杜仲皮提取物通过 TGF-β1/Smad 信号通路缓解腺嘌呤诱导的慢性肾功能衰竭小鼠肾脏纤维化。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2024-10-24 DOI:10.1007/s11418-024-01848-5

Wenyi Jiang, Zhengyou He, Ruijiao Yao, Wenyan Xiao, Zhiyang Chen, Xia Zeng, Miao Zheng, Jing Wang, Jia Li, Yong Jiang

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引用次数: 0

摘要

慢性肾脏病（CKD）是一种以肾脏纤维化和持续炎症为特征的疾病，对草药治疗慢性肾脏病（CKD）的潜在疗效进行研究已成为一种流行趋势。杜仲（Eucommiae cortex，EC）是一种强筋健骨、补肾益肝的重要草药。在这项研究中，C57 BL/6小鼠通过食用含0.2%腺嘌呤的食物来建立慢性肾脏病模型。研究结果表明，补充外源性EC能成功降低肌酐和尿素氮的水平，下调TGF-β1/Smad信号通路中TGF-β1、α-SMA、Smad3和phospho-Smad3的表达水平，并防止肾脏纤维化。因此，可以确定欧共体可能具有保护肾脏的作用。

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Eucommiae cortex extract alleviates renal fibrosis in CKD mice induced by adenine through the TGF-β1/Smad signaling pathway.

Research into the potential therapeutic benefits of herbal remedies for treating chronic kidney disease (CKD), a condition marked by renal fibrosis and persistent inflammation, has become popular. Eucommiae cortex (EC) is a vital herb for strengthening bones and muscles and tonifying the kidneys and liver. In the study, C57 BL/6 mice were given a diet containing 0.2% adenine to create a CKD model. The findings demonstrated that exogenous EC supplementation successfully decreased the levels of creatinine and urea nitrogen, down-regulated the TGF-β1/Smad signaling pathway's expression levels of TGF-β1, α-SMA, Smad3, and phospho-Smad3, and prevented renal fibrosis. Consequently, it was determined that EC might have a nephroprotective impact.

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.