Journal of Materials Science: Materials in Medicine最新文献

{"title":"Correction to: Thermal annealed silk fibroin membranes for periodontal guided tissue regeneration","authors":"Catarina Geão, Ana R. Costa-Pinto, Cassilda Cunha-Reis, Viviana P. Ribeiro, Sílvia Vieira, Joaquim M. Oliveira, Rui L. Reis, Ana L. Oliveira","doi":"10.1007/s10856-026-07115-1","DOIUrl":"10.1007/s10856-026-07115-1","url":null,"abstract":"","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13627238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aloe vera integrated ZnO/SWCNT/Ag nanocomposites for accelerated wound repair and scar reduction","authors":"Mariam H. Omran,&nbsp;Mohamed Abd Elkodous,&nbsp;Hossam Tohamy,&nbsp;Nourhan G. Naga,&nbsp;Jihad El-Qassas,&nbsp;Samir Nouh,&nbsp;Mahmoud El-Kammar,&nbsp;Howaida Abu-Ahmed,&nbsp;Hoda Elkhenany","doi":"10.1007/s10856-026-07109-z","DOIUrl":"10.1007/s10856-026-07109-z","url":null,"abstract":"<div><p>For centuries, natural extracts such as Aloe vera have been used in wound care due to their soothing, anti-inflammatory, and healing properties. However, their clinical efficacy can be limited by instability, low bioavailability, and restricted antimicrobial potency. Nanotechnology offers promising strategies to enhance and complement the therapeutic benefits of herbal extracts. In this study, we investigated the wound-healing potential of Aloe vera gel combined with ZnO/SWCNT/Ag (zinc oxide-single-walled carbon nanotubes-silver nanoparticles) nanocomposite. Forty full-thickness excisional wounds (15 mm) were created on the dorsum of 20 Sprague Dawley rats and divided into four treatment groups: ZnO/SWCNT/Ag alone (1 mg/mL), Aloe vera gel (30 mg/mL), the combination of Aloe vera gel with the NPs, and control (saline 0.9%). Wound areas were tracked at days 0, 3, 10, 15, and 21 using calibrated imaging, and skin samples were harvested for histopathological analysis. The ZnO/SWCNT/Ag nanocomposite alone accelerated wound closure compared to Aloe vera and saline control, while combining Aloe vera with the nanocomposite improved wound healing compared to Aloe vera alone at day 10 (<i>p</i> &lt; 0.05). Although wound closure was similar across all groups by day 21, nanoparticle-treated wounds showed less variability and more uniform healing. Scar area analysis revealed significant reductions for ZnO/SWCNT/Ag based treatment and the combination compared to Aloe vera (<i>p</i> &lt; 0.05), whereas differences versus saline control were not statistically significant. Additionally, the formulations demonstrated strong antibacterial activity against Escherichia coli and enhanced antioxidant properties. These findings suggest that ZnO/SWCNT/Ag nanoparticles may serve as a supportive platform to enhance the wound-healing behaviour of Aloe vera.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148682977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan-based nano-encapsulation enhances the anti-diabetic efficacy of Eremina desertorum extract by ameliorating hyperglycemia, oxidative stress, and inflammation in diabetic rats","authors":"Sahar Fakhry,&nbsp;Salwa Fouad,&nbsp;Alyaa Farid","doi":"10.1007/s10856-026-07042-1","DOIUrl":"10.1007/s10856-026-07042-1","url":null,"abstract":"<div><p>This study developed a novel <i>Eremina desertorum</i> snail extract (Ere extract) loaded-chitosan nanoparticles (Ere-CS NPs) to enhance the anti-diabetic efficacy of <i>Eremina desertorum</i> snail extract. The nanoparticles, synthesized via ionic gelation, were spherical (~80 nm) and exhibited storage stability when lyophilized, with consistent physicochemical properties upon reconstitution over a 90-day period, high encapsulation efficiency (73.56%) and a sustained, pH-dependent release profile. Biochemical analysis confirmed the successful loading of the extract’s rich profile of amino acids, fatty acids, minerals, and vitamins. In vitro, Ere-CS NPs demonstrated significantly superior antioxidant (scavenging DPPH, H₂O₂, OH^-, O₂⁻), anti-inflammatory (inhibiting erythrocyte hemolysis), and antimicrobial activities compared to the free extract and blank nanoparticles, alongside high biocompatibility. In a streptozotocin-induced diabetic rat model, an 8-week oral treatment with Ere-CS NPs (100 and 200 mg/kg) produced a potent, dose-dependent anti-diabetic effect, outperforming the unencapsulated extract. The nano-formulation effectively normalized hyperglycemia, hypoinsulinemia, and body weight, and reduced serum fructosamine. It also provided significant hepatorenal protection, corrected diabetic dyslipidemia by normalizing hepatic and serum triglycerides, cholesterol, LDL-C, and HDL-C, and markedly alleviated pancreatic oxidative stress by reducing malondialdehyde (MDA) and restoring superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. Concurrently, Ere-CS NPs potently suppressed pancreatic levels of the pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6). These findings demonstrate that chitosan nano-encapsulation robustly enhances the bioavailability and multi-targeted therapeutic potential of <i>Eremina desertorum</i> extract, positioning Ere-CS NPs as a promising comprehensive nanomedicine for managing diabetes and its complications.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07042-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148986332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapamycin-loaded chitosan functionalized poly (lactic-co-glycolic acid) (PLGA) nanoparticles for potential wet age-related macular degeneration treatment: an in vivo study","authors":"Yuan Hu, Lijuan Wei, Haijun Yang, Jianhong Sun, LI Donglei, Qian Liu","doi":"10.1007/s10856-026-07060-z","DOIUrl":"https://doi.org/10.1007/s10856-026-07060-z","url":null,"abstract":"Wet age-related macular degeneration (Wet AMD) is a major cause of vision loss and has been linked to abnormal choroidal neovascularization (CNV). Current therapies require frequent intravitreal injections, which leads to poor patient adherence. Herein, this study was designed to investigate rapamycin-loaded chitosan-coated poly(lactic-co-glycolic acid) nanoparticles, which represent a sustained-release drug delivery system for wet AMD. The Rap@CS/PLGA NPs were synthesized using emulsion solvent evaporation, followed by coating with chitosan. The obtained Rap@CS/PLGA NPs exhibited a size of 265.9 ± 6.30 nm and encapsulation efficiency (EE) of 60.30 ± 1.20%. The drug release profile showed a biphasic pattern with reduced initial burst release (6 ± 0.6%) followed by sustained release (46 ± 4.1%) over 72 h, which indicates improved delivery control. In vitro cytotoxicity on ARPE and HUVEC cells showed minimal toxicity, with more than 85% viability at dosages up to 100 μg/mL. In vivo anti-angiogenic assays using the chick chorioallantoic membrane (CAM) model showed that the Rap@CS/PLGA group (13 ± 3 vessels) significantly reduced the vessel formation vs Rap (26 ± 2 vessels), confirming superior anti-angiogenic effects. Moreover, the laser-induced CNV mouse model, Rap@CS/PLGA NPs, significantly reduced levels of inflammatory cytokine (TNF-α and IL-6) and restored antioxidant enzyme (SOD, CAT). This showed that protection against oxidative stress in CNV-affected tissue promotes angiogenic gene expression (VEGFA, CCL2), while preserving retinal structure. These findings propose that Rap@CS/PLGA NPs can effectively and control drug delivery for wet-AMD with long-lasting efficacy.","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan and chitosan–silver nanoparticles as adjuncts to platelet-rich plasma in canine full-thickness cutaneous wound healing","authors":"Mohab Ragab,&nbsp;Awad Rizk,&nbsp;Zeinab Shouman,&nbsp;Alaa A. Omar,&nbsp;Adel Zaghloul,&nbsp;Marwa Abass","doi":"10.1007/s10856-026-07050-1","DOIUrl":"10.1007/s10856-026-07050-1","url":null,"abstract":"<div><p>Enhancing full-thickness cutaneous wound repair in dogs remains challenging, particularly when infection risk and delayed regeneration are expected. Platelet-rich plasma (PRP) delivers a concentrated pool of growth factors, while chitosan-based nanoparticles—especially silver-functionalized systems—may provide antimicrobial protection and support tissue remodeling. This study evaluated PRP alone or combined with chitosan nanoparticles (PRP/CS NPs) or chitosan-capped silver nanoparticles (PRP/CS/Ag NPs) in experimentally induced full-thickness skin wounds in dogs. Twenty-four healthy male mongrel dogs were randomized into four groups (<i>n</i> = 6): saline control, PRP, PRP/CS NPs, and PRP/CS/Ag NPs. Standardized 2 × 2 cm full-thickness wounds were created surgically and followed for 21 days using clinical wound assessment, wound area and contraction measurements, histopathology, collagen deposition analysis, and immunohistochemical staining for EGF and α-SMA. All treatments significantly reduced wound size and increased contraction versus controls over time (<i>p</i> &lt; 0.001). PRP/CS/Ag NPs achieved the greatest wound size reduction, particularly on days 7, 14, and 21, with a significant difference from controls at day 14 (<i>p</i> &lt; 0.001). PRP promoted higher early collagen deposition (day 7), whereas PRP/CS/Ag NPs induced sustained and significantly greater collagen deposition at days 14 and 21. Immunohistochemistry showed consistently higher EGF expression in the PRP/CS/Ag NPs group across time points, while PRP/CS NPs increased α-SMA expression, consistent with enhanced myofibroblast activity. PRP accelerates early wound repair, while chitosan-based nanoparticles modulate later healing events.PRP combined with PRP/CS/Ag NPs produced the most consistent improvement in wound closure, collagen remodeling, and epithelial regeneration, supporting silver-functionalized chitosan nanoparticles as a promising adjunct to PRP for managing full-thickness cutaneous wounds in dogs.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><img></picture></div><div><p>Schematic overview of the experimental design and main outcomes of canine full-thickness wound healing following treatment with saline, PRP, PRP/CS NPs, and PRP/CS/Ag NPs.</p></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13391740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lansoprazole incorporated β-chitin-lyophilised PRF composite hydrogel for treatment of gastric ulcer","authors":"R. Sri Manjari,&nbsp;Varsha Jayaprakash,&nbsp;Meghna Mohandas,&nbsp;Abhirami Preetha,&nbsp;Tetsuya Furuike,&nbsp;Hiroshi Tamura,&nbsp;Jayakumar Rangasamy","doi":"10.1007/s10856-026-07107-1","DOIUrl":"10.1007/s10856-026-07107-1","url":null,"abstract":"<div><p>A gastric ulcer (GU) that leads to acute or persistent bleeding poses a considerable risk of fatalities. Despite their overall primacy, the current treatments for GU have major downsides of incomplete healing, antibiotic resistance, and secondary injury. To address these challenges, researchers have turned their attention to hydrogels to solve the therapeutic bottleneck of GU treatment. Based on this, we developed a β-chitin (β-ch) hydrogel incorporating Lyophilised Platelet-rich fibrin (L-PRF) with anti-ulcer drug Lansoprazole (Lns). The prepared hydrogel was characterized using FESEM and FT-IR. In vitro studies of all samples showed good controlled swelling behaviour and degradation rate. Incorporation of Lansoprazole (Lns) facilitates healing and promotes and gastric mucosal regeneration, potentially through its acid-suppressive effects, whereas the in vitro drug release study proved the sustained release of Lns from the prepared hydrogel. The in vitro growth factor release study using ELISA revealed a sustained release of TGFα and PDGF BB. The Lansoprazole incorporated hydrogels exhibited good antioxidant activity. Further, β-ch–L-PRF-Lns hydrogel was demonstrated to be biocompatible in nature, and enhanced cell attachment of β-ch –L-PRF-Lns hydrogel was also observed in intestinal cells (INT 407). The INT 407 cells exposed to Lns incorporated β-ch-L-PRF hydrogel showed enhanced cell migration. Therefore, this unique strategy accelerates regenerative processes, making it a possible effective therapeutic alternative for treating GU.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07107-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ATR-FTIR assessment of degree of conversion across curing-state transitions in Bis-EMA- and UDMA-based microfilled dental resins for additive manufacturing","authors":"Frank Alifui-Segbaya","doi":"10.1007/s10856-026-07110-6","DOIUrl":"10.1007/s10856-026-07110-6","url":null,"abstract":"<div><p>Assessing the degree of conversion is important for evaluating processing quality in additively manufactured dental methacrylates. However, the widely used attenuated total reflectance-Fourier transform infrared (ATR-FTIR) method, based on the 1637/1608 cm⁻¹ ratio, may be unstable in contemporary methacrylate systems because of spectral congestion and the formulation-dependent behaviour of the aromatic reference band. This study evaluated a low-variance ATR-FTIR protocol based on a polymerisation-sensitive, ester-associated band pair at 1320/1352 cm⁻¹ to estimate surface or near-surface conversion in two commercially available microfilled dental resins for additive manufacturing, with matrices dominated by ethoxylated bisphenol A dimethacrylate (Bis-EMA) and urethane dimethacrylate (UDMA). The conventional 1637/1608 cm⁻¹ ratio was analysed in parallel as a comparative method. Across the manufacturer-recommended processing stages, from the green state before postcuring to the final postcured state, the 1320/1352 cm⁻¹ model yielded chemically plausible and statistically stable conversion trajectories. In contrast, the conventional aromatic-normalised method showed greater dependence on formulation and workflow, and lower analytical stability. In the UDMA-dominant resin, conversion increased from 68.44% to 91.61% after light postcuring. For the Bis-EMA-dominant resin, the same model revealed a significant processing-stage effect, with a practical plateau near 91% after combined light and thermal treatment. The coefficients of variation for the 1320/1352 cm⁻¹ protocol were low (0.54–5.58%) compared with those of the conventional method (29.13–673.09%), which also yielded nonphysical negative estimates in some groups. Under the conditions tested, these findings support the 1320/1352 cm⁻¹ ATR-FTIR workflow as a practical approach for surface or near-surface characterisation of the two material-workflow systems studied. However, broader validation against orthogonal analytical methods and performance-related outcomes is needed before wider adoption.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13658418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148468231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in biomaterials and technologies applied in craniofacial regeneration","authors":"Farah Asa’ad","doi":"10.1007/s10856-026-07105-3","DOIUrl":"10.1007/s10856-026-07105-3","url":null,"abstract":"","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07105-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148409990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of carminic acid-loaded polymer coated manganese dioxide nanomaterials for apoptosis synergistic chemo/photodynamic therapy for anaplastic thyroid cancer.","authors":"Shao-Jun Cai, Zi-Han Tang, Teng-Hong Liu, Shou-Yi Yan, Meng-Ting Lin, Wen-Xin Zhao, Li-Yong Zhang","doi":"10.1007/s10856-026-07026-1","DOIUrl":"https://doi.org/10.1007/s10856-026-07026-1","url":null,"abstract":"<p><p>Thyroid cancer is a significant worldwide health challenge, requiring sophisticated treatment strategies to minimize off-target side effects. In this study, we developed biodegradable polyethylene glycol (PEG)-coated manganese dioxide (MD) nanomaterials, coupled with carminic acid (CA), for thyroid cancer chemo-photodynamic therapy (PDT). The pH-responsive PMD-CA NMs facilitates effective CA release at acidic pH. PMD-CA NMs enhances the efficiency of chemo-PDT through a synergistic reaction. PXRD examination of PMD-CA NMs confirmed a crystal structure. Surface morphology was validated by TEM and SEM analysis, which revealed a spherical shape. The anticancer efficacy of PMD-CA NMs was evaluated against the SW-1736 anaplastic thyroid cancer cells by an MTT assay. Furthermore, it can prevent the proliferation of SW-1736 cells, regardless of light exposure. The apoptosis induced by the PMD-CA NMs in SW-1736 cells was evidenced using calcein AM and PI staining, as well as Annexin V-FITC staining. Further, we demonstrated that PMD-CA NMs increased ROS levels and depolarized mitochondrial membrane potential (MMP), thereby initiating programmed cell death. The results indicate that the responsive PMD-CA NMs system is a promising strategy for thyroid cancer therapy with less cytotoxicity.</p>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc-polydopamine nanozyme promotes mitochondrial biogenesis and alleviates inflammation and muscle atrophy during the perioperative period of surgery","authors":"Haoran Guo,&nbsp;Ruixing Wan,&nbsp;Qingqing Qin,&nbsp;Wenqiang Liang,&nbsp;Huaibin Zhang,&nbsp;Xin Wang","doi":"10.1007/s10856-026-07080-9","DOIUrl":"10.1007/s10856-026-07080-9","url":null,"abstract":"<div><p>Cisplatin is a commonly used chemotherapeutic agent for the treatment of diverse malignancies; however, its clinical use often results in skeletal muscle atrophy (SMA). Excessive generation of reactive oxygen species (ROS) and persistent unsettled inflammation are significant contributors to cisplatin (CPT)-induced skeletal muscle atrophy (CiSMA). Nanoparticles capable of scavenging ROS and alleviating inflammation may effectively address CiSMA. We developed a straightforward, fast one-step method for fabricating tailored zinc-polydopamine (Zn-PD) nanozymes and confirmed their promising therapeutic agents for CiSMA. Zn-PD, which exhibits diverse enzyme-mimicking capabilities, Zn-PD effectively inhibits ROS-triggered myotube apoptosis, rectifies mitochondrial dysfunction, and enhances mitochondrial biogenesis, demonstrating significant anti-inflammatory effects by obstructing the M1 macrophage infiltration into the muscle milieu, thereby mitigating CiSMA in mice. Collectively, this study proposes a treatment approach for CiSMA and underscores the potential of Zn-PD-based therapies for treating muscle atrophy during the perioperative period of surgery.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07080-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148349966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}