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[18F]FDHT tumour imaging for predicting response to treatment based on androgen receptor 基于雄激素受体的[18F]FDHT肿瘤成像预测治疗反应
IF 1.6 3区 化学
Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2024-08-14 DOI: 10.1007/s10967-024-09673-6
Abdullah Mujahid Muhammad, Wenhao Dun, Zarif Ashhar, Muhammad Fakhrurazi Ahmad Fadzil
{"title":"[18F]FDHT tumour imaging for predicting response to treatment based on androgen receptor","authors":"Abdullah Mujahid Muhammad, Wenhao Dun, Zarif Ashhar, Muhammad Fakhrurazi Ahmad Fadzil","doi":"10.1007/s10967-024-09673-6","DOIUrl":"https://doi.org/10.1007/s10967-024-09673-6","url":null,"abstract":"<p>The preliminary role of [<sup>18</sup>F]fluoro-5α-dihydrotestosterone ([<sup>18</sup>F]FDHT) in identifying receptor status and managing cancer patients is promising. In this work, we compiled studies regarding the ability of [<sup>18</sup>F]FDHT to predict response to treatment in different stages of drug development. In the chemical development, the androgen receptor (AR) ligands of [<sup>18</sup>F]FDHT were the candidates evaluated and identified using preclinical methods. High uptake of [<sup>18</sup>F]FDHT levels was observed in cell lines and xenograft tumours in mice having glucuronidation-competent cells mimicking the sensitive type of castration-resistant prostate cancer (CRPC) treated with androgen deprivation therapy (ADT). In clinical trials, the detection of lesions with [<sup>18</sup>F]FDHT was in agreement with the standard radiotracer [<sup>18</sup>F]FDG in advanced prostate cancer (PC) and was even better in AR-positive without glycolytic activity (AR<sub>1</sub>Glyc<sub>0</sub>) subtypes, demonstrating the specific role of [<sup>18</sup>F]FDHT for the detection of tumour localisation. Moreover, the immunohistochemistry (IHC) correlation between [<sup>18</sup>F]FDHT and AR was stronger than the correlation between [<sup>68</sup> Ga]Ga-PSMA-11 and prostate-specific membrane antigen (PSMA), suggesting that [<sup>18</sup>F]FDHT can be a standalone modality for the monitoring of AR-targeted therapy.</p>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142227433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing k0-NAA with different irradiation regimes for analysis of coral skeleton as a potential climate proxy indicator 优化不同辐照制度下的 k0-NAA 以分析作为潜在气候替代指标的珊瑚骨骼
IF 1.6 3区 化学
Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2024-08-14 DOI: 10.1007/s10967-024-09679-0
Dina Hajjar, Arwa A. Makki, Mahmoud Mohery, Mohamed Soliman
{"title":"Optimizing k0-NAA with different irradiation regimes for analysis of coral skeleton as a potential climate proxy indicator","authors":"Dina Hajjar, Arwa A. Makki, Mahmoud Mohery, Mohamed Soliman","doi":"10.1007/s10967-024-09679-0","DOIUrl":"https://doi.org/10.1007/s10967-024-09679-0","url":null,"abstract":"<p>The elemental composition of coral skeletons supplies essential information about palaeoceanographic reconstructions. The present work aims to optimize the neutron activation analysis (NAA) protocol for determining Ca-substituting elements in coral skeletons, which can be considered as a potential indicator for reconstructing past climate variability. Conventional and epithermal NAA schemes have been applied to determine 22 elements. The results reveal that the use of epithermal NAA significantly improved the limits of detection, up to 10 times, for specific elements, e.g. As, Ba, Cd, Mn, Sr, etc. The Compton suppression counting regime yielded an additional improvement in the limits of detection.</p>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142219597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STL decomposition analysis for anomaly detection in soil radon and thoron concentrations along Chite fault in Aizawl 通过 STL 分解分析检测艾扎尔 Chite 断层沿线土壤氡和钍浓度的异常情况
IF 1.6 3区 化学
Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2024-08-14 DOI: 10.1007/s10967-024-09685-2
Sanjay Singh, Hari Prasad Jaishi, Raghavendra Prasad Tiwari, Ramesh Chandra Tiwari
{"title":"STL decomposition analysis for anomaly detection in soil radon and thoron concentrations along Chite fault in Aizawl","authors":"Sanjay Singh, Hari Prasad Jaishi, Raghavendra Prasad Tiwari, Ramesh Chandra Tiwari","doi":"10.1007/s10967-024-09685-2","DOIUrl":"https://doi.org/10.1007/s10967-024-09685-2","url":null,"abstract":"<p>This paper explores the correlation between soil radon and thoron concentrations and seismic events at Chite fault in Aizawl over a three year period using SSNTDs. The data analysis was done using STL method which decomposes a time series into three components: seasonal, trend, and remainder. Elevated residual concentrations of these gases were observed prior to the M5.4 earthquake that occurred at a distance of 123.9 km from the monitoring station, suggesting a potential link between gas emanation and seismicity. The results of the study demonstrated the effectiveness of the STL method in detecting anomalies in diverse time series datasets.</p>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142219595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optical characterization of a new composition of acrylic acid hydrogel dosimeter for quality assurance in radiotherapy treatment 用于放射治疗质量保证的丙烯酸水凝胶剂量计新成分的光学特性分析
IF 1.6 3区 化学
Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2024-08-12 DOI: 10.1007/s10967-024-09690-5
Khalid A. Rabaeh, Belal Moftah, Akram A. Moussa, Abdullah S. Bani Issa, Md A. Al Kafi
{"title":"Optical characterization of a new composition of acrylic acid hydrogel dosimeter for quality assurance in radiotherapy treatment","authors":"Khalid A. Rabaeh, Belal Moftah, Akram A. Moussa, Abdullah S. Bani Issa, Md A. Al Kafi","doi":"10.1007/s10967-024-09690-5","DOIUrl":"https://doi.org/10.1007/s10967-024-09690-5","url":null,"abstract":"<p>A new polymer hyrogel dosimeter based on acrylic acid in polyvinyl alcohol hydrogel matrix was prepared to be used in radiation measurments for radiotherapy treatment. The hydrogel dosimeters were exposed to ionizing radiation using a medical linear accelerator. The hydrogel samples were irradiated at 6 MV beam energy, 600 cGy min<sup>−1</sup> dose rate, and various doses up to 50 Gy. UV–VIS Spectrophotometry was used to readout the dose response of non-irradiated and irradiated hydrogel samples at absorbance of 630 nm. The results show the dose response increases strongly with increasing abosrbed doses, with a large linear dose range (2–30 Gy) and dose sensitivity of 0.013 Gy<sup>−1</sup> s<sup>−1</sup>. Moreover, no significant variation in dose response was obseved when the gel samples are irridiated under different dose-rates as well as radiation beam energies. A noticeble change in the stability of the irradiated hydrogel samples was found within the first three days of irradiation, followed by a high post-irradiation stability, for the next 14 days. The non-irridiated samples were stable, up to 10 weeks.</p>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141939140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response surface prediction model of radon exhalation rate on beach surface of uranium tailings pond based on single factor law 基于单因素定律的铀尾矿库滩面氡挥发率响应面预测模型
IF 1.6 3区 化学
Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2024-08-12 DOI: 10.1007/s10967-024-09687-0
Yifan Chen, Zhangkai Chen, Xianwei Wu, Juntao Huang, Yong Liu
{"title":"Response surface prediction model of radon exhalation rate on beach surface of uranium tailings pond based on single factor law","authors":"Yifan Chen, Zhangkai Chen, Xianwei Wu, Juntao Huang, Yong Liu","doi":"10.1007/s10967-024-09687-0","DOIUrl":"https://doi.org/10.1007/s10967-024-09687-0","url":null,"abstract":"<p>Radon is a natural radioactive gas, which has great radiation hazards. Mastering the radon exhalation law under complex conditions is of great significance to the safety and stability of uranium tailings pond. Based on the self-developed artificial microclimate chamber, the single factor influence of water content, temperature and crack rate of overburden soil on radon exhalation rate of uranium tailings pond was explored through simulation experiments, and the corresponding single factor mathematical model was obtained. The response surface model of radon exhalation rate was constructed by combining whale optimization algorithm to achieve accurate prediction of radon exhalation rate. The test results of simulated seismic station vibration test also confirm the scientificity of the model. The results of this study can be used not only to guide the prediction and prevention of radon, but also to guide the early warning of uranium tailings pond instability.</p>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141939139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vertical distribution of radioactive cesium rich microparticles in Fukushima soils 福岛土壤中富放射性铯微粒的垂直分布
IF 1.5 3区 化学
Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2024-08-09 DOI: 10.1007/s10967-024-09691-4
T. Tatsuno, Hiromichi Waki, Minato Kakuma, N. Nihei, Nobuhito Ohte
{"title":"Vertical distribution of radioactive cesium rich microparticles in Fukushima soils","authors":"T. Tatsuno, Hiromichi Waki, Minato Kakuma, N. Nihei, Nobuhito Ohte","doi":"10.1007/s10967-024-09691-4","DOIUrl":"https://doi.org/10.1007/s10967-024-09691-4","url":null,"abstract":"","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141921798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Model of U and 226Ra uptake by Spergularia rubra (L.) J. Presl & C. Presl in an area affected by Cu ore mining 受铜矿开采影响地区的 Spergularia rubra (L.) J. Presl & C. Presl 对铀和 226Ra 的吸收模型
IF 1.5 3区 化学
Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2024-08-09 DOI: 10.1007/s10967-024-09626-z
V. Expósito-Suárez, J. A. Suárez-Navarro, A. Caro, M. B. Sanz, M. B. Gómez-Mancebo, M. Barragán, M. J. Suarez-Navarro, A. Ferreiro, T. Fitzgerald, P. Sánchez-Sánchez, E. Gil-Pacheco
{"title":"Model of U and 226Ra uptake by Spergularia rubra (L.) J. Presl & C. Presl in an area affected by Cu ore mining","authors":"V. Expósito-Suárez, J. A. Suárez-Navarro, A. Caro, M. B. Sanz, M. B. Gómez-Mancebo, M. Barragán, M. J. Suarez-Navarro, A. Ferreiro, T. Fitzgerald, P. Sánchez-Sánchez, E. Gil-Pacheco","doi":"10.1007/s10967-024-09626-z","DOIUrl":"https://doi.org/10.1007/s10967-024-09626-z","url":null,"abstract":"","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141921506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distribution characteristics of radionuclides (226Ra, 234U, and 238U) and ratios (226Ra/234U, 226Ra/238U, and 234U/238U) in quarry lake environment: experimental and model assessment 采石湖环境中放射性核素（226Ra、234U 和 238U）的分布特征和比率（226Ra/234U、226Ra/238U 和 234U/238U）：实验和模型评估
IF 1.5 3区 化学
Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2024-08-09 DOI: 10.1007/s10967-024-09678-1
Van Thang Nguyen, C. Le
{"title":"Distribution characteristics of radionuclides (226Ra, 234U, and 238U) and ratios (226Ra/234U, 226Ra/238U, and 234U/238U) in quarry lake environment: experimental and model assessment","authors":"Van Thang Nguyen, C. Le","doi":"10.1007/s10967-024-09678-1","DOIUrl":"https://doi.org/10.1007/s10967-024-09678-1","url":null,"abstract":"","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141925039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of thorium oxalate particles in a micro-reactor: Studying the effect of temperature and reactant concentration 在微型反应器中合成草酸钍颗粒：研究温度和反应物浓度的影响
IF 1.5 3区 化学
Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2024-08-09 DOI: 10.1007/s10967-024-09683-4
Sareh Ammari Allahyari, P. Zaheri, A. Charkhi
{"title":"Synthesis of thorium oxalate particles in a micro-reactor: Studying the effect of temperature and reactant concentration","authors":"Sareh Ammari Allahyari, P. Zaheri, A. Charkhi","doi":"10.1007/s10967-024-09683-4","DOIUrl":"https://doi.org/10.1007/s10967-024-09683-4","url":null,"abstract":"","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141921824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TDCR Cherenkov counting for determining 90Y activity in blood samples 用于确定血液样本中 90Y 活性的 TDCR 切伦科夫计数法
IF 1.5 3区 化学
Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2024-08-09 DOI: 10.1007/s10967-024-09688-z
Yan Ma, Jie Gao, Ruoqi Wang, Yonggang yang, Xiongxin Dai
{"title":"TDCR Cherenkov counting for determining 90Y activity in blood samples","authors":"Yan Ma, Jie Gao, Ruoqi Wang, Yonggang yang, Xiongxin Dai","doi":"10.1007/s10967-024-09688-z","DOIUrl":"https://doi.org/10.1007/s10967-024-09688-z","url":null,"abstract":"","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141924640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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