Nutrition and Cancer-An International Journal最新文献

Exploring the Relationship Between Supplement Usage and Quality of Life Among Cancer Patients in Jordan: A Cross-Sectional Study. 探索约旦癌症患者补充剂使用与生活质量之间的关系：一项横断面研究。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-10-09 DOI: 10.1080/01635581.2025.2569903

Mohammad Alali, Suha Omran, Wafa'a Ta'an

{"title":"Exploring the Relationship Between Supplement Usage and Quality of Life Among Cancer Patients in Jordan: A Cross-Sectional Study.","authors":"Mohammad Alali, Suha Omran, Wafa'a Ta'an","doi":"10.1080/01635581.2025.2569903","DOIUrl":"https://doi.org/10.1080/01635581.2025.2569903","url":null,"abstract":"This study explores the use of nutrition supplements by Jordanian cancer patients regarding symptoms of quality of life. It explores the prevalence of the use of nutrition supplements by cancer patients and the related demographic and disease-specific factors. A cross-sectional study was conducted on cancer patients at three major hospitals in Jordan. A total of 220 participants completed structured questionnaires. The EORTC QLQ-C15 scale was used to collect data on supplement usage patterns and quality of life. Chi-square tests and regression analysis were performed to assess the association between supplement use and QoL outcomes. Supplement use was noted in 65.9% of participants; the most used supplements were vitamin D, calcium, and omega-3. Supplement use was significantly associated with age, gender, income, and education level but showed a positive association between supplement use and improved QoL (p = 0.028). The findings suggest that the use of supplements is associated with improved quality of life among cancer patients in Jordan. It is important to consider integrating patient education and professional guidance regarding safe supplement use into cancer care. Further, longitudinal studies are needed to generalize these findings and to explore the long-term effect of supplements on QoL.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Geriatric Nutritional Risk Index and Gastrointestinal Cancer Risk in Older Adults: Insights from the National Health and Nutrition Examination Survey 1999-2020. 老年营养风险指数与老年人胃肠道癌风险的关系：来自1999-2020年全国健康与营养调查的见解

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-10-01 DOI: 10.1080/01635581.2025.2567025

Fangzhe Zhou, Lannan He, Meijuan Zhu, Yanhua Zhou, Deng Fan

{"title":"Association Between Geriatric Nutritional Risk Index and Gastrointestinal Cancer Risk in Older Adults: Insights from the National Health and Nutrition Examination Survey 1999-2020.","authors":"Fangzhe Zhou, Lannan He, Meijuan Zhu, Yanhua Zhou, Deng Fan","doi":"10.1080/01635581.2025.2567025","DOIUrl":"https://doi.org/10.1080/01635581.2025.2567025","url":null,"abstract":"The Geriatric Nutritional Risk Index (GNRI) is a valuable tool to assess nutritional status in older adults, but its association with gastrointestinal (GI) cancer risk remains unclear. This study aimed to investigate the association between GNRI and GI cancer risk in the elderly population. Data from 18,889 participants aged 60 and older were analyzed from the National Health and Nutrition Examination Survey (NHANES) between 1999-2020. Multivariable logistic regression models were used to examine the association between GNRI and GI cancer risk, adjusting for confounding factors including age, sex, race, education, poverty-income ratio (PIR), smoking status, alcohol drinking, hypertension, and diabetes. Potential non-linear relationships were explored using generalized additive models, smooth curve fitting, and piece-wise regression analysis. A significant negative association was observed between GNRI and GI cancer risk (p = 0.005), after fully adjusting for confounders. Participants in the third quartile of GNRI had a 35% lower risk of GI cancers compared to those in the lowest quartile (p = 0.010). Piece-wise regression analysis identified a GNRI threshold of 95.25. These findings provide evidence that elevated GNRI is remarkably associated with reduced GI cancer risk among geriatric individuals.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined Effects of Psychological Intervention and Enhanced Nutritional Support on Postoperative Recovery in Gastric Cancer Patients. 心理干预加营养支持对胃癌患者术后康复的影响。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-09-25 DOI: 10.1080/01635581.2025.2564748

Gang Wang, Shengjie Pan

引用次数: 0

Flaxseed Oil Inhibits Hepatic Preneoplastic Lesions, DNA Damage, and γ-H2AX Expression During Initial Phases of Hepatocarcinogenesis. 亚麻籽油抑制肝癌发生初期肝脏肿瘤前病变、DNA损伤和γ-H2AX表达。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-09-25 DOI: 10.1080/01635581.2025.2562639

Renato Heidor, Roberto Carvalho Yamamoto, Camila Fonseca Amorim da Silva, Jossana Rodrigues Ruff, Eduardo Purgatto, Fernando Salvador Moreno

{"title":"Flaxseed Oil Inhibits Hepatic Preneoplastic Lesions, DNA Damage, and γ-H2AX Expression During Initial Phases of Hepatocarcinogenesis.","authors":"Renato Heidor, Roberto Carvalho Yamamoto, Camila Fonseca Amorim da Silva, Jossana Rodrigues Ruff, Eduardo Purgatto, Fernando Salvador Moreno","doi":"10.1080/01635581.2025.2562639","DOIUrl":"https://doi.org/10.1080/01635581.2025.2562639","url":null,"abstract":"Hepatocellular carcinoma (HCC) is the most common primary liver cancer and is often diagnosed at advanced stages, limiting therapeutic options. Therefore, preventive strategies are crucial for its control. Among these, the use of nutrients and bioactive food compounds, such as omega-3 polyunsaturated fatty acids (n-3 PUFAs), has gained attention. Alpha-linolenic acid (ALA), a plant-derived n-3 PUFA abundant in flaxseed oil (FSO), has shown chemopreventive effects in various cancer models. This study investigated the chemopreventive potential of FSO in rats subjected to the resistant hepatocyte (RH) model of hepatocarcinogenesis, which generates preneoplastic lesions that may either progress to HCC (pPNL) or revert to a normal phenotype (rPNL). FSO treatment led to a reduction in the number of liver nodules and decreased both the number and size of pPNL. These effects were associated with increased hepatic ALA levels. FSO did not affect cell proliferation or apoptosis; however, it reduced DNA damage and inhibited γ-H2AX expression in preneoplastic livers, particularly in pPNL. Given that pPNL shares molecular alterations with HCC, the inhibition of γ-H2AX suggests a relevant mechanism by which FSO contributes to the chemoprevention of hepatocarcinogenesis.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-12"},"PeriodicalIF":2.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing Appetite and Dietary Intake Responses to Resistance Exercise in Breast Cancer Survivors Undergoing Adjuvant Endocrine Therapy Versus Individuals Without Cancer: A Secondary Analysis. 比较接受辅助内分泌治疗的乳腺癌幸存者与非癌症患者的食欲和饮食摄入对抵抗运动的反应：一项次要分析。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-06-22 DOI: 10.1080/01635581.2025.2518611

Sarah A Purcell, Tanya M Halliday, Edward L Melanson, Anosheh Afghahi, Virginia F Borges, Isabella Sinelli, Marc-Andre Cornier

{"title":"Comparing Appetite and Dietary Intake Responses to Resistance Exercise in Breast Cancer Survivors Undergoing Adjuvant Endocrine Therapy Versus Individuals Without Cancer: A Secondary Analysis.","authors":"Sarah A Purcell, Tanya M Halliday, Edward L Melanson, Anosheh Afghahi, Virginia F Borges, Isabella Sinelli, Marc-Andre Cornier","doi":"10.1080/01635581.2025.2518611","DOIUrl":"10.1080/01635581.2025.2518611","url":null,"abstract":"Breast cancer survivors (BCS) undergoing adjuvant endocrine therapy have increased risk of obesity. Estrogen and exercise suppress appetite in non-BCS populations, but their combined effects in BCS are unknown. This secondary analysis compared the impact of acute resistance exercise (REx) on appetite and energy intake in estrogen-suppressed BCS versus females without cancer ('non-BCS'). Premenopausal inactive BCS (stage 0-III estrogen receptor-positive breast cancer, <5 years post-diagnosis, undergoing estrogen-targeted therapy) and non-BCS completed REx or sedentary (SED) conditions 35 min after a standardized breakfast. Appetite visual analog scales and hormones (ghrelin and peptide-YY [PYY]) were measured before and after breakfast and REx/SED; energy intake was assessed 3 h post-breakfast (1.5 h post-REx or SED). Fifteen BCS (age: 46 ± 7; BMI: 25.0 ± 3.8 kg/m2) and 12 non-BCS (age: 37 ± 8; BMI: 29.0 ± 5.1 kg/m2) were included. BCS showed greater PYY 90 and 120 min post-breakfast compared to non-BCS, particularly after REx (group x time x condition: p = 0.009, p = 0.005, respectively). No group effects were observed for ghrelin. BCS had lower body mass-adjusted energy intake compared to non-BCS (p = 0.036), despite similar appetite ratings. Estrogen-suppressed BCS exhibit heightened PYY and lower energy intake after REx, revealing novel effects of exercise on appetite in a state of low estrogen.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-12"},"PeriodicalIF":2.4,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Health Literacy and Adherence to the Eat-Lancet Sustainable Reference Diet Among Cancer Survivors. 癌症幸存者健康素养与坚持饮食-柳叶刀可持续参考饮食之间的关系

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-06-20 DOI: 10.1080/01635581.2025.2518609

Luíza de Carvalho Almeida, Leandro Teixeira Cacau, Antônio Vinício Pontes de Freitas, Davi Jacome Santos Vasconcelos, Eliane Mara Viana Henriques, Patrícia Cândido Alves, Antônio Augusto Ferreira Carioca, Helena Alves de Carvalho Sampaio

引用次数: 0

Effect of Creatine Supplementation on Body Composition in Cancer Patients: A Systematic Review. 补充肌酸对癌症患者体成分的影响：一项系统综述。

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-06-19 DOI: 10.1080/01635581.2025.2519965

Asier Del Arco, Saioa Aguirre-Elordui, Jurgi Olasagasti-Ibargoien, Arkaitz Castañeda-Babarro

{"title":"Effect of Creatine Supplementation on Body Composition in Cancer Patients: A Systematic Review.","authors":"Asier Del Arco, Saioa Aguirre-Elordui, Jurgi Olasagasti-Ibargoien, Arkaitz Castañeda-Babarro","doi":"10.1080/01635581.2025.2519965","DOIUrl":"https://doi.org/10.1080/01635581.2025.2519965","url":null,"abstract":"Creatine is a naturally occurring compound stored in muscles, obtainable through diet and supplementation, known to enhance strength, exercise capacity, and recovery. Recent research suggests it may aid in treating some chronic diseases. This review analyzed the effects of creatine supplementation (CrS) on body composition in cancer patients or survivors. Following PRISMA guidelines, five databases were searched for studies up to September 12, reviewing seven articles with 463 participants (316 men, 147 women; average age 62.95 years). Five studies assessed CrS effects on body weight: three found no changes, while two reported increases. For lean body mass, three trials noted increases in both creatine and placebo groups, but differences were not significant. Fat mass results varied, showing reductions, no changes, or mitigated increases during hormone therapy. Although CrS showed potential improvements, evidence of significant effects on body composition in cancer patients remains limited. CrS appears safe and might be more beneficial with less aggressive treatments or in non-metastatic cases. Further research is needed to clarify its role in this context.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-12"},"PeriodicalIF":2.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acupuncture Potentiates anti-PD-1 Efficacy by Promoting CD5⁺ Dendritic Cells and T Cell-Mediated Tumor Immunity in a Mouse Model of Breast Cancer. 针刺通过促进CD5+树突状细胞和T细胞介导的肿瘤免疫在乳腺癌小鼠模型中增强抗pd -1疗效

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-06-16 DOI: 10.1080/01635581.2025.2517737

Xiaoru Xu, Nan Wang, Yufen Li, Shasha Fan, Baohui Mu, Jianxun Zhu

{"title":"Acupuncture Potentiates anti-PD-1 Efficacy by Promoting CD5+ Dendritic Cells and T Cell-Mediated Tumor Immunity in a Mouse Model of Breast Cancer.","authors":"Xiaoru Xu, Nan Wang, Yufen Li, Shasha Fan, Baohui Mu, Jianxun Zhu","doi":"10.1080/01635581.2025.2517737","DOIUrl":"https://doi.org/10.1080/01635581.2025.2517737","url":null,"abstract":"Acupuncture has been recognized as a complementary therapy for various malignancies by modulating immune responses. However, the impact of acupuncture on the antitumor immune efficacy of PD-1 inhibitors remains unclear. This study evaluates the effectiveness of acupuncture in conjunction with PD-1 inhibitors in enhancing the antitumor immune response against breast cancer and elucidates the potential molecular mechanisms through RNA-Seq transcriptome analysis in a 4T1 xenograft BALB/c mouse model of breast cancer. The findings indicate that the combination of acupuncture and PD-1 inhibitors significantly impedes tumor development by promoting tumor cell apoptosis and inhibiting tumor growth, angiogenesis, and metastasis. RNA-Seq analysis revealed that differentially expressed genes following acupuncture intervention were primarily enriched in immune response pathways, T cell activation, and cytokine interactions, including immune cell-related CD genes such as CD5, CD4, and CD8. Notably, acupuncture stimulation enhanced CD5 expression, which correlated positively with overall survival in breast cancer patients. Furthermore, the combination treatment led to improved immunity characterized by an increase in CD5+ dendritic cells, as well as CD4+ and CD8+ T cell populations, alongside elevated serum levels of various cytokines (IL-2, IL-6, TNF-α, IFN-γ). Collectively, this study demonstrates that acupuncture intervention enhances the antitumor immune response associated with PD-1 inhibitors, suggesting a promising therapeutic approach for immune checkpoint inhibitor therapy in breast cancer.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-14"},"PeriodicalIF":2.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Role of Genetically Predicted Serum Iron Status on Thyroid Cancer. 基因预测血清铁水平在甲状腺癌中的风险作用。

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-06-10 DOI: 10.1080/01635581.2025.2515659

Xiao Tian, Ting Liu, Xiubao Ren

{"title":"Risk Role of Genetically Predicted Serum Iron Status on Thyroid Cancer.","authors":"Xiao Tian, Ting Liu, Xiubao Ren","doi":"10.1080/01635581.2025.2515659","DOIUrl":"https://doi.org/10.1080/01635581.2025.2515659","url":null,"abstract":"Previous research has not clearly illustrated the impact of serum iron status on thyroid cancer. Bi-directional and multivariable Mendelian randomization (MVMR) analyses were conducted to determine the causative effects of serum iron status on thyroid cancer. Genetic markers for serum iron status, including serum iron, ferritin, transferrin saturation (TSTA), and transferrin, were acquired from the Genetics of Iron Status. The primary analytical method employed was inverse variance weighting, supplemented by other sensitivity approaches to validate the consistency of the results. Genetically predicted serum iron, ferritin, and TSTA were found to increase the risk of thyroid cancer. However, there was no causal link between transferrin levels and the risk of thyroid cancer. The causal link remained strong in the reverse MR and MVMR. Furthermore, serum iron status had no causal effect on benign neoplasms of the thyroid gland based on the two-sample MR analysis. Our MR study provides novel evidence that serum iron, ferritin, and TSTA are associated with thyroid cancer, but not with benign neoplasms of the thyroid gland. These markers could be useful for differential diagnosis. Strategies to lower serum iron levels may reduce the burden of thyroid cancer.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-13"},"PeriodicalIF":2.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of Urinary Equol Level and Equol-Producer Status with Endogenous Sex Hormone Levels in Premenopausal Japanese Women. 绝经前日本妇女尿雌酚水平和雌酚生成状态与内源性性激素水平的关系

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-06-10 DOI: 10.1080/01635581.2025.2514784

Michiko Tsuji, Keiko Wada, Makoto Hayashi, Noriyuki Takeda, Keigo Yasuda, Tomomi Ueno, Shigeto Uchiyama, Yasuhiro Abiru, Chisato Nagata

{"title":"Associations of Urinary Equol Level and Equol-Producer Status with Endogenous Sex Hormone Levels in Premenopausal Japanese Women.","authors":"Michiko Tsuji, Keiko Wada, Makoto Hayashi, Noriyuki Takeda, Keigo Yasuda, Tomomi Ueno, Shigeto Uchiyama, Yasuhiro Abiru, Chisato Nagata","doi":"10.1080/01635581.2025.2514784","DOIUrl":"https://doi.org/10.1080/01635581.2025.2514784","url":null,"abstract":"The potential protective effects of soy isoflavones against breast cancer have been suggested. Equol, the end product of daidzein by intestinal bacteria, is superior to other isoflavones in its estrogenic activity. However, not all humans can produce equol. We cross-sectionally assessed the associations between equol-excretion status and endogenous sex hormone levels relevant to the etiology of breast cancer in premenopausal Japanese women. Fasting plasma concentrations of estradiol, estrone, testosterone, dehydroepiandrosterone (DHEA) sulfate, sex hormone-binding globulin, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured in 348 premenopausal women with regular menstrual cycles. After controlling for covariates, urinary equol level was not significantly associated with the levels of any hormone. To approximate the ability to convert daidzein to equol, equol-producer status was defined among 141 women with urinary daidzein levels of 10 nmol/mg creatinine or higher. Among them, 30.5% had detectable levels of equol (equol producers). The plasma estrone level was significantly lower by 21.6% in equol producers than in non-producers. These data suggest that the ability to produce equol, but not equol itself, may be associated with the hormonal profile of premenopausal women. Further studies on factors related to equol production are needed.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-7"},"PeriodicalIF":2.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0