBNP-ANA) grafts promoted axonal regeneration, myelin sheath formation, and macrophage polarization toward the M2 phenotype. Furthermore, satisfactory tissue regeneration and functional recovery were observed in long-term studies. This study provides a promising strategy for combining stem cells and nanomaterials to enhance peripheral nerve repair. The potential of this approach in clinical application awaits further preclinical testing.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 21","pages":"10917–10931 10917–10931"},"PeriodicalIF":5.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}