Association of Preoperative Sarcopenia with the Risk of Anastomotic Leakage in Surgical Esophageal Cancer Patients: A Meta-Analysis.

IF 2 4区医学 Q3 NUTRITION & DIETETICS

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-03-18 DOI:10.1080/01635581.2025.2479878

Long Tian, Yan Wang, Guowei Che

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引用次数: 0

Abstract

Background: Whether preoperative sarcopenia predicts increased risk of anastomotic leakage in operated esophageal cancer patients remains unclear. This study aimed to identify the relationship between preoperative sarcopenia and the incidence of anastomotic leakage in surgical esophageal cancer.

Methods: PubMed, EMBASE, CNKI and Web of Science databases were searched up to October 11, 2024. Odds ratios (ORs) and 95% confidence intervals (CIs) were combined and subgroup analysis based on the pathological type, definition of sarcopenia and history of neoadjuvant therapy were performed.

Results: Fifteen studies with 3,785 patients were included and 368 patients developed the anastomotic leakage (9.72%). Pooled results demonstrated that preoperative sarcopenia was significantly associated with the occurrence of anastomotic leakage among surgical esophageal cancer patients (OR = 1.57, 95% CI: 1.29-1.90, p < 0.001). Subgroup analysis by the pathological type and definition of sarcopenia revealed similar results. However, subgroup analysis by the neoadjuvant therapy indicated that preoperative sarcopenia was only related to anastomotic leakage among patients without the history of neoadjuvant therapy (OR = 2.40. 95% CI: 1.61-3.58, p < 0.001), and sarcopenia was not a significant risk factor for anastomotic leakage in neoadjuvant therapy treated patients (OR = 1.06, p = 0.845).

Conclusion: Preoperative sarcopenia could serve as a risk indicator in surgical esophageal cancer patients without neoadjuvant therapy.

查看原文本刊更多论文

食管癌手术患者术前肌肉减少与吻合口瘘风险的关系：一项荟萃分析。

背景：食管癌手术患者术前肌肉减少是否预示吻合口漏风险增加尚不清楚。本研究旨在探讨食管癌手术患者术前肌肉减少与吻合口瘘发生率的关系。方法：检索截止到2024年10月11日的PubMed、EMBASE、CNKI和Web of Science数据库。结合优势比（ORs）和95%置信区间（CIs），并根据病理类型、肌肉减少症的定义和新辅助治疗史进行亚组分析。结果：纳入15项研究，3785例患者，发生吻合口瘘368例（9.72%）。综合结果显示，手术食管癌患者术前肌肉减少与吻合口瘘发生显著相关（OR = 1.57, 95% CI: 1.29-1.90, p p p = 0.845）。结论：术前肌肉减少可作为未经新辅助治疗的食管癌手术患者的危险指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition and Cancer-An International Journal 医学-营养学

CiteScore

5.80

自引率

3.40%

发文量

172

审稿时长

3 months

期刊介绍： This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.