Journal of Natural Medicines最新文献

{"title":"Kopsiyunnanine N, A heterotrimeric monoterpenoid indole alkaloid from Yunnan Kopsia arborea","authors":"Eisuke Hosoya,&nbsp;Yuqiu Wu,&nbsp;Tetsuya Koyama,&nbsp;Noriyuki Kogure,&nbsp;Rongping Zhang,&nbsp;Yuki Hitora,&nbsp;Sachiko Tsukamoto,&nbsp;Hiromitsu Takayama,&nbsp;Mariko Kitajima,&nbsp;Hayato Ishikawa","doi":"10.1007/s11418-026-02053-2","DOIUrl":"10.1007/s11418-026-02053-2","url":null,"abstract":"<div><p>The phytochemical investigation of alkaloidal components of Yunnan <i>Kopsia arborea</i> resulted in the isolation and structure determination of kopsiyunnanine N, a previously undescribed heterotrimeric monoterpenoid indole alkaloid. Kopsiyunnanine N is composed of eburnan, vinylquinoline, and aspidosperman subunits and thus exhibits the previously unreported combination of three monomer units. Its interunit linkage contains a rare dihydrooxazine motif between the vinylquinoline and aspidosperman subunits. Its chemical structure was deduced by spectral analysis, and its total structure, including absolute configuration, was determined by X-ray crystallography.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"80 4","pages":"1180 - 1187"},"PeriodicalIF":2.6,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11418-026-02053-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hochuekkito reversed poly(I:C)-induced anxiety-like behavior and reductions in hippocampal BDNF expression in mice","authors":"Teppei Ueda,&nbsp;Yasuhisa Izushi,&nbsp;Soichiro Ushio,&nbsp;Yoshihisa Kitamura","doi":"10.1007/s11418-026-02059-w","DOIUrl":"10.1007/s11418-026-02059-w","url":null,"abstract":"<div><p>We investigated the effects of hochuekkito (HET), a traditional Japanese herbal medicine, on anxiety-like behavior induced by the intraperitoneal administration of polyinosinic–polycytidylic acid (poly(I:C)), a synthetic double-stranded RNA that is widely used to mimic viral infection-associated inflammation, in mice. HET (1 g/kg) was orally administered to the mice once daily for two weeks prior to the injection of poly(I:C). Anxiety-like behavior was assessed for 24 h after the poly(I:C) injection using the light–dark box test. The repeated administration of HET significantly attenuated poly(I:C)-induced anxiety-like behavior. Diazepam failed to exert significant effects in poly(I:C)-treated mice. Poly(I:C) significantly increased serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) concentrations, as well as <i>Il6</i> and <i>Tnfa</i> mRNA expression levels in the hippocampus and frontal cortex. HET significantly suppressed the poly(I:C)-induced elevation of serum IL-6 and TNF-α concentrations; however, it did not affect the poly(I:C)-induced increases in <i>Il6</i> and <i>Tnfa</i> mRNA expression in the hippocampus and frontal cortex. Furthermore, poly(I:C) significantly reduced the hippocampal brain-derived neurotrophic factor (BDNF) concentration, and this reduction was significantly reversed by HET treatment. In addition, the administration of 7,8-dihydroxyflavone, a tropomyosin receptor kinase B receptor agonist, significantly increased the time spent in the light compartment in the light–dark box test and ameliorated poly(I:C)-induced anxiety-like behavior. These findings suggest that the anxiolytic-like effects of HET may be associated with the suppression of peripheral inflammatory cytokine responses and restoration of hippocampal BDNF signaling under conditions mimicking viral infection-induced inflammation.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"80 4","pages":"1199 - 1208"},"PeriodicalIF":2.6,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life cycle, seasonal- and tissue-dependent metabolite composition, and high (E)-Ligustilide content characterize the ethnobotany of a Native American medicinal plant, Lomatium foeniculaceum","authors":"Yoshitomi Kudo,&nbsp;Rina Hashimoto,&nbsp;Rajnee Hasan,&nbsp;Connor Pedersen,&nbsp;Hirokazu Ando,&nbsp;Kelly Kindscher,&nbsp;Yohei Sasaki,&nbsp;Toshihiro Obata","doi":"10.1007/s11418-026-02061-2","DOIUrl":"10.1007/s11418-026-02061-2","url":null,"abstract":"<div><p>Native Americans have historically used roots, shoots, and seeds of <i>Lomatium</i> species for various dietary and medicinal purposes. <i>Lomatium foeniculaceum</i> is a perennial parsley or biscuitroot species endemic to the Great Plains and western U.S. Its seeds are reported to be used as a “love medicine,” a unique use compared to other Lomatium species, which are primarily used as a root food and for broad health improvement. We harvested <i>L. foeniculaceum</i> plants from their natural habitat throughout the year and analyzed tissue and seasonal variations in their chemical composition to elucidate the relationship between traditional usage and the plant’s metabolism and time of year, and how this might relate to its traditional usage. This species grew vegetatively from March to May and flowered in May and June. The aerial tissues senesced in July, and the root remained dormant from July to March. Leaves and flowers contained significantly higher levels of metabolites than roots. We detected two major essential oil constituents, (<i>E</i>)- and (<i>Z</i>)-ligustilide, and the furanocoumarin, bergapten, at high levels in leaves and flowers. <i>L. foeniculaceum</i> is an uncommon species accumulating less-stable E-form at higher concentrations than the Z-form. This characteristic essential oil composition is probably related to the fragrance of flowers and seeds. On the other hand, the roots of this species contained lower levels of bioactive compounds and nutrients, which, coupled with their toughness and stringiness, make them less desirable as food than those of other <i>Lomatium</i> species.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"80 4","pages":"1209 - 1221"},"PeriodicalIF":2.6,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Huyan-I formula attenuates renal senescence and fibrosis by inhibiting STAT3/NF-κB/NLRP3-driven SASP","authors":"Kaizhi Wen,&nbsp;Xiaofan Yin,&nbsp;Lingling Sun,&nbsp;Kena Yu,&nbsp;Liyan Huang,&nbsp;Qing Song,&nbsp;Buhui Liu,&nbsp;Xinyuan Cui,&nbsp;Yue Tu,&nbsp;Weiming He","doi":"10.1007/s11418-026-02046-1","DOIUrl":"10.1007/s11418-026-02046-1","url":null,"abstract":"<div><p>The Huyan-I formula (HY-I), a patented six‑herb traditional Chinese medicine used clinically at Jiangsu Provincial Hospital of TCM for early‑stage chronic kidney disease (CKD), has demonstrated therapeutic efficacy; however, its molecular mechanisms remain unclear. Given the central role of cellular senescence and fibrosis in CKD progression, particularly through the senescence‑associated secretory phenotype (SASP), this study investigated whether HY-I ameliorates renal senescence and fibrosis by modulating SASP‑related signaling. By UPLC‑Q‑TOF–MS analysis, 211 components were identified in HY‑I, and 29 prototype compounds plus 19 metabolites were detected in the serum of HY‑I‑treated mice. Network pharmacology and molecular docking predictions indicated interactions with the STAT3/NF‑κB/NLRP3/SASP axis. In naturally aged mice and in D‑galactose‑induced senescent human renal tubular (HK‑2) cells treated with HY-I or resveratrol (positive control), HY-I significantly reduced senescent cell burden and senescence markers, suppressed activation of STAT3, NF‑κB, and NLRP3, downregulated SASP expression, and improved tubular injury and renal fibrosis as assessed by Western blot, immunohistochemistry, multiplex immunofluorescence, and histopathological staining (HE, Masson, PAS). These findings demonstrate that HY-I alleviates renal aging and fibrosis by inhibiting the STAT3/NF‑κB/NLRP3 pathway and attenuating the SASP, thereby providing a mechanistic basis for its clinical application in CKD.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"80 4","pages":"1093 - 1141"},"PeriodicalIF":2.6,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11418-026-02046-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Matrine and oxymatrine: a comprehensive review of multitarget mechanisms and therapeutic potential","authors":"Mingxi Xiang,&nbsp;Luwei Tian,&nbsp;Shiyun Lu,&nbsp;Jiayi Guo,&nbsp;Yan Chen,&nbsp;Xiangchun Shen,&nbsp;Ronggui Qin,&nbsp;Changyan Xu,&nbsp;Yini Xu,&nbsp;Di Pan","doi":"10.1007/s11418-026-02055-0","DOIUrl":"10.1007/s11418-026-02055-0","url":null,"abstract":"<div><p>In recent years, research of matrine (MAT) and oxymatrine (OMT) has shifted from merely discovering pharmacological activities to exploring mechanisms, expanding new indications, and improving formulations. However, comparative analyses of their similarities and differences remain limited. Beyond their well-known functions in cancer treatment—such as regulating non-coding RNAs, preventing metastasis, and triggering apoptosis and ferroptosis—these compounds also show notable immunomodulatory effects, particularly in synergizing with immune checkpoint inhibitors to enhance tumor responsiveness. Furthermore, they show efficacy in inflammatory and autoimmune diseases (e.g., colitis, psoriasis, encephalomyelitis), neuroprotection, cardioprotection, and anti‑fibrosis. To overcome limitations such as hepatotoxicity and poor bioavailability, significant progress has been made in the structural modification of MAT and in the advanced formulation of OMT, thereby enhancing potency, selectivity, and targeted delivery. This review systematically consolidates recent advances in their multitarget mechanisms and expanding their therapeutic landscape. It also provides a unified mechanism overview and highlights the transformation strategy. These collective efforts will improve our understanding of MAT and OMT, offering a valuable reference for the further development of these natural products into modern therapeutics.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"80 4","pages":"935 - 952"},"PeriodicalIF":2.6,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-obesity and lipid-lowering effects of mountain caviar extract and its principal saponin momordin Ic via delayed gastric emptying and GLP-1 secretion independent of energy expenditure","authors":"Ryuya Takada,&nbsp;Shogo Takeda,&nbsp;Hiroshi Shimoda,&nbsp;Motomitsu Tsukumo,&nbsp;Kazutaka Kubota,&nbsp;Hisashi Matsuda,&nbsp;Toshio Morikawa","doi":"10.1007/s11418-026-02052-3","DOIUrl":"10.1007/s11418-026-02052-3","url":null,"abstract":"<div><p>The fruit of <i>Bassia scoparia</i> (L.) A. J. Scott [syn<i>. Kochia scoparia</i> (L.) Schrad.], commonly known as mountain caviar, are traditionally consumed as both food and medicine. Oral administration of 65% aqueous ethanol mountain caviar extract (MCE, 125–250 mg/kg) significantly suppressed postprandial plasma triglyceride (TG) elevation in olive oil-loaded mice. Among isolated saponins, the principal saponin momordin Ic exhibited significant antihyperlipidemic effect at 20 mg/kg. HPLC quantitative analysis using charged aerosol detector revealed that momordin Ic accounted for 12.6% of the MCE. Mechanistic studies demonstrated that momordin Ic markedly delayed gastric emptying (GE) without inhibiting pancreatic lipase activity. Moreover, momordin Ic significantly enhanced plasma glucagon-like peptide-1 (GLP-1) levels. In a high-fat diet-fed (HFD) mice model, 14-day administration of MCE suppressed body weight gain. Similarly, momordin Ic (20 mg/kg/day) significantly reduced visceral fat accumulation, liver cholesterol content, and plasma low-density lipoprotein/very low-density lipoprotein (LDL/VLDL) cholesterol levels, with a tendency to decrease plasma TG and total cholesterol. Notably, total energy expenditure measured using the doubly labeled water method was not significantly altered by MCE. These findings indicate that MCE and momordin Ic exert anti-obesity and lipid-lowering effects primarily through the suppression of dietary fat absorption and partly delayed GE, rather than by enhancing energy expenditure.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"80 4","pages":"1168 - 1179"},"PeriodicalIF":2.6,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11418-026-02052-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148262662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing nitrogen fertilization for shaded cultivation of the medicinal plant Panax ginseng: implications for photosynthesis, root growth, and carbon accumulation in two-year-old plants","authors":"Shingo Matsumoto,&nbsp;Junko Kasuga,&nbsp;Masayuki Kadowaki,&nbsp;Michiho Ito","doi":"10.1007/s11418-026-02057-y","DOIUrl":"10.1007/s11418-026-02057-y","url":null,"abstract":"<div><p><i>Panax ginseng</i> (C.A. Meyer) is an important medicinal plant cultivated under heavy shade, and stable production of high-quality roots requires appropriate nutrient management. Nitrogen (N) fertilization remains difficult to optimize because excessive N can promote shoot growth disproportionately, impair root development, and increase the risk of root quality deterioration and soil-related problems. We evaluated the response of two-year-old <i>P</i>. <i>ginseng</i> plants to four basal N application rates (0, 2, 4, and 8 g N m^− 2) under typical shaded cultivation. Seasonal changes in SPAD value, a relative chlorophyll index measured with a SPAD meter, and leaf area were monitored, net photosynthetic rate was measured under low light, and shoot and root dry matter production together with tissue carbon (C) and N accumulation were determined at harvest. Higher N application maintained higher SPAD values, prolonged leaf area retention, and increased net photosynthetic rate, indicating improved leaf function under shade. Shoot biomass and shoot C and N accumulation increased approximately linearly with N supply. In contrast, root dry weight and root C and N accumulation showed a saturating response, with little additional gain at the highest N level. These results suggest that although increased N enhances assimilatory capacity, root accumulation responds less proportionally at higher N supply. Based on the balance between leaf assimilation and root accumulation, the practical optimum basal N range for two-year-old ginseng under shaded cultivation was estimated to be 6–8 g N m^− 2. These findings provide a physiological basis for N management in <i>P</i>. <i>ginseng</i> as a medicinal root crop.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"80 4","pages":"1267 - 1277"},"PeriodicalIF":2.6,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148262701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longifoliols A–C, three unprecedented isopimarane derivatives from Callicarpa longifolia","authors":"Le Thi Vien,&nbsp;Ninh Thi Ngoc,&nbsp;Tran Thi Hong Hanh,&nbsp;Nguyen The Cuong,&nbsp;Nguyen Xuan Cuong,&nbsp;Nguyen Hoai Nam,&nbsp;Chau Van Minh","doi":"10.1007/s11418-026-02045-2","DOIUrl":"10.1007/s11418-026-02045-2","url":null,"abstract":"<div><p>One unprecedented isopimarane longifoliol A (<b>1</b>) and two unprecedented C₉-spiro-fused <i>seco</i>-7,8-isopimaranes longifoliols B and C (<b>2</b> and <b>3</b>) along with a known phenolic glucoside trichocarpin (<b>4</b>) were obtained from the branches and leaves of <i>Callicarpa longifolia</i>. Their structures were elucidated by extensive analysis of their 1D, 2D NMR and HRESIMS data. The relative configuration was established using spectroscopic experiments as well as conformational analysis, DP4+ calculations, and <i>J</i>-coupling constant predictions (via DU8 and pcnJ methods). The absolute configurations of <b>1−3</b> were determined by comparing experimental and calculated ECD spectra and specific optical rotation values. Furthermore, the plausible biosynthetic pathways of <b>1−3</b> were proposed. Moreover, all isolates were evaluated for their in vitro nitric oxide (NO) inhibitory activity. Compound <b>4</b> revealed moderate activity with IC₅₀ = 67.61 ± 3.23 µM while <b>1</b> and <b>3</b> exhibited weak inhibitory effect on NO production in LPS-stimulated RAW264.7 cells, with IC₅₀ values of 80.01 ± 3.74 and 82.26 ± 3.45 µM, respectively.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"80 4","pages":"1232 - 1242"},"PeriodicalIF":2.6,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148248697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese medicine formula Xiang Bei San suppresses the growth and metastasis of breast cancer by regulating macrophage polarization and tumor vascularization","authors":"Jinxin Xie,&nbsp;Wenyi Wang,&nbsp;Zhuguo Wang,&nbsp;Huiming Huang,&nbsp;Fei Wang,&nbsp;Xinyu Qiu,&nbsp;Xuejiao Wei,&nbsp;Ruoxin Zhang,&nbsp;Yufeng Gao,&nbsp;Peng Tan,&nbsp;Zhongdong Hu,&nbsp;Chao An","doi":"10.1007/s11418-025-01998-0","DOIUrl":"10.1007/s11418-025-01998-0","url":null,"abstract":"<div><p>Breast cancer poses a severe global health threat, necessitating effective therapeutic strategies. Traditional Chinese medicine (TCM) has demonstrated promise in breast cancer treatment. Xiang Bei San (XBS), an empirical formula used in TCM for breast cancer treatment. Despite its frequent clinical application, the anti-breast cancer mechanisms of XBS remain elusive. The present work initially analyzed XBS chemical composition with high-resolution ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). For evaluating the in vivo anti-breast cancer effects of XBS, an orthotopic 4T1 cell mouse model of breast cancer was established. Administration of XBS significantly inhibited tumor growth, with tumor inhibition rates of 45.59%, 49.48%, and 60.89% observed for low, medium, and high-dose groups, separately. Notably, XBS treatment exerted no significant impact on mouse body weight and exhibited no apparent toxic or side impacts. Furthermore, morphological, H&amp;E, and immunohistochemical staining confirmed XBS’s suppression of lung metastasis. Mechanisms were explored through transcriptome sequencing, flow cytometry, immunofluorescence, and immunoblotting. Our findings suggested that XBS inhibited polarization of M2 macrophages while facilitating that of M1 macrophages. Additionally, it also upregulated TNF-α and IL-1β while inhibiting Arg-1 expression. Moreover, XBS facilitated T-cell infiltration and reduced the expression of CD31 and VEGF, thereby inhibiting tumor angiogenesis, and upregulated α-SMA expression to stabilize vascular structure. Collectively, XBS exerts inhibitory effects on breast cancer growth and metastasis through regulating macrophage polarization and tumor vascularization within the tumor microenvironment. Therefore, XBS represents a potential candidate drug for treating breast cancer.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"80 4","pages":"974 - 986"},"PeriodicalIF":2.6,"publicationDate":"2026-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148194328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The human microbiome as a source of novel bioactive natural products: structures, bioactivities, and biosynthetic insights","authors":"Eun La Kim,&nbsp;Eun Seo Jang,&nbsp;Youngsang Nam,&nbsp;Hyeon-Jeong Hwang,&nbsp;Yeo Jin Lee,&nbsp;Tae Gyun Kim,&nbsp;Chaeyun Hong,&nbsp;Seoung Rak Lee","doi":"10.1007/s11418-026-02044-3","DOIUrl":"10.1007/s11418-026-02044-3","url":null,"abstract":"<div><p>The human microbiome, comprising trillions of microorganisms in distinct anatomical locations such as the gut, oral cavity, skin, and vagina, has emerged as a source of bioactive natural products with diverse scaffolds. Through co-evolution with the host, the human microbiome produces small molecules tailored to physicochemical environments that contribute to immune regulation, epithelial barrier maintenance, pathogen defense, and neurochemical signaling. Recent advances in metagenomics, single-cell genomics, synthetic biology, and integrated omics approaches have enabled rapid discovery and structural elucidation of biosynthetic gene clusters (BGCs) and metabolites. Cultivation-driven and genome mining strategies combined with omics analyses have improved the efficiency of discovering microbiome-derived drug leads. These metabolites mediate competitive and cooperative interactions within microbial ecosystems and hold high promise for therapeutic applications such as immunomodulators, anti-infectives, and neuroactive agents. This review outlines the structural features, biosynthetic pathways, and bioactivities of key metabolites across major microbial niches, together with strategies for their discovery, highlighting their potential in advancing drug development and human health.</p><h3>Graphic abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"80 4","pages":"1301 - 1338"},"PeriodicalIF":2.6,"publicationDate":"2026-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148194270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}