Nawaz Ahmed, Sarah Walker, Alessia Roma, Mark D Minden, Paul A Spagnuolo
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Abstract
Hematopoietic stem cells (HSCs) maintain production of all functional blood cells and are located within the bone marrow. In pathological conditions, such as obesity or leukemia, changes in these cells contribute to disease pathophysiology. In this study, we examined the impact of metabolic modulation of stem and progenitor cells within the bone marrow during diet-induced obesity (DIO) and leukemia relapse. Avocatin B (Avo), an inhibitor of fatty acid oxidation (FAO), was provided in the diet and its impact on stem cells using two disease models was tested. In DIO, high fat diet(HFD)-induced alterations in HSC number and function were attenuated with Avo (HFD: 46.9% decrease compared to control; p < 0.001; whereas DIO + Avo: 58.8% recovery; p < 0.05). In leukemia relapse, dietary Avo delayed disease reoccurrence. Taken together, addition of Avo into the diet imparts protection in the bone marrow.
造血干细胞（hsc）位于骨髓内，维持所有功能性血细胞的产生。在病理条件下，如肥胖或白血病，这些细胞的变化有助于疾病病理生理。在这项研究中，我们研究了饮食性肥胖（DIO）和白血病复发期间骨髓内干细胞和祖细胞代谢调节的影响。牛油果素B （Avo）是一种脂肪酸氧化（FAO）抑制剂，在饮食中提供，并通过两种疾病模型测试其对干细胞的影响。在DIO中，高脂肪饮食（HFD）引起的HSC数量和功能的改变随着Avo的减弱而减弱(HFD：与对照组相比下降46.9%；p p
期刊介绍：
This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.
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