Journal of Radioanalytical and Nuclear Chemistry最新文献

{"title":"Improving the accuracy of tritium bioassay measurements through quench curve customization","authors":"Raissa N. Chunko,&nbsp;Matthew E. Gooden,&nbsp;Dylan C. Flanagan,&nbsp;Robert E. Steiner,&nbsp;Ralf Sudowe","doi":"10.1007/s10967-026-10797-0","DOIUrl":"10.1007/s10967-026-10797-0","url":null,"abstract":"<div><p>The precision and accuracy of a Revvity 6220 GCT Liquid Scintillation Counter (LSC) was tested with a certified tritiated water standard and using a combination of variables including vial type, cocktail selection, and quench curve parameters. Differences in the vial and cocktail choice used for quench measurements and samples were shown to drastically affect the accuracy of the tritium activity measured. Additionally, chemical-based and urine-based quench curves were generated to most closely match the sample matrices analyzed for bioassay samples. Lab generated quench curves designed for programmatic samples performed with improved accuracy compared to commercially available quench standards.</p></div>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":"335 3","pages":"2295 - 2302"},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid source preparation of plutonium for alpha spectrometry from complex matrices","authors":"Hilary P. Emerson,&nbsp;Matthew RisenHuber,&nbsp;José M. Veleta,&nbsp;Caleb Allen,&nbsp;Morgan Haney,&nbsp;Samuel Emmons,&nbsp;Staci Herman,&nbsp;Amanda French,&nbsp;Kirby Hobbs,&nbsp;Chelsie Beck","doi":"10.1007/s10967-026-10758-7","DOIUrl":"10.1007/s10967-026-10758-7","url":null,"abstract":"<div><p>Plutonium exhibits complex and unique redox chemistry. Its detection and quantification is pivotal for understanding behavior in environmental systems, including for remediation, consequence management, and nuclear forensics analyses. The objective of this work was to determine whether microprecipitation is a viable, rapid method for sample preparation as compared to standard methods, when utilized in conjunction with separations to allow for parallel measurement of multiple radionuclides via different techniques. Here, neodymium fluoride microprecipitation was compared with electrodeposition and stippling, based on an evaluation of the peak full width at half maximum, recovery of Pu-242 after analysis by alpha spectrometry, and the time requirements for each method. These results highlight the robustness of microprecipitation methods under a range of conditions.</p></div>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":"335 3","pages":"2025 - 2034"},"PeriodicalIF":1.6,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioactivity levels in some commercial Mexican peloids","authors":"Alejandro M. Neyra-Suárez,&nbsp;Héctor Cartas-Águila,&nbsp;Clara M. Melián-Rodríguez,&nbsp;Juan J. Piña-Leyte-Vidal,&nbsp;Patricia González-Hernández,&nbsp;Nadia V. Martínez-Villegas,&nbsp;María Lourdes Mourelle-Mosqueira,&nbsp;Oscar Díaz-Rizo","doi":"10.1007/s10967-026-10795-2","DOIUrl":"10.1007/s10967-026-10795-2","url":null,"abstract":"<div><p>Radioactivity levels of natural radionuclides (²²⁶Ra, ²³²Th, ⁴⁰K) and the anthropogenic radionuclide (¹³⁷Cs) in peloids from five Mexican locations—Los Azufres (LA), La Bocana (LBC), Catemaco (C), Taninul Pool (TP), and Taninul Extemporaneous (TE)—were investigated. The radionuclide concentrations, in Bq kg⁻¹ dry weight, ranged as follows: ²²⁶Ra (19–1213), ²³²Th (19–96), measured ⁴⁰K (&lt; 20–572), and ¹³⁷Cs (&lt; 7), which are consistent with values reported for therapeutic peloids used worldwide. The estimated annual effective dose for ²²⁶Ra-enriched peloids, considering the short exposure times typical of therapeutic practices at spas, is well below the accepted skin dose limits for the general public. Therefore, the radioactivity levels found in the studied peloids are not significant and do not pose a radiological risk, making them safe for use in therapeutic and cosmetic applications.</p></div>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":"335 4","pages":"2595 - 2601"},"PeriodicalIF":1.6,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147734937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of radiation dose rates, health risks and radionuclide effects of wood and wood-based materials in indoor areas","authors":"Taner Taşdemir,&nbsp;Evren Osman Çakıroğlu,&nbsp;Serdar Dizman,&nbsp;Yaşar Kobya,&nbsp;Cafer Mert Yeşilkanat","doi":"10.1007/s10967-026-10807-1","DOIUrl":"10.1007/s10967-026-10807-1","url":null,"abstract":"<div><p>This study addresses the limited comparative data in the literature by systematically evaluating natural radioactivity and radiological hazard indices across 15 different solid wood species commonly used in indoor building applications. Gamma spectrometric analyses performed using a high-sensitivity HPGe detector revealed that the activity concentrations of the isotopes Ra-226, Th-232, and K-40 were in the ranges of 1.64–13.26, 0.76–9.46 and 6.08–163.66 Bq kg⁻¹, respectively. In addition, some radiological risk parameters originating from natural radiation were also calculated for the samples examined. All obtained parameters were below the threshold values reported by international organizations, suggesting that wooden building materials are suitable for indoor use.</p></div>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":"335 4","pages":"2785 - 2796"},"PeriodicalIF":1.6,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147734939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigation of volatile cesium species with fly ash and subsequent conversion into glasses for immobilization","authors":"Jinimol Joy,&nbsp;R. Kumaresan,&nbsp;Kitheri Joseph,&nbsp;M. Venkatesh,&nbsp;D. Sujish","doi":"10.1007/s10967-026-10811-5","DOIUrl":"10.1007/s10967-026-10811-5","url":null,"abstract":"<div><p>Volatile radioactive cesium disperses in the atmosphere at a faster rate, posing a serious health hazard. This study explores the potential of fly ash to trap cesium species and convert them into a stable glass form with improved chemical durability. Class F fly ash (FA) was examined for trapping volatile cesium species at elevated temperatures ranging from 700 to 900 °C. Sintered fly ash porous pellets were used to trap volatile cesium species from different cesium sources, such as cesium nitrate, cesium iodide and cesium carbonate. Various techniques, including X-ray diffraction, scanning electron microscopy, Raman spectroscopy and Fourier-transform infrared spectroscopy, were employed to characterise cesium-reacted fly ash pellets. XRD analysis indicated the formation of nepheline (CsAlSiO₄) and pollucite (CsAlSi₂O₆) phases upon reaction of Cs vapour with fly ash. The cesium-reacted fly ash pellets were converted into glass using different additives at a temperature of 1100 °C. The cesium-loaded fly ash glasses were characterised using XRD, differential scanning calorimetry, and dilatometry. XRD analysis revealed the glassy nature of the Cs-loaded fly ash glass. The chemical durability of the cesium-loaded glass matrices was assessed using the Product Consistency Test-B method. The cesium leach rate was found to be in the range of 10⁻⁵ g/cm²/day.</p></div>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":"335 4","pages":"2811 - 2824"},"PeriodicalIF":1.6,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147734962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[225Ac]Ac–anti-DLL3 targeted alpha therapy for neuroendocrine tumors: preclinical radiosynthesis, biodistribution, and therapeutic efficacy","authors":"Syed Qaiser Shah,&nbsp;Ralph Santos-Oliveira,&nbsp;Derya Ilam-Ozdemir","doi":"10.1007/s10967-026-10809-z","DOIUrl":"10.1007/s10967-026-10809-z","url":null,"abstract":"<div><p>High-grade neuroendocrine tumors (NETs) exhibit aggressive progression and limited response to existing systemic therapies. Delta-like ligand 3 (DLL3) is selectively overexpressed on high-grade NETs, offering an attractive target for precision radiotherapeutics. Targeted alpha therapy (TAT) with actinium-225 (²²⁵Ac) enables high-LET, short-range cytotoxicity ideal for eliminating resistant tumor populations. The aim was to develop, radiolabel, and preclinically evaluate a Macropa–PEG₄–anti-DLL3 (rovalpituzumab) antibody conjugate labeled with ²²⁵Ac for NET-directed alpha therapy. Rovalpituzumab was conjugated via thiol-maleimide chemistry to Macropa-PEG₄ and radiolabeled with ²²⁵Ac under mild conditions. Radiochemical purity, stability, and immunoreactivity were evaluated by SEC-HPLC and iTLC. Binding, internalization, apoptosis, and clonogenic assays were conducted in DLL3-positive H727 and NCI-H69 cells. Biodistribution, dosimetry, and therapy studies were performed in H727 and NCI-H69 xenograft mice. Conjugation yielded ~ 3.7 chelators/antibody with 85% recovery, and radiolabeling achieved &gt; 98% purity with &gt; 88% stability over 7 days in human serum. The radioconjugate exhibited high-affinity DLL3 binding (Kd ≈ 0.5 nM) and efficient internalization (78% and 56% total cell-associated activity at 24 h in H727 and NCI-H69 cells, respectively). In vitro, [²²⁵Ac]Ac–Macropa–PEG₄–rovalpituzumab induced ~ 70% apoptosis and reduced clonogenic survival to ~ 15% at 5 kBq/mL with minimal non-targeted cytotoxicity. In vivo biodistribution studies showed tumor uptake of 19.5%ID/g at 24 h in H727 xenografts, with ~ 70% reduction in blocking cohorts (<i>p</i> &lt; 0.01), confirming DLL3-mediated targeting. A single 250 kBq therapeutic dose induced substantial tumor regression and significantly extended median survival from 22–24 to 46 days (<i>p</i> &lt; 0.001) with acceptable acute tolerability over 60 days. [²²⁵Ac]Ac–Macropa–PEG₄–rovalpituzumab demonstrates favorable radiochemical properties (&gt; 98% purity, &gt; 88% seven-day stability), high-affinity DLL3 binding (Kd ≈ 0.5 nM), and potent DLL3-specific cytotoxicity in vitro. In H727 subcutaneous xenografts, a single 250 kBq dose induced tumor regression and significantly extended median survival (46 vs. 22–24 days, <i>p</i> &lt; 0.001) with acceptable acute tolerability. These preclinical findings support further evaluation of DLL3-targeted alpha therapy for neuroendocrine tumors, with additional studies needed to assess long-term toxicity, dose optimization, and efficacy in clinically relevant tumor models.</p></div>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":"335 4","pages":"2825 - 2844"},"PeriodicalIF":1.6,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147734958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-driven isotope detection: applying deep learning to gamma spectral analysis","authors":"Yasas Patikirige,&nbsp;Lyda Pav,&nbsp;Shakhboz Khasanov,&nbsp;Jagath Pitawala","doi":"10.1007/s10967-026-10808-0","DOIUrl":"10.1007/s10967-026-10808-0","url":null,"abstract":"<div><p>The rapid development of Machine Learning (ML) and Deep Learning (DL) methods in recent years has made them popular among the scientific community. These methods have been applied across various fields, including radiation detection and the nuclear industry. These techniques have demonstrated the potential to enhance the performance and efficiency of automated radiation detection practices and nuclear safety and security practices. This paper will discuss incorporating deep learning techniques, Fully Connected Artificial Neural Networks (FCANN), and Convolutional Neural Networks (CNN) to detect radioactive isotopes with low-resolution gamma spectral data. Further, our work aims to enhance the performance of identification while exploring the explainability of these models. Using saliency mapping methods, we visualize the networks’ regions of interest for a better understanding of the underlying decision-making processes. Both CNN and FCANN models demonstrated high accuracies exceeding 97%, while saliency mapping highlighted the relevant spectral features for underlying decision making process of each type of model.</p></div>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":"335 4","pages":"2773 - 2783"},"PeriodicalIF":1.6,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147735008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statistical analysis of Japanese Fukushima radioactive foodstuff CRM verification by international comparison study","authors":"N. Alan Heckert,&nbsp;James J. Sr. Filliben,&nbsp;Kenneth G. W. Inn,&nbsp;Chushiro Yonezawa,&nbsp;Shoji Hirai,&nbsp;Yoshitaka Minai","doi":"10.1007/s10967-026-10768-5","DOIUrl":"10.1007/s10967-026-10768-5","url":null,"abstract":"<div><p>Following the Japan Fukushima incident, radioactive foodstuff Certified Reference Materials (CRMs) were urgently required. The Brown Rice, Dried Fish Meal, and Fish Bone Ash CRMS containing Cs-134, Cs-137, K-40 and Sr-90 were manufactured and certified by 16 experienced Japanese radiochemistry laboratories. Following the certification of massic activities of the selected radionuclides in their natural matrix CRMs, a group of 11 radiometrology National Metrology Institutes (NMI), environmental, and health and safety laboratories were invited to verify the certified values. The process of comparing the CRM certified values to those from the International Comparison Study (ICS) required special statistical tools. The questions posed and the results are as follows: 1) Do the participating international laboratories have consistent location, i.e. central tendency, among laboratories with no significant bias? 2) Do the participating international laboratories have consistent variation, i.e., no significant difference in uncertainty determinations. 3) Are the Japanese CRM certified values consistent with those from the ICS?</p></div>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":"335 3","pages":"2267 - 2275"},"PeriodicalIF":1.6,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enrichment and sensitive determination of uranium (VI) by using a thermosensitive shape memory polymer","authors":"Arslan Karaköse,&nbsp;Orhan Hazer","doi":"10.1007/s10967-026-10803-5","DOIUrl":"10.1007/s10967-026-10803-5","url":null,"abstract":"<div><p>In this study, SAMB-Aox, a heat-sensitive shape memory polymer previously developed and characterized, was evaluated as a functional adsorbent in a solid-phase extraction (SPE) system for uranium recovery. The contribution of shape memory functionality was systematically examined by separating thermal and mechanical effects during adsorption and elution. While uranium adsorption efficiencies at 25 and 60 min remained comparable regardless of shape recovery, a pronounced enhancement was observed during the elution stage. Activation of shape memory recovery enabled near-quantitative uranium elution, reaching a recovery of 94.7% within 60 min, corresponding to an approximately twofold increase compared to non-shape-memory controls. In parallel, the required eluent volume was reduced from 40 to 20 mL, and effective elution was achieved at shorter contact times. These improvements resulted in a substantially enhanced enrichment factor and accelerated SPE performance. The findings demonstrate that macroscopic shape recovery plays a decisive role in mechanically assisted desorption, providing a mechanistic insight into the behavior of stimuli-responsive sorbents.</p></div>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":"335 4","pages":"2625 - 2635"},"PeriodicalIF":1.6,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147734938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of iodine-126 contamination in the production of iodine-125 at the IEA-R1 reactor for brachytherapy applications","authors":"Ilca Marli Moitinho Amaral Medeiros,&nbsp;João Augusto Moura,&nbsp;José Agostinho Gonçalves de Medeiros,&nbsp;Ana Catarina Souza Silva Koka,&nbsp;Lucas Verdi Angelocci,&nbsp;Maria Elisa Chuery Martins Rostelato,&nbsp;Carlos Alberto Zeituni","doi":"10.1007/s10967-026-10781-8","DOIUrl":"10.1007/s10967-026-10781-8","url":null,"abstract":"<div><p>This work developed a method to determine the contamination rates of iodine-126 (¹²⁶I) in the sodium iodide (NaI) solution used in the production of iodine-125 (¹²⁵I) seeds for brachytherapy. The production of ¹²⁵I is carried out at the IEA-R1 Reactor of the Nuclear and Energy Research Institute (IPEN-CNEN/SP) by irradiation with natural xenon. For the radionuclide analysis, a High-Purity Germanium (HPGe) radiation detector (ORTEC model GEM-C5970-B, coaxial detection system and beryllium window, nominal efficiency of 43% at 1333 keV of cobalt-60) was used, in which the activity of ¹²⁵I was determined by the sum-peak method and the activity of ¹²⁶I by an efficiency curve using a ¹⁶⁶^mHo calibration source (A = (1832 ± 2) Bq, T_1/2 = 1.20 × 10³ years and reference date: Feb 23rd 2024). The results demonstrated the predictions of ¹²⁵I production in the IEA-R1 Reactor with ¹²⁶I contamination levels below 0.005%, meeting the production requirements for clinical use.</p></div>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":"335 4","pages":"2567 - 2581"},"PeriodicalIF":1.6,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10967-026-10781-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147734879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}