Automated synthesis of [64Cu]Cu-NOTA-JR11 using a solid target medical cyclotron and its preclinical evaluation for SSTR imaging

Abstract

[⁶⁴Cu]Cu-NOTA-JR11 was successfully prepared using a low-energy medical cyclotron and a fully automated solid target purification and synthesis platform. The tracer exhibited excellent radiochemical purity, in vitro stability, and PET imaging properties in preliminary animal studies. The method supports scalable production of ⁶⁴Cu-labeled SSTR antagonists and provides a basis for further preclinical development and clinical translation.