从海洋真菌 Didymella aeria 中分离出的芳香族多酮化合物及其神经保护活性。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2024-11-08 DOI:10.1007/s11418-024-01858-3

Hitoshi Kamauchi, Mayu Tanaka, Kakeru Koyama, Yuka Kiba, Masashi Kitamura, Yoshiaki Sugita

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引用次数: 0

摘要

从海洋源真菌 Didymella aeria 中分离出了两种新型芳香族多酮化合物--青霉素 J 和 K（1, 2），以及已知化合物 integrastatin B（3）。新化合物的结构是通过核磁共振光谱和合成方法确定的。对分离出的化合物进行了单胺氧化酶（MAO）B抑制、抗淀粉样蛋白β（Aβ）聚集和保护人神经母细胞瘤SH-SY5Y细胞免受H2O2诱导的细胞死亡的活性测试。Integrastatin B (3) 在抑制 Aβ 聚集和防止 H2O2 诱导的细胞死亡方面显示出潜在的活性。

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Aromatic polyketides isolated from the marine-derived fungus Didymella aeria and their neuroprotective activity.

Two novel aromatic polyketides, penicanesins J and K (1, 2), were isolated from the marine-derived fungus Didymella aeria, along with the known compound integrastatin B (3). The structures of the new compounds were determined by NMR spectroscopy and synthetic methods. The isolated compounds were tested for monoamine oxidase (MAO) B inhibition, anti-amyloid beta (Aβ) aggregation, and protective activity against H₂O₂-induced cell death in human neuroblastoma SH-SY5Y cells. Integrastatin B (3) showed potential activity for inhibition of Aβ aggregation and protection against H₂O₂-induced cell death.

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.