Nutrition and Cancer-An International Journal最新文献_第9页

Dietary Flavonoids and Lung Cancer: A GRADE-Assessed Systematic Review and Meta-Analysis of Observational Studies. 膳食类黄酮与肺癌：经 GRADE 评估的观察性研究系统综述和元分析》（A GRADE-Assessed Systematic Review and Meta-Analysis of Observational Studies）。

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-10-24 DOI: 10.1080/01635581.2024.2417457

Kimia Rostampour, Kimia Alipour, Fatemeh Mirjalili, Bita Forootani, Hooman Yekrang Safakar, Sara Beigrezaei, Scott C Forbes, Amin Salehi-Abargouei

{"title":"Dietary Flavonoids and Lung Cancer: A GRADE-Assessed Systematic Review and Meta-Analysis of Observational Studies.","authors":"Kimia Rostampour, Kimia Alipour, Fatemeh Mirjalili, Bita Forootani, Hooman Yekrang Safakar, Sara Beigrezaei, Scott C Forbes, Amin Salehi-Abargouei","doi":"10.1080/01635581.2024.2417457","DOIUrl":"10.1080/01635581.2024.2417457","url":null,"abstract":"Individual observational studies examining the association between polyphenols and the risk of lung cancer have reported mixed findings. Therefore, we performed a systematic review and meta-analysis to determine the pooled effects between polyphenol intake and lung cancer risk. A systematic search was performed on PubMed, Scopus, and Web of Science databases in April 2023. Random-effect models were used to estimate odd ratios (OR) and 95% confidence intervals (95% CI). In total, 20 studies were included in the systematic review. The pooled analyses indicated that a higher intake of flavonoids (OR = 0.81; 95% CI: 0.67,0.98; p = 0.03) and isoflavone (OR = 0.82; 95% CI: 0.74,0.92; p < 0.001) were associated with lower odds of lung cancer. In addition, the ingestion of anthocyanidin (OR = 0.80; 95% CI: 0.65,0.98; p = 0.04), kaempferol (OR = 0.78; 95% CI: 0.64,0.96; p = 0.02), quercetin (OR = 0.66; 95% CI: 0.48,0.91; p = 0.01) and flavanones (OR = 0.71; 95% CI: 0.59,0.85; p < 0.001) reduced the likelihood of developing lung cancer. Overall, our findings suggest that flavonoids, isoflavones, anthocyanidin, kaempferol, quercetin, and flavanones may protect against lung cancer.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"164-178"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diet as an Adjunct Therapy in Reducing Chemotherapy Toxicities and Improving Patients Quality of Life: A Systematic Review and Meta-Analysis. 饮食作为降低化疗毒性和改善患者生活质量的辅助疗法：系统回顾和荟萃分析。

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-12-12 DOI: 10.1080/01635581.2024.2437833

Jessica Abene, Sherilyn Tyburski, Tanja V E Kral, Ryan Quinn, Jie Deng

{"title":"Diet as an Adjunct Therapy in Reducing Chemotherapy Toxicities and Improving Patients Quality of Life: A Systematic Review and Meta-Analysis.","authors":"Jessica Abene, Sherilyn Tyburski, Tanja V E Kral, Ryan Quinn, Jie Deng","doi":"10.1080/01635581.2024.2437833","DOIUrl":"10.1080/01635581.2024.2437833","url":null,"abstract":"This review analyzed existing literature regarding the relationship between different diets and chemotherapy toxicities, as well as the quality of life (QOL) among patients undergoing treatment. It aims to identify the most advantageous diet for cancer patients. PubMed, CINAHL, and Embase were used to select randomized control trials (RCTs) assessing the relationship between a specific diet and chemotherapy toxicities and/or QOL in patients as of October 2023. Out of 1,419 records, 11 RCTs were included. Analyses were stratified by diet type. Pooled odds ratios and 95% confidence intervals (CI) were obtained from the random-effect model using STATA. We included 7 studies testing fasting variations; 1 testing a ketogenic diet; 1 testing a Mediterranean diet; 1 testing a plant-based, high-protein diet; and 1 testing an anti-inflammatory diet. Four fasting studies were in the meta-analysis. The random-effects meta-analysis showed no significant difference in the incidence of chemotherapy toxicities between fasting and non-fasting patients. There is insufficient evidence to determine which dietary intervention is the most advantageous, however, there is evidence that all the diets examined may complement conventional cancer therapy by helping to reduce chemotherapy toxicities. No intervention can be ruled out. More research is needed in this field.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"341-359"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Dietary Patterns, Nutrient Intake, and Immune Modulation in Glioma Risk and Management. 饮食模式、营养摄入和免疫调节在神经胶质瘤风险和管理中的作用。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-08-07 DOI: 10.1080/01635581.2025.2539538

Mohammad Ghasemi Dehcheshmeh, Niloofar Eshaghian, Samine Mashayekhi, Fatemeh Atayie, Faezeh Samii Kondrud, Ladan Tavakoli, Mohammad Amin Mohammadi, Masoomeh Asadi, Gholamreza Askari, Ali Khodadadi, Omid Sadeghi

{"title":"The Role of Dietary Patterns, Nutrient Intake, and Immune Modulation in Glioma Risk and Management.","authors":"Mohammad Ghasemi Dehcheshmeh, Niloofar Eshaghian, Samine Mashayekhi, Fatemeh Atayie, Faezeh Samii Kondrud, Ladan Tavakoli, Mohammad Amin Mohammadi, Masoomeh Asadi, Gholamreza Askari, Ali Khodadadi, Omid Sadeghi","doi":"10.1080/01635581.2025.2539538","DOIUrl":"10.1080/01635581.2025.2539538","url":null,"abstract":"Glioma is the most common primary brain tumor, accounting for approximately 70% of adult brain malignancies. Although this cancer is relatively rare, it causes significant mortality. Among environmental risk factors, frequent exposure to ionizing radiation has significantly increased the risk of glioma. Special attention has been paid to diet and dietary factors in recent decades. Although the role of diet in some cancers has been confirmed in previous studies, the link between dietary intake, the immune system, and glioma is still questionable. In the current review, a higher dietary intake of vitamin C, folate, vitamin A, phytochemicals, and calcium might be associated with immune system activation and reduced risk of glioma. In addition, adherence to a high-carbohydrate diet is associated with a high risk of glioma. Despite the evidence, limited data are available for some important fatty acids, B vitamins, protein, vitamins D, E, K, magnesium, copper, zinc, iron, and selenium, and some healthy dietary patterns regarding glioma risk. In terms of clinical outcomes, the ketogenic diet might play a role in the management of glioma and might be used as an adjunctive therapy in these patients. Although observational studies have shown that a higher dietary intake of folate, vitamin C, calcium, and vitamin A was associated with the activation of the immune system and reduced risk of glioma, the complex interactions between diet, immune system, and glioma on the clinical outcomes of patients with glioma have not been investigated. Therefore, further studies are needed in this regard.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"959-982"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Whole-Course Immunonutrition Management on Patients With Stage III and IV Nasopharyngeal Carcinoma Undergoing Concurrent Chemoradiotherapy: A Randomized Controlled Trial. 全程免疫营养管理对III期和IV期鼻咽癌同步放化疗患者的影响：一项随机对照试验。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-08-14 DOI: 10.1080/01635581.2025.2528269

Yuchen Hua, Shu Zhou, Weilin Xu, Yuandong Cao, Xinchen Sun, Menglin Chao, Minqiong Cheng, Yuanyuan Tang

{"title":"The Impact of Whole-Course Immunonutrition Management on Patients With Stage III and IV Nasopharyngeal Carcinoma Undergoing Concurrent Chemoradiotherapy: A Randomized Controlled Trial.","authors":"Yuchen Hua, Shu Zhou, Weilin Xu, Yuandong Cao, Xinchen Sun, Menglin Chao, Minqiong Cheng, Yuanyuan Tang","doi":"10.1080/01635581.2025.2528269","DOIUrl":"10.1080/01635581.2025.2528269","url":null,"abstract":"Objective: To evaluate the effects of whole-course immunonutrition management (WIM) on patients with stage III and IV nasopharyngeal carcinoma (NPC) undergoing radiotherapy.Methods: A total of 103 patients with NPC admitted to our hospital between October 2021 and June 2023 were assigned to receive either conventional nursing (routine group, n = 51) or WIM therapy (experimental group, n = 52) according to different nursing methods. Outcome measures included nutritional status assessment, haematological indicators, adverse reactions and the social support situation.Results: Following the intervention, the WIM approach was associated with a significantly lower incidence of adverse reactions compared with routine nursing care (p < 0.05). Specifically, the experimental group had a significantly lower incidence of nausea (p = 0.0341), vomiting (p = 0.0279) and high-level oral mucositis (III/IV) (p = 0.0238) compared with the routine group. In terms of the nutritional status, patients in the experimental group maintained better body mass index (BMI) and body weight, with significant differences observed in total protein levels (p < 0.05) throughout the trial, indicating improved nutritional outcomes. However, no significant differences were found in the changes of BMI between the two groups. The social support situation was also significantly better in the experimental group, as evidenced by a greater improvement in the social support rating scale scores (p = 0.0017).Conclusions: Whole-course immunonutrition management can improve the nutritional status of patients with NPC treated with concurrent chemoradiotherapy, reduce the severity of radiation-induced nasopharyngeal and oral reactions and relieve side effects.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1035-1042"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Oral Nutritional Supplements in Gastric Cancer Patients with Malnutrition-Sarcopenia Syndrome. 口服营养补充剂对胃癌营养不良-肌肉减少综合征患者的影响。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-09-02 DOI: 10.1080/01635581.2025.2553381

Yinfan Wu, Yan Wu, Huiping Ding, Qiong Wang, Haiyan Han, Tianze Yu, Yiqin Pan, Yiqun Ling

{"title":"Effects of Oral Nutritional Supplements in Gastric Cancer Patients with Malnutrition-Sarcopenia Syndrome.","authors":"Yinfan Wu, Yan Wu, Huiping Ding, Qiong Wang, Haiyan Han, Tianze Yu, Yiqin Pan, Yiqun Ling","doi":"10.1080/01635581.2025.2553381","DOIUrl":"10.1080/01635581.2025.2553381","url":null,"abstract":"Malnutrition and sarcopenia may occur concurrently (Malnutrition-sarcopenia syndrome, MSS) in gastric cancer patients, affecting the prognosis and clinical outcomes. This study aimed to evaluate MSS prevalence and oral nutritional supplements (ONS) efficacy. This study included a retrospective analysis of 761 gastric cancer patients post-resection to assess MSS prevalence/prognosis, and a prospective non-randomized trial enrolled 81 MSS patients comparing ONS (500 kcal/day ×4 wk) versus standard care. In the retrospective cohort, MSS prevalence was 20.2%, and MSS independently predicted higher postoperative complication (OR: 2.330, 95% CI: 1.256-4.321, p = 0.007), recurrence/metastasis (OR: 4.162, 95% CI: 1.965-8.815, p < 0.001) and worse overall survival (HR: 1.649, 95% CI: 1.007-2.700, p = 0.047). In the prospective trial, ONS significantly improved weight maintenance compared to standard care (p = 0.032). Non-significant trends were observed in ONS group for shorter postoperative length of stay (PLOS) (6.8 vs 8.0 days), fewer complications (5.0% vs 22.0%) and improved handgrip strength (HGS) recovery (0.1 kg vs -0.9 kg). MSS is prevalent in gastric cancer and associated with adverse outcomes. ONS effectively preserves weight and shows recovery benefits, supporting its integration into MSS management.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1132-1141"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a Machine Learning-Based Nutrition-Related Surgical Risk Assessment Model for Older Patients with Gastrointestinal Malignancies. 基于机器学习的老年胃肠道恶性肿瘤患者营养相关手术风险评估模型的建立

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-09-02 DOI: 10.1080/01635581.2025.2552461

Shishu Yin, Xu Liu, Xianglong Cao, Jian Cui, Jinxin Shi, Fuhai Ma, Tianming Ma, Qi An, Tao Yu, Zijian Li, Gang Zhao

{"title":"Development of a Machine Learning-Based Nutrition-Related Surgical Risk Assessment Model for Older Patients with Gastrointestinal Malignancies.","authors":"Shishu Yin, Xu Liu, Xianglong Cao, Jian Cui, Jinxin Shi, Fuhai Ma, Tianming Ma, Qi An, Tao Yu, Zijian Li, Gang Zhao","doi":"10.1080/01635581.2025.2552461","DOIUrl":"10.1080/01635581.2025.2552461","url":null,"abstract":"Older patients with gastrointestinal cancer are at a high risk of postoperative complications; however, no accurate preoperative assessment is available. This study developed a prognostic model that leveraged machine learning and multidimensional clinical data to predict postoperative complications in older patients. This study assessed 365 older patients with gastrointestinal cancer who underwent radical surgery at Beijing Hospital. Patients were randomly allocated to training and test sets (7:3 ratio). Multiplex machine learning was used for feature selection and model development. The efficacies of the models were assessed using receiver operating characteristic curves. An imbalance rfsrc + ranger model (IRM) was created using the \"shiny\" R package. All statistical analyses were performed using R software. The overall rate of postoperative complications was 19.2%. IRM was the most accurate among the 361 models developed using 19 machine learning algorithms and 19 sets of clinical features. Body mass index was the most important variable for predicting postoperative complications in these patients, followed by hemoglobin level, albumin level, and surgical approach. This study developed a nutrition-related surgical risk assessment model that includes malnutrition, comorbidities, and surgical approaches to improve the outcome of older patients with gastrointestinal malignancies, aiding in managing preoperative risk factors and improving surgical safety.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1121-1131"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VDR-Mediated Inhibition of Glycolysis and Metastasis by Calcitriol in Triple-Negative Breast Cancer. vdr介导的骨化三醇对三阴性乳腺癌糖酵解和转移的抑制作用。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-09-13 DOI: 10.1080/01635581.2025.2557593

Jingjing Lu, Dongxuan Wang, Hongjin Huo, Hao Jiang, Wei Wei, Jie Sun, Fei Jiang

{"title":"VDR-Mediated Inhibition of Glycolysis and Metastasis by Calcitriol in Triple-Negative Breast Cancer.","authors":"Jingjing Lu, Dongxuan Wang, Hongjin Huo, Hao Jiang, Wei Wei, Jie Sun, Fei Jiang","doi":"10.1080/01635581.2025.2557593","DOIUrl":"10.1080/01635581.2025.2557593","url":null,"abstract":"Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with high metastatic potential and limited therapeutic options. This study investigates the effects of calcitriol, an active metabolite of vitamin D, on TNBC progression by targeting the vitamin D receptor (VDR)-mediated hypoxia-inducible factor-1α (HIF-1α) axis. We established in vivo TNBC xenograft models using 4T1 cells and in vitro models with MDA-MB-231 and 4T1 cells overexpressing HIF-1α. Results showed that calcitriol inhibited lung metastasis and downregulated glycolytic activity in TNBC xenografts without affecting primary tumor growth. In vitro, calcitriol reduced cell viability, migration, and invasion by suppressing HIF-1α expression. It also decreased glucose uptake, lactate production, and ATP levels while downregulating key glycolytic regulators. VDR knockdown abolished these effects, confirming VDR as the critical mediator. Our findings suggest that calcitriol exerts anti-metastatic effects in TNBC by modulating the VDR-HIF-1α axis, inhibiting glycolysis, and suppressing the epithelial-mesenchymal transition. This study highlights the potential therapeutic role of calcitriol in TNBC treatment by targeting both metabolic reprogramming and invasive capacity. Future research should further explore the mechanisms underlying calcitriol-mediated HIF-1α suppression and its clinical application in TNBC.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1200-1211"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rauvolfia Verticillata Pectic Polysaccharides Alleviate Inflammation-Associated Colorectal Cancer and Correlate with Modulation of Gut Microbiota, Short-Chain Fatty Acid Metabolism, and NF-κB/IL-6/STAT3 Signaling Pathways. 黄连果胶多糖减轻炎症相关性结直肠癌，并与肠道菌群、短链脂肪酸代谢和NF-κB/IL-6/STAT3信号通路的调节相关

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-08-28 DOI: 10.1080/01635581.2025.2551294

Yi-Fan Guo, Yujie Wang, Haidong Wu, Liudan Wang, Xinpu Miao

{"title":"Rauvolfia Verticillata Pectic Polysaccharides Alleviate Inflammation-Associated Colorectal Cancer and Correlate with Modulation of Gut Microbiota, Short-Chain Fatty Acid Metabolism, and NF-κB/IL-6/STAT3 Signaling Pathways.","authors":"Yi-Fan Guo, Yujie Wang, Haidong Wu, Liudan Wang, Xinpu Miao","doi":"10.1080/01635581.2025.2551294","DOIUrl":"10.1080/01635581.2025.2551294","url":null,"abstract":"Background: Colorectal cancer (CRC) is increasingly common in younger individuals and strongly linked to chronic inflammation. Gut microbiota and pathways like NF-κB/STAT3 play key roles, which highlights the therapeutic potential of natural compounds that target intestinal immunity and microbial balance. Objective: To investigate the therapeutic effects of pectic polysaccharides (PPs) from Rauvolfia verticillata in inflammation-associated CRC via the modulation of of gut microbiota and NF-κB/IL-6/STAT3 signaling pathways. Methods: C57BL/6 mice were subjected to azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC and treated with PP (100 mg/kg/day), the STAT3 inhibitor W2014-S (10 mg/kg), or fecal microbiota transplantation (FMT) from PP-treated donors. Histopathology, immunohistochemistry (IHC), Western blot, immunofluorescence (IF), 16S rRNA sequencing, and SCFA analysis were performed to assess inflammation, signaling pathways, gut microbiota composition, and metabolic changes. Results: PP intervention significantly mitigated AOM/DSS-induced weight loss, intestinal lesions, and disease activity index (DAI) scores while suppressing NF-κB and STAT3 activation. PP restored gut microbiota diversity, reduced pro-inflammatory genera, and regulated SCFA levels, particularly hexanoic those of and isohexanoic acids. FMT from PP-treated donors similarly attenuated colitis and inhibited NF-κB/STAT3 pathways. Conclusions: PP alleviates CRC and is associated with modulation of gut microbiota, SCFA metabolism, and NF-κB/IL-6/STAT3 signaling, offering a potential therapeutic strategy for inflammation-driven CRC.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1183-1199"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation of the WNT7B/β-Catenin Pathway Initiates GLUT1 Expression and Promotes Aerobic Glycolysis in Colorectal Cancer Cells. 激活 WNT7B/β-Catenin 通路可启动 GLUT1 表达并促进结直肠癌细胞的有氧糖酵解。

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-10-21 DOI: 10.1080/01635581.2024.2418607

Fan Jiang, Zhiju Chen, Xiang Wang, Chuangyu Huang, Yiwei Li, Ning Liu

{"title":"Activation of the WNT7B/β-Catenin Pathway Initiates GLUT1 Expression and Promotes Aerobic Glycolysis in Colorectal Cancer Cells.","authors":"Fan Jiang, Zhiju Chen, Xiang Wang, Chuangyu Huang, Yiwei Li, Ning Liu","doi":"10.1080/01635581.2024.2418607","DOIUrl":"10.1080/01635581.2024.2418607","url":null,"abstract":"Glucose is an important energy source for tumors, however the molecular mechanisms by which tumor cells regulate glucose uptake remain unclear. In this study, we aimed to investigate the regulation mechanism of the WNT7B/β-catenin pathway for glucose transporter 1 (GLUT1)-mediated glucose metabolism in colorectal cancer. Here, we found that WNT7B expression levels were significantly increased in colorectal cancer tissues and closely associated with the clinical stage and lymph node metastasis in patients with colorectal cancer. Next, we confirmed that WNT7B significantly increased the glucose consumption and lactic acid levels in SW480 cells by overexpressing WNT7B. Additionally, gene and protein levels of GLUT1 were increased in WNT7B-overexpressing SW480 cells. However, WNT7B knockdown reversed these effects. WNT7B also enhanced GLUT1-mediated cell proliferation, invasion, and migration. WNT7B overexpression inhibited the effect of glucose deprivation on apoptosis. The WNT/β-catenin signaling pathway inhibitor, LGK974, inhibited WNT7B secretion, leading to GLUT1 levels downregulation and promotion of cell apoptosis. Ectopic tumor xenograft model experiments revealed that WNT7B promoted tumor progression in mice. Overall, our results suggest that WNT7B promotes β-catenin entry into the nucleus to initiates GLUT1 transcription, increases glucose transport and consumption, and enhances aerobic glycolysis, thus promoting tumor progression in colorectal cancer cells.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"311-323"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coconut Milk Consumption and Breast Cancer Risk in Thai Women: A Case-Control Study. 泰国妇女的椰奶消费与乳腺癌风险：病例对照研究

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-08-12 DOI: 10.1080/01635581.2024.2390202

Phornsawan Leechanavanicpan, Pakkapong Phucharoenrak, Phenphop Phansuea, Dunyaporn Trachootham

{"title":"Coconut Milk Consumption and Breast Cancer Risk in Thai Women: A Case-Control Study.","authors":"Phornsawan Leechanavanicpan, Pakkapong Phucharoenrak, Phenphop Phansuea, Dunyaporn Trachootham","doi":"10.1080/01635581.2024.2390202","DOIUrl":"10.1080/01635581.2024.2390202","url":null,"abstract":"Coconut milk contains plant-based saturated fat and phytochemicals with antioxidant activities. However, its role in breast cancer risk remains unclear. A case-control study was conducted on 244 participants to study the association. The Case group includes 61 newly diagnosed breast cancer patients receiving < 6 months of therapies. The Control group includes 183 healthy people with matched characteristics. A new questionnaire was developed, validated, and used in this study to estimate the frequency of coconut milk-containing food intake. Results show that the questionnaire has satisfactory content validity, test-retest reliability, and criterion-related validity. From the case-control study, either consuming 1-3 or 4-6 times/week of coconut-milk-containing curry or consuming 4-6 times/week of coconut milk-topped desserts are associated with increased risk of breast cancer (OR = 5.23, 5.6, and 2.6 respectively, p < 0.01). Consuming less than half of coconut milk liquid in desserts correlated with a reduced risk (OR = 0.43, p < 0.05). The findings suggest that moderate (less than half of a serving) and infrequent (less than once a week) consumption of coconut milk may be beneficial for breast cancer prevention. A larger scale study is warranted to confirm the findings and provide evidence for dietary recommendations.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"51-61"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0