Journal of Materials Science: Materials in Medicine最新文献

{"title":"In-vitro study of the wear behavior of telescopic crowns made of CoCr, zirconia or PEEK","authors":"PC. Pott,&nbsp;N. v. Maltzahn,&nbsp;C. Brachmann,&nbsp;M. Stiesch,&nbsp;P. Kohorst","doi":"10.1007/s10856-025-06891-6","DOIUrl":"10.1007/s10856-025-06891-6","url":null,"abstract":"<div><p>Purpose: Double-crown-retained dentures (DCRD) are an established treatment in dentistry. In some cases, the retention between primary crown (PC) and secondary crown (SC) loosens due to wear during daily handling of the denture. The aim of the present study was to examine modern materials for PCs and SCs with regard to their wear behavior. Materials and Methods: Cyclic pull-off tests were conducted on each 40 specimens in five test groups. PCs made of CoCr, PEEK and ZrO₂ were cemented onto a prepared resin tooth. SCs were made of the same materials and combined to the following PC-SC combinations: CoCr-CoCr, CoCr-PEEK, PEEK-PEEK, ZrO₂-PEEK, ZrO₂-ZrO₂. The wear areas on the contact surfaces between the PCs and the SCs were examined on SEM images. Results: Wear marks in form of scratches, chipping, ductile deformation or combinations of these forms were observed on the PCs and SCs in the various material combinations. The greatest wear on PCs was observed in the PEEK-PEEK group, while the greatest wear on SCs was observed in the ZrO₂-ZrO₂ group. The least wear was observed on SCs made of PEEK in combination with PCs made of ZrO₂. Conclusion: When using modern materials for DCRDs, the combination of different materials for PCs and SCs must be taken into account. The data found in this study show that only minor wear occurs at SCs made of PEEK, especially in combination with PCs made of ZrO₂. Therefore, this combination seems particularly suitable for increasing the longevity of DCRDs.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06891-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in hydrogel research: a 25-year bibliometric overview","authors":"Dongbin Zhang,&nbsp;Mengru Qiu,&nbsp;Yu Tian,&nbsp;Shuo Zhang,&nbsp;Fan Wu","doi":"10.1007/s10856-025-06887-2","DOIUrl":"10.1007/s10856-025-06887-2","url":null,"abstract":"<div><p>This study presents a comprehensive bibliometric analysis of hydrogel research from 2000 to 2025, examining 101,291 publications from the OpenAlex database to highlight the field’s evolution, trends, and impact, providing a better landscape of the field. The analysis demonstrates significant growth in the research output, from ~350 publications in 2000 to nearly 11,000 in 2024, with 37% being open access. Publication patterns demonstrate Physical Sciences leading with about 50,000 publications, followed by Life Sciences (~30,000) and Health Sciences (~21,000). The citation analysis emphasizes that 20% of all citations result from the top 1% of papers, demonstrating the concentration of the research impact. The study identifies key research hubs, with China as a leader in the publication (27,931 publications), while the United States maintains the highest citation impact (&gt;1 million citations). Network analysis reveals increasingly complicated international collaborations, particularly between the United States and China. Topic modeling using Latent Dirichlet Allocation identifies 17 distinct research themes, emphasizing the field’s diversification from fundamental material features to advanced applications in the tissue engineering, drug delivery, and regenerative medicine. This analysis provides valuable insights into the dynamic landscape of hydrogel research, highlighting opportunities for future innovation and collaboration.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06887-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic blood compatibility assessment of coronary stents using an innovative pneumatic blood pump to generate physiological flow rates in small sample chambers","authors":"Anne-Sophie Hönicke,&nbsp;Emilia Paz Gross,&nbsp;Simon Beydoun,&nbsp;Felix Pfisterer,&nbsp;Michael Kirschbaum","doi":"10.1007/s10856-025-06882-7","DOIUrl":"10.1007/s10856-025-06882-7","url":null,"abstract":"<div><p>According to ISO 10993-4, shear-dependent processes must be considered in the blood compatibility testing of cardiovascular implants, which demands controlled and physiological flow conditions in the test environment. For very small test objects such as coronary stents with a diameter below 5 mm, this is difficult to achieve, as previous test methods are either unable to represent the required flow velocities in small-lumen sample chambers, or can only do so under high pump shear stress, which in extreme cases can mask the effects of the tiny test objects. In this paper, we present a novel concept for dynamic in vitro models based on pneumatically generated blood flow (<i>AirDrive</i> technology), which can achieve flow rates and velocities up to 450 ml min⁻¹ or 930 mm s⁻¹, respectively. This allows for hemocompatibility testing of coronary stents under physiologically high flow rates without generating major shear stress from the pump mechanism. In an initial feasibility study, single coronary stents with different surface finishes (polished/unpolished) were subjected to flow velocities of up to 560 mm s⁻¹ in a 3.2 mm diameter sample chamber. Blood samples were collected before and after perfusion, and haematological and coagulation markers were analysed. Unpolished stents elicited higher shear-induced blood responses than polished stents. This demonstrates that our experimental setup is highly sensitive and enables precise and robust investigation of blood compatibility under physiologically relevant flow conditions, even for the smallest objects under investigation. To show the superiority of this novel model in creating high flow rates while maintaining minimal blood damage, the <i>AirDrive</i> system was compared to the commonly used roller pump closed-loop system, with the former exhibiting significantly less blood damage. This further confirms that the <i>AirDrive</i> technology we present in this paper is of the highest value for developmental or regulatory testing of blood compatibility of small- and medium-sized test objects.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06882-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CA1 induced dental follicle stem cells co-culture with dental pulp stem cells and loaded three-dimensional printed PCL/β-TCP scaffold: a novel strategy for alveolar cleft bone regeneration","authors":"Hao-Ran Zhao,&nbsp;Jin-Ze Zhao,&nbsp;Ning Zhao,&nbsp;Ling-Fa Xue,&nbsp;Yao-Xiang Xu,&nbsp;Jin Yue,&nbsp;Wen-Lin Xiao","doi":"10.1007/s10856-025-06889-0","DOIUrl":"10.1007/s10856-025-06889-0","url":null,"abstract":"<div><h3>Background</h3><p>Bone tissue engineering for alveolar clefts is in the early stages of development, and more research is needed to determine the optimal cell types, growth factors and delivery methods for the therapy.</p><h3>Methods</h3><p>We co-cultured Carbonic anhydrase 1 (CA1) induced dental follicle stem cells (DFSCs) with dental pulp stem cells (DPSCs). In vitro, the Lentivirus vector overexpressing CA1 (LV-CA1) gene was constructed, transfected into DFSCs, and co-cultured with DPSCs indirectly. Osteoblast biomarkers in differentiated DFSCs were detected using quantitative real-time polymerase chain reaction and Western blotting. In vivo, establish a rat alveolar cleft model, transplanted stem cell Polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) three-dimensional printed composite scaffold and samples were collected at 4 and 8 weeks postoperatively. The osteogenic effect was evaluated through micro computed tomography and histomorphometric analysis.</p><h3>Results</h3><p>In vitro, the activity of DFSCs in the LV-CA1+Co-culture group was increased, and the mRNA and protein expressions of CA1, Alkaline phosphatase (ALP), Bone morphogenetic proteins 2 (BMP2), and Runt-related transcription factor 2 (RUNX2) were amplified to varying degrees <i>(P</i> &lt; 0.05<i>)</i>. In vivo, micro-CT displayed at 4 and 8 weeks postoperatively, the LV-CA1+Co-culture group had a considerably higher percentage of new bone development (39.1% and 56.9%) (<i>P</i> &lt; 0.05) than the other two groups. Histomorphometric analysis displayed the LV-CA1+Co-culture group had more newly formed bone trabeculae and immature collagen.</p><h3>Conclusion</h3><p>A strategy based on a novel osteogenic gene CA1 and dental-derived mesenchymal stem cells co-culture is applied to the alveolar cleft, providing a novel idea for the application of bone tissue engineering in alveolar cleft bone grafting.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06889-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological applications on a novel composite hydrogel containing mesoporous silica nanoparticles loaded with insulin-like growth Factor-1 and Vancomycin","authors":"Haiyong Ren,&nbsp;Qiaofeng Guo,&nbsp;Bingyuan Lin,&nbsp;Yiyang Liu,&nbsp;Xiang Wang,&nbsp;Kai Huang,&nbsp;Kaiting Wu","doi":"10.1007/s10856-025-06884-5","DOIUrl":"10.1007/s10856-025-06884-5","url":null,"abstract":"<div><p>Polymer nanocomposites have prolific applications in the environmental and health domain. Healthcare workers have constantly faced a challenge in constructing an effective sustained-release system for drugs, especially in areas where it is difficult to follow traditional treatment guidelines. To achieve a dual sustained release of vancomycin and cell growth factors, we designed a composite hydrogel, which was polymerized under ultraviolet irradiation to form a methacrylate gelatin (GelMA)/polyethylene glycol diacrylate (PEGDA) cross-linked system. The hydrogel showed antibacterial and pro-osteogenic differentiation activities by blending it with vancomycin and insulin-like growth factor 1 (IGF-1)-loaded silica particles. The experimental results showed that with increased PEGDA concentration, the hydrogels were degraded by swelling with a longer sustained release time. After 144-h immersion, the hydrogel still showed sustained release of IGF-1. The antibacterial experiment showed that the hydrogel pair had an obvious antibacterial effect against S. aureus. The results of live/dead staining and Cell Counting kit-8 assay indicated excellent biocompatibility of the hydrogel. Alizarin Red staining (ARS) further demonstrated that this hydrogel could induce bone marrow stem cells to initiate osteogenic differentiation. This hydrogel material exhibited excellent antibacterial and pro-osteogenic differentiation properties and might be promising for chronic osteomyelitis treatment.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06884-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of structural, optical, and thermal properties in MoS2 based nanocomposites into cancer therapy","authors":"Afsaneh Abareshi,&nbsp;Mohammad Mahdi Shahidi,&nbsp;Nasrin Salehi","doi":"10.1007/s10856-025-06883-6","DOIUrl":"10.1007/s10856-025-06883-6","url":null,"abstract":"<div><p>The objective of the present study is to evaluate the potential of novel molybdenum disulfide (MoS₂)-based nanocomposites for photothermal therapy. For this purpose, MoS₂-CuS (MoCS) and MoS₂-AuNR (MoAu) nanocomposites were synthesized by physically mixing MoS₂ suspensions with CuS and AuNRs, respectively. The structural and optical properties of these nanocomposites were characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), ultraviolet-visible (UV–Vis) spectroscopy, and Fourier transform infrared (FTIR) spectroscopy. The photothermal performance of the nanocomposites was assessed under near-infrared (NIR) radiation at a power density of 1 W/cm² for 10 min. The results demonstrated that both MoCS and MoAu nanocomposites exhibited enhanced photothermal heating compared to their individual components. Furthermore, the MoAu nanocomposite generated higher photothermal heat than the MoCS nanocomposite. These findings suggest that the MoCS and MoAu nanocomposites have strong potential as novel photothermal agents for cancer therapy.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06883-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New electrical method for obtaining graphic information on the evaluation of the uniformity of ZrO2-3 mol% and Y2O3 coatings deposited by electrophoresis. Application in protection and finishing of dental parts","authors":"Jesús M. Rodríguez-Rego,&nbsp;Antonio Macías-García,&nbsp;Laura Mendoza-Cerezo,&nbsp;Antonio Díaz-Parralejo,&nbsp;Alfonso C. Marco-Romero","doi":"10.1007/s10856-025-06876-5","DOIUrl":"10.1007/s10856-025-06876-5","url":null,"abstract":"<div><p>In recent years, the use of ceramic coatings has increased in industrial applications, using techniques such as immersion and electrophoretic deposition (EPD). High conductivity electrodes and metallic substrates, such as austenitic stainless steels, are crucial for uniform deposition, especially in the chemical and biomedical industries. ZrO₂-3mol% Y2O3 ceramic solutions serve as precursors in the fabrication of functional materials such as solid oxide fuel cells and biomedical applications. This work presents a novel electrical method to evaluate the homogeneity and uniformity of ceramic coatings on metallic specimens. The method is based on the application of an alternating current in a frequency range between 10 Hz and 10 MHz, measuring the impedance at 16 equidistant points. The impedance is decomposed into its real and imaginary components, and a map of the coating surface is generated, which allows the uniformity of the coating to be accurately assessed. To evaluate the results, the ZrO2-3mol% Y2O3 solution, the AISI 310 stainless steel metal substrate and the substrates coated (at different concentrations, for different times and current densities) and sintered at different temperatures were characterised. It was observed that the ZrO₂-3mol% Y₂O₃ solution at the following conditions (42.9 g-L^-1, 20 min, 1.5 A-cm^-2, 500 °C) presented the highest uniformity and homogeneity. In view of all the results, the proposed electrical method confirmed the uniformity and homogeneity of the coated surface from the capacitance values and their representation on a surface map. It is presented as a simple, inexpensive and non-destructive technique that provides information on the accuracy and sensitivity of the coating thickness and opens up its application to different industrial sectors. It also has great potential to revolutionise the field of medicine, offering more durable, biocompatible and efficient implantable devices.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06876-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of clove/gelatin coated silk sutures for surgical site infection and wound healing","authors":"Hamza Ghafoor,&nbsp;Muhammad Shoaib Butt","doi":"10.1007/s10856-025-06886-3","DOIUrl":"10.1007/s10856-025-06886-3","url":null,"abstract":"<div><p>Surgical Site infections (SSIs) affect up to 5% of surgical procedures, posing a significant postoperative complication. This study aims to develop and evaluate antibacterial clove/gelatin-coated sutures to reduce SSI infection. Clove extract, known for its antimicrobial properties, was incorporated into a gelatin matrix as a biocompatible coating for silk-braided sutures. Sutures were dip-coated in clove/gelatin solutions at concentrations of 5, 10, 15, and 20%. The surface morphology, chemical composition, and mechanical strength of the coated suture were characterized by using scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and tensile testing. Antimicrobial efficacy was assessed via zone-of-inhibition assays against (<i>Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Enterococcus faecalis</i>). The 20% Clove/gelatin coating exhibited the highest antibacterial activity (17.5 ± 0.875 mm) and demonstrated low cytotoxicity in MTT assay with human primary dermal fibroblast. Hemolytic assays revealed that all composite concentrations resulted in &lt;1% hemolytic activity. Approximately 93% of drug release was observed in 20% formulation within 72 h which is promising results compared with untreated sutures. Based on its superior antibacterial performance, the 20% formulation was selected for in vivo studies. In a rat abdominal incision model, wounds closed with coated sutures exhibited complete healing, while those closed with uncoated sutures remained partially healed. These findings highlight the potential of clove/gelatin-coated sutures for enhanced antimicrobial protection and improved wound healing in surgical applications.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06886-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3-Dimensional printing and bioprinting in neurological sciences: applications in surgery, imaging, tissue engineering, and pharmacology and therapeutics","authors":"Sreejita Dhar,&nbsp;Faraz Ahmad,&nbsp;Aditi Deshpande,&nbsp;Sandeep Singh Rana,&nbsp;Toufeeq Ahmed A,&nbsp;Swagatika Priyadarsini","doi":"10.1007/s10856-025-06877-4","DOIUrl":"10.1007/s10856-025-06877-4","url":null,"abstract":"<div><p>The rapid evolution of three-dimensional printing (3DP) has significantly impacted the medical field. In neurology for instance, 3DP has been pivotal in personalized surgical planning and education. Additionally, it has facilitated the creation of implants, microfluidic devices, and optogenetic probes, offering substantial implications for medical and research applications. Additionally, 3D printed nasal casts are showing great promise for targeted brain drug delivery. 3DP has also aided in creating 3D “phantoms” aligning with advancements in neuroimaging, and in the design of intricate objects for investigating the neurobiology of sensory perception. Furthermore, the emergence of 3D bioprinting (3DBP), a fusion of 3D printing and cell biology, has created new avenues in neural tissue engineering. Effective and ethical creation of tissue-like biomimetic constructs has enabled mechanistic, regenerative, and therapeutic evaluations. While individual reviews have explored the applications of 3DP or 3DBP, a comprehensive review encompassing the success stories across multiple facets of both technologies in neurosurgery, neuroimaging, and neuro-regeneration has been lacking. This review aims to consolidate recent achievements of both 3DP and 3DBP across various neurological science domains to encourage interdisciplinary research among neurologists, neurobiologists, and engineers, in order to promote further exploration of 3DP and 3DBP methodologies to novel areas of neurological science research and practice.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06877-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable bioactive scaffold able to stimulate oral bone regeneration on demand","authors":"Anna Tampieri,&nbsp;Marta Tavoni,&nbsp;Teresa Vicidomini,&nbsp;Hina Inam,&nbsp;Elisa Restivo,&nbsp;Livia Visai,&nbsp;Umberto Romeo,&nbsp;Simone Sprio","doi":"10.1007/s10856-025-06879-2","DOIUrl":"10.1007/s10856-025-06879-2","url":null,"abstract":"<div><p>Bone regeneration in oral surgery remains a challenge, due to the features of the oral environment, characterized by the presence of saliva and extensive interaction with external pathogens. Recent advances in this field highlighted that biomimetic apatites in which Ca²⁺ is replaced by Fe²⁺/Fe³⁺ ions are promising candidates to guide bone regeneration with on demand activation control. In this study the Fe-doped apatite nanoparticles (FeHA) were developed and compared with magnetite nanoparticles, as new magnetic bio-activator, to be embedded in apatitic injectable paste/cement. Upon self-hardening, the new injectable cement generates a mechanically competent 3D superparamagnetic scaffold, endowed with remote activation by using static magnetic fields. We investigated the alkaline phosphatase expression and activity, as well as the behaviour of cells, when seeded onto the scaffold. The results show the ability of the cement to stimulate cell colonization and differentiation and how, when magnetized, they can further boost such phenomena. The proposed devices, in association with a magnetic aligner, can represent a new approach in oral surgery, able to tune the bone remodelling on demand, when the regenerative potential is impaired by physiological conditions such as aging or chronic diseases.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06879-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}