Preventive and therapeutic effects of ephedrine alkaloids-free Ephedra Herb extract on paclitaxel-induced neuropathic pain.

IF 2.5 4区 医学 Q3 CHEMISTRY, MEDICINAL
Xuedan Huang, Sumiko Hyuga, Michiho Ito, Yukihiro Goda, Yoshinori Kobayashi
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Abstract

Currently, there are no effective prophylactic or therapeutic drugs for the treatment of paclitaxel (PTX)-induced peripheral neuropathic pain (PTX-PNP), highlighting the urgent need for the development of effective prophylactic and therapeutic drugs. In this study, we initially compared the efficacy of Ephedra Herb extract (EHE) with that of ephedrine alkaloids-free Ephedra Herb extract (EFE), which lacked ephedrine alkaloids (EAs)-associated side effects, against the onset of PTX-induced mechanical allodynia, thermal hyperalgesia, and cold allodynia in mice. EHE and EFE demonstrated comparable preventive effects on the PTX-PNP in a dose-dependent manner. These results indicated that the preventive properties of EHE were independent of the EAs. Since elderly people are overwhelmingly more susceptible to developing cancer, we considered that EFE has greater benefits than EHE, so we conducted a study focused on the effects of EFE. EFE showed dose-dependent preventive effects on the onset of PTX-PNP. As a result of detailed investigation, coadministration of PTX and EFE (Co-EFE) was more effective than preadministration of EFE alone (Pre-EFE). And the effects of Co-EFE was same with the effect of preadministration of EFE and then coadministration of PTX and EFE (P&C-EFE). Additionally, Co-EFE after the onset of PTX-PNP improved PTX-induced mechanical allodynia, thermal hyperalgesia, and cold allodynia, confirming the therapeutic efficacy of EFE on PTX-PNP. In contrast, goshajinkigan, a Kampo medicine, and diclofenac, a non-steroidal anti-inflammatory drug, showed minimal therapeutic effects on PTX-PNP. These findings demonstrate the significant potential of EFE as a novel, safe prophylactic and therapeutic agent against PTX-PNP.

不含麻黄碱的麻黄草提取物对紫杉醇诱导的神经性疼痛的预防和治疗作用
目前,治疗紫杉醇(PTX)诱导的周围神经病理性疼痛(PTX-PNP)尚无有效的预防或治疗药物,因此迫切需要开发有效的预防和治疗药物。在这项研究中,我们初步比较了麻黄草提取物(EHE)和不含麻黄碱的麻黄草提取物(EFE)对 PTX 诱导的小鼠机械异感、热痛和冷异感的疗效。EHE和EFE对PTX-PNP的预防效果相当,且呈剂量依赖性。这些结果表明,EHE 的预防特性与 EAs 无关。由于老年人是癌症的高发人群,我们认为 EFE 比 EHE 有更大的益处,因此我们对 EFE 的作用进行了重点研究。EFE 对 PTX-PNP 的发病有剂量依赖性的预防作用。经过详细研究,联合使用 PTX 和 EFE(Co-EFE)比单独使用 EFE(Pre-EFE)更有效。联合给药的效果与先给药后联合给药的效果相同。此外,在PTX-PNP开始后联合EFE可改善PTX诱导的机械异感、热痛和冷异感,这证实了EFE对PTX-PNP的疗效。相比之下,康波药物戈沙金刚和非甾体抗炎药双氯芬酸对 PTX-PNP 的治疗效果甚微。这些研究结果表明,EFE 作为一种新型、安全的 PTX-PNP 预防和治疗药物具有巨大的潜力。
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来源期刊
CiteScore
6.90
自引率
3.00%
发文量
79
审稿时长
1.7 months
期刊介绍: The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.
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