{"title":"金属对间充质干细胞干性影响的研究进展","authors":"Roya Valizadeh, Halimeh Amirazad, Tahura Fayeghi, Hanieh Mousazadeh, Nosratollah Zarghami, Abbas Ebrahimi-Kalan, Effat Alizadeh","doi":"10.1007/s10856-025-06865-8","DOIUrl":null,"url":null,"abstract":"<div><p>The metal-based devices may corrode, degrade, or release metal ions and fragments after being implanted in the body, exhibiting their own consequences on hosting organs/tissues. The biocompatibility of metal implants has been investigated in various studies using a number of cell types. Mesenchymal stem cells (MSCs) are more relevant cells than others for evaluating the cytocompatibility of metal-based orthopedic implants because they are essential cells for bone regeneration and a promising cell population in regenerative medicine. In this regard, stemness preservation of MSCs is a key property in both body’s own repair process and success of renewing/compensating approaches. In general, MSCs adhesion, viability, and function at the cell–metal interface is directly dependent on the metal alloys composing elements, which, along with consideration of compatibility, could guarantee the success of implants. This review scrutinizes the effects of orthopedic metal materials on the biocompatibility and stemness of MSCs at metal interface. Additionally, in vivo, host responses to metal implants are investigated.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06865-8.pdf","citationCount":"0","resultStr":"{\"title\":\"An update on the effect of metals on stemness properties of mesenchymal stem cells\",\"authors\":\"Roya Valizadeh, Halimeh Amirazad, Tahura Fayeghi, Hanieh Mousazadeh, Nosratollah Zarghami, Abbas Ebrahimi-Kalan, Effat Alizadeh\",\"doi\":\"10.1007/s10856-025-06865-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The metal-based devices may corrode, degrade, or release metal ions and fragments after being implanted in the body, exhibiting their own consequences on hosting organs/tissues. The biocompatibility of metal implants has been investigated in various studies using a number of cell types. Mesenchymal stem cells (MSCs) are more relevant cells than others for evaluating the cytocompatibility of metal-based orthopedic implants because they are essential cells for bone regeneration and a promising cell population in regenerative medicine. In this regard, stemness preservation of MSCs is a key property in both body’s own repair process and success of renewing/compensating approaches. In general, MSCs adhesion, viability, and function at the cell–metal interface is directly dependent on the metal alloys composing elements, which, along with consideration of compatibility, could guarantee the success of implants. This review scrutinizes the effects of orthopedic metal materials on the biocompatibility and stemness of MSCs at metal interface. Additionally, in vivo, host responses to metal implants are investigated.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":647,\"journal\":{\"name\":\"Journal of Materials Science: Materials in Medicine\",\"volume\":\"36 1\",\"pages\":\"\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-05-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s10856-025-06865-8.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Materials Science: Materials in Medicine\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10856-025-06865-8\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Materials Science: Materials in Medicine","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s10856-025-06865-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
An update on the effect of metals on stemness properties of mesenchymal stem cells
The metal-based devices may corrode, degrade, or release metal ions and fragments after being implanted in the body, exhibiting their own consequences on hosting organs/tissues. The biocompatibility of metal implants has been investigated in various studies using a number of cell types. Mesenchymal stem cells (MSCs) are more relevant cells than others for evaluating the cytocompatibility of metal-based orthopedic implants because they are essential cells for bone regeneration and a promising cell population in regenerative medicine. In this regard, stemness preservation of MSCs is a key property in both body’s own repair process and success of renewing/compensating approaches. In general, MSCs adhesion, viability, and function at the cell–metal interface is directly dependent on the metal alloys composing elements, which, along with consideration of compatibility, could guarantee the success of implants. This review scrutinizes the effects of orthopedic metal materials on the biocompatibility and stemness of MSCs at metal interface. Additionally, in vivo, host responses to metal implants are investigated.
期刊介绍：
The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.
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