Nutrition and Cancer-An International Journal最新文献

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Impact of Low BMI and Nutritional Status on Quality of Life and Disease Outcome in Breast Cancer Patients: Insights From a Tertiary Cancer Center in India. 低体重指数和营养状况对乳腺癌患者生活质量和疾病预后的影响:来自印度一家三级癌症中心的启示。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-06-05 DOI: 10.1080/01635581.2024.2347396
Tanuma Mistry, Ranita Pal, Sushmita Ghosh, Trisha Choudhury, Syamsundar Mandal, Partha Nath, Neyaz Alam, Vilas D Nasare
{"title":"Impact of Low BMI and Nutritional Status on Quality of Life and Disease Outcome in Breast Cancer Patients: Insights From a Tertiary Cancer Center in India.","authors":"Tanuma Mistry, Ranita Pal, Sushmita Ghosh, Trisha Choudhury, Syamsundar Mandal, Partha Nath, Neyaz Alam, Vilas D Nasare","doi":"10.1080/01635581.2024.2347396","DOIUrl":"10.1080/01635581.2024.2347396","url":null,"abstract":"<p><p>This study investigates the impact of Body Mass Index (BMI) on Quality of Life (QoL) and treatment outcomes in breast cancer (BC) patients, particularly focusing on underweight individuals with compromised nutritional status. A nonrandomized prospective study comprising 121 newly diagnosed patients across various BMI categories utilized FACT-B & FACIT-Sp-12 questionnaires. Follow-ups occurred at baseline, during (3rd and 6th), and after (12th month) anthracycline-taxane chemotherapy, either sequentially or concomitantly. Patients with low BMI (<18.5 kg/m<sup>2</sup>; 53.7%) exhibited significantly poorer QoL, marked by compromised nutritional indicators (low MUAC and SFT). Repeated measures ANOVA identified significant correlations between BMI groups in functional, social, and emotional QoL aspects (<i>p</i> < 0.05), with no notable differences in other domains. A Chi-square (ꭓ2) test underscored a significant link between BMI and treatment response (<i>p</i> < 0.0001), showing higher rates of non-responders among underweight patients (<i>p</i> = 4.259e<sup>-14</sup>). The study advocates pretreatment consultation with a dietitian as standard care for Indian BC patients, offering complimentary nutritional support for improved QoL outcomes and treatment responses.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"596-607"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enteral Nutritional Therapy in Pediatric Autologous Transplantation: A Descriptive Cohort Study. 小儿自体移植中的肠内营养疗法:描述性队列研究
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-07-19 DOI: 10.1080/01635581.2024.2377341
Andressa Florencio da Silva, Vera Lucia Bosa, Estela Beatriz Behling
{"title":"Enteral Nutritional Therapy in Pediatric Autologous Transplantation: A Descriptive Cohort Study.","authors":"Andressa Florencio da Silva, Vera Lucia Bosa, Estela Beatriz Behling","doi":"10.1080/01635581.2024.2377341","DOIUrl":"10.1080/01635581.2024.2377341","url":null,"abstract":"<p><p><b>Introduction</b>: Pediatric hematopoietic stem cell transplantation requires individualized nutritional therapy, and the use of early enteral nutrition is beneficial. This study aims to analyze the use of enteral nutrition therapy in pediatric patients undergoing autologous transplantation. <b>Methods</b>: This is a descriptive cohort study conducted with data from electronic medical records of pediatric patients undergoing autologous transplantation from 2017 to 2022, using enteral nutrition. Nutritional and clinical variables and biochemical markers were assessed at four time points: day 0, day +5, day +10 and day +15. <b>Results</b>: The sample consisted of 50 patients. On average, the nasoenteral tube was inserted on D-4 and the enteral feeding started on D-3. On D0, most patients used a normocaloric polymeric enteral formula, but on <i>D</i> + 10, when diarrhea (<i>p</i> = 0.017) and mucositis (<i>p</i> < 0.001) worsened, the most commonly used enteral formula was a hypocaloric pediatric semi-elemental formula. On <i>D</i> + 15, 35% of patients were receiving parenteral nutrition. At discharge, the patient's nutritional status had worsened compared to admission (<i>p</i> < 0.001). <b>Discussion</b>: Early use of enteral nutrition was observed, as adopted in other transplant centers and recommended in the literature. Protocols and guidelines are needed to support enteral nutritional therapy in pediatric transplantation.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"936-942"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141725112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutrient Intakes and Gastrointestinal Symptoms Among Esophagogastric Cancer Survivors up to 5 Years Post-Surgery. 食管胃癌术后五年内幸存者的营养摄入量和胃肠道症状。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-03-14 DOI: 10.1080/01635581.2024.2328380
A E Bennett, L O'Neill, S L Doyle, E M Guinan, J O'Sullivan, J V Reynolds, J Hussey
{"title":"Nutrient Intakes and Gastrointestinal Symptoms Among Esophagogastric Cancer Survivors up to 5 Years Post-Surgery.","authors":"A E Bennett, L O'Neill, S L Doyle, E M Guinan, J O'Sullivan, J V Reynolds, J Hussey","doi":"10.1080/01635581.2024.2328380","DOIUrl":"10.1080/01635581.2024.2328380","url":null,"abstract":"<p><p>A cross-sectional analysis explored nutritional intakes and gastrointestinal (GI) symptoms among esophagogastric cancer survivors up to 12, 13-36, and 37+ months post-surgery. Participants were identified from the Upper GI Cancer Registry at St James' Hospital, Ireland. The Short Nutritional Assessment Questionnaire, European Prospective Investigation of Cancer Food Frequency Questionnaire, World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Score, and Gastrointestinal Symptoms Rating Scale assessed malnutrition risk, nutritional intake, adherence to (secondary) cancer prevention recommendations, and GI symptoms, respectively. Most (82.5%, <i>n</i>33) participants (<i>n</i>40) were male. Mean age was 65.5 ± 9.3 years. Time post-surgery ranged from 6-62 months. Half (50.0%, <i>n</i>20) had a BMI in the healthy range. A quarter (27.5%, <i>n</i>11) were at risk of malnutrition. Intakes of meat and meat products exceeded recommendations and intakes of fruits, vegetables, and fiber were below recommendations, with no significant between-group differences. The mean WCRF/AICR score was 3.6 ± 1.1, indicating adherence to 3.6 of 7 cancer prevention recommendations. It was not significantly different between subgroups. Minor to mild GI discomfort was reported, with no significant between-group differences in symptoms. As rates of long-term survivorship continue to increase, survivors must be supported to sustain behaviors that enhance quality of life and reduce secondary cancer risk.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"442-451"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Vitamin B12 Intake and Mortality in Patients with Colorectal Cancer: The US National Health and Nutrition Examination Survey, 1999-2018. 维生素 B12 摄入量与结直肠癌患者死亡率之间的关系:1999-2018年美国全国健康与营养调查》。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-05-22 DOI: 10.1080/01635581.2024.2353938
Yuanchen Zhou, Qianqian Wang, Tengfei Yin, Dongyan Zhao, Geyujia Zhou, Xizhen Sun, Chang Tan, Lei Zhou, Shukun Yao
{"title":"Association Between Vitamin B12 Intake and Mortality in Patients with Colorectal Cancer: The US National Health and Nutrition Examination Survey, 1999-2018.","authors":"Yuanchen Zhou, Qianqian Wang, Tengfei Yin, Dongyan Zhao, Geyujia Zhou, Xizhen Sun, Chang Tan, Lei Zhou, Shukun Yao","doi":"10.1080/01635581.2024.2353938","DOIUrl":"10.1080/01635581.2024.2353938","url":null,"abstract":"<p><p>Vitamin B12 plays a role in DNA methylation, influencing the 1-carbon cycle; However, its effect on colorectal cancer (CRC) mortality remains uncertain. This study assessed the relationship between vitamin B12 intake and all-cause and cancer-specific mortality among CRC patients. We analyzed data from the NHANES from 1999 to 2018, using multivariable Cox regression, competing risk model, Kaplan-Meier survival curves, and stratified analysis with interaction effects. The studied involved 4,554 cancer patients (mean age 65.8 years, 47.6% males). Results from multivariate Cox regression indicated that each additional 1 mcg/day of dietary vitamin B12 independently increased the risk of all-cause (HR, 1.07; 95% CI: 1.04-1.09, <i>p</i> < 0.001) and cancer-specific mortality (HR, 1.04; 95% CI, 1.02-1.06; <i>p</i> < 0.001). Kaplan-Meier curves indicated a higher risk of all-cause mortality with increased vitamin B12 intake (Log rank <i>p</i> = 0.01). Subgroup analysis suggested that higher vitamin B12 intake correlated with increased all-cause mortality risk, especially in individuals with higher protein (HR, 1.04; 95% CI, 1.02-1.06; <i>p</i> = 0.019) or carbohydrate intake (HR, 1.03; 95% CI, 1.01-1.05; <i>p</i> = 0.04). Thus, higher vitamin B12 intake correlates with increased all-cause and cancer-specific mortality in CRC patients, particularly those with higher protein or carbohydrate intake.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"619-627"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141077321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Changes in Nutritional Status of Elderly Patients with Lung Cancer Undergoing Chemotherapy Are Positively Related with Symptoms of Depression: A Prospective Follow-Up Study. 接受化疗的老年肺癌患者营养状况的早期变化与抑郁症状呈正相关:一项前瞻性随访研究
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-07-07 DOI: 10.1080/01635581.2024.2375019
Wioleta Umławska, Katarzyna Pawłowska-Seredyńska, Malwina Goździk, Irena Porębska
{"title":"Early Changes in Nutritional Status of Elderly Patients with Lung Cancer Undergoing Chemotherapy Are Positively Related with Symptoms of Depression: A Prospective Follow-Up Study.","authors":"Wioleta Umławska, Katarzyna Pawłowska-Seredyńska, Malwina Goździk, Irena Porębska","doi":"10.1080/01635581.2024.2375019","DOIUrl":"10.1080/01635581.2024.2375019","url":null,"abstract":"<p><p>This study aims to assess early effects of chemotherapy on symptom alleviation, nutritional status, and mental health in elderly patients with advanced non-small-cell lung cancer (NSCLC). This prospective study included 45 NSCLC patients (32 males, 13 females) aged 65-82 years (mean age 70.0 ± 4.5 years) with good performance status. Assessments were conducted immediately after diagnosis and after two chemotherapy cycles, focusing on nutritional status (assessed with MNA questionnaire), quality of life (QoL, based on FACT-L and FACT-TOI questionnaires), lung cancer-related symptoms (based on LCSS), and mental health (based on PHQ-9 questionnaire). Despite significant alleviation of symptoms like cough, dyspnea, and body weight loss, there was no significant correlation between changes in symptoms burden and changes in nutritional status (<i>r</i><sup>2</sup> = 0.122, <i>P</i> = 0.427), and change of patients' mental condition (<i>r</i><sup>2</sup> = -0.141, <i>P</i> = 0.255). No significant QoL changes were noted, but a decrease in severe depression frequency was observed. The improvement of patients' mental condition was related strictly to the improvement of nutritional status (<i>r</i><sup>2</sup> = -0.589, <i>P</i> < 0.001). The study highlights the vital link between nutritional status and mental health in elderly NSCLC patients, emphasizing the need for integrated care approaches that address both aspects to enhance treatment effectiveness and patient well-being.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"927-935"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional Status as a Risk Factor for Doxorubicin Cardiotoxicity in Mexican Children with Acute Lymphoblastic Leukemia. 营养状况是墨西哥急性淋巴细胞白血病患儿出现多柔比星心脏毒性的风险因素。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-07-12 DOI: 10.1080/01635581.2024.2378502
Jesús Alonso Gándara-Mireles, Ismael Lares-Asseff, Elio Aarón Reyes Espinoza, Lourdes Patricia Córdova Hurtado, Hugo Payan Gándara, Mauricio Botello Ortiz, Verónica Loera Castañeda, Leslie Patrón Romero, Horacio Almanza Reyes
{"title":"Nutritional Status as a Risk Factor for Doxorubicin Cardiotoxicity in Mexican Children with Acute Lymphoblastic Leukemia.","authors":"Jesús Alonso Gándara-Mireles, Ismael Lares-Asseff, Elio Aarón Reyes Espinoza, Lourdes Patricia Córdova Hurtado, Hugo Payan Gándara, Mauricio Botello Ortiz, Verónica Loera Castañeda, Leslie Patrón Romero, Horacio Almanza Reyes","doi":"10.1080/01635581.2024.2378502","DOIUrl":"10.1080/01635581.2024.2378502","url":null,"abstract":"<p><p>Acute lymphoblastic leukemia (ALL) is the most common childhood cancer in the world. Doxorubicin (Dox) is a very useful drug in these patients, however, one of the main adverse effects caused by the use of Dox is cardiotoxicity (CT). Protein-calorie malnutrition (PCM) is a factor that, among others, can influence the development of CT due to Dox. The aim of our study was to associate PCM as a risk factor for CT induced by Dox in Mexican children with ALL. We included 89 children with ALL who were treated with Dox, from October 2018 to July 2023, and of whom 14 developed some type of CT, 15 were underweight and 3 were overweight. The analysis of the association risk of CT due to PCM shows a statistically significant association of risk of developing CT due to PCM. On the other hand, healthy weight was associated with protection for developing CT due to Dox use. Of the total number of girls who presented CT, all had systolic dysfunction, while 6 of them also had diastolic dysfunction. On the other hand, of the total number of boys who presented CT, all of them had systolic dysfunction and only one of them also had diastolic dysfunction. These results show that in patients in which Dox is being administered, special attention is suggested for girls with PCM, since systolic failure is a precursor and occurs before diastolic failure in girls with PCM.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"952-962"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adherence to Healthy or Unhealthy Pro-Vegetarian Plant-Based Diets Have Different Impact on Prostate Cancer Severity: Preliminary Findings. 坚持健康或不健康的植物性植物性饮食对前列腺癌症严重程度有不同影响:初步发现。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2023-12-27 DOI: 10.1080/01635581.2023.2279240
Salvatore Sciacca, Arturo Lo Giudice, Maria Giovanna Asmundo, Sebastiano Cimino, Giuseppe Morgia, Ali A Alshatwi, Andrea Cocci, Giorgio Ivan Russo
{"title":"Adherence to Healthy or Unhealthy Pro-Vegetarian Plant-Based Diets Have Different Impact on Prostate Cancer Severity: Preliminary Findings.","authors":"Salvatore Sciacca, Arturo Lo Giudice, Maria Giovanna Asmundo, Sebastiano Cimino, Giuseppe Morgia, Ali A Alshatwi, Andrea Cocci, Giorgio Ivan Russo","doi":"10.1080/01635581.2023.2279240","DOIUrl":"10.1080/01635581.2023.2279240","url":null,"abstract":"<p><p>Prostate cancer (PCa) is a prevalent malignancy affecting men worldwide, and plant-based diets have been widely advocated for their health benefits. The aim of this study was to test the association between general, healthy, and unhealthy pro-vegetarian plant-based diets and PCa severity on 118 consecutive patients undergoing prostatectomy in a university hospital in Italy. Food frequency questionnaires were used to calculate scores for dietary patterns. Multivariate logistic regression analyses were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to test the associations. A general plant-based diet was not associated with cancer severity, while patients reporting a higher adherence to a healthy plant-based diet were less likely to have a more severe PCa (for medium/high vs. low-risk PCa, OR = 0.27, 95% CI: 0.08, 0.88; for high vs. medium/low-risk PCa, OR = 0.09, 95% CI: 0.02, 0.39). Patients resulting in higher adherence to an unhealthy plant-based diet were more likely to be diagnosed with more severe PCa (OR = 6.15, 95% CI: 1.70, 22.24). In conclusion, plant-based dietary patterns may have a different impact on PCa severity depending on the quality of the foods included.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"98-105"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71523403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Malnutrition in Patients with Hepatocellular Carcinoma: A Comparative Study of GLIM Criteria, NRS2002, and PG-SGA, and Identification of Independent Risk Factors. 肝细胞癌患者营养不良的发生率:GLIM 标准、NRS2002 和 PG-SGA 的比较研究以及独立风险因素的识别。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-02-20 DOI: 10.1080/01635581.2024.2314317
Shengqiang Tan, Jie Jiang, Liulin Qiu, Yaohao Liang, Jianyi Meng, Ning Tan, Bangde Xiang
{"title":"Prevalence of Malnutrition in Patients with Hepatocellular Carcinoma: A Comparative Study of GLIM Criteria, NRS2002, and PG-SGA, and Identification of Independent Risk Factors.","authors":"Shengqiang Tan, Jie Jiang, Liulin Qiu, Yaohao Liang, Jianyi Meng, Ning Tan, Bangde Xiang","doi":"10.1080/01635581.2024.2314317","DOIUrl":"10.1080/01635581.2024.2314317","url":null,"abstract":"<p><strong>Aim: </strong>Malnutrition is prevalent in hepatocellular carcinoma (HCC) patients, linked to poor outcomes, necessitating early intervention. This study aimed to investigate malnutrition in HCC patients, assess Nutrition Risk Screening 2002 (NRS-2002) and Patient-Generated Subjective Global Assessment (PG-SGA) <i>vs.</i> Global Leadership Initiative on Malnutrition (GLIM) criteria, and identify independent risk factors.</p><p><strong>Method: </strong>A cross-sectional retrospective study was conducted on 207 patients with HCC. Nutritional screening/assessment results and blood samples were collected within 72 h of admission. This study assessed the prevalence of malnutrition using the NRS-2002 and PG-SGA and retrospectively using the GLIM criteria. The performance of the screening tools was evaluated using kappa (<i>K</i>) values. Logistic regression analyses were performed to determine whether laboratory parameters were associated with malnutrition as identified by the GLIM criteria.</p><p><strong>Results: </strong>Of the participants, 30.4% were at risk of malnutrition according to NRS-2002. The agreement between the NRS-2002 and GLIM criteria was substantial. The GLIM criteria and PG-SGA diagnosed malnutrition in 43 and 54.6% of the participants, respectively. Age, anemia, and ascites correlated with malnutrition in regression.</p><p><strong>Conclusion: </strong>The GLIM criteria, along with NRS-2002 and PG-SGA, aid in diagnosing malnutrition in HCC patients. Recognizing risk factors improves accuracy, enabling timely interventions for better outcomes.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"335-344"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139914065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical, Functional, and Nutritional Efficacy of a Glutamine-Enriched Oligomeric Diet in Patients with Rectal Cancer. 富含谷氨酰胺的低聚物饮食对直肠癌患者的临床、功能和营养效果。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2023-12-27 DOI: 10.1080/01635581.2023.2286698
Johanna Del Carmen Peña Vivas, Andrea Carolina Orduz Arena, Ana Alonso García, Carlos Fernando Carrascal Gordillo, Rocío Martínez Gutiérrez, Cristina Rodríguez-Acosta Caballero, Ignacio Fernández Freije, Ana Belén Paino Martínez, Tamara Belloso Cuesta, Germán Juan Rijo, Alicia Calleja Fernández
{"title":"Clinical, Functional, and Nutritional Efficacy of a Glutamine-Enriched Oligomeric Diet in Patients with Rectal Cancer.","authors":"Johanna Del Carmen Peña Vivas, Andrea Carolina Orduz Arena, Ana Alonso García, Carlos Fernando Carrascal Gordillo, Rocío Martínez Gutiérrez, Cristina Rodríguez-Acosta Caballero, Ignacio Fernández Freije, Ana Belén Paino Martínez, Tamara Belloso Cuesta, Germán Juan Rijo, Alicia Calleja Fernández","doi":"10.1080/01635581.2023.2286698","DOIUrl":"10.1080/01635581.2023.2286698","url":null,"abstract":"<p><strong>Aims: </strong>This work aims to evaluate the efficacy of nutritional supplementation with a glutamine-enriched oligomeric diet (GEOD) compared to a standard polymeric diet (SPD) in terms of oncology treatment-related diarrhea (OTRD) (frequency and consistency of stools), gastrointestinal toxicity, and functional and nutritional progress.</p><p><strong>Methods: </strong>This prospective cohort study compared two groups of patients with rectal cancer in treatment with neoadjuvant chemotherapy and radiotherapy who were at risk of malnutrition. Patients were randomized to receive either 400 ml of GEOD or of SPD from the start of radiotherapy to 30 days after its completion.</p><p><strong>Results: </strong>Eighty patients were recruited, 40 per arm. The GEOD arm had improved stool consistency and a greater reduction in the number of stools compared to the SPD arm (<i>p</i> < 0.001). The relative risk (RR) of developing diarrhea in the GEOD arm was 0.059 (95% CI 0.015-0.229). There was a reduced risk of developing intestinal mucositis in the GEOD arm compared to the SPD arm [RR 0.202 (95% CI 0.102 - 0.399)]. The GEOD arm had greater improvements in functional and nutritional status (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>GEOD had a protective effect in terms of the development of gastrointestinal toxicity associated with chemotherapy and radiotherapy treatment in patients with rectal cancer.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"128-136"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138296543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary Branched Chain Amino Acids Association with Cancer and Mortality: A Systematic Review and Meta-Analysis of Observational Studies. 膳食支链氨基酸与癌症和死亡率的关系:观察性研究的系统回顾和元分析》。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-01-18 DOI: 10.1080/01635581.2023.2292820
Mahdieh Tabesh, Farshad Teymoori, Hamid Ahmadirad, Parvin Mirmiran, Seyedeh Tayebeh Rahideh
{"title":"Dietary Branched Chain Amino Acids Association with Cancer and Mortality: A Systematic Review and Meta-Analysis of Observational Studies.","authors":"Mahdieh Tabesh, Farshad Teymoori, Hamid Ahmadirad, Parvin Mirmiran, Seyedeh Tayebeh Rahideh","doi":"10.1080/01635581.2023.2292820","DOIUrl":"10.1080/01635581.2023.2292820","url":null,"abstract":"<p><p>The present study aimed to investigate the association of dietary branched-chain amino acids (BCAAs) and its components with cancer, cancer mortality, and all-cause mortality in a meta-analysis of observational studies. A comprehensive search was conducted between electronic databases (PubMed, Scopus, and Web of Science) until September 2022. Odds ratios (OR), hazard ratios (HR), and relative risks (RR) were extracted. Eight articles (six studies on breast cancer (BC) and digestive cancers risk, and three studies on both BC and digestive cancers mortality, and all-cause mortality) were included. The present study showed no statistically significant association between dietary BCAAs and its components with BC and digestive cancers (RR<sub>BCAA</sub>: 0.87, 95% CI: 0.68-1.10, RR<sub>Leucine</sub>: 0.74, 95% CI: 0.52-1.04, RR<sub>Isoleucine</sub>: 0.98, 95% CI: 0.93-1.04, RR<sub>Valine</sub>: 0.76, 95% CI: 0.55-1.05). Also, no statistically significant relationship between dietary BCAAs and its components with both BC and digestive cancers mortality (RR<sub>BCAA</sub>: 0.95, 95% CI: 0.68-1.33, RR<sub>Leucine</sub>: 0.95, 95% CI: 0.79-1.15, RR<sub>Isoleucine</sub>: 0.95, 95% CI: 0.79-1.14, RR<sub>Valine</sub>: 1.01, 95% CI: 0.84-1.21) and all-cause mortality (RR<sub>BCAA</sub>: 0.98, 95% CI: 0.73-1.32, RR<sub>Leucine</sub>: 1.02, 95% CI: 0.81-1.29, RR<sub>Isoleucine</sub>: 0.96, 95% CI: 0.73-1.27, RR<sub>Valine</sub>: 1.02, 95% CI: 0.79-1.32) were observed. Our findings showed no significant association between dietary BCAAs and its components with BC and digestive cancers, BC and digestive cancers mortality, and all-cause mortality.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"160-174"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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