Nutrition and Cancer-An International Journal最新文献_第4页

Prognostic Factors Affecting Iodine-131 Treatment Efficacy in Patients With Differentiated Thyroid Carcinoma: A Risk-Stratified Analysis. 影响分化型甲状腺癌患者碘-131治疗效果的预后因素：风险分层分析

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2025-12-07 DOI: 10.1080/01635581.2025.2596905

Jinhao Li, Huixia Geng, Junbo Nan, Fangfang Mao, Luoping Zhai, Wanchun Zhang

{"title":"Prognostic Factors Affecting Iodine-131 Treatment Efficacy in Patients With Differentiated Thyroid Carcinoma: A Risk-Stratified Analysis.","authors":"Jinhao Li, Huixia Geng, Junbo Nan, Fangfang Mao, Luoping Zhai, Wanchun Zhang","doi":"10.1080/01635581.2025.2596905","DOIUrl":"10.1080/01635581.2025.2596905","url":null,"abstract":"To analyze factors influencing iodine-131 (I-131) treatment efficacy in differentiated thyroid carcinoma (DTC). This retrospective study classified 299 patients with DTC into medium-low-risk and high-risk groups, assessing clinical data (preoperative stimulated thyroglobulin [ps-Tg], urinary iodine, gender, T stage, diet). Patients followed normal or iodine-restricted diets. Statistical analyses included t-tests, chi-squared tests and logistic regression. Medium-low risk and higher ps-Tg levels and urinary iodine concentrations correlated with less favorable outcomes (p < 0.001). High-risk patients showed significant differences in gender, T stage and ps-Tg level (p < 0.001). Multivariate analysis identified risk level, T stage and ps-Tg level as key prognostic factors (p < 0.001), with urinary iodine concentration having a minor effect (p = 0.003). Risk stratification, T stage and ps-Tg level were the primary prognostic determinants. Dietary interventions showed different effects in different risk-stratified patients, requiring individualized consideration. These findings emphasize the importance of comprehensive assessment in DTC management.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"181-188"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GLR in Cholangiocarcinoma: A Practical Biomarker in Need of Validation. 胆管癌GLR：一种需要验证的实用生物标志物。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2025-10-11 DOI: 10.1080/01635581.2025.2570558

Pınar Peker, Aslı Geçgel, Oğuzcan Özkan

引用次数: 0

Optimizing Nutritional Support in Advanced Non-Small Cell Lung Cancer: Evidence and Controversies in Oral, Enteral, and Parenteral Approaches. 优化晚期非小细胞肺癌的营养支持：口服、肠内和肠外途径的证据和争议。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2026-02-23 DOI: 10.1080/01635581.2026.2632656

Elvis Obomanu, Chidiebube Ugwu, Muluken Megiso, Colton Jones, Tarfa Verinumbe, Akshay Ratnani, Sam King, Danielle Palaferro, Swe Swe Hlaing, Zachary Cohn

{"title":"Optimizing Nutritional Support in Advanced Non-Small Cell Lung Cancer: Evidence and Controversies in Oral, Enteral, and Parenteral Approaches.","authors":"Elvis Obomanu, Chidiebube Ugwu, Muluken Megiso, Colton Jones, Tarfa Verinumbe, Akshay Ratnani, Sam King, Danielle Palaferro, Swe Swe Hlaing, Zachary Cohn","doi":"10.1080/01635581.2026.2632656","DOIUrl":"10.1080/01635581.2026.2632656","url":null,"abstract":"Malnutrition and cachexia affect the majority of patients with advanced lung cancer, driven by systemic inflammation (IL-6, TNF-α), metabolic dysregulation, and anorexia. These conditions worsen prognosis, reduce treatment tolerance, and diminish quality of life (QoL) and survival. Early recognition, utilizing tools such as the Patient-Generated Subjective Global Assessment (PG-SGA), is crucial. Nutritional support should align with patient-centered goals, prioritizing function and QoL rather than survival alone. Oral nutritional supplements (ONS), especially high-protein/EPA (eicosapentaenoic acid)- enriched formulas, enhance weight, muscle mass, and QoL but often face adherence challenges. Enteral nutrition (EN) supports patients with functional GI tracts and impaired intake (e.g., dysphagia), improving biomarkers and reducing complications. Parenteral nutrition (PN) should be limited to patients with intestinal failure due to infection risks and minimal survival benefits. Multimodal care, encompassing nutrition, exercise, and pharmacotherapy (e.g., appetite stimulants, investigational agents such as anamorelin), is crucial. Ethical, cultural, and legal considerations must guide decisions around artificial nutrition, emphasizing autonomy, informed consent, and respect for cultural beliefs. Barriers such as inconsistent screening and limited resources persist. Future research should focus on lung cancer-specific trials of EN, standardized cachexia definitions, and equitable access to nutritional support, especially in underserved populations.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"265-278"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147277682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2026-03-02 DOI: 10.1080/01635581.2026.2638057

引用次数: 0

Effectiveness of Nutritional Screening Tools in Predicting the Impact of Malnutrition on Hospital and Intensive Care Unit Stay. 营养筛查工具在预测营养不良对住院和重症监护病房的影响方面的有效性。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2025-11-19 DOI: 10.1080/01635581.2025.2584487

Chung-Yan Lee, Ping-Wen Shih, Chun-Hao Yin, Yao-Shen Chen, Ko-Huei Wu, Ying-Chun Li, Yi-Chia Su

{"title":"Effectiveness of Nutritional Screening Tools in Predicting the Impact of Malnutrition on Hospital and Intensive Care Unit Stay.","authors":"Chung-Yan Lee, Ping-Wen Shih, Chun-Hao Yin, Yao-Shen Chen, Ko-Huei Wu, Ying-Chun Li, Yi-Chia Su","doi":"10.1080/01635581.2025.2584487","DOIUrl":"10.1080/01635581.2025.2584487","url":null,"abstract":"Malnutrition commonly occurs in patients with esophageal cancer (EC) and head and neck cancers (HNCs), adversely affecting clinical outcomes. The comparative effectiveness of nutritional screening tools in predicting prolonged length of stay (PLOS) and intensive care unit (ICU) admission in this population remains unclear. We aimed to investigate the effectiveness of various nutritional screening techniques in predicting the hospital and ICU LOS of patients with HNCs/EC. We retrospectively analyzed the data of 374 patients aged ≥18 years with EC/HNC who underwent first-time surgery between January 2013 and December 2023. Nutritional status was assessed using the Malnutrition Universal Screening Tool (MUST), Controlling Nutritional Status (COUNT), Geriatric Nutritional Risk Index (GNRI), and Prognostic Nutritional Index (PNI). Patients were classified into low-risk and high-to-moderate-risk groups. The outcomes included ICU stay >2 days and PLOS (>16 days). The COUNT, GNRI, and PNI were significantly associated with ICU stays >2 days and PLOS. The PNI had the highest predictive accuracy (ICU >2 days: adjusted odds ratio [aOR] = 8.44; area under the ROC curve [AUC-ROC] = 0.864; PLOS: aOR = 6.39; AUC-ROC = 0.859). The PNI, COUNT, and GNRI effectively predicted ICU stay and PLOS among surgical patients with EC and HNC.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"158-168"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Scoping Review of Ultra-Processed Food Consumption and Cancer Risk: Implications for Public Health, Registered Dietitian Nutritionists and Other Healthcare Professionals. 超加工食品消费与癌症风险的范围综述：对公众健康、注册营养师、营养学家和其他医疗保健专业人员的影响。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2025-10-14 DOI: 10.1080/01635581.2025.2572122

Gabrielle DeVito, Patricia Sheean

{"title":"A Scoping Review of Ultra-Processed Food Consumption and Cancer Risk: Implications for Public Health, Registered Dietitian Nutritionists and Other Healthcare Professionals.","authors":"Gabrielle DeVito, Patricia Sheean","doi":"10.1080/01635581.2025.2572122","DOIUrl":"10.1080/01635581.2025.2572122","url":null,"abstract":"Foods that are industrially created and/or heavily manipulated in the manufacturing process are conceptualized as ultra processed foods (UPFs), reflecting an emerging dietary target for chronic disease prevention. This scoping review provides updated evidence on associations between UPF consumption and cancer risk and identifies potential carcinogenic properties within UPFs, highlighting implications for food policies, Registered Dietitian Nutritionists (RDNs) and other healthcare professionals. Using the PubMed and Scopus databases, a comprehensive search was conducted (2010-2025). Eligible articles were required to be peer reviewed, published in English, observational in design, utilize the NOVA classification system, and examine cancer incidence. A total of 23 articles were included, and 15 reported a positive association between UPF intake and cancer incidence. This appeared more pronounced when cancer was considered one of many chronic diseases, and factoring in subgroup analyses within larger populations. Sugar-sweetened beverages and ultra-processed meats were isolated UPFs associated with higher cancer risk, allowing RDNs and other healthcare practitioners tangible dietary targets to impact cancer risk. Given the collective evidence, significant investment is needed in methodologies to comprehensively and reliably classify UPFs and to integrate UPFs into public health nutrition campaigns, dietary guidelines and food labels promoting a better food environment for all.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"99-110"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On FFMI as a Proxy for Muscle Mass, or How Redundancy and Multicollinearity Distort Inference. 关于FFMI作为肌肉质量的代理，或者冗余和多重共线性如何扭曲推理。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2025-10-27 DOI: 10.1080/01635581.2025.2581337

Jenny G Turcott, Eduardo Rios-Garcia, Cittim Palomares-Palomares, Oscar Arrieta

引用次数: 0

Association Between Fat Mass Index, Fat Free Mass Index and Metabolic Syndrome, Cachexia, and All-Cause Mortality Among Patients with Cancer. 脂肪质量指数、无脂肪质量指数与癌症患者代谢综合征、恶病质和全因死亡率的关系

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2025-11-06 DOI: 10.1080/01635581.2025.2581336

Hai-Ying Tian, Chen-An Liu, Han-Ping Shi

{"title":"Association Between Fat Mass Index, Fat Free Mass Index and Metabolic Syndrome, Cachexia, and All-Cause Mortality Among Patients with Cancer.","authors":"Hai-Ying Tian, Chen-An Liu, Han-Ping Shi","doi":"10.1080/01635581.2025.2581336","DOIUrl":"10.1080/01635581.2025.2581336","url":null,"abstract":"Background and objective: This study examined the associations of fat mass index (FMI) and fat free mass index (FFMI) with metabolic syndrome (MetS), cachexia, and all-cause mortality in cancer patients, given the limited existing evidence on these relationships.Materials and methods: This analysis included 3,247 subjects enrolled in a cohort study. Cox regression analyses calculated hazard ratios (HRs) with corresponding 95% confidence intervals (95% CIs). Logistic models generated odds ratios (ORs) and 95% CIs. Mediation effects of FMI and FFMI on the cachexia-mortality association were evaluated.Results: FMI and FFMI were significantly associated with MetS and cachexia, respectively. FMI (HR [95% CI] = 0.96 (0.94, 0.99), p = 0.003), FFMI (HR [95% CI] = 0.94 (0.91, 0.97), p < 0.001) were significantly associated with mortality. FMI (proportion mediated%=10.21, p = 0.03) and FFMI (proportion mediated%=13.16, p = 0.016) mediate the correlation between cachexia and mortality. Subgroup analysis showed that FMI had a significant mediating effect in gastrointestinal cancer, while FFMI had a significant mediating effect in lung cancer.Conclusion: FMI and FFMI were positively correlated with MetS, negatively correlated with cachexia and mortality. FMI and FFMI mediate the association between cachexia and mortality, with FFMI having a higher mediating effect than FMI, however, the mediating effect was differentiated by tumor types.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"123-133"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flaxseed Oil Inhibits Hepatic Preneoplastic Lesions, DNA Damage, and γ-H2AX Expression During Initial Phases of Hepatocarcinogenesis. 亚麻籽油抑制肝癌发生初期肝脏肿瘤前病变、DNA损伤和γ-H2AX表达。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2025-09-25 DOI: 10.1080/01635581.2025.2562639

Renato Heidor, Roberto Carvalho Yamamoto, Camila Fonseca Amorim da Silva, Jossana Rodrigues Ruff, Eduardo Purgatto, Fernando Salvador Moreno

{"title":"Flaxseed Oil Inhibits Hepatic Preneoplastic Lesions, DNA Damage, and γ-H2AX Expression During Initial Phases of Hepatocarcinogenesis.","authors":"Renato Heidor, Roberto Carvalho Yamamoto, Camila Fonseca Amorim da Silva, Jossana Rodrigues Ruff, Eduardo Purgatto, Fernando Salvador Moreno","doi":"10.1080/01635581.2025.2562639","DOIUrl":"10.1080/01635581.2025.2562639","url":null,"abstract":"Hepatocellular carcinoma (HCC) is the most common primary liver cancer and is often diagnosed at advanced stages, limiting therapeutic options. Therefore, preventive strategies are crucial for its control. Among these, the use of nutrients and bioactive food compounds, such as omega-3 polyunsaturated fatty acids (n-3 PUFAs), has gained attention. Alpha-linolenic acid (ALA), a plant-derived n-3 PUFA abundant in flaxseed oil (FSO), has shown chemopreventive effects in various cancer models. This study investigated the chemopreventive potential of FSO in rats subjected to the resistant hepatocyte (RH) model of hepatocarcinogenesis, which generates preneoplastic lesions that may either progress to HCC (pPNL) or revert to a normal phenotype (rPNL). FSO treatment led to a reduction in the number of liver nodules and decreased both the number and size of pPNL. These effects were associated with increased hepatic ALA levels. FSO did not affect cell proliferation or apoptosis; however, it reduced DNA damage and inhibited γ-H2AX expression in preneoplastic livers, particularly in pPNL. Given that pPNL shares molecular alterations with HCC, the inhibition of γ-H2AX suggests a relevant mechanism by which FSO contributes to the chemoprevention of hepatocarcinogenesis.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"80-91"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrition Screening and Assessment Tools for Adult Patients with Cancer and Survivors of Cancer: A Systematic Review. 成年癌症患者和癌症幸存者的营养筛查和评估工具：系统综述。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2025-10-15 DOI: 10.1080/01635581.2025.2567026

Sara Klöczl Kring, Anne Marie Beck, Irene Wessel, Kim Skov Ustrup, Karin B Dieperink, Ann-Dorthe Zwisler, Marianne Boll Kristensen

{"title":"Nutrition Screening and Assessment Tools for Adult Patients with Cancer and Survivors of Cancer: A Systematic Review.","authors":"Sara Klöczl Kring, Anne Marie Beck, Irene Wessel, Kim Skov Ustrup, Karin B Dieperink, Ann-Dorthe Zwisler, Marianne Boll Kristensen","doi":"10.1080/01635581.2025.2567026","DOIUrl":"10.1080/01635581.2025.2567026","url":null,"abstract":"Malnutrition and nutrition impact symptoms are common during and after anticancer treatment. This systematic review aimed to identify nutrition screening and assessment tools validated in patients with cancer and/or survivors, and to provide an overview. Comprehensive searches were conducted. Covidence was used for reference screening, data extraction, and quality assessment by two reviewers independently. Studies were included if they tested concurrent validity of a tool reporting: sensitivity, specificity, area under the curve (AUC), Pearson's/Spearman's correlation coefficient, or kappa. Data were summarized in tables and described narratively. Of 6,332 screened records, 486 were full-text reviewed, and 98 articles covering 161 validation studies of 47 tools were included. Most articles included mixed cancer diagnoses, followed by head and neck and gastrointestinal cancer; few included survivors. The most frequently validated tools were Nutritional Risk Screening 2002 (NRS 2002), Malnutrition Screening Tool (MST), Malnutrition Universal Screening Tool (MUST), and the Scored Patient-Generated Subjective Global Assessment (PG-SGA). Several reference standards were used. Sensitivity ranged from 6% to 100%, specificity from 11% to 100%, and validity from 'Poor' to 'Good'. The absence of a universal gold standard complicates identification of a superior tool. Nonetheless, rather than ranking tools, this review provides an overview of their validity across different reference standards, offering guidance for clinicians. PROSPERO: CRD42018096678.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"7-29"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0