Enhanced biological performance of Sr2+-doped nanorods on titanium implants by surface thermal-chemical treatment.

IF 4.2 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Xinrui Dai, Jianghui Zhao, Shengcai Qi, Ping Liu, Wei Li, Ke Zhang, Xiaohong Chen, Fengcang Ma
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Abstract

Titanium alloys, as artificial implants for orthopedic diseases, are prone to aseptic loosening and infection after surgery because their smooth surface restricts the attachment and movement of osteoblasts, resulting in a lack of osteogenic and antimicrobial properties. This study aimed to prepare SrTiO3 nanostructures with varying Sr content on the surface of titanium through a thermal-chemical treatment, enhancing the osteogenic capacity of titanium while providing antibacterial properties. The results indicated that the SrTiO3 nanostructures are primarily composed of pure titanium and SrTiO3 phases, exhibiting a rod-like surface morphology. Sr is uniformly distributed across the surface of the samples, and increasing the Sr content does not alter the morphology of the nanostructures. Wettability tests demonstrated that the SrTiO3 nanostructures exhibited superhydrophilicity, promoting cell adhesion. Electrochemical tests revealed that the SrTiO3 nanostructures prepared on the titanium surface significantly enhanced its corrosion resistance. After 14 days of immersion in simulated body fluids, a significant amount of hydroxyapatite formed on the surface of STN3, indicating that the SrTiO3 nanostructures possess good bioactivity. In vitro antimicrobial tests demonstrated that SrTiO3 nanostructures were effective against both Escherichia coli and Staphylococcus aureus, with the antimicrobial rates increasing alongside the Sr content, reaching 48.1% and 38.6%, respectively.

表面热化学处理增强了Sr2+掺杂纳米棒在钛植入体上的生物性能。
钛合金作为骨科疾病的人工植入物,由于其光滑的表面限制了成骨细胞的附着和运动,导致其缺乏成骨和抗菌性能,术后容易发生无菌性松动和感染。本研究旨在通过热化学处理在钛表面制备不同Sr含量的SrTiO3纳米结构,增强钛的成骨能力,同时提供抗菌性能。结果表明:SrTiO3纳米结构主要由纯钛和SrTiO3相组成,表面形貌呈棒状;Sr在样品表面均匀分布,增加Sr含量不会改变纳米结构的形貌。润湿性测试表明,SrTiO3纳米结构具有超亲水性,促进细胞粘附。电化学测试表明,在钛表面制备的SrTiO3纳米结构显著提高了钛的耐腐蚀性。在模拟体液中浸泡14天后,STN3表面形成了大量的羟基磷灰石,表明SrTiO3纳米结构具有良好的生物活性。体外抗菌实验表明,SrTiO3纳米结构对大肠杆菌和金黄色葡萄球菌均有良好的抑菌效果,且抑菌率随Sr含量的增加而增加,分别达到48.1%和38.6%。
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来源期刊
Journal of Materials Science: Materials in Medicine
Journal of Materials Science: Materials in Medicine 工程技术-材料科学:生物材料
CiteScore
8.00
自引率
0.00%
发文量
73
审稿时长
3.5 months
期刊介绍: The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.
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