两种新的栲叶丁内酯木脂素二聚体及其抗炎活性。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2024-11-29 DOI:10.1007/s11418-024-01864-5

Ya-Feng Wang, Ping Lin, Nao Pang, Zhang-Bin Liu, Bing-Yuan Yang, Rui-Jie He, Yong-Lin Huang

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引用次数: 0

摘要

蓖麻属（壳斗科）富含植物多酚，常被用作药用植物。本研究从Castanopsis chinensis叶片80%甲醇提取物中分离鉴定了2个新的具有抗炎活性的木脂素二聚体化合物和4个已知化合物。计算化学和广泛的光谱分析支持了结构的确定。两种新的木脂素二聚体化合物在10µM条件下显著抑制lps诱导的RAW 264.7细胞NO生成，且无细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Two novel butyrolactone lignan dimers from leaves of Castanopsis chinensis and their anti-inflammatory activities

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Two novel butyrolactone lignan dimers from leaves of Castanopsis chinensis and their anti-inflammatory activities

Castanopsis genus (Fagaceae) were rich in plant polyphenols and often used as medicinal plants. In this study, two new lignan dimer compounds with anti-inflammatory activity and four known compounds were isolated and identified from 80% methanolic extract of Castanopsis chinensis leaves. The structure determination supported by computational chemistry and extensive spectroscopic analysis. Two new lignan dimer compounds significantly inhibited LPS-induced NO production in RAW 264.7 cells at 10 µM without cytotoxicity.

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.