Utility of low specific activity 90Y produced in a medium flux research reactor in the preparation of radioactive patch for the treatment of skin ailments

IF 1.6 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2025-08-02 DOI:10.1007/s10967-025-10276-y

K. V. Vimalnath, A. Rajeswari, Sai Kishore, Nandini Pandit, Sudipta Chakraborty

引用次数: 0

Abstract

The article discusses the application of low-specific-activity ⁹⁰Y [T_½ = 64.1 h, E_β-(max) = 2.28 MeV] in the preparation of radioactive patch sources for the treatment of superficial skin conditions, particularly keloids. Yttrium-90 was produced with 688 ± 41 MBq/mg specific activity and > 99.9% radionuclide purity in a medium flux research reactor. A simple and reproducible method was established to prepare radioactive patch sources, incorporating 92 ± 8 MBq of ⁹⁰Y in each source with uniform distribution of radioactivity, without any surface contamination and almost no leaching of radioactivity. Preliminary investigations with developed sources in recalcitrant keloids showed promising outcome.

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在中等通量研究反应器中产生的低比活度90Y在制备治疗皮肤病的放射性贴片中的用途

本文讨论了低比活度(9⁰Y [T½= 64.1 h, Eβ-(max) = 2.28 MeV]在制备用于治疗浅表皮肤状况，特别是瘢痕疙瘩的放射性贴片源中的应用。钇-90的比活度为688±41 MBq/mg，放射性核素纯度为99.9%。建立了一种简单、可重复的制备放射性贴片源的方法，每个源中加入92±8 MBq的90Y，放射性分布均匀，无表面污染，几乎没有放射性浸出。对顽固性瘢痕疙瘩的初步调查显示了良好的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.