Journal of Materials Science: Materials in Medicine最新文献

{"title":"Immuno-instructive biomaterials for coronary artery disease and myocardial infarction repair","authors":"Xuanfu Chi,&nbsp;Chaowei Wu,&nbsp;Feifei Ni,&nbsp;Tai Zeng,&nbsp;Songsong Wu,&nbsp;Yunrui Zhang","doi":"10.1007/s10856-026-07096-1","DOIUrl":"10.1007/s10856-026-07096-1","url":null,"abstract":"<div><p>Coronary artery disease (CAD) and myocardial infarction (MI) feature a highly dynamic inflammatory milieu. While reperfusion remains essential, it does not sufficiently correct immune dysregulation or prevent adverse remodeling. Biomaterials offer a complementary strategy by enabling spatiotemporally controlled immunomodulation and tissue repair. By providing localized delivery of bioactive cues, mechanical support to stabilize the infarct wall, and immuno-instructive interfaces that steer macrophages toward reparative phenotypes, biomaterial platforms can reshape the post-infarction microenvironment. This review summarizes recent biomaterial-mediated strategies for the treatment of coronary heart disease. By integrating advances in immunomodulatory design, controlled drug delivery, and cardiac tissue engineering, it highlights how biomaterials can reshape the post-ischemic microenvironment to improve repair and limit adverse remodeling. These insights not only clarify current opportunities and translational barriers, but also provide guidance for developing next-generation, phase-adaptive and clinically scalable biomaterial platforms.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07096-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of topical nanoemulsion of minoxidil on animal hair growth: an in vivo study","authors":"Farzaneh Saeedi Landi,&nbsp;Mahdi Gholami,&nbsp;Negar Abdollahzadeh,&nbsp;Fariba Esmaeili,&nbsp;Amir Amani","doi":"10.1007/s10856-026-07094-3","DOIUrl":"10.1007/s10856-026-07094-3","url":null,"abstract":"<div><p>Topical minoxidil is typically administered over an extended period for the therapeutic management of androgenic alopecia. Given the adverse effects of commercial preparations of minoxidil (i.e., minoxidil solution), researchers are increasingly looking for alternative preparations that offer enhanced efficacy and reduced side effects. To do so, in this study, nanoemulsions containing 1%, 2%, and 5% minoxidil were formulated, and their stability was studied. Then, ex vivo permeation as well as in vivo irritation test and hair growth effects were investigated against commercial minoxidil solutions (2% and 5%). The prepared nanoemulsion exhibited particle sizes in the range of 11–12 nm. Permeation studies revealed no significant differences between the nanoemulsion and commercial formulations for both 2% and 5% minoxidil. The nanoemulsion did not cause skin irritation. Plasma concentrations of minoxidil were below the quantifiable range of the analytical method applied under the experimental conditions. From the animal hair growth studies, the 5% minoxidil nanoemulsion demonstrated enhanced hair growth. From the findings, the nanoemulsion formulation improved in vivo hair growth and follicle count compared to commercial formulations, despite the absence of statistically significant differences in ex vivo permeation.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07094-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress and challenges of tantalum-containing biomaterials in regenerative medicine applications","authors":"Yang Yang,&nbsp;Jinan Wu,&nbsp;Guanyi Liu,&nbsp;Junsi Luo,&nbsp;Xiaoli Xie","doi":"10.1007/s10856-026-07090-7","DOIUrl":"10.1007/s10856-026-07090-7","url":null,"abstract":"<div><p>Tissue regeneration is a significant medical challenge in repairing damaged tissues and organs, driving the need for novel biomaterials with both excellent bioactivity and mechanical properties. Tantalum (Ta) is a promising biomedical metal due to its mechanical stability, biocompatibility, and biological functions. However, the high density, cost, and processing difficulty of pure Ta limit its direct application. Consequently, research strategies have shifted to constructing a new generation of Ta-containing biomaterials by compositing Ta with other materials to retain its biological advantages while optimizing overall performance. Despite these advances, a comprehensive review systematically linking the fundamental properties of Ta with diverse material strategies and their clinical applications is still missing. To address this gap, the primary objective of this review is to provide a comprehensive framework that bridges Ta’s material science with its clinical application strategies. Accordingly, we systematically examine Ta’s properties, regeneration mechanisms, and the applications of four types of Ta-containing materials in hard and soft tissue regeneration, followed by an analysis of current challenges and future directions. This work represents the first comprehensive integration from basic properties to clinical applications, providing a systematic overview and a solid theoretical foundation for optimizing design, accelerating translation, and advancing regenerative medicine.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07090-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective cytotoxicity of zinc peroxide and tetrapodal zinc oxide micro-nanoparticles against breast cancer cells: synthesis, characterization, and therapeutic potential","authors":"Tehseen Riaz,&nbsp;Marcus Lettau,&nbsp;Mady Elbahri,&nbsp;Marie Elis,&nbsp;Nicholas Dunne,&nbsp;Tanya J. Levingstone,&nbsp;Jörg P. Weimer,&nbsp;Marion van Mackelenbergh,&nbsp;Norbert Arnold,&nbsp;Nicolai Maass,&nbsp;Dirk Bauerschlag,&nbsp;Fabian Schütt,&nbsp;Rainer Adelung,&nbsp;Nina Hedemann","doi":"10.1007/s10856-026-07091-6","DOIUrl":"10.1007/s10856-026-07091-6","url":null,"abstract":"<div><p>Breast cancer remains a global challenge, with rising incidence rates. While treatment advancements have improved outcomes, systemic administration of cytostatic agents continues to cause severe adverse effects, including myelosuppression, heart failure, and infertility, due to non-specific biodistribution. Nanoparticle-based drug delivery systems have been explored as an alternative approach to improve therapeutics delivery and reduce non-specific effects. Zinc-based nanoparticles demonstrate ability to induce cytotoxic responses in cancer cells in vitro, making them suitable systems for probing cell-type-specific effects. In this study, we evaluated the in vitro cytotoxic effects of spherical zinc peroxide (ZnO₂) nanoparticles (20–80 nm and 50–300 nm), commercial ZnO nanoparticles, and tetrapodal ZnO (T-ZnO) microparticles in MCF-7 breast cancer cells and RMF-EG fibroblasts. ZnO₂ nanoparticles demonstrated dose-dependent cytotoxicity (1 µg/mL–10 mg/mL), inducing a significantly higher death rate of cancer cells than normal fibroblasts, which retained &gt;75% viability at comparable doses. Flow cytometry investigations revealed that ZnO₂ nanoparticles exhibited preferential cellular uptake in MCF-7 cells as compared to fibroblasts. Overall, these findings indicate different cytotoxic responses of ZnO-based micro and nanoparticles between MCF-7 cells and RMF-EG fibroblasts under in vitro conditions. Further studies are required to validate these observations in more complex biological systems and to clarify the underlying mechanisms.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07091-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronizing degradation with regeneration: a model-driven framework for designing biodegradable biomaterials in bone tissue engineering","authors":"Vahid Zarghami","doi":"10.1007/s10856-026-07102-6","DOIUrl":"10.1007/s10856-026-07102-6","url":null,"abstract":"<div><p>Bone regeneration is a complex biological process, and the repair of critical-sized bone defects is often difficult, highlighting the need to develop biodegradable scaffolds that can effectively synergize with tissue repair. This paper introduces a model-based bone repair design framework that matches the kinetics of material degradation with the spatiotemporal stages of bone repair. We systematically evaluated the degradation mechanisms and tunability of four classes of biomaterials—metals (Mg, Fe, Zn), ceramics (HA, β-TCP, bioactive glass), polymers (PLGA, PCL), and composites—and mapped established mathematical models (linear partial differential equations, sigmoid curves, response-diffusion partial differential equations, and mechanobiological finite element models) to specific bone defect sizes and clinical scenarios. Based on this classification, we propose a four-step clinical design to guide researchers in completing the following steps: (1) calculating patient-specific healing timelines using first-order heuristics; (2) selecting appropriate material classes based on mechanical and biological requirements; (3) designing degradation kinetics to match the healing stages; and (4) validating scaffold-tissue alignment. To achieve quantitative assessment, we introduce the synchronization index (SI), a provisional index designed to quantify the correlation between actual implant degradation and patient-specific target curves. While the SI and the healing timeline formula are currently proposed only as conceptual design tools and require prospective experimental and clinical validation, their integration provides a structured path for scaffold development, moving it from experimental trial and error to precise, model-based engineering design. The goal of this framework is to facilitate the rational design of smart, resorbable implants that dynamically match the biological and mechanical requirements of bone regeneration.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial nanocellulose: biosynthesis, structural properties and vascular tissue engineering applications","authors":"Saeed Sharifpoor Kermani,&nbsp;Jens Wippermann,&nbsp;Priya Veluswamy,&nbsp;Max Wacker","doi":"10.1007/s10856-026-07098-z","DOIUrl":"10.1007/s10856-026-07098-z","url":null,"abstract":"<div><p>Coronary artery bypass grafting (CABG) via autologous vein or artery is still the gold standard surgery operative revascularization. However autologous vein/artery may represent some limitations like varicose veins or unavailability of veins due to reoperations especially in older patients. consequently, the research focus directed towards identification and characterization of biocompatible alternative material. Bacterial nanocellulose (BNC) as a natural material has gained substantial recognition in the research field of tissue engineering due to it exceptional attributes, including biocompatibility, enhanced mechanical properties, non-toxicity and unique physicochemical properties. Nevertheless, BNC is associated with some restrictions in endothelial cell adhesion and mimicking the physiochemical and mechanical properties of autologous vein as a promising alternative. To address these challenges, future research must focus on the development of BNC with controlled surface and mechanical characteristic. This review aims to address diverse aspect of controlling BNC production and methodologies in order to optimize the mechanical and physiochemical properties of grafts as an alternative in cardiovascular tissue engineering. Created with BioRender.com.</p><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07098-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148281597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic antioxidant and anti-inflammatory scaffold based on ascorbic acid-enriched hydroxyapatite-PEG-ZnO composite from natural bone waste","authors":"Ananthika Vijayan,&nbsp;Aswin Gopakumar,&nbsp;Sobha V. Nair,&nbsp;Balakrishnan Shankar,&nbsp;Gurunathan Saravana Kumar,&nbsp;Sreedha Sambhudevan","doi":"10.1007/s10856-026-07078-3","DOIUrl":"10.1007/s10856-026-07078-3","url":null,"abstract":"<div><p>Hydroxyapatite (HAp) derived from bovine bone waste was used to develop a bioactive composite scaffold incorporating polyethylene glycol (PEG), ZnO nanoparticles, and ascorbic acid (AA). This study aimed to fabricate a PEG-based HAp composite enriched with ZnO and AA and to evaluate the influence of these additives on the structural characteristics and biological performance of the scaffold. The resulting HAp–PEG–ZnO–AA composite was designed to provide a sustained release of Zn²⁺ ions while leveraging the antioxidant functionality of AA to enhance biological activity. X-ray diffraction (XRD) analysis indicated that PEG incorporation altered the crystallinity and grain size of HAp, while high-resolution transmission electron microscopy (HRTEM) and X-ray photoelectron spectroscopy (XPS) confirmed the successful integration of ZnO nanoparticles and AA within the HAp matrix. The composite exhibited enhanced antioxidant and anti-inflammatory activity compared to the HAp–PEG–ZnO scaffold without AA, whereas antibacterial performance was primarily attributed to the ZnO component. In vitro cytotoxicity assays using RAW 264.7 macrophage cells demonstrated that the composite was biocompatible at lower concentrations (cell viability &gt; 90% at 6.25 µg mL⁻¹), while higher concentrations resulted in a marked reduction in viability accompanied by observable morphological changes. Overall, these findings suggest that AA incorporation synergistically improves the antioxidant and anti-inflammatory properties of the HAp–PEG–ZnO scaffold without compromising its antimicrobial activity or its biocompatibility at low dosages.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148282837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication and characterization of Schwann cell-derived acellular matrix and chemical-ionic dual crosslinking strategy to produce bioinks for peripheral nerve regeneration","authors":"Nasera Rizwana,&nbsp;Poorvi Shivakumar,&nbsp;Vipul Agarwal,&nbsp;Manasa Nune","doi":"10.1007/s10856-026-07097-0","DOIUrl":"10.1007/s10856-026-07097-0","url":null,"abstract":"<div><p>Peripheral nerve injury (PNI) is a common neurological problem that can hamper the quality of life causing sensory and motor dysfunction. While small peripheral nerve defects get repaired by themselves, larger defects require tissue engineering substitutes to bridge the nerve gap. One of the recent technologies and strategies to address the peripheral nerve regeneration is through 3D bioprinting. In this study, we show an effective method to fabricate acellular matrix (ACM) from rat Schwann RSC96 cells and incorporate it into alginate hydrogel. We observed that ACM showed presence of ~400 µg/ml of proteins and specific Schwann cell marker (S100) and myelination markers (PMP22, MPZ) with significant DNA reduction, indicating effective decellularization and minimal immunogenicity. Cytochemical and immunofluorescence staining confirmed presence of extracellular matrix (ECM) proteins, collagen I and fibronectin. We also developed a novel dual crosslinking strategy using glutaraldehyde (pre-print crosslinking) and calcium chloride (post-print crosslinking) to facilitate efficient bioprinting. Further, rat Schwann RSC96 cells were blended with alginate/ACM hydrogel to prepare a functional bioink. Our results demonstrated good cell viability and functionality in the printed structures, highlighting the potential role of rat Schwann RSC96-derived ACM as well as a dual crosslinking strategy for peripheral nerve tissue regeneration.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div><div><p>Peripheral nerve injuries can result in significant sensory and motor dysfunction, particularly when the nerve gap is too large for regeneration to take place. To address this challenge, tissue-engineered solutions have been explored, with 3D bioprinting emerging as a promising strategy for creating biomimetic nerve guidance conduits. This study introduces a novel bioink composed of alginate hydrogel integrated with a cell-derived acellular matrix (ACM) obtained from rat Schwann RSC96 cells. ACM provides a biomimetic environment that closely resembles native extracellular matrix, offering enhanced support for cellular functions critical to nerve regeneration. A dual crosslinking strategy using glutaraldehyde and calcium chloride was developed to improve the shape fidelity of the printed constructs. The bioink demonstrated good printability and biocompatibility and supported high cell viability. This approach successfully mimics the natural cellular microenvironment and facilitates Schwann cell functionality, which is crucial for peripheral nerve regeneration. This study presents an efficient method for fabricating functional ACM-based bioinks and highlights the synergistic role of dual crosslinking in achieving 3D bioprinted structures.</p></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07097-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148262669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid mineralization of hydrothermally induced TiO2 coating on titanium and early osteogenic responses in vitro","authors":"Faleh Abushahba,&nbsp;Sherif A. Mohamad,&nbsp;Adrian Stiller,&nbsp;Polina Sinitsyna,&nbsp;Nagat Areid,&nbsp;Jan-Henrik Smått,&nbsp;Leena Hupa,&nbsp;Pekka K. Vallittu,&nbsp;Terhi J. Heino,&nbsp;Timo Närhi","doi":"10.1007/s10856-026-07095-2","DOIUrl":"10.1007/s10856-026-07095-2","url":null,"abstract":"<div><p>This study evaluated hydrothermally induced nanostructured TiO₂ coatings (HT-TiO₂) on Grade 1 titanium (Ti) with a focus on surface mineralization behavior and early cellular responses. Rapid mineralization (RM) was achieved by immersion in modified simulated body fluid (m-SBF). Ti discs were subjected to hydrothermal treatment (HT) to produce a TiO₂ coating, then mineralized in m-SBF for 2, 4, or 6 h. Surface characterization was conducted using SEM, EDX, XRD, and FTIR. Cellular responses were assessed using pre-osteoblastic cells and mesenchymal stem cell (MSC)‑like cells in vitro. Cell proliferation on Ti substrates was evaluated over 7 days, and alkaline phosphatase (ALP) activity in MSC-like cells was measured at days 7 and 14 across four groups: NC (non-coated), HT-TiO₂, RM4 (HT-TiO₂ with 4-h RM), and RM6 (HT-TiO₂ with 6-h RM) discs. Cell attachment and spreading were evaluated by fluorescence microscopy at days 3 and 7. The intensity of the Ca–P layer and the molar composition increased with mineralization time (2–6 h). All surfaces supported pre-osteoblast proliferation without significant differences between groups. ALP activity was significantly elevated in the HT-TiO₂ and RM6 groups compared to controls, indicating early osteogenic activity in a subset of cells. Fluorescence imaging showed flattened cell morphology on HT-TiO₂-discs and more elongated morphology on RM discs at day 3, while comparable cell confluency was observed on all surfaces by day 7. Overall, hydrothermally-induced nanostructured TiO₂ coatings on Ti surfaces can be rapidly mineralized, and the resulting Ca–P layer supports cell attachment, proliferation, and early osteogenic activity in vitro. These findings highlight the potential of surface‑driven mineralization strategies for modulating early cellular responses to titanium implants.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07095-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148262646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A conductive antibacterial composite film containing chopped fibers and ciprofloxacin loaded PCL particles for wound dressing application","authors":"Naghmeh Nademi,&nbsp;Pouriya Toloee,&nbsp;Mojdeh Mohseni,&nbsp;Mostafa Dahmardehei,&nbsp;Azam Molafilabi,&nbsp;Najmeh Najmoddin","doi":"10.1007/s10856-026-07092-5","DOIUrl":"10.1007/s10856-026-07092-5","url":null,"abstract":"<div><p>Designing multifunctional wound dressings with admirable mechanical virtues, appropriate electrical conductivity, and good antibacterial performance is critical for preventing infection and promoting tissue repair. Herein, a conductive gellan–agar composite film reinforced with chopped PCL–gelatin electrospun fibers containing polyaniline–graphene (PAG) and loaded with ciprofloxacin (Cip)–encapsulated PCL particles, was developed. The highest electrical conductivity (5.6 × 10^–5 S.cm^–1) was donated to the PCL-gelatin fibers with 1.5 wt.% PAG. The conductive film revealed desirable mechanical characteristics including tensile strength (8.51 ± 0.06 MPa) and elastic modulus (5.92 ± 0.09 MPa) by addition of PCL-gelatin-1.5 wt.% PAG chopped fibers, indicating effective reinforcement of the hydrogel-based matrix. Moreover, the system enabled sustained Cip release, and the release kinetics was well described by a first-order model. The developed film demonstrated antibacterial activity against both Gram-positive and Gram-negative strains, showing inhibition zones of 9 ± 3 mm for <i>Staphylococcus aureus</i> and 16 ± 1 mm for <i>Escherichia coli</i>. In addition, the film displayed appropriate swelling and degradation behavior, supporting its suitability as a wound-contact dressing. The developed multifunctional film in this research would be a worthy asset to prevent infection and accelerate wound repair in future studies.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07092-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148248680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}