Journal of Materials Science: Materials in Medicine最新文献_第3页

Arginine-loaded silica nanoparticles inhibit E. faecalis in root canals. 精氨酸负载二氧化硅纳米颗粒抑制根管中的粪肠杆菌。

IF 4.5 3区医学

Journal of Materials Science: Materials in Medicine Pub Date : 2026-04-14 DOI: 10.1007/s10856-026-07034-1

Meng-Ya Li, Wen Zhang, Yi-Yuan Xia, Jian Sun, Qing-An Xu

{"title":"Arginine-loaded silica nanoparticles inhibit E. faecalis in root canals.","authors":"Meng-Ya Li, Wen Zhang, Yi-Yuan Xia, Jian Sun, Qing-An Xu","doi":"10.1007/s10856-026-07034-1","DOIUrl":"https://doi.org/10.1007/s10856-026-07034-1","url":null,"abstract":"<p><p>Bacterial infection of the root canal system, especially by Enterococcus faecalis (E. faecalis), is the primary cause of root canal treatment failure, and intracanal medication has been proven to be an effective method for controlling root canal infection. Mesoporous silica nanoparticles (MSNs) with their sponge-like structure, tunable particle size, surface functionalization, and favorable biocompatibility offer promise for intracanal drug delivery. This study evaluated the antibacterial efficacy of an arginine-loaded MSN system (MSN@Arg) against E. faecalis, its effects on osteogenic differentiation in MC3T3-E1 cells, and its ability to control infection within the root canal system. The physicochemical properties and drug release profile of MSN@Arg were assessed using electron microscopy and other analytical techniques. Antibacterial activity was evaluated through bacterial culture assays. Alkaline phosphatase and Alizarin Red staining were performed to evaluate osteogenic differentiation. An E. faecalis-infected root canal model was established in extracted teeth, and the antibacterial efficacy of MSN@Arg, chlorhexidine (CHX), and calcium hydroxide was compared at 3, 7, 14, and 21 days after drug sealing. The synthesized MSNs (diameter < 100 nm) exhibited extensive distribution within dentinal tubules. MSN@Arg enabled sustained and stable release of arginine, inhibited E. faecalis in both planktonic and biofilm states, and promoted ALP expression and mineralized nodule formation in MC3T3-E1 cells, with high biocompatibility. MSN@Arg demonstrated greater antibacterial efficacy than calcium hydroxide on days 3 and 7, was comparable to CHX on day 14, and slightly more effective than CHX on day 21. Given its deep penetration into dentinal tubules and sustained drug release capacity, MSN@Arg represents a promising agent for root canal disinfection.</p>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photosensitive and extracellular matrix-mimicking hydrogels promote the tendon-bone healing in rotator cuff injury. 光敏和细胞外基质模拟水凝胶促进肌腱-骨愈合在肩袖损伤。

IF 4.5 3区医学

Journal of Materials Science: Materials in Medicine Pub Date : 2026-04-14 DOI: 10.1007/s10856-026-07039-w

Yuxuan Liu, Huanv Mao, Ziyang Tian, Xiaoting Wang, Chunyan Bao, Bingchen An, Chunxi Yang

{"title":"Photosensitive and extracellular matrix-mimicking hydrogels promote the tendon-bone healing in rotator cuff injury.","authors":"Yuxuan Liu, Huanv Mao, Ziyang Tian, Xiaoting Wang, Chunyan Bao, Bingchen An, Chunxi Yang","doi":"10.1007/s10856-026-07039-w","DOIUrl":"https://doi.org/10.1007/s10856-026-07039-w","url":null,"abstract":"<p><p>The healing of the tendon-bone interface remains a significant challenge due to the lack of suitable bioactive materials for promoting interface regeneration. To address this, we developed a photosensitive hydrogel system designed to mimic the extracellular matrix. This system is based on light-induced imine crosslinking between type I collagen (Col I) and o-nitrobenzyl alcohol (NB)-modified hyaluronic acid (HANB). Experimental results demonstrate that the hydrogel (Col I-HANB) exhibits excellent controllability, low swelling rate, biodegradability, and tissue-adhesive properties. Using a fluorescent dye (8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt, HPTS) as a model molecule, we confirmed that the hydrogel enables localized and sustained release, high-lighting its potential as a drug-delivery platform for tissue engineering. To further enhance tendon-bone interface repair, the hydrogel was functionalized with two key components: (I) The E7 peptide, known for its stem cell-homing properties, was covalently immobilized into the hydrogel network via conjugation to bovine serum albumin (BSA) and followed by imine-ligation between UV-triggered aldehyde generation from HANB and BSA's amino groups; and (II) Kartogenin (KGN)-loaded nanoparticles (KGN-NPs) were incorporated to potentially promote chondrogenic differentiation, with release assays confirming sustained KGN delivery over 21 days. The composite hydrogel demonstrated excellent biocompatibility in cytotoxicity and live/dead assays. Importantly, in a rabbit rotator cuff tear model, it effectively promoted fibrocartilage regeneration and significantly improved tendon-bone healing, creating a favorable microenvironment for repair. The results above indicate that the hydrogel system provides a good microenvironment for rotator cuff injury repair and is a promising scaffold applied in treatment of rotator cuff injury.</p>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ag-enhanced β titanium alloys for surgical implants: microstructural regulation achieves superior strength, corrosion resistance and biocompatibility. 用于外科植入物的ag增强β钛合金：显微结构调节可实现卓越的强度、耐腐蚀性和生物相容性。

IF 4.5 3区医学

Journal of Materials Science: Materials in Medicine Pub Date : 2026-04-07 DOI: 10.1007/s10856-026-07038-x

Xiqun Ma, Yufei Tang, Sen Yu, Wenhao Zhou, Jun Cheng, Tian Bai, Lan Wang, Hanyuan Liu, Xiyuan Zhang

{"title":"Ag-enhanced β titanium alloys for surgical implants: microstructural regulation achieves superior strength, corrosion resistance and biocompatibility.","authors":"Xiqun Ma, Yufei Tang, Sen Yu, Wenhao Zhou, Jun Cheng, Tian Bai, Lan Wang, Hanyuan Liu, Xiyuan Zhang","doi":"10.1007/s10856-026-07038-x","DOIUrl":"https://doi.org/10.1007/s10856-026-07038-x","url":null,"abstract":"<p><p>β-titanium alloys attract great interest in surgical implants due to its low elastic modulus. The addition of Ag further enhances the strength, ductility, corrosion resistance and biocompatibility of such alloys, which optimizes their compatibility with human bones. In this study, Ti-15Mo-xAg (x = 1, 5 wt.%) alloy rods were prepared by optimized melting, forging and rolling processes. The microstructural evolution, mechanical properties, corrosion behavior and biocompatibility of the alloy were systematically studied by X-ray diffraction (XRD), optical microscopy (OM), transmission electron microscopy (TEM), mechanical testing, electrochemical analysis and biocompatibility assays. The results showed that the aged Ti-15Mo-5Ag alloy presented a special heterogeneous microstructure of β matrix and micro-nano scale precipitated phase (α<sub>1</sub> + α<sub>2</sub> + Ti<sub>2</sub>Ag), which enabled it to achieve excellent mechanical adaptability. Its tensile strength reached 1208 MPa, and the elongation was 11.5%, while the alloy maintained a low elastic modulus of 98 GPa. The self-corrosion current density of the alloy in the simulated body fluids was as low as 1.176 × 10<sup>-8 </sup>A·cm<sup>-2</sup>. In vitro biological tests indicated good biocompatibility. This alloy is expected to become a candidate material for future surgical implant applications.</p>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic bone scaffold functionalized with traditional Chinese medicine ingredients and collagen-binding IGF-1 for bone regeneration. 中药成分和胶原结合IGF-1功能化的骨再生仿生支架。

IF 4.5 3区医学

Journal of Materials Science: Materials in Medicine Pub Date : 2026-04-06 DOI: 10.1007/s10856-026-07041-2

Xiaobo Gao, Bocheng Lei, Xiaomin Zhao, Ying Zhang

{"title":"Biomimetic bone scaffold functionalized with traditional Chinese medicine ingredients and collagen-binding IGF-1 for bone regeneration.","authors":"Xiaobo Gao, Bocheng Lei, Xiaomin Zhao, Ying Zhang","doi":"10.1007/s10856-026-07041-2","DOIUrl":"https://doi.org/10.1007/s10856-026-07041-2","url":null,"abstract":"<p><p>Many active ingredients from traditional Chinese medicine (TCM) have been applied in bone tissue engineering. However, the fuzzy mechanism of these ingredients limits their application. In this study, a novel biomimetic bone scaffold functionalized with two TCM ingredients, nano deer bone meals (nBM) and neferine (Nef), as well as collagen-binding IGF-1 (CBD-IGF-1) was fabricated via a combination of phase inversion and particle leaching methods. The biomimetic CIGF1&Nef@PLGA/nBM scaffold mimicked cancellous bone in terms of its porous structure and bone matrix composition rich in collagen. Both Nef contained in the scaffold and CBD-IGF-1 bound to collagen matrix could be slowly released from the scaffold, exerting long-term and safe bioactivity. In vitro tests showed that the CIGF1&Nef@PLGA/nBM composite significantly enhanced the adhesion, proliferation and osteogenic differentiation of MC3T3-E1 cells on the material. Nef and IGF-1 in CIGF1&Nef@PLGA/nBM scaffold exerted a synergistic effect on IGF-1-mediated osteogenic differentiation via IGF-1R axis to ensure the osteogenic activity of the biomimetic scaffold. In vivo skull defect repair experiment confirmed that CIGF1&Nef@PLGA/nBM could promote the neocortical bone formation and osseous maturation, further accelerating the bone defect repair. The findings of this research demonstrated that the biomimetic CIGF1&Nef@PLGA/nBM scaffold is a promising implantation in bone defect therapy.</p>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrospun CHIR99021-loaded cellulose acetate scaffolds stimulate osteogenic differentiation and mineralization in vitro. 静电纺丝chir99021负载醋酸纤维素支架刺激体外成骨分化和矿化。

IF 4.5 3区医学

Journal of Materials Science: Materials in Medicine Pub Date : 2026-04-03 DOI: 10.1007/s10856-026-07032-3

Samir A Bello, Aimeé Rodríguez-Monroig, Andrea Vargas-Morales, Alondra S Rodríguez-Rolón, Claudia C Zuluaga-Gómez, Dina Paola Bracho-Rincón, Eduardo Nicolau

{"title":"Electrospun CHIR99021-loaded cellulose acetate scaffolds stimulate osteogenic differentiation and mineralization in vitro.","authors":"Samir A Bello, Aimeé Rodríguez-Monroig, Andrea Vargas-Morales, Alondra S Rodríguez-Rolón, Claudia C Zuluaga-Gómez, Dina Paola Bracho-Rincón, Eduardo Nicolau","doi":"10.1007/s10856-026-07032-3","DOIUrl":"https://doi.org/10.1007/s10856-026-07032-3","url":null,"abstract":"<p><p>Glycogen synthase kinase-3 (GSK-3) inhibitors are a diverse class of small molecules known to promote osteogenic differentiation in cell monolayers. However, the osteoinductive capacity of GSK-3 inhibitors loaded into scaffolds remains underexplored. To address this, the study first evaluated three GSK-3 inhibitors-DIPQUO, 1-Azakenpaullone (Azak), and CHIR99021 (CHIR)-for their ability to enhance matrix mineralization in pre-osteoblast monolayers. The results showed that only Azak and CHIR induced a significant osteogenic response. Consequently, these two inhibitors were incorporated separately into cellulose acetate solutions to fabricate electrospun scaffolds. The physicochemical properties, molecular integrity, and release profiles of Azak and CHIR from the membranes were next characterized. Subsequently, biocompatibility and osteoinductive potential of the GSK-3 inhibitor-loaded membranes were assessed. In terms of scaffold characteristics, CHIR loading significantly reduced the water contact angle. Both inhibitors exhibited a burst release profile consistent with first-order kinetics. Pre-osteoblasts demonstrated comparable growth on unloaded and GSK-3 inhibitor-loaded scaffolds, with no evidence of cytotoxicity. Importantly, CHIR-loaded mats enhanced cell adhesion, proliferation, and osteogenic differentiation, whereas Azak-loaded membranes inhibited matrix mineralization. Taken together, these findings indicate that CHIR-loaded scaffolds possess in vitro bioactivity and may be promising for bone tissue engineering applications.</p>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano-dicalcium silicate promotes angiogenesis via enhancing endothelial cell proliferation, migration and tube formation. 纳米硅酸二钙通过促进内皮细胞增殖、迁移和管的形成来促进血管生成。

IF 4.5 3区医学

Journal of Materials Science: Materials in Medicine Pub Date : 2026-04-02 DOI: 10.1007/s10856-026-07033-2

Ruolan Wang, Yuntao Lin, Yuling Chen, Hongyu Yang

{"title":"Nano-dicalcium silicate promotes angiogenesis via enhancing endothelial cell proliferation, migration and tube formation.","authors":"Ruolan Wang, Yuntao Lin, Yuling Chen, Hongyu Yang","doi":"10.1007/s10856-026-07033-2","DOIUrl":"https://doi.org/10.1007/s10856-026-07033-2","url":null,"abstract":"<p><p>Bone defects, especially critical-sized ones, pose a significant challenge in clinical orthopedics due to their impaired self-regeneration ability. Our previous experiments have confirmed that dicalcium silicate nanoparticles(nC<sub>2</sub>S) exhibit excellent osteogenic activity, but whether they also possesses good angiogenic activity remains unelucidated. In this study, we established a co-culture model of nC2S and HUVECs to further explore its angiogenic effect. CCK-8 assay, immunofluorescence (IF) staining, and Western Blotting (WB) analysis were utilized to systematically assess the effects of nC₂S on the proliferative capacity, migratory potential, and tube formation ability of HUVECs-three core functional hallmarks of angiogenesis. In vivo, nC₂S scaffolds were implanted into bone defect models to validate their ability in promoting neovascularization within bone defect sites. Furthermore, RNA sequencing was employed to explore the potential molecular mechanisms of nC₂S-induced angiogenesis. We found that nC2S can promote HUVECs proliferation, migration, and tube formation. RNA-seq result showed upregulation of MAPK, PI3K/Akt pathway. Thus, we speculate that nC<sub>2</sub>S may promote angiogenesis through cell proliferation. This study aims to investigate the role of dicalcium silicate in promoting angiogenesis during bone defect repair, and to provide an important theoretical basis and practical guidance for the development of novel bone regeneration materials.</p>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Evaluation of nickel release from Ni-Ti stents in various media for safety assessment purposes 修正：评价镍钛支架在不同介质中释放镍的安全性评估。

IF 4.5 3区医学

Journal of Materials Science: Materials in Medicine Pub Date : 2026-04-01 DOI: 10.1007/s10856-026-07037-y

Bin Liu, Yafan Hu, Kai Xu, Bo Zhang, Dong Liu, Changyan Wu, Xiuyun Han, Peng Han, Jian Lu, Naishui Han

引用次数: 0

Harnessing biopolymeric double network hydrogels for cartilage repair: a review of current strategies 利用生物聚合物双网水凝胶修复软骨：当前策略的回顾。

IF 4.5 3区医学

Journal of Materials Science: Materials in Medicine Pub Date : 2026-03-28 Epub Date: 2026-04-01 DOI: 10.1007/s10856-026-07023-4

Vahid Rahimkhoei, Yuksel Akinay, Ali Akbari, Aseel M. Aljeboree, Forat H. Alsultany, Masoud Salavati-Niasari

{"title":"Harnessing biopolymeric double network hydrogels for cartilage repair: a review of current strategies","authors":"Vahid Rahimkhoei, Yuksel Akinay, Ali Akbari, Aseel M. Aljeboree, Forat H. Alsultany, Masoud Salavati-Niasari","doi":"10.1007/s10856-026-07023-4","DOIUrl":"10.1007/s10856-026-07023-4","url":null,"abstract":"<div><p>Hydrogels with a double network (DN) structure that are based on carbohydrates have shown potential as scaffolds for the regeneration of cartilage. We postulate that these hydrogels can aid in the repair of cartilage and sustain the regeneration of tissue because of their ability to hold large quantities of water and large amounts of bioactive molecules. Some recent preclinical studieswith DN hydrogels that have been modified with growth factors, other biological molecules, and or therapeutic agents have shown enhanced growth of the cartilage tissue, hydration, and structural integrity of the tissue. In this review, we detail these advancements as potential carbohydrate-based double network hydrogels for the treatment of cartilage defects and osteoarthritis. Optimized DN hydrogels are tissue engineering scaffolds for cartilage regeneration, with the potential to translate to clinical practice.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07023-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of cercosporin-loaded polydopamine- cloaked mesoporous silica nanoparticles enhanced photothermal-photodynamic and anticancer activity in pancreatic cancer 制备含cercosporin的聚多巴胺包裹介孔二氧化硅纳米颗粒增强了胰腺癌的光热-光动力学和抗癌活性。

IF 4.5 3区医学

Journal of Materials Science: Materials in Medicine Pub Date : 2026-03-27 Epub Date: 2026-04-01 DOI: 10.1007/s10856-026-07007-4

Jingsheng Hua, Bo Ning, Hongxin Zhang

{"title":"Fabrication of cercosporin-loaded polydopamine- cloaked mesoporous silica nanoparticles enhanced photothermal-photodynamic and anticancer activity in pancreatic cancer","authors":"Jingsheng Hua, Bo Ning, Hongxin Zhang","doi":"10.1007/s10856-026-07007-4","DOIUrl":"10.1007/s10856-026-07007-4","url":null,"abstract":"<div><p>The lack of tumor targeting ability and the failure of single therapeutic approaches are two challenges in the treatment of pancreatic cancer. Mesoporous silica (MS) nanoparticles of two sizes (MS50 and MS100) were fabricated and functionalized with polydopamine (PD), cercosporin (CE), and arginine-glycine-aspartic acid peptide (RP) for the dual purposes of photodynamic therapy (PDT) and photothermal therapy (PTT) aimed at integrin αvβ3 in pancreatic cancer. MS@PD-RP-CE were examined using several approaches, exhibiting selective drug release, enhanced photothermal conversion efficiency, and reactive oxygen species (ROS) generation under laser irradiation. MS100@PD-RP-CE exhibited enhanced cellular uptake and cytotoxicity against pancreatic cancer (PANC-1) in vitro, while selectively targeting pancreatic cancer cells over normal cells, in comparison to MS50@PD-RP-CE. The mechanism of cell death was analyzed utilizing Calcein-AM/PI, and nuclear staining techniques. MS100@PD-RP-CE demonstrated considerable biocompatibility, as shown by the hemolytic assay. Thus, MS100@PD-RP-CE demonstrates significant promise for the prospective treatment of pancreatic cancer.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07007-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimisation of electrospinning parameters to successfully obtain high ratios of medium chain length polyhydroxyalkanoate in electrospun fibres with drug loading for wound healing applications 优化静电纺丝参数，成功获得高比例中链长聚羟基烷酸酯的静电纺丝纤维与药物负载的伤口愈合应用。

IF 4.5 3区医学

Journal of Materials Science: Materials in Medicine Pub Date : 2026-03-26 Epub Date: 2026-04-01 DOI: 10.1007/s10856-026-07030-5

Robyn A. Macartney, Annabelle T. R. Fricker, Gusti U. N. Tajalla, Andrew M. Smith, Shosei Kishida, Stefano Fedele, Ipsita Roy, Jonathan C. Knowles

{"title":"Optimisation of electrospinning parameters to successfully obtain high ratios of medium chain length polyhydroxyalkanoate in electrospun fibres with drug loading for wound healing applications","authors":"Robyn A. Macartney, Annabelle T. R. Fricker, Gusti U. N. Tajalla, Andrew M. Smith, Shosei Kishida, Stefano Fedele, Ipsita Roy, Jonathan C. Knowles","doi":"10.1007/s10856-026-07030-5","DOIUrl":"10.1007/s10856-026-07030-5","url":null,"abstract":"<div><p>Chronic wounds, burns and ulceration of dermal and mucosal tissues are extremely common and can arise for a wide variety of reasons causing extreme pain and reducing patient quality of life. Current treatment regimens involve the use of topical corticosteroids for prolonged treatment periods. Due to issues surrounding the use of topical ointments there is inadequate drug contact with the wound site and non-specific tissue interaction, potentially leading to significant development of fungal infections as a side effect to corticosteroid treatment. Medium chain length (MCL) and short chain length (SCL) polyhydroxyalkanoates (PHAs) may be applicable to optimise material properties for wound dressing applications. Initial work focussed on defining the optimal electrospinning parameters for suitably elastic fibres whilst subsequent work focussed on achieving an optimised dosing of clobetasol propionate (CP) and fluconazole (FLU) for incorporation with the electrospun fibres without detrimentally compromising the properties of the scaffolds for wound healing applications. Physical and mechanical analysis showed that the 80:20 blend of MCL:SCL polymer at an electrospinning solution concentration of 10% (w/v) gave defect-free fibres with the best elastic properties for wound dressing applications. CP and FLU incorporation into the electrospun fibres did not cause any significant decrease in oral mucosal cell viability. Following in vitro wound healing study promising formulations containing 2% and 10% CP and FLU, respectively, were identified.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07030-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0