固体靶医用回旋加速器自动合成[64Cu]Cu-NOTA-JR11及其用于SSTR成像的临床前评价

IF 1.6 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2025-08-28 DOI:10.1007/s10967-025-10323-8

Fanhui Yang, Yousheng Zhan, Fei Luo, Lingzhi Cao, Fei Chen, Hao Zhang, Suping Li, Hao Xu

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引用次数: 0

摘要

利用低能医用回旋加速器和全自动化固体靶纯化合成平台成功制备了[64Cu]Cu-NOTA-JR11。该示踪剂在初步动物实验中表现出优异的放射化学纯度、体外稳定性和PET成像性能。该方法支持64cu标记的SSTR拮抗剂的规模化生产，并为进一步的临床前开发和临床转化提供了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Automated synthesis of [64Cu]Cu-NOTA-JR11 using a solid target medical cyclotron and its preclinical evaluation for SSTR imaging

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Automated synthesis of [64Cu]Cu-NOTA-JR11 using a solid target medical cyclotron and its preclinical evaluation for SSTR imaging

[⁶⁴Cu]Cu-NOTA-JR11 was successfully prepared using a low-energy medical cyclotron and a fully automated solid target purification and synthesis platform. The tracer exhibited excellent radiochemical purity, in vitro stability, and PET imaging properties in preliminary animal studies. The method supports scalable production of ⁶⁴Cu-labeled SSTR antagonists and provides a basis for further preclinical development and clinical translation.

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.