Cathagines A-D, Catharanthus roseus 中新的双吲哚生物碱。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2024-11-14 DOI:10.1007/s11418-024-01857-4

Yusuke Hirasawa, Chiaki Kasagi, Erika Koyama, Hitomi Myojin, Takahiro Tougan, Toshihiro Horii, Nahoko Uchiyama, Toshio Kaneda, Hiroshi Morita

{"title":"Cathagines A-D, Catharanthus roseus 中新的双吲哚生物碱。","authors":"Yusuke Hirasawa, Chiaki Kasagi, Erika Koyama, Hitomi Myojin, Takahiro Tougan, Toshihiro Horii, Nahoko Uchiyama, Toshio Kaneda, Hiroshi Morita","doi":"10.1007/s11418-024-01857-4","DOIUrl":null,"url":null,"abstract":"Four new bisindole alkaloids, cathagines A (1)-D (4) consisting of an aspidosperma and the fused tetracyclic 3-spirooxindole derived from an iboga type skeleton were isolated from the whole plant of Catharanthus roseus. The structures including absolute stereochemistry were elucidated on the basis of 2D NMR data and CD spectra. Cathagine B (2) showed moderate anti-malarial activity against Plasmodium falciparum 3D7.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cathagines A-D, new bisindole alkaloids from Catharanthus roseus.\",\"authors\":\"Yusuke Hirasawa, Chiaki Kasagi, Erika Koyama, Hitomi Myojin, Takahiro Tougan, Toshihiro Horii, Nahoko Uchiyama, Toshio Kaneda, Hiroshi Morita\",\"doi\":\"10.1007/s11418-024-01857-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Four new bisindole alkaloids, cathagines A (1)-D (4) consisting of an aspidosperma and the fused tetracyclic 3-spirooxindole derived from an iboga type skeleton were isolated from the whole plant of Catharanthus roseus. The structures including absolute stereochemistry were elucidated on the basis of 2D NMR data and CD spectra. Cathagine B (2) showed moderate anti-malarial activity against Plasmodium falciparum 3D7.\",\"PeriodicalId\":654,\"journal\":{\"name\":\"Journal of Natural Medicines\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-11-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Natural Medicines\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s11418-024-01857-4\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Medicines","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11418-024-01857-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

摘要

从长春花全株中分离出了四种新的双吲哚生物碱，即由一种表吲哚和融合的四环 3-螺氧吲哚组成的长春花碱 A (1)-D (4)，它们都来自一种伊勃加类型的骨架。根据二维核磁共振数据和 CD 光谱阐明了它们的结构，包括绝对立体化学结构。Cathagine B (2) 对恶性疟原虫 3D7 具有中等抗疟活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Cathagines A-D, new bisindole alkaloids from Catharanthus roseus.

Four new bisindole alkaloids, cathagines A (1)-D (4) consisting of an aspidosperma and the fused tetracyclic 3-spirooxindole derived from an iboga type skeleton were isolated from the whole plant of Catharanthus roseus. The structures including absolute stereochemistry were elucidated on the basis of 2D NMR data and CD spectra. Cathagine B (2) showed moderate anti-malarial activity against Plasmodium falciparum 3D7.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.