Nutrition and Cancer-An International Journal最新文献_第10页

The Role of Diet and the Gut Microbiota in the Obesity-Colorectal Cancer Link. 饮食和肠道菌群在肥胖-结直肠癌中的作用。

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-03-19 DOI: 10.1080/01635581.2025.2476779

Audrey A Goldbaum, Laura W Bowers, Abigail D Cox, Molly Gillig, Anna Clapp Organski, Tzu-Wen L Cross

{"title":"The Role of Diet and the Gut Microbiota in the Obesity-Colorectal Cancer Link.","authors":"Audrey A Goldbaum, Laura W Bowers, Abigail D Cox, Molly Gillig, Anna Clapp Organski, Tzu-Wen L Cross","doi":"10.1080/01635581.2025.2476779","DOIUrl":"10.1080/01635581.2025.2476779","url":null,"abstract":"Obesity is positively associated with colorectal cancer (CRC) risk. Diet not only contributes to obesity, but also strongly influences the gut microbiota, a factor that is thought to independently affect CRC. To isolate the role of obesity-associated gut microbiota in CRC and to assess the impact of diet composition on this relationship, we transplanted the gut microbiota from donor mice that developed obesity or remained lean on a high-fat diet (HFD), Western diet (WD), or low-fat diet (LFD) into antibiotic-treated recipient mice that subsequently received azoxymethane to induce CRC. We hypothesized that the obesogenic diets of the donor mice, rather than their obesity status, would be a stronger driver of gut microbiota-mediated CRC development. Interestingly, while evidence supporting our hypothesis was observed, differential effects on CRC outcomes based on the type of obesogenic diets were found, such that HFD-associated gut microbiota promotes tumor incidence whereas WD-associated gut microbiota promotes tumor growth. Significantly enriched bacterial taxa present before tumor induction may be mediating these results through intestinal permeability or inflammation, such as Sutterella and Dorea in mice received HFD-associated gut microbiota, and Bacteroidetes in mice received WD-microbiota. Overall, our results demonstrated that diet drives the gut microbiota-derived impact on CRC development.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"626-639"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Impact of Sarcopenic Obesity on Postoperative Outcomes in Colorectal Cancer Patients Undergoing Surgery: A Systematic Review and Meta-Analysis. 肌肉减少性肥胖对大肠癌手术患者术后预后的影响：系统回顾和荟萃分析

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-01-11 DOI: 10.1080/01635581.2025.2450843

Tuba Nur Yıldız Kopuz, Hanifi Furkan Yıldız, Sadettin Er, Mehmet Fisunoğlu

{"title":"Prognostic Impact of Sarcopenic Obesity on Postoperative Outcomes in Colorectal Cancer Patients Undergoing Surgery: A Systematic Review and Meta-Analysis.","authors":"Tuba Nur Yıldız Kopuz, Hanifi Furkan Yıldız, Sadettin Er, Mehmet Fisunoğlu","doi":"10.1080/01635581.2025.2450843","DOIUrl":"10.1080/01635581.2025.2450843","url":null,"abstract":"Sarcopenic obesity is a condition in which the coexistence of sarcopenia and obesity may have unfavorable prognostic implications in cancer. This meta-analysis aims to evaluate the effects of sarcopenic obesity on postoperative outcomes in patients undergoing colorectal cancer surgery. A systematic literature search was conducted in the Scopus, PubMed, and Web of Science databases for articles up to February 8, 2024. The primary outcomes were overall and major complications and overall survival. A random- or fixed-effects model was used in each case based on heterogeneity, and both subgroup and sensitivity analyses were performed. Twenty studies with 11,264 patients were included. The prevalence of sarcopenic obesity was 14.5%. Sarcopenic obesity was found to be a risk factor for overall complications [pooled OR: 1.69 (95% CI: 1.26-2.26); p < 0.001] and major complications [pooled OR: 1.64 (95% CI: 1.06-2.55); p = 0.028]. The effect on overall survival was not significant [pooled HR: 1.24 (95% CI: 0.98-1.56); p = 0.076], but significance varied in some subgroups. Furthermore, sarcopenic obesity was associated with an increased risk of 30-day mortality, but not with prolonged hospitalization. In conclusion, sarcopenic obesity is associated with unfavorable outcomes after colorectal cancer surgery; therefore, it may be useful to include a diagnosis of sarcopenic obesity when formulating the disease prognosis.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"360-371"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Omega-3 Fatty Acids on Oral Mucositis Induced by Anticancer Therapy: A Meta-Analysis. Omega-3脂肪酸对抗癌治疗所致口腔黏膜炎的影响：一项荟萃分析。

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-04-18 DOI: 10.1080/01635581.2025.2492135

Xuan Tang, Wenxi Li, Qianmei Zhong, Li Wan

{"title":"Effects of Omega-3 Fatty Acids on Oral Mucositis Induced by Anticancer Therapy: A Meta-Analysis.","authors":"Xuan Tang, Wenxi Li, Qianmei Zhong, Li Wan","doi":"10.1080/01635581.2025.2492135","DOIUrl":"10.1080/01635581.2025.2492135","url":null,"abstract":"Oral mucositis (OM) is a serious complication of anticancer therapy that can substantially affect patient quality of life and treatment outcomes. This meta-analysis evaluated the efficacy of omega-3 fatty acids in the prevention and treatment of OM in patients diagnosed with cancer undergoing anticancer therapy. A systematic literature search of the PubMed, Embase, Web of Science, Cochrane Library, CNKI, and Wanfang databases for relevant studies, published up to September 24, 2024, was performed. Risk ratio (RR) or standardized mean difference (SMD) with corresponding 95% confidence interval (CIs) were calculated using Review Manager version 5.3. Five studies, including 337 patients, were included in this meta-analysis. Results of analysis revealed that, although omega-3 fatty acids did not significantly reduce the overall incidence of OM (RR 0.50, 95% CI 0.25-1.01), it significantly reduced the incidence of severe OM (RR 0.31, 95% CI 0.17-0.56), with no heterogeneity was observed (p = 0.96; I2= 0%). Furthermore, omega-3 fatty acids were found to significantly alleviate OM-associated pain (SMD -1.61, 95% CI -2.79 to -0.43), with no heterogeneity was detected (p = 0.32; I2 = 0%). Omega-3 fatty acids effectively reduced the incidence of severe OM and alleviated OM-related pain in patients undergoing anticancer therapy.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"600-609"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Obesity on the Surgical Outcomes After Laparoscopic Liver Resection for Liver Tumors: A Meta-Analysis. 肥胖对腹腔镜肝肿瘤切除术后手术结果的影响：一项荟萃分析

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-04-02 DOI: 10.1080/01635581.2025.2486153

Faying Liu, Yang Zou, Qing Chen, Tao Chen, He Xiao, Tingbing Xie, Lihe Zheng, Qi Ruan, Wang Liu

{"title":"Impact of Obesity on the Surgical Outcomes After Laparoscopic Liver Resection for Liver Tumors: A Meta-Analysis.","authors":"Faying Liu, Yang Zou, Qing Chen, Tao Chen, He Xiao, Tingbing Xie, Lihe Zheng, Qi Ruan, Wang Liu","doi":"10.1080/01635581.2025.2486153","DOIUrl":"10.1080/01635581.2025.2486153","url":null,"abstract":"Objective: The impact of obesity on the surgical outcomes in patients after laparoscopic liver resection (LLR) is unclear. We aimed at conducting a meta-analysis to evaluate the associations between overweight and obesity and major surgical outcomes after LLR for liver tumors.Methods: We searched PubMed, Cochrane Library, Embase, and Web of Science databases for eligible studies. Odds ratios (ORs) and mean differences (MDs) with 95% confidence intervals (CIs) were calculated.Results: Eight studies were included, with a total of 7,580 patients. Findings indicated that, relative to individuals of normal weight, those in the higher body mass index (BMI) category (overweight and obese) had prolonged operation time (MD, 15.46 mins), increased blood loss (MD, 39.40 mL), overall complications (OR 1.20), conversion (OR 1.41), and surgical site infection (SSI) (OR 1.77). In addition, subgroup analysis showed that although overweight did not increase the risk of overall postoperative complications and SSI, obesity significantly increased the risk of overall postoperative complications, SSI, and conversion to laparotomy.Conclusion: In conclusion, higher BMI, especially obesity, is closely associated with higher risk of morbidity after laparoscopic liver resection.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"675-686"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Waist Circumference as a Tool for Identifying Visceral Fat in Women with Non-Metastatic Breast Cancer. 腰围是识别非转移性乳腺癌女性内脏脂肪的工具。

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-02-05 DOI: 10.1080/01635581.2024.2304691

Vanusa Felício de Souza Mamede, Rayne de Almeida Marques Bernabé, Larissa Leopoldino da Silva, Thalita Gonçalves Santos, Luana Gomes Fontana, Janine Martins Machado, Ben-Hur Albergaria, Jose Luiz Marques-Rocha, Valdete Regina Guandalini

{"title":"Waist Circumference as a Tool for Identifying Visceral Fat in Women with Non-Metastatic Breast Cancer.","authors":"Vanusa Felício de Souza Mamede, Rayne de Almeida Marques Bernabé, Larissa Leopoldino da Silva, Thalita Gonçalves Santos, Luana Gomes Fontana, Janine Martins Machado, Ben-Hur Albergaria, Jose Luiz Marques-Rocha, Valdete Regina Guandalini","doi":"10.1080/01635581.2024.2304691","DOIUrl":"10.1080/01635581.2024.2304691","url":null,"abstract":"Abdominal adiposity is associated with tumor development and poor clinical outcomes in breast cancer (BC) and can be identified by the measurement of waist circumference (WC) and visceral adipose tissue (VAT). This study aimed to evaluate the association between waist circumference (WC) and imaging measurement of central adiposity according to age group in women with BC. Abdominal adiposity was assessed by WC and VAT, obtained by dual-energy X-ray absorptiometry (DXA). Body mass index (BMI) was assessed. The presence of inflammation was investigated by measuring C-Reactive Protein (CRP) levels. Multivariate linear regression models were applied to verify the association between WC and VAT. The significance level adopted for all tests was 5%. This study included 112 women with a mean age of 55.5 ± 11.4 years. After adjusted models, WC remained associated with VAT and for every centimeter increase in WC, there was an increase of 3.12 cm2 (CI: 2.40 - 3.85; p < 0.001) in VAT. WC was associated with VAT in women with breast cancer, proving to be a simple, fast, and noninvasive approach that can be used as a proxy to identify visceral fat.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"316-324"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139693553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Low BMI and Nutritional Status on Quality of Life and Disease Outcome in Breast Cancer Patients: Insights From a Tertiary Cancer Center in India. 低体重指数和营养状况对乳腺癌患者生活质量和疾病预后的影响：来自印度一家三级癌症中心的启示。

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-06-05 DOI: 10.1080/01635581.2024.2347396

Tanuma Mistry, Ranita Pal, Sushmita Ghosh, Trisha Choudhury, Syamsundar Mandal, Partha Nath, Neyaz Alam, Vilas D Nasare

{"title":"Impact of Low BMI and Nutritional Status on Quality of Life and Disease Outcome in Breast Cancer Patients: Insights From a Tertiary Cancer Center in India.","authors":"Tanuma Mistry, Ranita Pal, Sushmita Ghosh, Trisha Choudhury, Syamsundar Mandal, Partha Nath, Neyaz Alam, Vilas D Nasare","doi":"10.1080/01635581.2024.2347396","DOIUrl":"10.1080/01635581.2024.2347396","url":null,"abstract":"This study investigates the impact of Body Mass Index (BMI) on Quality of Life (QoL) and treatment outcomes in breast cancer (BC) patients, particularly focusing on underweight individuals with compromised nutritional status. A nonrandomized prospective study comprising 121 newly diagnosed patients across various BMI categories utilized FACT-B & FACIT-Sp-12 questionnaires. Follow-ups occurred at baseline, during (3rd and 6th), and after (12th month) anthracycline-taxane chemotherapy, either sequentially or concomitantly. Patients with low BMI (<18.5 kg/m2; 53.7%) exhibited significantly poorer QoL, marked by compromised nutritional indicators (low MUAC and SFT). Repeated measures ANOVA identified significant correlations between BMI groups in functional, social, and emotional QoL aspects (p < 0.05), with no notable differences in other domains. A Chi-square (ꭓ2) test underscored a significant link between BMI and treatment response (p < 0.0001), showing higher rates of non-responders among underweight patients (p = 4.259e-14). The study advocates pretreatment consultation with a dietitian as standard care for Indian BC patients, offering complimentary nutritional support for improved QoL outcomes and treatment responses.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"596-607"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enteral Nutritional Therapy in Pediatric Autologous Transplantation: A Descriptive Cohort Study. 小儿自体移植中的肠内营养疗法：描述性队列研究

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-07-19 DOI: 10.1080/01635581.2024.2377341

Andressa Florencio da Silva, Vera Lucia Bosa, Estela Beatriz Behling

{"title":"Enteral Nutritional Therapy in Pediatric Autologous Transplantation: A Descriptive Cohort Study.","authors":"Andressa Florencio da Silva, Vera Lucia Bosa, Estela Beatriz Behling","doi":"10.1080/01635581.2024.2377341","DOIUrl":"10.1080/01635581.2024.2377341","url":null,"abstract":"Introduction: Pediatric hematopoietic stem cell transplantation requires individualized nutritional therapy, and the use of early enteral nutrition is beneficial. This study aims to analyze the use of enteral nutrition therapy in pediatric patients undergoing autologous transplantation. Methods: This is a descriptive cohort study conducted with data from electronic medical records of pediatric patients undergoing autologous transplantation from 2017 to 2022, using enteral nutrition. Nutritional and clinical variables and biochemical markers were assessed at four time points: day 0, day +5, day +10 and day +15. Results: The sample consisted of 50 patients. On average, the nasoenteral tube was inserted on D-4 and the enteral feeding started on D-3. On D0, most patients used a normocaloric polymeric enteral formula, but on D + 10, when diarrhea (p = 0.017) and mucositis (p < 0.001) worsened, the most commonly used enteral formula was a hypocaloric pediatric semi-elemental formula. On D + 15, 35% of patients were receiving parenteral nutrition. At discharge, the patient's nutritional status had worsened compared to admission (p < 0.001). Discussion: Early use of enteral nutrition was observed, as adopted in other transplant centers and recommended in the literature. Protocols and guidelines are needed to support enteral nutritional therapy in pediatric transplantation.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"936-942"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141725112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrient Intakes and Gastrointestinal Symptoms Among Esophagogastric Cancer Survivors up to 5 Years Post-Surgery. 食管胃癌术后五年内幸存者的营养摄入量和胃肠道症状。

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-03-14 DOI: 10.1080/01635581.2024.2328380

A E Bennett, L O'Neill, S L Doyle, E M Guinan, J O'Sullivan, J V Reynolds, J Hussey

{"title":"Nutrient Intakes and Gastrointestinal Symptoms Among Esophagogastric Cancer Survivors up to 5 Years Post-Surgery.","authors":"A E Bennett, L O'Neill, S L Doyle, E M Guinan, J O'Sullivan, J V Reynolds, J Hussey","doi":"10.1080/01635581.2024.2328380","DOIUrl":"10.1080/01635581.2024.2328380","url":null,"abstract":"A cross-sectional analysis explored nutritional intakes and gastrointestinal (GI) symptoms among esophagogastric cancer survivors up to 12, 13-36, and 37+ months post-surgery. Participants were identified from the Upper GI Cancer Registry at St James' Hospital, Ireland. The Short Nutritional Assessment Questionnaire, European Prospective Investigation of Cancer Food Frequency Questionnaire, World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Score, and Gastrointestinal Symptoms Rating Scale assessed malnutrition risk, nutritional intake, adherence to (secondary) cancer prevention recommendations, and GI symptoms, respectively. Most (82.5%, n33) participants (n40) were male. Mean age was 65.5 ± 9.3 years. Time post-surgery ranged from 6-62 months. Half (50.0%, n20) had a BMI in the healthy range. A quarter (27.5%, n11) were at risk of malnutrition. Intakes of meat and meat products exceeded recommendations and intakes of fruits, vegetables, and fiber were below recommendations, with no significant between-group differences. The mean WCRF/AICR score was 3.6 ± 1.1, indicating adherence to 3.6 of 7 cancer prevention recommendations. It was not significantly different between subgroups. Minor to mild GI discomfort was reported, with no significant between-group differences in symptoms. As rates of long-term survivorship continue to increase, survivors must be supported to sustain behaviors that enhance quality of life and reduce secondary cancer risk.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"442-451"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Vitamin B12 Intake and Mortality in Patients with Colorectal Cancer: The US National Health and Nutrition Examination Survey, 1999-2018. 维生素 B12 摄入量与结直肠癌患者死亡率之间的关系：1999-2018年美国全国健康与营养调查》。

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-05-22 DOI: 10.1080/01635581.2024.2353938

Yuanchen Zhou, Qianqian Wang, Tengfei Yin, Dongyan Zhao, Geyujia Zhou, Xizhen Sun, Chang Tan, Lei Zhou, Shukun Yao

{"title":"Association Between Vitamin B12 Intake and Mortality in Patients with Colorectal Cancer: The US National Health and Nutrition Examination Survey, 1999-2018.","authors":"Yuanchen Zhou, Qianqian Wang, Tengfei Yin, Dongyan Zhao, Geyujia Zhou, Xizhen Sun, Chang Tan, Lei Zhou, Shukun Yao","doi":"10.1080/01635581.2024.2353938","DOIUrl":"10.1080/01635581.2024.2353938","url":null,"abstract":"Vitamin B12 plays a role in DNA methylation, influencing the 1-carbon cycle; However, its effect on colorectal cancer (CRC) mortality remains uncertain. This study assessed the relationship between vitamin B12 intake and all-cause and cancer-specific mortality among CRC patients. We analyzed data from the NHANES from 1999 to 2018, using multivariable Cox regression, competing risk model, Kaplan-Meier survival curves, and stratified analysis with interaction effects. The studied involved 4,554 cancer patients (mean age 65.8 years, 47.6% males). Results from multivariate Cox regression indicated that each additional 1 mcg/day of dietary vitamin B12 independently increased the risk of all-cause (HR, 1.07; 95% CI: 1.04-1.09, p < 0.001) and cancer-specific mortality (HR, 1.04; 95% CI, 1.02-1.06; p < 0.001). Kaplan-Meier curves indicated a higher risk of all-cause mortality with increased vitamin B12 intake (Log rank p = 0.01). Subgroup analysis suggested that higher vitamin B12 intake correlated with increased all-cause mortality risk, especially in individuals with higher protein (HR, 1.04; 95% CI, 1.02-1.06; p = 0.019) or carbohydrate intake (HR, 1.03; 95% CI, 1.01-1.05; p = 0.04). Thus, higher vitamin B12 intake correlates with increased all-cause and cancer-specific mortality in CRC patients, particularly those with higher protein or carbohydrate intake.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"619-627"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141077321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Changes in Nutritional Status of Elderly Patients with Lung Cancer Undergoing Chemotherapy Are Positively Related with Symptoms of Depression: A Prospective Follow-Up Study. 接受化疗的老年肺癌患者营养状况的早期变化与抑郁症状呈正相关：一项前瞻性随访研究

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-07-07 DOI: 10.1080/01635581.2024.2375019

Wioleta Umławska, Katarzyna Pawłowska-Seredyńska, Malwina Goździk, Irena Porębska

{"title":"Early Changes in Nutritional Status of Elderly Patients with Lung Cancer Undergoing Chemotherapy Are Positively Related with Symptoms of Depression: A Prospective Follow-Up Study.","authors":"Wioleta Umławska, Katarzyna Pawłowska-Seredyńska, Malwina Goździk, Irena Porębska","doi":"10.1080/01635581.2024.2375019","DOIUrl":"10.1080/01635581.2024.2375019","url":null,"abstract":"This study aims to assess early effects of chemotherapy on symptom alleviation, nutritional status, and mental health in elderly patients with advanced non-small-cell lung cancer (NSCLC). This prospective study included 45 NSCLC patients (32 males, 13 females) aged 65-82 years (mean age 70.0 ± 4.5 years) with good performance status. Assessments were conducted immediately after diagnosis and after two chemotherapy cycles, focusing on nutritional status (assessed with MNA questionnaire), quality of life (QoL, based on FACT-L and FACT-TOI questionnaires), lung cancer-related symptoms (based on LCSS), and mental health (based on PHQ-9 questionnaire). Despite significant alleviation of symptoms like cough, dyspnea, and body weight loss, there was no significant correlation between changes in symptoms burden and changes in nutritional status (r2 = 0.122, P = 0.427), and change of patients' mental condition (r2 = -0.141, P = 0.255). No significant QoL changes were noted, but a decrease in severe depression frequency was observed. The improvement of patients' mental condition was related strictly to the improvement of nutritional status (r2 = -0.589, P < 0.001). The study highlights the vital link between nutritional status and mental health in elderly NSCLC patients, emphasizing the need for integrated care approaches that address both aspects to enhance treatment effectiveness and patient well-being.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"927-935"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0