Journal of Materials Science: Materials in Medicine最新文献

{"title":"Molecular dynamics simulation of polymerization kinetics, dimensional stability, and in silico toxicity of nextgeneration silicone impression materials in dentistry.","authors":"Ravinder S Saini, Doni Dermawan, Abdullah Hasan A Alshehri, Rayan Ibrahim H Binduhayyim, Rajesh Vyas, Abdulkhaliq Ali F Alshadidi, Lujain Ibrahim N Aldosari, Masroor Ahmed Kanji, Mario Alberto Alarcón-Sánchez, Artak Heboyan","doi":"10.1007/s10856-025-06944-w","DOIUrl":"10.1007/s10856-025-06944-w","url":null,"abstract":"<p><p>This study evaluates how next-generation silicone impression materials intended for dental use behave during polymerization, as well as their dimensional stability, mechanical properties, degradation patterns, and in silico toxicity levels. Silicone materials are preferred for dental applications because of their outstanding mechanical properties and compatibility with biological tissues. The performance of these materials is susceptible to environmental conditions including temperature changes, humidity levels, and exposure to oral fluids. Patient safety requires evaluation of degradation product toxicity concerns. It is crucial to examine these properties at the molecular level to enhance material durability and safety during clinical use. The structural, mechanical, and stability properties of silicone materials were modeled through molecular dynamics (MD) simulations using BIOVIA Materials Studio 2020. Material characterization and evaluation of mechanical properties were performed with the Forcite module using the COMPASSIII force field. The study simulated polymerization dynamics to understand the reaction mechanisms while employing the Kinetix and DMol3 modules to analyze dimensional stability under various environmental stresses. The CASTEP and DMol3 modules, along with the OSIRIS DataWarrior, were employed to forecast degradation pathways and potential toxicity. The combination of an elastic modulus of 2.533 GPa and tensile strength of 5.387 MPa allows Polydimethylsiloxane (PDMS) to show superior flexibility and rigidity, which qualifies it as the best choice for dental impression materials. Methacryloxypropyltrimethoxysilane (3.248 GPa) and hexaphenylcyclotrisiloxane (3.017 GPa) exhibited enhanced stiffness, suggesting their usefulness in load-bearing scenarios. In silico toxicity predictions indicated that most silicone derivatives demonstrated acceptable biocompatibility, although some silane compounds showed potential risks requiring further experimental validation. Under simulated conditions, the materials maintained stable configurations and exhibited positive polymerization dynamics, indicating that they could provide high durability along with dimensional stability for dental usage. This study highlights the superior balance of flexibility, rigidity, and safety exhibited by PDMS, while also identifying Methacryloxypropyltrimethoxysilane and hexaphenylcyclotrisiloxane as candidates for specialized load-bearing dental applications. Promising in silico findings require experimental validation and clinical testing to establish their practical applications.</p>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":"73"},"PeriodicalIF":4.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel synthesis of Al2O3 short fibers/Ti-12Mo-6Zr composites for cranial reconstruction applications: spark plasma sintering, microstructure and nanomechanical properties","authors":"Walid M. Daoush,&nbsp;Fawad Inam,&nbsp;Hee S. Park,&nbsp;Byung K. Lim,&nbsp;Soon H. Hong","doi":"10.1007/s10856-025-06919-x","DOIUrl":"10.1007/s10856-025-06919-x","url":null,"abstract":"<div><p>Ceramic-Titanium matrix composites have recently attracted significant interest as a new type of biomaterials protecting the brain from external force and infections of cranial defects due to its biocompatibility and good mechanical and corrosion properties matched with the bone tissue. Spark plasma sintering (SPS) is one of powder technology techniques that can be utilised in the fabrication of final net complex and irregular shape parts used for cranial reconstruction and maxillofacial trauma by reconstruction and cranioplasty. The present work studies the effect of alumina (Al₂O₃) short fibers reinforcement addition on the nanomechanical properties estimated by the nanoindentation measurements of the Ti-12Mo-6Zr and its correlation with the microstructure. Al₂O₃ short fibers/Ti-12Mo-6Zr of different Al₂O₃ reinforcement short fibers content up to 5 wt.% were fabricated by Spark Plasma Sintering technique. Powders of Ti, Mo, and Zr powders were mechanically wet milled with different wt.% of Al₂O₃ reinforced short fibers. The mechanically mixed Al₂O₃ short fibers/Ti-12Mo-6Zr samples of different compositions were consolidated by SPS at 1000 ^oC for 5 min under vacuum and 50 Mpa compaction pressure. Optical microscopy (OM), high-resolution scanning electronic microscopy (HRSEM) conducted with Electron dispersive spectroscopy (EDAX) unite and X-Ray Diffraction (XRD) are used to evaluate the particle size and shape, surface morphology, microstructure, the chemical compositions and the phase identifications for the investigated samples. The samples were determined by the rule of mixture (ROM) as well as the Archimedes’ principle. The nanomechanical properties were estimated by measuring the nanoindentation of the produced Al₂O₃ short fibers/Ti-12Mo-6Zr sintered samples using a Berkovich indenter with continuous stiffness measurement (CSM) method. The hardness and the Young modulus were estimated from the obtained data of the applied load-displacement in the depth curves. The obtained Al₂O₃ short fibers/Ti-12Mo-6Zr composites have good mechanical properties which revealed the efficiency of the sintering process by spark plasma sintering. Also, the estimated hardness and Young’s modulus are increased by increasing the content of the Al₂O₃ reinforcement nanoparticles from 1 to 5 wt.% in the Ti-12Mo-6Zr metal matrix. Based on our findings of the nanoindentation studies; it was expected that the produced Al₂O₃ short fibers/Ti-12Mo-6Zr new composites have appropriate physical and mechanical properties for cranial reconstruction applications.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06919-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro experimental study of MC-PMMA containing vancomycin for the prevention of infection in open bone defects","authors":"Haitao Liu,&nbsp;Yu Bo,&nbsp;Pengcheng Gao,&nbsp;Zhizhong Li,&nbsp;Shaodong Qiu,&nbsp;Gangning Feng,&nbsp;Zongqiang Yang,&nbsp;He Zhang,&nbsp;Zhanhu Mi","doi":"10.1007/s10856-025-06912-4","DOIUrl":"10.1007/s10856-025-06912-4","url":null,"abstract":"<div><p>In this study, vancomycin, bone cement (PMMA) and mineralized collagen (MC) were mixed in order to obtain a new composite drug-carrying biomaterial, which has good results in both drug slow release, good biocompatibility, and good growth of osteoblasts, osteoclasts, and mesenchymal stem cells on the surface of the biomaterial, which provides a new therapeutic idea for the clinical treatment of bone defect infections. In this study, the drug retardation system of vancomycin and mineralized collagen composite bone cement-carrying biomaterials was prepared in proportion to the drug retardation system, and the experimental studies were carried out using electron microscope scanning, HPLC drug retardation analysis, in vitro antimicrobials, and co-cultivation of osteoclasts, osteoblasts, and mesenchymal stem cells. We found that the composite drug-carrying material of vancomycin, bone cement and mineralized collagen had good slow-release effect and antimicrobial properties, and the addition of vancomycin and bone cement to mineralized collagen material had even better drug-release efficiency than that of bone cement plus vancomycin alone. In vitro antimicrobial showed that the composite material has excellent antimicrobial effect against Staphylococcus aureus. Co-culture of osteoblasts, osteoclasts and mesenchymal stem cells with the material showed that the cells were morphologically complete on the surface of the composites with good growth status. Vancomycin, bone cement and mineralized collagen composite drug-carrying biomaterials have excellent slow-release effect and antimicrobial properties with good biocompatibility, which is a new therapeutic idea for the future clinical treatment of bone defect infections.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06912-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo responses of β-tricalcium phosphate–based paste-like artificial bone with antibacterial properties under potentially infectious conditions using a rabbit model","authors":"H. Miyashita,&nbsp;Y. Kamaya,&nbsp;K. Suzuki,&nbsp;S. Kato,&nbsp;S. Morikawa,&nbsp;T. Soma,&nbsp;M. Nasu,&nbsp;K. Munakata,&nbsp;T. Nakagawa,&nbsp;M. Aizawa","doi":"10.1007/s10856-025-06932-0","DOIUrl":"10.1007/s10856-025-06932-0","url":null,"abstract":"<div><p>Calcium-phosphate cement (CPC), a paste-like artificial bone, is a material form that allows minimally invasive treatment. However, CPC is not infection resistant, which may lead to surgical site infections. We recently developed a paste-like organic/inorganic hybrid artificial bone that is compatible with the bone remodeling cycle. In this study, we added silver-loaded tricalcium phosphate, which has antibacterial properties, to the hybrid CPC and fabricated a prototype “antibacterial CPC”. Antibacterial and non-antibacterial CPCs were implanted into a rabbit jaw defect model in which infection could occur, and the in vivo responses were compared. In cement specimens retrieved from rabbit jaws, residual material was observed with the non-antibacterial CPC, whereas with the antibacterial CPC, almost all of the material was resorbed and replaced with host bone. These results suggest that placement of antibacterial CPC in a rabbit jaw bone defect model susceptible to bacterial infection promotes material resorption and bone formation. The antibacterial CPC developed in this study is thus a novel paste artificial bone exhibiting good bioresorption and osteogenic potential in biological hard tissues.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06932-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144920523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the release kinetics of dalbavancin from bone allografts","authors":"Roger Erivan,&nbsp;Nicolas Bourzat,&nbsp;Mouloud Yessaad,&nbsp;Guillaume Villatte,&nbsp;Stéphane descamps,&nbsp;Stéphane Boisgard,&nbsp;Philip Chennell","doi":"10.1007/s10856-025-06930-2","DOIUrl":"10.1007/s10856-025-06930-2","url":null,"abstract":"<div><p>Bone infections are common and difficult to treat, and secondary bone defects, which are often observed, may require a bone allograft. In this case, the surgeon will add antibiotics (usually vancomycin) in direct contact with the bone graft during the procedure, in order to allow in-situ release after implantation in the operating site. Dalbavancin is a novel antibiotic indicated for treating acute bacterial infections resistant to vancomycin. Its modified chemical structure grants it an increased half-life that could modify its release kinetics from the bone allograft. The aim of this study was to determine the release kinetics of dalbavancin from bone grafts after they were immersed in a dalbavancin solution. The study was conducted using a Design of Experiments (DoE) protocol. Decellularized and delipidated allograft bone cubes were preliminarily characterized and put into contact with dalbavancin solutions. The parameters that were studied where the allograft mass, initial dalbavancin concentration and contact time. The samples were then transferred into the release media, which was sampled over time and dalbavancin was quantified using a high pressure liquid chromatography with diode array detector method that was developed for the occasion. Our results showed that on average, dalbavancin was fully released after 5 min for the lower mass bone grafts, but after 60 min for the high mass and high concentration conditions. Contact time had no impact, thus indicating a fast loading process of dalbavancin into the allograft. Although our study revealed the possible benefits of using dalbavancin in bone grafting, an in-vivo study is required to confirm our hypotheses.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06930-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human bone marrow derived stem cell differentiation on 3D printed bioactive glass scaffolds","authors":"Siwei Li,&nbsp;Ali A. Mohammed,&nbsp;Amy Nommeots-Nomm,&nbsp;Xiaomeng Shi,&nbsp;Fadi Barrak,&nbsp;Agathe Heyraud,&nbsp;Julian R. Jones","doi":"10.1007/s10856-025-06918-y","DOIUrl":"10.1007/s10856-025-06918-y","url":null,"abstract":"<div><p>Bioactive glass particles have previously been found to stimulate new bone growth in vivo and have a long clinical track record. The effect of bioactive glasses on human bone marrow derived stromal cells (hBMSCs) has not been clearly ascertained previously. Recently, 3D printed scaffolds of the ICIE16 glass composition (49.46 mol% SiO₂, 36.6 mol% CaO, 6.6 mol% Na₂O, 6.6 mol% K₂O, 1.07 mol% P₂O₅) were found to produce high quality bone ingrowth in vivo in a rabbit model. This composition was chosen because it can be sintered into scaffolds without crystallisation. Here, we cultured hBMSCs on the 3D printed ICIE16 scaffolds to determine whether the scaffolds can support cell growth and osteogenic differentiation in vitro, with and without the presence of osteogenic supplements. This was compared to a control of culture media containing dissolution products of the bioactive glass scaffold. Our hypothesis was that the cells cultured on the scaffolds would undergo more osteogenic differentiation than cells cultured in media containing only the dissolution ions of the scaffolds, even without osteogenic supplements. hBMSCs cultured on ICIE16 scaffolds significantly increased expression of osteogenic differentiation and matrix formation markers, including Runx 2, Col1a1, Osteopontin, Osteocalcin and Alkaline Phosphatase, in comparison to monolayer cultures in basal conditions with bioactive glass dissolution products, at all time points up to 6 weeks. Six weeks was chosen as it is the time scale for bone fracture healing. The presence of osteogenic supplements appeared to have synergetic effects with 3D scaffolds, especially during early stages of osteogenic differentiation (week 2 and 4). By week 6, there was no significant difference in the expression of osteogenic markers by hBMSCs cultured on ICE16 scaffolds with and without osteogenic supplements. These findings support our hypothesis and highlight that the 3D structure and the dissolution of ICIE16 bioactive glass ionic products both independently influence osteogenic differentiation of hBMSCs.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06918-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polydopamine/polyvinyl alcohol/graphene oxide transition layer for enhancing adhesive performance of HA coating on Cf/C composites prepared by hydrothermal electrodeposition/hydrothermal treatment","authors":"Shaoqing Chen,&nbsp;Caiqin Liang,&nbsp;Pengyin Li,&nbsp;Chun Liu,&nbsp;Xierong Zeng,&nbsp;Xinbo Xiong,&nbsp;Xinye Ni","doi":"10.1007/s10856-025-06922-2","DOIUrl":"10.1007/s10856-025-06922-2","url":null,"abstract":"<div><p>Hydroxyapatite (HA) coatings on carbon fiber-reinforced carbon (C_f/C) composites hold promise for orthopedic implants. However, the interface between HA and C_f/C is prone to delamination, limiting its application. To address this, a polydopamine (PDA)-polyvinyl alcohol (PVA)-graphene oxide (GO) transition layer was introduced to reinforce and toughen HA coatings on C_f/C composites (PDA-PVA-GO/C_f/C) via hydrothermal electro-deposition/post-hydrothermal treatment. For comparison, the PDA and PDA/PVA transition layers were also prepared on C_f/C, designated as PDA/C_f/C and PDA-PVA/C_f/C, respectively. The precursor and transformed coatings obtained were monetite and HA. XRD analyses revealed that PDA and PVA infiltrated the monetite lattice without affecting the HA lattice parameters. Remarkably, scratch tests demonstrated that the HA/PVD-PVA-GO coating on C_f/C exhibited a dense configuration and compact interfacial structure, achieving a maximum critical load of 51.5 N, surpassing other reported electrochemically prepared HA coatings. Moreover, scratch tests indicated a more homogeneous scratch pattern with no sudden delamination of the coating from the matrix. In vitro assessments revealed that all HA coatings with the transition layer exhibited enhanced bioactivity and cell compatibility compared with HA alone. In particular, PDA/PVA/GO-C_f/C exhibited the best superior efficacy in promoting the proliferation of mouse embryonic osteoblast precursor (MC3T3-E1) cells and significantly increased Alkaline phosphatase (ALP) production in rat bone marrow mesenchymal stem cells (BMSCs). These findings underscore the potential of PDA-PVA-GO/C_f/C as a promising biomaterial for bone regeneration.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06922-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144880964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of magnesium hydrogels in bone regeneration: a systematic review and meta-analysis","authors":"Zhifeng Chen,&nbsp;Dan Yang,&nbsp;Shan Wang,&nbsp;Chunbo Hao","doi":"10.1007/s10856-025-06881-8","DOIUrl":"10.1007/s10856-025-06881-8","url":null,"abstract":"<div><p>Magnesium, an essential element in human physiology, is predominantly located in bone tissue. Since the early 20th century, magnesium-based biomaterials have demonstrated osteoinductive and angiogenic potential, positioning them as promising candidates for bone regeneration strategies. Hydrogels, composed of crosslinked hydrophilic polymers, provide a three-dimensional microenvironment mimicking the extracellular matrix (ECM), thereby supporting cell adhesion, nutrient diffusion, and controlled release of bioactive ions such as Mg²⁺. Recent advances in material science have enabled the design of multifunctional magnesium-loaded hydrogels that synergistically combine mechanical stability, immunomodulation, and spatiotemporal Mg²⁺ release to address critical-sized bone defects. This review systematically examines hydrogel classifications and elucidates magnesium-mediated biological signaling pathways that drive bone repair. A meta-analysis of 10 studies retrieved from PubMed, Web of Science, Scopus, and Embase was performed to assess the efficacy of magnesium-containing hydrogels in bone repair. The findings demonstrate that magnesium significantly enhances bone repair processes, underscoring its potential as a therapeutic agent for bone defect treatment.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06881-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poloxamer-based hydrogel with EGCG and rhEGF for diabetic foot ulcer treatment","authors":"Ahe Mo Se,&nbsp;Linwei Li,&nbsp;Mengting Yu","doi":"10.1007/s10856-025-06917-z","DOIUrl":"10.1007/s10856-025-06917-z","url":null,"abstract":"<div><p>A thermosensitive hydrogel dressing was developed for the healing of diabetic foot ulcers (DFUs) using <i>Epigallocatechin gallate</i> (EGCG) and recombinant human epidermal growth factor (rhEGF). Hyaluronic acid (HA), poloxamer 407 (P407), and pectin (PE) were used to form the sol-gel transition matrix, which exhibited a sol-to-gel transition around 30 °C. The hydrogel was physiologically stable. Structural and morphological characterization using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) confirmed the efficient incorporation of EGCG and rhEGF in a porous nanoarchitecture. Rheological analysis showed the storage modulus is quite constant over the frequency range (0.01–10 Hz), and compression analysis showed a compressive strength of 40.85 kPa, ensuring mechanical appropriateness for various wound conditions. This hydrogel had a water content of 76.64% and a water vapor transmission rate of 6011.44 g/m²/day, favorable to maintain a moist wound surface. Antibacterial tests showed inhibition rates of 73.53% against <i>Escherichia coli</i> and 75.37% against <i>Staphylococcus aureus</i>. In vitro with RAW 264.7 macrophages and L929 fibroblasts showed &gt;90% cell survival, increased migration with 92.53% wound closure by 48 h, strong antioxidant activity, and considerable decrease in TNF-α and IL-6 (pro-inflammatory cytokines). Combining a natural antioxidant and bioactive protein within a responsive hydrogel matrix presented a synergistic solution, holding significant promise for enhancing diabetic wound healing by antimicrobial, anti-inflammatory, and regenerative processes.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div><div><p>The fabrication of the EGCG-rhEGF@HA-P407-PE hydrogel, an advanced wound dressing designed for diabetic foot ulcers</p></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06917-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of La2Sn2O7, Mg2SnO4, and MgSn(OH)6 and their antiviral/antibacterial activities","authors":"Ryuju Kiribayashi,&nbsp;Kayano Sunada,&nbsp;Yasuhide Mochizuki,&nbsp;Toshihiro Isobe,&nbsp;Keiichi Kobayashi,&nbsp;Takeshi Nagai,&nbsp;Hitoshi Ishiguro,&nbsp;Akira Nakajima","doi":"10.1007/s10856-025-06921-3","DOIUrl":"10.1007/s10856-025-06921-3","url":null,"abstract":"<div><p>In order to develop inorganic antibacterial and antiviral materials that function in the dark, we synthesized La₂Sn₂O₇, Mg₂SnO₄, and MgSn(OH)₆, which are compounds of La₂O₃ and MgO, which have solid basicity, and SnO₂, which has the Mars-van Krevelen (MvK) mechanism. After obtaining each sample as a single-phase white powder through hydrothermal or coprecipitation method, their antibacterial and antiviral activities were evaluated with reference to ISO procedures in the dark for bacteria and viruses with different characteristics. The dependence of activity on the evaluation method suggested that, except for Mg₂SnO₄, the proximity or contact of the viruses or bacteria to the sample surface played an important role in activity. Comparison of the activity of each sample with those of the simple oxides of constituent elements, La₂O₃, MgO, and SnO₂, clarified that pH, solid basicity, phosphate affinity, and the MvK mechanism contribute to antibacterial and antiviral activity. The extent of these contributions varied depending on the sample. The study results revealed that La₂Sn₂O₇ not only exhibits high antibacterial and antiviral activity against bacteria and viruses in the dark; it also has the ability to decompose organic dyes under UV irradiation. This material might be used as a newly developed environmental purification material providing continuous antibacterial and antiviral effects day and night, able to clean surfaces during UV light exposure.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}