Nutrition and Cancer-An International Journal最新文献

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Nutritional Status and Its Determinants among Adults with Cancer Prior to the Initiation of Chemotherapy: An Ordinal Regression Analysis. 化疗开始前成人癌症患者的营养状况及其决定因素:有序回归分析。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-07-23 DOI: 10.1080/01635581.2025.2535056
Awole Seid, Zelalem Debebe, Abebe Ayelign, Bilal Shikur Endris, Mathewos Assefa, Ahmedin Jemal
{"title":"Nutritional Status and Its Determinants among Adults with Cancer Prior to the Initiation of Chemotherapy: An Ordinal Regression Analysis.","authors":"Awole Seid, Zelalem Debebe, Abebe Ayelign, Bilal Shikur Endris, Mathewos Assefa, Ahmedin Jemal","doi":"10.1080/01635581.2025.2535056","DOIUrl":"https://doi.org/10.1080/01635581.2025.2535056","url":null,"abstract":"<p><p>The nutritional status of adults before the initiation of chemotherapy in low-income countries has been poorly explored. This study aimed to determine the prevalence of malnutrition and its associated factors before initiating chemotherapy at major cancer centers in Ethiopia. A multicenter cross-sectional study was conducted from February 13 to June 4, 2024, involving 400 adults diagnosed with solid tumors. The Patient-Generated Subjective Global Assessment (PG-SGA) was used to evaluate nutritional status. A multiple ordinal logistic regression model was used to determine associated factors. The results showed that 65% (60.2 - 69.5%) of patients were malnourished. Of these, 26% exhibited moderate malnutrition, and 39% experienced severe malnutrition. The factors that increased the odds of the highest category (severe malnutrition) were male sex (adjusted odds ratio [AOR] = 1.83), lack of regular physical activity (AOR = 1.59), presence of nutrition-impact symptoms (AOR = 33.1), gastrointestinal cancer diagnosis (AOR = 3.3), stage 4 cancer (AOR = 2.2), and preexisting comorbidities (AOR = 1.96). Conversely, a history of surgery was associated with lower odds of malnutrition (AOR = 0.46). Overall, two-thirds of adults with cancer were malnourished. Therefore, early nutritional assessment, management of nutritional impact symptoms, increased cancer awareness for early detection, and regular physical activity are recommended.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-13"},"PeriodicalIF":2.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Cross-Sectional Study of Dietary Patterns and Helicobacter pylori Infection Among American Indian Adults in the Southwest. 西南地区美国印第安成年人饮食模式和幽门螺杆菌感染的横断面研究。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-07-22 DOI: 10.1080/01635581.2025.2535055
Dornell Pete, Johanna W Lampe, Hongjiao Liu, Nina R Salama, Michael C Wu, Amanda I Phipps
{"title":"A Cross-Sectional Study of Dietary Patterns and <i>Helicobacter pylori</i> Infection Among American Indian Adults in the Southwest.","authors":"Dornell Pete, Johanna W Lampe, Hongjiao Liu, Nina R Salama, Michael C Wu, Amanda I Phipps","doi":"10.1080/01635581.2025.2535055","DOIUrl":"https://doi.org/10.1080/01635581.2025.2535055","url":null,"abstract":"<p><p>High sodium diets have been shown to promote stomach colonization and the induction of tissue damage by <i>Helicobacter pylori</i> (<i>H. pylori</i>), a risk factor for gastric cancer. Among American Indians in the Southwest, where the <i>H. pylori</i> prevalence is 60%, the association between diet and <i>H. pylori</i> infection has not been studied. We conducted a cross-sectional pilot study with 93 adults (51%, 18-44 years, 73% female) in the Navajo Nation to assess their diet with self-administered food questionnaires and to detect <i>H. pylori</i> from stool samples using droplet digital PCR. Three diet patterns were identified using Principal Component Analysis: 1) Western, 2) Soups and Mixed Dishes, and 3) Fruits and Vegetables. Participants in the highest and middle tertiles of the Soups and Mixed Dishes pattern scores had higher odds of having <i>H. pylori</i> (OR<sub>Highest</sub>=5.59, 95% CI, 1.50-23.70; OR<sub>Middle</sub>=3.48, 95% CI, 1.08-12.32) than those in the lowest tertile. This positive association may be linked to the sodium content of foods in this diet pattern. Soups and Mixed Dishes may contribute to <i>H. pylori</i> infection and may be incorporated in nutrition education for individuals positive for <i>H. pylori</i> infection in the Navajo Nation.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-9"},"PeriodicalIF":2.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Problem-Oriented Nursing Model Combined with Early Enteral Nutrition Support in the Perioperative Period of Stage II/III Gastric Cancer Patients. 问题导向护理模式结合早期肠内营养支持在II/III期胃癌患者围手术期的应用
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-07-20 DOI: 10.1080/01635581.2025.2525928
Shuangshuang Han, Yuping Chen, Yanli Wang, Haili Xu
{"title":"Application of Problem-Oriented Nursing Model Combined with Early Enteral Nutrition Support in the Perioperative Period of Stage II/III Gastric Cancer Patients.","authors":"Shuangshuang Han, Yuping Chen, Yanli Wang, Haili Xu","doi":"10.1080/01635581.2025.2525928","DOIUrl":"https://doi.org/10.1080/01635581.2025.2525928","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the effects of a problem-oriented nursing model combined with early enteral nutrition (EEN) during the perioperative period in patients with stage II/III gastric cancer (GC).</p><p><strong>Methods: </strong>One hundred patients with stage II/III GC were randomly divided into a control group (conventional perioperative care and routine nutritional support) and an intervention group (problem-oriented nursing model plus EEN). Clinical outcomes, body mass index (BMI), emotional status, nutritional and inflammatory markers, complication rates, and patient satisfaction were compared.</p><p><strong>Results: </strong>Versus the control group, the intervention group exhibited shorter times to first flatus, hospital stay, ambulation, and defecation (Cohen's <i>d</i> = 1.93, 1.24, 1.49, 1.57), higher postoperative PA, Hb, and ALB levels (Cohen's d = -0.63, -0.78, -0.70), lower CRP, IL-6, and TNF-α levels (Cohen's <i>d</i> = 0.48, 1.07, 0.90), and lower SAS and SDS scores (Cohen's <i>d</i> = 1.80, 0.89). At discharge, the intervention group exhibited a higher BMI (Cohen's d = -2.13), lower overall incidence of complications (OR = 6.00), and higher patient satisfaction (OR = 0.17) (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>The problem-oriented nursing model combined with EEN support improves nutritional status, accelerates recovery, and enhances postoperative rehabilitation in patients with stage II/III GC undergoing surgery.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-7"},"PeriodicalIF":2.0,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ketogenic Diets Are Associated with an Elevated Risk for All Cancers: Insights from a Cross-Sectional Analysis of the NHANES 2001-2018. 生酮饮食与所有癌症风险升高有关:来自2001-2018年NHANES横断面分析的见解
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-07-10 DOI: 10.1080/01635581.2025.2497095
Yuping Liu, Xiaolong Qu, Dingsheng Liu, Dongming Yang
{"title":"Ketogenic Diets Are Associated with an Elevated Risk for All Cancers: Insights from a Cross-Sectional Analysis of the NHANES 2001-2018.","authors":"Yuping Liu, Xiaolong Qu, Dingsheng Liu, Dongming Yang","doi":"10.1080/01635581.2025.2497095","DOIUrl":"https://doi.org/10.1080/01635581.2025.2497095","url":null,"abstract":"<p><p>Ketogenic diet (KD) has increasingly been applied in anti-cancer therapy in recent years; however, its effect on cancer development risk remains controversial. We examined the association between dietary ketogenic ratio (DKR) and cancer incidence using cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2018. Dietary intake information was collected <i>via</i> a detailed 24-h dietary recall survey, and DKR values were calculated using a specialized formula. Multivariate logistic regression analysis was performed to evaluate the correlation between DKR and tumor occurrence, with restricted cubic splines (RCS) utilized to assess potential nonlinear relationships. Furthermore, a two-stage linear regression analysis was carried out to determine the inflection point. Furthermore, subgroup analyses were conducted stratified by demographic variables, including age, gender, race, body mass index (BMI), smoking status, and diabetes mellitus. A significant association was observed between DKR and cancer risk in multivariate logistic regression models fully adjusted for all potential confounding factors (OR, 1.58; 95%CI: 1.08, 1.54; <i>p</i> = 0.049). Moreover, individuals in the highest quartile of DKR exhibited a significantly increased risk for all cancers compared to those in the lowest quartile (Q4: OR, 1.29; 95%CI: 1.08, 1.34; <i>p</i> = 0.005). The RCS analysis revealed a non-linear relationship between DKR and cancer risk (<i>p</i> < 0.001, P for nonlinear trend = 0.003), with a turning point identified at 0.44 units on the scale used in this study. Piecewise regression analysis based on this threshold indicated that DKR values below 0.44 (DKR < 0.44) were significantly associated with an increased risk for all cancers within the context of this investigation (OR, 1.08; 95%CI: 1.04, 1.12; <i>p</i> < 0.001), while no significant correlation was observed for DKR values above this threshold (DKR ≥ 0.44) (OR, 1.01; 95%CI: 0.95, 1.07; <i>p</i> = 0.77). Furthermore, the findings from the subgroup analyses were consistent with the overall results. Therefore, we conclude that a KD might elevate the risk for all cancers, and further studies are warranted to validate this hypothesis.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-11"},"PeriodicalIF":2.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "Impact of Intermittent Fasting with a Ketogenic Diet on AMPK Levels in Breast Cancer Patients Receiving Chemotherapy". 对“间歇禁食加生酮饮食对接受化疗的乳腺癌患者AMPK水平的影响”的评论。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-07-02 DOI: 10.1080/01635581.2025.2527426
Qi Xu, Xiaohui Chen
{"title":"Comment on \"Impact of Intermittent Fasting with a Ketogenic Diet on AMPK Levels in Breast Cancer Patients Receiving Chemotherapy\".","authors":"Qi Xu, Xiaohui Chen","doi":"10.1080/01635581.2025.2527426","DOIUrl":"https://doi.org/10.1080/01635581.2025.2527426","url":null,"abstract":"<p><p>The recent study by Lughmani et al. demonstrated that a 30-day regimen of 23:1 intermittent fasting combined with a ketogenic diet significantly elevated serum AMPK levels and reduced CA 15-3 in breast cancer patients undergoing chemotherapy. While these findings highlight the potential of metabolic interventions to modulate key signaling pathways, important questions remain regarding clinical translation and patient heterogeneity. First, the impact of fasting and ketogenic strategies on chemotherapy-related toxicity, treatment tolerability, and quality of life was not evaluated; integrating standardized toxicity grading (e.g., CTCAE v5.0), patient-reported outcome measures, and chemotherapy dose intensity metrics could determine whether AMPK activation confers meaningful protective benefits. Second, breast cancer subtypes exhibit distinct metabolic dependencies and AMPK pathway alterations; prespecifying subgroup analyses by receptor status and correlating intratumoral AMPK activity with molecular subtype would inform personalized dietary adjuncts. Addressing these dimensions will be pivotal for validating intermittent fasting plus ketogenic diets as safe, tailored adjuncts to standard chemotherapy.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-2"},"PeriodicalIF":2.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of SmofKabiven® Versus Hospital-Compounded All-in-One Parenteral Nutrition in Chinese Patients Undergoing Gastrointestinal Surgery: A Multicenter, Randomized, Active-Controlled, Phase III Trial. SmofKabiven®与医院复合全合一肠外营养在中国胃肠手术患者中的疗效和安全性:一项多中心、随机、主动对照的III期试验
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-07-01 DOI: 10.1080/01635581.2025.2523034
Guocong Wu, Jiongqiang Huang, Xiaogang Zhong, Xiaogang Bi, Guohao Wu, Xudong Wang, Dejun Wu, Shijun Xiang, Liming Cheng, Jiawei He, Ying Chen, Hongwei Jia, Zhongtao Zhang
{"title":"Efficacy and Safety of SmofKabiven<sup>®</sup> Versus Hospital-Compounded All-in-One Parenteral Nutrition in Chinese Patients Undergoing Gastrointestinal Surgery: A Multicenter, Randomized, Active-Controlled, Phase III Trial.","authors":"Guocong Wu, Jiongqiang Huang, Xiaogang Zhong, Xiaogang Bi, Guohao Wu, Xudong Wang, Dejun Wu, Shijun Xiang, Liming Cheng, Jiawei He, Ying Chen, Hongwei Jia, Zhongtao Zhang","doi":"10.1080/01635581.2025.2523034","DOIUrl":"https://doi.org/10.1080/01635581.2025.2523034","url":null,"abstract":"<p><p>This multicenter, randomized, non-inferiority phase III trial (NCT03792100) aimed to evaluate the efficacy and safety of SmofKabiven<sup>®</sup>, a three-chamber parenteral nutrition (PN) emulsion in adult patients undergoing gastrointestinal surgery. Eligible participants were randomized to either SmofKabiven<sup>®</sup> group (SEG) (<i>n</i> = 135) or hospital-compounded PN group (HCG) (<i>n</i> = 134) for five consecutive postoperative days. The primary endpoint was the change in serum prealbumin levels from baseline to day 6, with a non-inferiority margin of -2.75 mg/dL. By day 6, change of serum prealbumin levels from baseline was 3.22 mg/dl in the SEG and 2.74 mg/dl in the HCG, with a difference of 0.48 mg/dl (95% confidence interval: -0.80 to 1.77), indicating comparable improvement in nutritional status. Linoleic acid decreased more with SEG than that with HCG (between-group difference: -7.84 mg/l, <i>P</i> = 0.0128), while arachidonic acid decreased more with HCG (between-group difference: 0.38 mg/l, <i>P</i> = 0.0025). Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were significantly higher with SEG (between-group difference: EPA, 0.48 mg/l, <i>P</i> < 0.0001; DHA, 0.64 mg/l, <i>P</i> < 0.0001, respectively), and taurine levels also increased significantly (between-group difference: 14.77 µM, <i>P</i> = 0.0217). Treatment-related adverse events were comparable in the two groups. SmofKabiven<sup>®</sup> was comparable to hospital-compounded PN in improving postoperative nutritional status and safety profile and its enrichment with omega-3 fatty acids and taurine may provide additional benefits.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-11"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Body Subcutaneous Fat Change Predicts Chemoradiotherapy Response and Prognosis of Esophageal Cancer Patients: A Cohort Study. 体表皮下脂肪变化预测食管癌患者放化疗反应和预后:一项队列研究。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-06-24 DOI: 10.1080/01635581.2025.2519971
Hsueh-Chien Chiang, Ching-Juei Yang, Jing-Yao Wang, Forn-Chia Lin, Nai-Jung Chiang, Ta-Jung Chung, Yau-Lin Tseng, Bor-Shyang Sheu, Wei-Lun Chang
{"title":"Body Subcutaneous Fat Change Predicts Chemoradiotherapy Response and Prognosis of Esophageal Cancer Patients: A Cohort Study.","authors":"Hsueh-Chien Chiang, Ching-Juei Yang, Jing-Yao Wang, Forn-Chia Lin, Nai-Jung Chiang, Ta-Jung Chung, Yau-Lin Tseng, Bor-Shyang Sheu, Wei-Lun Chang","doi":"10.1080/01635581.2025.2519971","DOIUrl":"https://doi.org/10.1080/01635581.2025.2519971","url":null,"abstract":"<p><strong>Background: </strong>Patients with esophageal cancer are prone to poor nutrition. Concurrent chemoradiation therapy (CCRT) may further influences body compositions including skeletal muscle (SM) and adipose tissue which are key indicators of nutritional status. This study aimed to evaluate whether body compositional change during CCRT could be a predictor of prognosis in esophageal cancer patients.</p><p><strong>Methods: </strong>From 2006 to 2018, esophageal cancer patients who received CCRT as initial treatment were consecutively enrolled. We assessed body compositions, including subcutaneous fat (SCF), intramuscular fat (IMF), and SM mass by measuring the cross-sectional area (CSA) of the fourth thoracic vertebral body on computed tomography (CT) scan. The body compositional change was assessed by comparing baseline and post-CCRT CSA. The association of body compositions and their changes during CCRT with patient prognosis was analyzed.</p><p><strong>Results: </strong>A total of 178 patients were enrolled with a mean baseline body mass index (BMI) of 22. After CCRT, there was a significant decrease in bodyweight (BW), SCF, IMF, and SM (<i>P</i> < 0.001). BMI and body compositions at baseline or post-CCRT were not significantly associated with patient prognosis. Patients with SCF loss during CCRT had significantly poorer CCRT response (OR 3.7, <i>P</i> < 0.001), shorter time to tumor progression (8.5 vs. 23.7 months, <i>P</i> = 0.011), and overall survival (13.7 vs. 25.9 months, <i>P</i> < 0.001) than patients with SCF gain/stable. IMF, SM, and BW change during CCRT did not correlate with CCRT response or survival. In multivariate Cox regression analysis, SCF change (HR 1.49, 95% CI: 1.03-2.14, <i>P</i> = 0.033) during CCRT was an independent predictor of survival after adjusting baseline BMI, cancer stage, treatment modality, and CCRT response.</p><p><strong>Conclusions: </strong>During the course of CCRT, SCF change is more sensitive than weight in assessing the nutritional status of esophageal cancer patients. SCF loss during CCRT is associated with worse CCRT response and survival in esophageal cancer patients.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-10"},"PeriodicalIF":2.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PI3K/AKT/mTOR Pathway in Breast Cancer Pathogenesis and Therapy: Insights into Phytochemical-Based Therapeutics. PI3K/AKT/mTOR通路在乳腺癌发病和治疗中的作用:基于植物化学的治疗方法。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-06-23 DOI: 10.1080/01635581.2025.2521884
Adil Farooq Wali, Siajunisa Talath, Mohamed El Tanani, Imran Rashid Rangraze, Rasha Babiker, Sadat Shafi, Ruby Bansal
{"title":"PI3K/AKT/mTOR Pathway in Breast Cancer Pathogenesis and Therapy: Insights into Phytochemical-Based Therapeutics.","authors":"Adil Farooq Wali, Siajunisa Talath, Mohamed El Tanani, Imran Rashid Rangraze, Rasha Babiker, Sadat Shafi, Ruby Bansal","doi":"10.1080/01635581.2025.2521884","DOIUrl":"https://doi.org/10.1080/01635581.2025.2521884","url":null,"abstract":"<p><p>Breast cancer (BC) is listed as the most prevalent cancer form in women worldwide, with major subtypes classified by hormone receptor (HR) and HER2 status including, HR+/HER2- (∼65-70%), HER2+ (∼15-20%), Triple-Negative-HR-/HER2- (∼10-15%) and rare sybtypes (<5%). Scientific evidence has revealed that PI3K/AKT/mTOR signaling cascade plays an important role in the development and progression of BC, contributing to key cellular processes including cell growth, proliferation, angiogenesis, and metastasis. Dysregulation of the components of this cascade including functional loss of Phosphatase and TENsin homolog (PTEN), PI3K hyperactivation, and gain-of-function of AKT, are frequently observed in BC subtypes, making it a promising target for therapeutic intervention. A myriad of studies have documented the potential of phytochemicals, including curcumin, chrysin, fisetin, genistein, resveratrol and lycopene as modulators of the PI3K/AKT/mTOR axis. These phytochemicals exhibit multifaceted mechanisms of action, including inhibition of key kinases, induction of apoptosis, suppression of angiogenesis, and reversal of resistance to chemotherapy. This review aims to provide a detailed overview about the role of PI3K/AKT/mTOR alteration in BC development and the current research on phytochemicals that modulate the PI3K/AKT/mTOR pathway in BC. We documented the molecular mechanisms through which these compounds exert their effects, their potential synergistic interactions with conventional therapies, and the challenges and prospects for their clinical application. The evidence presented underscores the promise of phytochemicals as novel, less toxic adjuncts to traditional BC therapies, warranting further exploration and development for clinical use.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-21"},"PeriodicalIF":2.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing Appetite and Dietary Intake Responses to Resistance Exercise in Breast Cancer Survivors Undergoing Adjuvant Endocrine Therapy Versus Individuals Without Cancer: A Secondary Analysis. 比较接受辅助内分泌治疗的乳腺癌幸存者与非癌症患者的食欲和饮食摄入对抵抗运动的反应:一项次要分析。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-06-22 DOI: 10.1080/01635581.2025.2518611
Sarah A Purcell, Tanya M Halliday, Edward L Melanson, Anosheh Afghahi, Virginia F Borges, Isabella Sinelli, Marc-Andre Cornier
{"title":"Comparing Appetite and Dietary Intake Responses to Resistance Exercise in Breast Cancer Survivors Undergoing Adjuvant Endocrine Therapy Versus Individuals Without Cancer: A Secondary Analysis.","authors":"Sarah A Purcell, Tanya M Halliday, Edward L Melanson, Anosheh Afghahi, Virginia F Borges, Isabella Sinelli, Marc-Andre Cornier","doi":"10.1080/01635581.2025.2518611","DOIUrl":"https://doi.org/10.1080/01635581.2025.2518611","url":null,"abstract":"<p><p>Breast cancer survivors (BCS) undergoing adjuvant endocrine therapy have increased risk of obesity. Estrogen and exercise suppress appetite in non-BCS populations, but their combined effects in BCS are unknown. This secondary analysis compared the impact of acute resistance exercise (REx) on appetite and energy intake in estrogen-suppressed BCS versus females without cancer ('non-BCS'). Premenopausal inactive BCS (stage 0-III estrogen receptor-positive breast cancer, <5 years post-diagnosis, undergoing estrogen-targeted therapy) and non-BCS completed REx or sedentary (SED) conditions 35 min after a standardized breakfast. Appetite visual analog scales and hormones (ghrelin and peptide-YY [PYY]) were measured before and after breakfast and REx/SED; energy intake was assessed 3 h post-breakfast (1.5 h post-REx or SED). Fifteen BCS (age: 46 ± 7; BMI: 25.0 ± 3.8 kg/m<sup>2</sup>) and 12 non-BCS (age: 37 ± 8; BMI: 29.0 ± 5.1 kg/m<sup>2</sup>) were included. BCS showed greater PYY 90 and 120 min post-breakfast compared to non-BCS, particularly after REx (group x time x condition: <i>p</i> = 0.009, <i>p</i> = 0.005, respectively). No group effects were observed for ghrelin. BCS had lower body mass-adjusted energy intake compared to non-BCS (<i>p</i> = 0.036), despite similar appetite ratings. Estrogen-suppressed BCS exhibit heightened PYY and lower energy intake after REx, revealing novel effects of exercise on appetite in a state of low estrogen.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-12"},"PeriodicalIF":2.0,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Health Literacy and Adherence to the Eat-Lancet Sustainable Reference Diet Among Cancer Survivors. 癌症幸存者健康素养与坚持饮食-柳叶刀可持续参考饮食之间的关系
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-06-20 DOI: 10.1080/01635581.2025.2518609
Luíza de Carvalho Almeida, Leandro Teixeira Cacau, Antônio Vinício Pontes de Freitas, Davi Jacome Santos Vasconcelos, Eliane Mara Viana Henriques, Patrícia Cândido Alves, Antônio Augusto Ferreira Carioca, Helena Alves de Carvalho Sampaio
{"title":"Association Between Health Literacy and Adherence to the Eat-<i>Lancet</i> Sustainable Reference Diet Among Cancer Survivors.","authors":"Luíza de Carvalho Almeida, Leandro Teixeira Cacau, Antônio Vinício Pontes de Freitas, Davi Jacome Santos Vasconcelos, Eliane Mara Viana Henriques, Patrícia Cândido Alves, Antônio Augusto Ferreira Carioca, Helena Alves de Carvalho Sampaio","doi":"10.1080/01635581.2025.2518609","DOIUrl":"10.1080/01635581.2025.2518609","url":null,"abstract":"<p><p>This study aimed to investigate whether there is an association between the health literacy of breast and prostate cancer survivors and their feeding, considering the planetary diet recommendation. This cross-sectional study utilized secondary data from 201 women with breast cancer and 106 men with prostate cancer. Health literacy was evaluated using the Brazilian version of the Health Literacy Questionnaire. The EAT-Lancet diet adherence was assessed using the Planetary Health Diet Index (PHDI). The mean PHDI score was 45.3 (9.0) points, without differences in consumption between men and women. The health literacy status and PHDI score were unassociated among cancer survivors. Adherence to a healthy and sustainable diet and health literacy were low among the studied population. Further studies should evaluate these conditions in other populations.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-9"},"PeriodicalIF":2.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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