Journal of Materials Science: Materials in Medicine最新文献

{"title":"Sustained intraocular pressure-lowering effect and biocompatibility of a single subconjunctival administration of hydrogel-encapsulated nano-brinzolamide","authors":"Jiahao Xu,&nbsp;Linyu Long,&nbsp;Xiaoyu Zhou,&nbsp;Xinyue Zhang,&nbsp;Li Liao,&nbsp;Dan Ji,&nbsp;Xuanchu Duan","doi":"10.1007/s10856-025-06896-1","DOIUrl":"10.1007/s10856-025-06896-1","url":null,"abstract":"<div><p>Brinzolamide is a widely used treatment for glaucoma, but its effectiveness relies on at least twice-daily dosing, which can be challenging for patient adherence. To overcome this limitation, we developed an injectable hydrogel-based delivery system designed to maintain therapeutic drug levels with a single administration. This approach aims to simplify treatment and improve clinical outcomes. Brinzolamide-loaded polyethylene glycol poly (lactic-co-glycolic acid) (PEG-PLGA) nanoparticles were encapsulated within a hydrogel synthesized through the crosslinking of oxidized hyaluronic acid (OHA) and carboxymethyl chitosan (CMC). In vitro studies were conducted to assess the nanoparticles’ characterization, release profile, and biocompatibility. In a steroid-induced high intraocular pressure (IOP) mouse model, the efficacy of a single subconjunctival injection in lowering IOP was evaluated. Additionally, both cellular and animal biocompatibility were assessed. The brinzolamide-loaded hydrogel system (Hydrogel@Brz) contained nanoparticles with an average diameter of 40.76 nm, exhibiting a stable size distribution and a spherical morphology. The hydrogel demonstrated excellent injectability, self-healing properties, and a porous structure conducive to nanoparticle encapsulation. In vitro release studies revealed a sustained drug release of 86% over 14 days. No cytotoxicity was observed in human primary trabecular meshwork cells (HTMCs), human Tenon’s capsule fibroblasts (HTFs), or the retinal ganglion cell line R28. In vivo, a single injection led to a prolonged IOP reduction lasting up to 21 days. No signs of drug toxicity were detected in ocular tissue sections, transverse optic nerve sections under transmission electron microscopy, or pathology slides of various organs. The brinzolamide-loaded hydrogel has demonstrated promising potential for sustained drug delivery and effective intraocular pressure reduction while maintaining good biocompatibility. However, further studies in larger animal models and long-term evaluations are needed to confirm its clinical applicability.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06896-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MXenes in the application of diabetic foot: mechanisms, therapeutic implications and future perspectives","authors":"Zhang Mengru,&nbsp;Wu Qinyi,&nbsp;Yao Zimo,&nbsp;Guo Bingqing,&nbsp;Xia Zhongyu,&nbsp;Jianda Xu","doi":"10.1007/s10856-025-06895-2","DOIUrl":"10.1007/s10856-025-06895-2","url":null,"abstract":"<div><p>Diabetic foot represents a significant healthcare challenge, accounting for a substantial portion of diabetes-related hospitalizations and amputations globally. The complexity of diabetic foot management stems from the interplay of poor glycemic control, neuropathy, and peripheral vascular disease, which hinder wound healing processes. The high incidence, recurrence, and amputation rates associated with diabetic foot underscore the urgency for innovative treatment strategies. Recent advancements in nanotechnology, particularly the emergence of MXenes (two-dimensional transition metal carbides and/or nitrides), have shown promising potential in addressing these challenges by offering unique physicochemical and biological properties suitable for various biomedical applications. It is a novel potential strategy for diabetic foot wound healing in the future. This review comprehensively summarizes current knowledge, unique characteristics, and underlying mechanisms of MXenes in the context of diabetic foot management. Additionally, we propose the potential application of MXenes-based therapeutic strategies in diabetes foot. Furthermore, we also provide an overview of their current challenges and the future perspectives in related fields of diabetic wound healing.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06895-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mineralized collagen-enhanced bone cement: A prospective, randomized controlled trial in total knee arthroplasty","authors":"Bin Feng,&nbsp;Zhanqi Wei,&nbsp;Wei Zhu,&nbsp;Yiming Xu,&nbsp;Zeng Li,&nbsp;Xisheng Weng","doi":"10.1007/s10856-025-06893-4","DOIUrl":"10.1007/s10856-025-06893-4","url":null,"abstract":"<div><p>Total knee arthroplasty (TKA) is a common procedure for end-stage osteoarthritis (OA). Traditional polymethylmethacrylate (PMMA) bone cement used in TKA has limitations, including lack of osteointegration and higher modulus than bone. We developed a novel bone cement, mineralized collagen (MC)-PMMA, to address these issues. In a prospective, randomized controlled trial, we compared TKA outcomes using MC-PMMA versus traditional PMMA (T-PMMA) in 34 patients with bilateral late-stage osteoarthritis. Evaluated parameters included patient-reported outcome measures (PROMs), knee range of motion, pain scores, complications, and radiographic evaluations over a 45.8-month follow-up. The MC-PMMA group showed significantly improved Knee Society function scores at one-year follow-up. No significant differences were found between groups in other PROMs, knee range of motion, or pain scores. Radiographic evaluations revealed no differences in postoperative Hip-Knee-Ankle (HKA) angle, anatomical axis angle, or radiolucent lines. Complication rates were similar, with no infections, aseptic loosening, peri-prosthetic fractures, or revisions. MC-PMMA is a promising biomaterial for TKA, offering comparable safety and mid-term clinical outcomes to T-PMMA. Its use may lead to earlier functional recovery, highlighting the potential of nanomaterials in orthopedic applications. <b>Trial registration number:</b> ChiCTR1800014811 (02/07/2018).</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06893-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vitro study of the wear behavior of telescopic crowns made of CoCr, zirconia or PEEK","authors":"PC. Pott,&nbsp;N. v. Maltzahn,&nbsp;C. Brachmann,&nbsp;M. Stiesch,&nbsp;P. Kohorst","doi":"10.1007/s10856-025-06891-6","DOIUrl":"10.1007/s10856-025-06891-6","url":null,"abstract":"<div><p>Purpose: Double-crown-retained dentures (DCRD) are an established treatment in dentistry. In some cases, the retention between primary crown (PC) and secondary crown (SC) loosens due to wear during daily handling of the denture. The aim of the present study was to examine modern materials for PCs and SCs with regard to their wear behavior. Materials and Methods: Cyclic pull-off tests were conducted on each 40 specimens in five test groups. PCs made of CoCr, PEEK and ZrO₂ were cemented onto a prepared resin tooth. SCs were made of the same materials and combined to the following PC-SC combinations: CoCr-CoCr, CoCr-PEEK, PEEK-PEEK, ZrO₂-PEEK, ZrO₂-ZrO₂. The wear areas on the contact surfaces between the PCs and the SCs were examined on SEM images. Results: Wear marks in form of scratches, chipping, ductile deformation or combinations of these forms were observed on the PCs and SCs in the various material combinations. The greatest wear on PCs was observed in the PEEK-PEEK group, while the greatest wear on SCs was observed in the ZrO₂-ZrO₂ group. The least wear was observed on SCs made of PEEK in combination with PCs made of ZrO₂. Conclusion: When using modern materials for DCRDs, the combination of different materials for PCs and SCs must be taken into account. The data found in this study show that only minor wear occurs at SCs made of PEEK, especially in combination with PCs made of ZrO₂. Therefore, this combination seems particularly suitable for increasing the longevity of DCRDs.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06891-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in hydrogel research: a 25-year bibliometric overview","authors":"Dongbin Zhang,&nbsp;Mengru Qiu,&nbsp;Yu Tian,&nbsp;Shuo Zhang,&nbsp;Fan Wu","doi":"10.1007/s10856-025-06887-2","DOIUrl":"10.1007/s10856-025-06887-2","url":null,"abstract":"<div><p>This study presents a comprehensive bibliometric analysis of hydrogel research from 2000 to 2025, examining 101,291 publications from the OpenAlex database to highlight the field’s evolution, trends, and impact, providing a better landscape of the field. The analysis demonstrates significant growth in the research output, from ~350 publications in 2000 to nearly 11,000 in 2024, with 37% being open access. Publication patterns demonstrate Physical Sciences leading with about 50,000 publications, followed by Life Sciences (~30,000) and Health Sciences (~21,000). The citation analysis emphasizes that 20% of all citations result from the top 1% of papers, demonstrating the concentration of the research impact. The study identifies key research hubs, with China as a leader in the publication (27,931 publications), while the United States maintains the highest citation impact (&gt;1 million citations). Network analysis reveals increasingly complicated international collaborations, particularly between the United States and China. Topic modeling using Latent Dirichlet Allocation identifies 17 distinct research themes, emphasizing the field’s diversification from fundamental material features to advanced applications in the tissue engineering, drug delivery, and regenerative medicine. This analysis provides valuable insights into the dynamic landscape of hydrogel research, highlighting opportunities for future innovation and collaboration.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06887-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic blood compatibility assessment of coronary stents using an innovative pneumatic blood pump to generate physiological flow rates in small sample chambers","authors":"Anne-Sophie Hönicke,&nbsp;Emilia Paz Gross,&nbsp;Simon Beydoun,&nbsp;Felix Pfisterer,&nbsp;Michael Kirschbaum","doi":"10.1007/s10856-025-06882-7","DOIUrl":"10.1007/s10856-025-06882-7","url":null,"abstract":"<div><p>According to ISO 10993-4, shear-dependent processes must be considered in the blood compatibility testing of cardiovascular implants, which demands controlled and physiological flow conditions in the test environment. For very small test objects such as coronary stents with a diameter below 5 mm, this is difficult to achieve, as previous test methods are either unable to represent the required flow velocities in small-lumen sample chambers, or can only do so under high pump shear stress, which in extreme cases can mask the effects of the tiny test objects. In this paper, we present a novel concept for dynamic in vitro models based on pneumatically generated blood flow (<i>AirDrive</i> technology), which can achieve flow rates and velocities up to 450 ml min⁻¹ or 930 mm s⁻¹, respectively. This allows for hemocompatibility testing of coronary stents under physiologically high flow rates without generating major shear stress from the pump mechanism. In an initial feasibility study, single coronary stents with different surface finishes (polished/unpolished) were subjected to flow velocities of up to 560 mm s⁻¹ in a 3.2 mm diameter sample chamber. Blood samples were collected before and after perfusion, and haematological and coagulation markers were analysed. Unpolished stents elicited higher shear-induced blood responses than polished stents. This demonstrates that our experimental setup is highly sensitive and enables precise and robust investigation of blood compatibility under physiologically relevant flow conditions, even for the smallest objects under investigation. To show the superiority of this novel model in creating high flow rates while maintaining minimal blood damage, the <i>AirDrive</i> system was compared to the commonly used roller pump closed-loop system, with the former exhibiting significantly less blood damage. This further confirms that the <i>AirDrive</i> technology we present in this paper is of the highest value for developmental or regulatory testing of blood compatibility of small- and medium-sized test objects.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06882-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CA1 induced dental follicle stem cells co-culture with dental pulp stem cells and loaded three-dimensional printed PCL/β-TCP scaffold: a novel strategy for alveolar cleft bone regeneration","authors":"Hao-Ran Zhao,&nbsp;Jin-Ze Zhao,&nbsp;Ning Zhao,&nbsp;Ling-Fa Xue,&nbsp;Yao-Xiang Xu,&nbsp;Jin Yue,&nbsp;Wen-Lin Xiao","doi":"10.1007/s10856-025-06889-0","DOIUrl":"10.1007/s10856-025-06889-0","url":null,"abstract":"<div><h3>Background</h3><p>Bone tissue engineering for alveolar clefts is in the early stages of development, and more research is needed to determine the optimal cell types, growth factors and delivery methods for the therapy.</p><h3>Methods</h3><p>We co-cultured Carbonic anhydrase 1 (CA1) induced dental follicle stem cells (DFSCs) with dental pulp stem cells (DPSCs). In vitro, the Lentivirus vector overexpressing CA1 (LV-CA1) gene was constructed, transfected into DFSCs, and co-cultured with DPSCs indirectly. Osteoblast biomarkers in differentiated DFSCs were detected using quantitative real-time polymerase chain reaction and Western blotting. In vivo, establish a rat alveolar cleft model, transplanted stem cell Polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) three-dimensional printed composite scaffold and samples were collected at 4 and 8 weeks postoperatively. The osteogenic effect was evaluated through micro computed tomography and histomorphometric analysis.</p><h3>Results</h3><p>In vitro, the activity of DFSCs in the LV-CA1+Co-culture group was increased, and the mRNA and protein expressions of CA1, Alkaline phosphatase (ALP), Bone morphogenetic proteins 2 (BMP2), and Runt-related transcription factor 2 (RUNX2) were amplified to varying degrees <i>(P</i> &lt; 0.05<i>)</i>. In vivo, micro-CT displayed at 4 and 8 weeks postoperatively, the LV-CA1+Co-culture group had a considerably higher percentage of new bone development (39.1% and 56.9%) (<i>P</i> &lt; 0.05) than the other two groups. Histomorphometric analysis displayed the LV-CA1+Co-culture group had more newly formed bone trabeculae and immature collagen.</p><h3>Conclusion</h3><p>A strategy based on a novel osteogenic gene CA1 and dental-derived mesenchymal stem cells co-culture is applied to the alveolar cleft, providing a novel idea for the application of bone tissue engineering in alveolar cleft bone grafting.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06889-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological applications on a novel composite hydrogel containing mesoporous silica nanoparticles loaded with insulin-like growth Factor-1 and Vancomycin","authors":"Haiyong Ren,&nbsp;Qiaofeng Guo,&nbsp;Bingyuan Lin,&nbsp;Yiyang Liu,&nbsp;Xiang Wang,&nbsp;Kai Huang,&nbsp;Kaiting Wu","doi":"10.1007/s10856-025-06884-5","DOIUrl":"10.1007/s10856-025-06884-5","url":null,"abstract":"<div><p>Polymer nanocomposites have prolific applications in the environmental and health domain. Healthcare workers have constantly faced a challenge in constructing an effective sustained-release system for drugs, especially in areas where it is difficult to follow traditional treatment guidelines. To achieve a dual sustained release of vancomycin and cell growth factors, we designed a composite hydrogel, which was polymerized under ultraviolet irradiation to form a methacrylate gelatin (GelMA)/polyethylene glycol diacrylate (PEGDA) cross-linked system. The hydrogel showed antibacterial and pro-osteogenic differentiation activities by blending it with vancomycin and insulin-like growth factor 1 (IGF-1)-loaded silica particles. The experimental results showed that with increased PEGDA concentration, the hydrogels were degraded by swelling with a longer sustained release time. After 144-h immersion, the hydrogel still showed sustained release of IGF-1. The antibacterial experiment showed that the hydrogel pair had an obvious antibacterial effect against S. aureus. The results of live/dead staining and Cell Counting kit-8 assay indicated excellent biocompatibility of the hydrogel. Alizarin Red staining (ARS) further demonstrated that this hydrogel could induce bone marrow stem cells to initiate osteogenic differentiation. This hydrogel material exhibited excellent antibacterial and pro-osteogenic differentiation properties and might be promising for chronic osteomyelitis treatment.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06884-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of structural, optical, and thermal properties in MoS2 based nanocomposites into cancer therapy","authors":"Afsaneh Abareshi,&nbsp;Mohammad Mahdi Shahidi,&nbsp;Nasrin Salehi","doi":"10.1007/s10856-025-06883-6","DOIUrl":"10.1007/s10856-025-06883-6","url":null,"abstract":"<div><p>The objective of the present study is to evaluate the potential of novel molybdenum disulfide (MoS₂)-based nanocomposites for photothermal therapy. For this purpose, MoS₂-CuS (MoCS) and MoS₂-AuNR (MoAu) nanocomposites were synthesized by physically mixing MoS₂ suspensions with CuS and AuNRs, respectively. The structural and optical properties of these nanocomposites were characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), ultraviolet-visible (UV–Vis) spectroscopy, and Fourier transform infrared (FTIR) spectroscopy. The photothermal performance of the nanocomposites was assessed under near-infrared (NIR) radiation at a power density of 1 W/cm² for 10 min. The results demonstrated that both MoCS and MoAu nanocomposites exhibited enhanced photothermal heating compared to their individual components. Furthermore, the MoAu nanocomposite generated higher photothermal heat than the MoCS nanocomposite. These findings suggest that the MoCS and MoAu nanocomposites have strong potential as novel photothermal agents for cancer therapy.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06883-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New electrical method for obtaining graphic information on the evaluation of the uniformity of ZrO2-3 mol% and Y2O3 coatings deposited by electrophoresis. Application in protection and finishing of dental parts","authors":"Jesús M. Rodríguez-Rego,&nbsp;Antonio Macías-García,&nbsp;Laura Mendoza-Cerezo,&nbsp;Antonio Díaz-Parralejo,&nbsp;Alfonso C. Marco-Romero","doi":"10.1007/s10856-025-06876-5","DOIUrl":"10.1007/s10856-025-06876-5","url":null,"abstract":"<div><p>In recent years, the use of ceramic coatings has increased in industrial applications, using techniques such as immersion and electrophoretic deposition (EPD). High conductivity electrodes and metallic substrates, such as austenitic stainless steels, are crucial for uniform deposition, especially in the chemical and biomedical industries. ZrO₂-3mol% Y2O3 ceramic solutions serve as precursors in the fabrication of functional materials such as solid oxide fuel cells and biomedical applications. This work presents a novel electrical method to evaluate the homogeneity and uniformity of ceramic coatings on metallic specimens. The method is based on the application of an alternating current in a frequency range between 10 Hz and 10 MHz, measuring the impedance at 16 equidistant points. The impedance is decomposed into its real and imaginary components, and a map of the coating surface is generated, which allows the uniformity of the coating to be accurately assessed. To evaluate the results, the ZrO2-3mol% Y2O3 solution, the AISI 310 stainless steel metal substrate and the substrates coated (at different concentrations, for different times and current densities) and sintered at different temperatures were characterised. It was observed that the ZrO₂-3mol% Y₂O₃ solution at the following conditions (42.9 g-L^-1, 20 min, 1.5 A-cm^-2, 500 °C) presented the highest uniformity and homogeneity. In view of all the results, the proposed electrical method confirmed the uniformity and homogeneity of the coated surface from the capacitance values and their representation on a surface map. It is presented as a simple, inexpensive and non-destructive technique that provides information on the accuracy and sensitivity of the coating thickness and opens up its application to different industrial sectors. It also has great potential to revolutionise the field of medicine, offering more durable, biocompatible and efficient implantable devices.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06876-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}