Nutrition and Cancer-An International Journal最新文献

How the Ketogenic Diet Shapes the Microbiome to Influence Cancer Immunotherapy Outcomes: An Exploration of Clinical Trials and Their Results. 生酮饮食如何塑造微生物组以影响癌症免疫治疗结果：临床试验及其结果的探索。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-05-04 DOI: 10.1080/01635581.2026.2658807

Jonah Bukovac, Marium Husain, Teryn Sapper, Angela O'Dell, Marisa Bittoni, Helena Gastier, Ashwini Chebbi, Victoria Hockenhull, Zachary Dohar, Jennifer Moon, Fred Tabung, Claire Verschraegen, Richard Wu, Kari Kendra, Yuanquan Yang, Jeff Volek, Daniel Spakowicz

{"title":"How the Ketogenic Diet Shapes the Microbiome to Influence Cancer Immunotherapy Outcomes: An Exploration of Clinical Trials and Their Results.","authors":"Jonah Bukovac, Marium Husain, Teryn Sapper, Angela O'Dell, Marisa Bittoni, Helena Gastier, Ashwini Chebbi, Victoria Hockenhull, Zachary Dohar, Jennifer Moon, Fred Tabung, Claire Verschraegen, Richard Wu, Kari Kendra, Yuanquan Yang, Jeff Volek, Daniel Spakowicz","doi":"10.1080/01635581.2026.2658807","DOIUrl":"https://doi.org/10.1080/01635581.2026.2658807","url":null,"abstract":"Ketogenic dietary interventions (KDIs) are increasingly explored as adjuncts in oncology due to their metabolic and immunomodulatory effects. One mechanism by which KDIs are expected to modulate the immune system is by altering the gut microbiome, which has been shown to affect treatment outcomes, particularly in the context of immunotherapies. This review synthesized findings from 43 clinical trials to evaluate the current landscape of KDIs in cancer care, with a focus on the gut microbiota and immunotherapy. Although 47% of identified trials are completed, none have yet published results combining KDIs with immunotherapy. Since 2020, however, there has been a significant increase in ongoing studies investigating this combination and incorporating microbiome endpoints. While KDIs may help shape an immunotherapy-permissive environment, further clinical evaluation is necessary to determine the full extent of KDIs on the microbiome. Future research should prioritize longitudinal microbiome profiling and standardized adherence reporting to clarify the therapeutic potential of KDIs as a metabolic adjuvant to immune checkpoint inhibitors.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-30"},"PeriodicalIF":2.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considering Body Mass Index for Skin Cancer Prevention Using Oral Nicotinamide. 考虑体重指数对口服烟酰胺预防皮肤癌的影响。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-05-01 DOI: 10.1080/01635581.2026.2657613

David Metsu, Vincent Sibaud

引用次数: 0

Evaluating the Prognostic Role of Body Fat Density in Colorectal Cancer: A Critical Appraisal. 评估体脂密度在结直肠癌预后中的作用：一项关键性评估。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-04-27 DOI: 10.1080/01635581.2026.2663589

Oğuzcan Özkan

引用次数: 0

Fatty Acid Intake and Bladder Cancer Risk: A Multicenter Case-Control Study in Iran. 脂肪酸摄入与膀胱癌风险：伊朗一项多中心病例对照研究

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-04-25 DOI: 10.1080/01635581.2026.2658800

Monireh Sadat Seyyedsalehi, Maryam Hadji, Hamideh Rashidian, Ahmad Naghibzadeh-Tahami, Maryam Marzban, Kazem Zendehdel, Paolo Boffetta

{"title":"Fatty Acid Intake and Bladder Cancer Risk: A Multicenter Case-Control Study in Iran.","authors":"Monireh Sadat Seyyedsalehi, Maryam Hadji, Hamideh Rashidian, Ahmad Naghibzadeh-Tahami, Maryam Marzban, Kazem Zendehdel, Paolo Boffetta","doi":"10.1080/01635581.2026.2658800","DOIUrl":"https://doi.org/10.1080/01635581.2026.2658800","url":null,"abstract":"Bladder cancer is a major public health concern worldwide. While smoking and occupational exposures are established risk factors, the role of dietary fatty acids (FAs) in bladder cancer risk remains unclear. Data were collected from 711 bladder cancer cases and 3,297 controls in the IROPICAN study (2017-2020) across ten Iranian provinces. Dietary intake was assessed using a validated food frequency questionnaire. Intakes of total fat, saturated FAs (SFAs), monounsaturated FAs (MUFAs), polyunsaturated FAs (PUFAs), and trans FAs (TFAs) were analyzed. Principal component analysis (PCA) identified fatty acid consumption patterns. Multivariable logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for confounders. PCA suggested that balancing FA intake, specifically increasing omega-3 FAs, moderating omega-6, and reducing saturated fats, was associated with a favorable profile for bladder cancer risk. OR for stearic acid intake was 0.28 (95% CI: 0.12-0.67). Conversely, OR for high intake of palmitoleic acid, alpha-linolenic acid (ALA), and docosapentaenoic acid (DPA) was elevated. Sex-specific effects were found stearic acid was protective in men, while PUFAs were protective in women. No associations were observed for total fat or cholesterol. These results highlight the importance of FA subtypes, rather than total fat intake, in dietary recommendations.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-12"},"PeriodicalIF":2.4,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to "Evaluating the Prognostic Role of Body Fat Density in Colorectal Cancer: A Critical Appraisal". 对“评估体脂密度在结直肠癌预后中的作用：一项关键评估”的回应。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-04-24 DOI: 10.1080/01635581.2026.2663585

Leonardo Borges Murad, Wilza Arantes Ferreira Peres

引用次数: 0

Comparison of Two Instruments to Assess the Impact of Cachexia on Quality of Life in Women with Cervical Cancer. 两种评估恶病质对宫颈癌妇女生活质量影响的仪器的比较。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-04-22 DOI: 10.1080/01635581.2026.2658765

Julissa Luvián-Morales, Luis Daniel Galvan-Cota, Luis David Galvan-Cota, Denisse Castro-Eguiluz, Luis F Oñate-Ocaña

{"title":"Comparison of Two Instruments to Assess the Impact of Cachexia on Quality of Life in Women with Cervical Cancer.","authors":"Julissa Luvián-Morales, Luis Daniel Galvan-Cota, Luis David Galvan-Cota, Denisse Castro-Eguiluz, Luis F Oñate-Ocaña","doi":"10.1080/01635581.2026.2658765","DOIUrl":"https://doi.org/10.1080/01635581.2026.2658765","url":null,"abstract":"Cancer-associated cachexia (CAC) is common in cervical cancer (CC) patients. This condition affects the Health-related quality of life (HRQL). This study aims to assess the impact of CAC on HRQL, comparing the Quality of Life Questionnaire (QLQ) QLQ-C30/QLQ-CAX24 and the Functional assessment of anorexia/cachexia therapy (FAACT) instruments. A cohort of CC patients answered the QLQ-C30/QLQ-CAX24 and the FAACT instruments between October 2020 and October 2021. The psychometric/clinimetric characteristics of the instruments were compared. 244 CC patients were included in the study. Correlations between scales ranged from 0.008 to 0.81. The summary score of QLQ-C30 correlated well with the FAACT total score (r = 0.684) and the FAACT Physical Well-being subscale (r = 0.81). The correlation with five nutritional parameters and prognostic indices was poor (r < 0.364). Most symptom scales of the QLQ-CAX24 presented a floor effect, and those of the FAACT did not. The Nausea/vomiting score of the QLQ-C30, and the Loss of control and Forced to eat scales of the QLQ-CAX24 were independently associated with overall survival. The QLQ-C30/QLQ-CAX24 and FAACT instruments differ substantially, but some scales are comparable. We propose an algorithm to select the appropriate instrument to asses HRQL for a research protocol.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-13"},"PeriodicalIF":2.4,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological Treatments for Cancer-Related Anorexia-Cachexia Syndrome: An Umbrella Review of Systematic Reviews and Meta-Analyses. 癌症相关厌食症-恶病质综合征的药物治疗：系统综述和荟萃分析综述。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-04-08 DOI: 10.1080/01635581.2026.2652000

Nazanin Zamanian, Arefeh Mohajerani, Maryam Barkhordar, Mehran Rahimlou, Reza Amiri Khosroshahi, Sepide Talebi, Mojtaba Azari, Ali Soleimani, Hamed Mohammadi

引用次数: 0

Statement of Retraction: Ketogenic Diets Are Associated with an Elevated Risk for All Cancers: Insights from a Cross-Sectional Analysis of the NHANES 2001-2018. 撤回声明：生酮饮食与所有癌症风险升高有关：来自2001-2018年NHANES横断面分析的见解。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-21 DOI: 10.1080/01635581.2026.2617810

引用次数: 0

Response to Letter to the Editor, "Association Between Immunotherapy and Overall Survival in Malnourished Patients with Advanced Non-Small Cell Lung Cancer: A Nationwide Retrospective Cohort Study in Japan". 对《营养不良晚期非小细胞肺癌患者免疫治疗与总生存率的关系：日本全国回顾性队列研究》致编辑的回复。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-19 DOI: 10.1080/01635581.2026.2615986

Maya Shimasaki, Yasutaka Ihara, Shoichiro Yamamoto, Shinji Akiyama

引用次数: 0

Letter to the Editor: Association Between Immunotherapy and Overall Survival in Malnourished Patients with Advanced Non-Small Cell Lung Cancer: A Nationwide Retrospective Cohort Study in Japan. 致编辑：免疫治疗与营养不良晚期非小细胞肺癌患者总生存率之间的关系：日本全国回顾性队列研究。

IF 2.4 4区医学