Journal of Materials Science: Materials in Medicine最新文献

{"title":"Antibacterial and osteogenic effect of EGCG/HAP/AgNPs composite coating on titanium surface","authors":"Jiayi Liao,&nbsp;Zhihua Li","doi":"10.1007/s10856-026-07083-6","DOIUrl":"10.1007/s10856-026-07083-6","url":null,"abstract":"<div><p>Titanium implants are widely used in dental applications; however, their clinical application is still limited by challenges such as bacterial infection and poor osseointegration. In this study, a composite coating consisting of epigallocatechin-3-gallate (EGCG), hydroxyapatite (HAP), and silver nanoparticles (AgNPs) was fabricated on the titanium surface to improve its antibacterial activity and osteogenic potential. The coating was prepared via alkali-thermal treatment, followed by EGCG adhesion and subsequent deposition of HAP and AgNPs. Surface characterization confirmed successful construction of the coating with improved hydrophilicity. The EGCG/HAP/AgNPs coating showed gradual changes in surface morphology and elemental composition after PBS immersion, suggesting partial coating degradation while retaining detectable residual Ag, Ca, and P on the titanium surface. The coating also exhibited effective antibacterial activity against <i>Staphylococcus aureus</i> and significantly promoted osteogenic differentiation of MC3T3-E1 cells, as evidenced by enhanced alkaline phosphatase activity and mineralized nodule formation. These results demonstrate that the EGCG/HAP/AgNPs composite coating possesses good antibacterial capacity, osteogenic activity, and biocompatibility, showing great potential for improving the clinical performance of titanium implants.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13429548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148100807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydration as a governing state variable in the mechanical and electrical response of decellularized extracellular matrix materials","authors":"Xinyu Wang,&nbsp;Dawei Zhang,&nbsp;Maryam Hamed Al Jabri,&nbsp;Vincent Chan,&nbsp;Lianxi Zheng,&nbsp;Kin Liao,&nbsp;Peter R. Corridon","doi":"10.1007/s10856-026-07075-6","DOIUrl":"10.1007/s10856-026-07075-6","url":null,"abstract":"<div><p>Decellularized extracellular matrix (dECM) materials derived from biological tissues continue to attract interest as sustainable biomaterials; however, their measured mechanical and electrical responses are highly sensitive to processing history and hydration state. While decellularization and subsequent lyophilization are widely employed to enable storage and handling, the role of hydration in governing experimentally measured dECM behavior remains insufficiently resolved. Here, hydration is examined as a governing state variable influencing the mechanical and electrical responses of dECM materials derived from ovine aortic tissue obtained from abattoir-sourced byproducts. Native, decellularized-lyophilized, and rehydrated samples were evaluated using uniaxial tensile testing, stress-relaxation analysis in circumferential and longitudinal orientations, and direct-current open-circuit potential (DC-OCP) measurements under defined testing conditions. Rehydration induced pronounced changes in early-strain stiffness, viscoelastic relaxation behavior, and electrical signal magnitude, indicating that water content and ionic environment dominate measured dECM responses. Comparable hydration-dependent trends were also observed in structurally distinct dECM tissues, supporting hydration state as a general materials variable rather than a tissue-specific effect. Importantly, the observed responses are interpreted as system-level interactions between dECM and its hydration environment, rather than recovery of native tissue properties. Collectively, these findings emphasize the need to explicitly control and report hydration conditions in dECM characterization and support a materials-centric framework for evaluating mechanical and electrical behavior in decellularized biomaterials.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13433499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148100798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiseptic chitosan acetate-chlorhexidine spray for wound cleaning","authors":"Lokitha Paduvetnaya,&nbsp;Joel Maria Joju,&nbsp;Tanushree Suresh,&nbsp;Anjana Ajithkumar,&nbsp;Harishkumar Madhyastha,&nbsp;Jayakumar Rangasamy","doi":"10.1007/s10856-026-07084-5","DOIUrl":"10.1007/s10856-026-07084-5","url":null,"abstract":"<div><p>The presence of microbial biofilms in acute and chronic wound infections creates a significant dermal complication as these biofilms interfere with wound healing and complicate the regenerative process. Effective cleaning of wound bed remains essential because it eliminates necrotic materials, biofilms, and contaminants leading to faster treatment and decreased secondary infections. A novel antiseptic spray formulation using chitosan acetate (CA) and chlorhexidine (CHX) was developed aiming infection control. In the present study, an antiseptic CA-CHX spray, with poly (vinyl alcohol) (PVA) as the film-forming agent was formulated. FTIR studies confirmed the incorporation of CHX in the CA-CHX spray. FESEM images showed spherical shape of the particles with an average size of 1μm. The CA-CHX spray exhibited excellent spraying ability, remarkable film-forming property and stability across different temperature ranges. In vitro antibacterial and anti-biofilm activity was studied against <i>Escherichia coli, Staphylococcus aureus</i>, and MRSA. In vivo fly infection model using wild-type <i>Drosophila melanogaster</i> further proved antibacterial property of the CA-CHX spray against these bacteria. To understand the cytotoxicity effect of CA and CA-CHX spray, cell viability study was conducted against the L929 cells. These research findings demonstrated that the developed antiseptic CA-CHX spray could be effectively used for wound cleaning.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07084-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148051910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemocompatibility and cytotoxicity evaluation of additively manufactured and surface-treated 316 L stainless steel aortic stents using laser powder bed fusion (L-PBF)","authors":"Philipp Lulla,&nbsp;Lukas Esper,&nbsp;Ulf Noster,&nbsp;Thomas Schratzenstaller,&nbsp;Christof Schmid,&nbsp;Karla Lehle","doi":"10.1007/s10856-026-07073-8","DOIUrl":"10.1007/s10856-026-07073-8","url":null,"abstract":"<div><p>New developments are needed in aortic replacement, with current hybrid solutions suffering from insufficient and rigid stent diameters, thus hindering minimization of false lumen in aortic dissection. Laser powder bed fusion (L-PBF) is an attractive method to generate a new-generation aortic stent. This study investigates the effects of 316 L stainless steel samples manufactured using the L-PBF process on the activity of fibroblasts, red blood cells, leukocytes and platelets on the modified surfaces. Cytotoxicity and hemocompatibility were analyzed under static culture conditions using immunofluorescence as well as scanning electron microscopic (SEM) techniques. Surfaces of additively manufactured samples were etched, electropolished, heat‑treated, and mechanically expanded to optimize the material’s mechanical performance. Alone heat treatment increased the ultimate tensile strength from 585 ± 5 MPa to 695 ± 6 MPa. The additive manufactured and post-processed stents were non-cytotoxic (viability, &gt; 70%, independent of the manufacturing status), non-hemolytic (hemolysis rate, &lt; 1%), and were covered with only a few neutrophils (median (IQR), 25 (12-48) per mm²) and platelets (cellular coverage, 0.5 - 10%). Material-induced formation of neutrophil extracellular traps (NETs) was low and not quantifiable. More than 80% of adherent platelets presented an activated conformation and increased expression of CD62P. In contrast, neither circulating leukocytes nor platelets in the supernatant showed any material-induced stimulation as detected via flow cytometry. The results described herein are encouraging and suggest that additive manufactured metallic stents are bio- and hemocompatible and an adequate candidate material for personalized stent production in a very short time.</p><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13216169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional hydrogel biomaterials for urological diagnosis and treatment—design strategies and application progress: a review","authors":"Kuntai Li,&nbsp;Huichong Yu","doi":"10.1007/s10856-026-07068-5","DOIUrl":"10.1007/s10856-026-07068-5","url":null,"abstract":"<div><p>In urology, the treatment of diseases such as bladder cancer, urethral stricture, and benign prostatic hyperplasia faces challenges such as short drug retention time, unstable therapeutic effects, and drug resistance. Traditional treatments, such as surgery, systemic drug therapy, and local drug instillation, although controlling the condition to some extent, still have many limitations, necessitating new localized treatment and precise diagnostic strategies. Hydrogels have made significant progress in urology, especially in the fields of drug delivery, disease diagnosis, and tissue repair. The biocompatibility, tunable physicochemical properties, and highly hydrated three-dimensional network structure of hydrogels give them broad application potential in the treatment of the urinary system. This narrative review highlights representative studies on hydrogel applications in anti-infection, anti-fibrosis, tissue repair, and cancer treatment, and discusses the composition, design strategies, and functional development of hydrogels. By analyzing material characteristics, response mechanisms, and therapeutic strategies, this article aims to provide guidance for future clinical applications of hydrogels in urology and serve as a reference for researchers in related fields.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13388777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial ZnO nanoparticle embedded polycaprolactone—polyhydroxybutyrate membranes for wound healing","authors":"Samanta Sam,&nbsp;Blessy Joseph,&nbsp;Neethu Ninan,&nbsp;Markos Negash Alemie,&nbsp;Krasimir Vasilev,&nbsp;Richard Bright,&nbsp;Sabu Thomas","doi":"10.1007/s10856-026-07071-w","DOIUrl":"10.1007/s10856-026-07071-w","url":null,"abstract":"<div><p>Wound management remains a significant clinical challenge, driving the development of multifunctional biomaterials that combine mechanical integrity, antibacterial activity, and biocompatibility. In this study, polycaprolactone–polyhydroxybutyrate (PCL–PHB) composite membranes incorporating zinc oxide nanoparticles (ZnO NPs) were fabricated via a solvent-casting approach and systematically optimised for wound-healing applications. ZnO NPs were incorporated at varying loadings (0.5–2 wt%), and the resulting membranes were characterised for morphology, chemical structure, crystallinity, surface wettability, mechanical performance, antibacterial efficacy, and cytocompatibility. FTIR, XRD, FESEM, and EDX analyses confirmed successful integration of ZnO nanoparticles within the PCL–PHB matrix, while FESEM observations suggested relatively uniform nanoparticle dispersion at lower ZnO concentrations. Incorporation of ZnO NPs significantly enhanced tensile strength and antibacterial performance, with optimal properties observed at intermediate nanoparticle loadings (1–1.5 wt%). Nanoparticle incorporation enhanced tensile strength from 2.0 MPa for the control membrane to a maximum of 4.8 MPa at 0.5 wt% ZnO loading. Higher ZnO concentrations led to nanoparticle aggregation and a decline in mechanical properties. The composite membranes exhibited pronounced antibacterial activity of about 90% against <i>Staphylococcus aureus</i> and moderate activity against <i>Pseudomonas aeruginosa</i> (32.5%). Importantly, all ZnO-containing membranes demonstrated high cytocompatibility with THP-1 monocyte-derived immune cells, maintaining cell viability above 80% and preserving normal cytoskeletal organisation. These findings highlight the importance of nanoparticle loading optimisation and nanoscale dispersion in the design of multifunctional antibacterial polymer nanocomposites for wound management.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13388433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PLA/hydroxyapatite composite scaffolds fabricated by digital light processing for bone regeneration","authors":"V. J. Garrido Hernández,&nbsp;D. Sánchez Campos,&nbsp;C. Velasco Santos,&nbsp;L. S. Villaseñor-Cerón,&nbsp;R. Villafuerte-Segura,&nbsp;V. Rodríguez Lugo","doi":"10.1007/s10856-026-07079-2","DOIUrl":"10.1007/s10856-026-07079-2","url":null,"abstract":"<div><p>Bone tissue regeneration faces a major challenge: traditional therapies such as autografts and allografts are limited by donor site morbidity, restricted availability, and potential immune rejection. Therefore, there is a pressing need to develop synthetic scaffolds that mimic the extracellular matrix while providing adequate mechanical, morphological, and biological properties to promote osteogenesis and angiogenesis. In this study, polylactic acid/hydroxyapatite (PLA/HAp) scaffolds were designed using Digital Light Processing (DLP) 3D printing technology, strategically integrating HAp nanoparticles (NPs) at concentrations ranging from 0 to 5 wt%. The scaffolds exhibited a biomimetic cylindrical architecture with interconnected square pores of 350 µm and a theoretical porosity of 78% calculated from the CAD models. Finite element analysis (FEM) revealed high structural stability under physiological loads, with maximum displacements of 3.09 × 10⁻² mm and stress levels well below the elastic limit of polylactic acid (PLA). Morphological characterization by scanning electron microscopy (SEM) showed a progressive increase in surface roughness with higher HAp content, without agglomeration, as confirmed by energy dispersive spectroscopy (EDS) mapping. Cell viability studies using 3T3-L1 fibroblasts demonstrated a significant increase in metabolic activity, with the M4 (4%) and M5 (5%) samples reaching viabilities of 79.8% and 86.1%, respectively, classifying them as highly biocompatible according to ISO 10993-5. These results demonstrate that DLP printing enables the synthesis and design of PLA/HAp cellular scaffolds with precise geometry, excellent mechanical performance, and tunable bioactive properties, positioning them as a promising alternative for bone tissue engineering.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13388430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface microstructures of tricalcium phosphate regulate the autophagy of osteoclasts through the MAPK/ERK signaling pathway","authors":"Yuchen Yang,&nbsp;Kairui Chen,&nbsp;Huadong Wu,&nbsp;Tao Li,&nbsp;Lihao Wang,&nbsp;Hong Li,&nbsp;Qiang Zhang","doi":"10.1007/s10856-026-07076-5","DOIUrl":"10.1007/s10856-026-07076-5","url":null,"abstract":"<div><p>Ceramics, including tricalcium phosphate (TCP), are widely used in bioengineering medicine due to their biocompatibility and bone conductivity. While calcium phosphate materials can induce bone formation without exogenous factors, the specific physical structures of these materials play a crucial role in their biological effects. Autophagy is involved in osteoclast proliferation, differentiation, and activation, with the MAPK signaling pathway being a key regulator of these processes. This study aimed to explore how the surface microstructures of TCP affect osteoclast function and illustrate the underlying mechanism related to autophagy. Three types of TCP disks with different surface microstructures (TCPc, TCPm, and TCPp) were prepared and characterized using scanning electron microscopy. Mouse mononuclear macrophage RAW264.7 cells were induced to differentiate into osteoclasts and cocultured with the TCP disks. Various experiments, including CCK-8 assays, MDC autophagy staining, quantitative real-time PCR, and Western blot analysis, were conducted to evaluate cell viability, autophagy activity, gene expression, and protein expression related to osteoclast function and the MAPK signaling pathway. The surface microstructures of the TCP disks significantly influenced osteoclast activity. TCPc promoted osteoclast proliferation and survival, while TCPm and TCPp inhibited osteoclast activity. The autophagosomes in the TCPm and TCPp groups were reduced, and the expression of autophagy-related proteins (Atg5, Atg7, LC3A, LC3B, Beclin-1) was lower compared to the TCPc and blank groups. The expression of osteoclast-related genes (TRAP, CTSK) was highest in the blank group, followed by the TCPc group, and lowest in the TCPm and TCPp groups. The phosphorylation levels of ERK, p38, and JNK in the TCP groups were lower than those in the blank group, indicating that TCP surface structures inhibit the MAPK signaling pathway. The study highlights the importance of material surface microstructures in bone tissue formation and suggests potential strategies for regulating bone metabolism through material design.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13388684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of curcumin-integrated starch biomaterials in wound regeneration","authors":"Tilottoma Kargupta,&nbsp;Pooja N,&nbsp;Shreya Shahapur,&nbsp;Bhisham Narayan Singh,&nbsp;Nirmal Mazumder","doi":"10.1007/s10856-026-07082-7","DOIUrl":"10.1007/s10856-026-07082-7","url":null,"abstract":"<div><p>Bioplastics are an eco-friendly alternative to conventional plastics, with potential applications in the biomedical field. Curcumin, a bioactive compound present in <i>Curcuma longa</i>, has antioxidant, anti-inflammatory, and wound healing properties. In this study, potato starch/curcumin biopolymer films were synthesized and evaluated for their mechanical, functional, and biodegradation properties, followed by in vivo wound healing assessment in Wistar albino rats. The incorporation of curcumin increased the film thickness from 0.12 ± 0.01 mm to 0.16 ± 0.02 mm, the tensile strength from 3.25 ± 0.15 MPa to 4.18 ± 0.12 MPa, and the water contact angle from 15.31° ± 0.5° to 68.42° ± 0.8°, indicating enhanced hydrophobicity and mechanical stability. The water solubility decreased from 38.5 ± 1.3% to 24.6 ± 1.1%, whereas the moisture content decreased from 12.3 ± 0.6% to 7.8 ± 0.4%. In vivo studies of excision wounds (15 mm diameter) revealed that, by day 14, curcumin-incorporated films achieved 96.8 ± 1.2% wound closure compared with 82.5 ± 2.1% in untreated controls and 88.4 ± 1.5% with starch-only films. The wound healing performance was comparable to that of the marketed placental extract gel, with no signs of infection. These findings demonstrate that the integration of curcumin significantly improves the mechanical, barrier, and therapeutic properties of starch-based biopolymers, making them promising, cost-effective, and biodegradable wound dressing materials.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13388637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural 2-phenyl chroman flavonoids against Streptococcus mutans: prospects of herbal remedies for dental caries","authors":"Priyabrata Pattanayak,&nbsp;Ananya Pradhan,&nbsp;Sudhansu Sekhar Rout,&nbsp;Gunjan Srivastava","doi":"10.1007/s10856-026-07056-9","DOIUrl":"10.1007/s10856-026-07056-9","url":null,"abstract":"<div><p>Dental caries is a multi-factorial oral infectious disease worldwide. Among the 600 different types of bacteria inhabiting the oral cavity, <i>Streptococcus mutans</i> is considered the most prolific colonizer contributing to dental caries. Although fluorides and broad-spectrum antimicrobials such as chlorhexidine remain the primary approaches for caries treatment, natural flavonoids can serve as helpful alternatives. Although flavonoids are effective against different biofilm-forming pathogens, in the present review, attempts have been made to emphasize the antibiofilm properties of only such flavonoids that are effective against <i>S. mutans</i> mediated biofilm formation, along with their possible mode of action and their future prospective as anticaries agent. Different flavonoids decrease bacterial virulence in the oral cavity by different mechanisms: decreasing biofilm adhesivity and formation, inhibiting sortase A (SrtA), inhibiting glucosyltransferase, etc. Fluorides and chlorohexidine, which show anticaries effects altogether by a different mechanism, can effectively combine with flavonoids in combating dental caries. Although most natural products are devoid of acute toxicity, the toxicity profile following brief exposure of topically applied flavonoids in the oral cavity must be assessed before clinical studies. Furthermore, innovative drug delivery systems could greatly enhance the applicability and utility of these flavonoids. This virulence-selective study will lay the foundation for preclinical and clinical studies to further investigate the potential of these flavonoids as possible anticariogenic drugs.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div><div><p>A schematic representation illustrating the mechanism of formation of biofilms</p></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148004213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}