An injectable calcium sulfate-monetite biphasic cement for the treatment of critical-sized calvarial defects

IF 4.5 3区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of Materials Science: Materials in Medicine Pub Date : 2025-07-29 DOI:10.1007/s10856-025-06911-5

Jianzhong Bai, Dachuan Liu, Luguang Ding, Guoping Liu, Jiaying Li, Huan Wang, Li Dong, Chen Cui, Youzhi Hong, Shuangjian He, Song Chen, Hongtao Zhang

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Abstract

The critical bone defect is a common clinical challenge worldwide, characterized by long recovery times, a substantial risk of infection, and high disability rates. There remains a significant demand for synthetic bone-repairing materials to address this issue. In this study, porous monetite was synthesized through the reaction between monocalcium phosphate monohydrate and β-tricalcium phosphate, using paraffin microspheres as pore-forming agents. An injectable biphasic cement was then developed by blending the monetite granules with hemihydrate calcium sulfate, designed for minimally invasive surgical applications. The cement demonstrated excellent biocompatibility and osteogenic properties in vitro. Furthermore, in vivo studies confirmed the cement’s superior bone repair capabilities, indicating its promising potential for the treatment of critical bone defects.

Graphical Abstract

A highly porous composite with gradient degradation was developed by mixing porous monetite granules and hemihydrate calcium sulfate, and the composite has the effect of promoting the formation of new bone.

Abstract Image

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一种可注射硫酸钙-蒙脱石双相骨水泥治疗临界尺寸颅骨缺损。

严重骨缺损是世界范围内常见的临床挑战，其特点是恢复时间长，感染风险大，致残率高。为了解决这个问题，合成骨修复材料的需求仍然很大。本研究以石蜡微球为成孔剂，以一水磷酸一钙和β-磷酸三钙为原料，通过反应合成了多孔的钱铁矿。然后，通过将montite颗粒与半水合硫酸钙混合，开发了一种可注射的双相水泥，用于微创手术应用。体外实验表明该骨水泥具有良好的生物相容性和成骨性能。此外，体内研究证实了骨水泥优越的骨修复能力，表明其在治疗严重骨缺损方面具有广阔的潜力。

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来源期刊

Journal of Materials Science: Materials in Medicine 工程技术-材料科学：生物材料

CiteScore

8.00

自引率

0.00%

发文量

审稿时长

3.5 months

期刊介绍： The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.