Nutrition and Cancer-An International Journal最新文献_第8页

International Survey on Consensus Definition on Nutrition Impact Symptoms in Patients with Cancer. 癌症患者营养影响症状共识定义国际调查。

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-10-09 DOI: 10.1080/01635581.2024.2411763

Koji Amano, Rony Dev, Tateaki Naito, Egidio Del Fabbro

{"title":"International Survey on Consensus Definition on Nutrition Impact Symptoms in Patients with Cancer.","authors":"Koji Amano, Rony Dev, Tateaki Naito, Egidio Del Fabbro","doi":"10.1080/01635581.2024.2411763","DOIUrl":"10.1080/01635581.2024.2411763","url":null,"abstract":"ABSTRACTA self-reported electronic questionnaire to advocate for a consensus definition of nutrition impact symptoms (NISs) was conducted in a diverse group of international healthcare providers. The questionnaire had 2 components: the definition of NISs and the relevance of each symptom as a NIS. Agreement on the tentative definition and 24 symptoms were evaluated using a seven-point Likert scale. For the factor validity and internal consistency of symptoms, an exploratory factor analysis was employed, and Cronbach's alpha coefficients (Cronbach's α) were calculated in each domain. A total of 66 healthcare providers responded. Regarding the tentative definition of NISs, the percentages of the number of participants with agree and strongly agree were 40.9% and 42.4%. Three conceptual groups were extracted as follows: 1) symptoms that interfere with patients' ability to ingest or digest nutrients, 2) symptoms that compromise patients' desire to eat and take nutrients, and 3) symptoms that indirectly compromise patients' food and nutrient intake. The values of Cronbach's α were 0.91, 0.92, and 0.87. We proposed a new definition - NISs are symptoms that compromise patients' desire or ability to eat, interfering with their nutritional needs and increasing the risk for malnutrition, loss of lean body mass, and impaired QOL.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"210-220"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Puerarin Ameliorates Ferroptosis in Neuronal Injury Through the PI3K/AKT Signaling Pathway. 葛根素通过 PI3K/AKT 信号通路改善神经元损伤中的铁突变现象

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-11-03 DOI: 10.1080/01635581.2024.2422637

Rong Hu, Zi-Tan Peng, Hui Liu

{"title":"Puerarin Ameliorates Ferroptosis in Neuronal Injury Through the PI3K/AKT Signaling Pathway.","authors":"Rong Hu, Zi-Tan Peng, Hui Liu","doi":"10.1080/01635581.2024.2422637","DOIUrl":"10.1080/01635581.2024.2422637","url":null,"abstract":"Ferroptosis plays an important role in the pathogenesis of neuronal damage, generally mediated by iron and lipid peroxidation. In the present study, we measured the protective effects of puerarin against corticosterone-induced neuronal injury via PI3K/AKT-mediated activation of nuclear factor erythroid 2-related factor 2 (Nrf2). After exposing corticosterone-treated PC12 cells to indicated compounds, we measured the key regulators of ferroptosis (ferritin, SLC7A11, and Ptgs2), ferroptosis events (levels of iron, ROS, MDA, and GSH), and the PI3K/AKT/Nrf2 axis. Corticosterone induced ferroptosis in PC12 cells, evidenced by reduced levels of ferritin, SLC7A11, and GSH and increased levels of iron, ROS, and MDA. These effects were reversed by inhibiting ferroptosis with ferrostatin-1. Puerarin-mediated activation of Nrf2 repressed ferroptosis in corticosterone-treated PC12 cells by upregulating ferritin and SLC7A11 expression. Moreover, the protective effects of puerarin on ferroptosis in corticosterone-treated cells relied on the activation of the PI3K/AKT pathway though the upregulation of nuclear Nrf2. These findings indicate that ferroptosis plays an essential role in corticosterone-induced neuronal damage, and puerarin protects against ferroptosis in corticosterone-treated cells via PI3K/AKT-mediated activation of Nrf2.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"424-432"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional Approach on Management of Diarrhea Induced by EGFR-TKI's in Advanced Non-Small Cell Lung Cancer Patients. 营养方法治疗晚期非小细胞肺癌患者EGFR-TKI所致腹泻

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-03-19 DOI: 10.1080/01635581.2025.2478649

Jenny G Turcott, Daniela Cárdenas-Fernández, Karla Sánchez-Lara, Cittim B Palomares-Palomares, Oscar Arrieta

{"title":"Nutritional Approach on Management of Diarrhea Induced by EGFR-TKI's in Advanced Non-Small Cell Lung Cancer Patients.","authors":"Jenny G Turcott, Daniela Cárdenas-Fernández, Karla Sánchez-Lara, Cittim B Palomares-Palomares, Oscar Arrieta","doi":"10.1080/01635581.2025.2478649","DOIUrl":"10.1080/01635581.2025.2478649","url":null,"abstract":"Lung cancer remains the leading cause of cancer-related mortality worldwide. Adenocarcinoma is the most prevalent subtype of Non-Small Cell Lung Cancer (NSCLC), and platinum-based chemotherapy is the standard first-line treatment. However, patients harboring EGFR mutations benefit significantly from tyrosine kinase inhibitor (TKI) therapy, which enhances treatment response, prolongs progression-free survival (PFS), and improves overall survival (OS). Despite these advantages, TKI-associated gastrointestinal toxicity, particularly mucositis and diarrhea, poses a major challenge that often affects treatment adherence and patient quality of life. Effective diarrhea management is crucial for maintaining therapeutic continuity, yet current clinical guidelines primarily focus on pharmacological approaches. This review highlights the critical role of nutritional strategies in preventing and mitigating TKI-induced diarrhea. Due to the irritative effects of TKIs on digestion, dietary modifications are crucial. Patients should avoid greasy, spicy, acidic, and high-fiber foods, along with alcohol, soft drinks, and coffee. Steamed, baked, or boiled foods are recommended. Glutamine and probiotics may aid mucosal recovery and microbiota balance. Ongoing nutritional oversight and individualized dietary guidance are essential for patients with NSCLC undergoing TKI therapy. Future research should establish evidence-based dietary guidelines to optimize treatment tolerance, enhance patient well-being, and improve clinical outcomes.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"567-574"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Use of Dietary Supplements for the Management of Adverse Effects of Treatment in Children and Adolescents with Leukemia: A Scoping Review. 膳食补充剂在儿童和青少年白血病治疗不良反应管理中的应用：一项范围综述。

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-12-27 DOI: 10.1080/01635581.2024.2435079

Juliana Priebe Steffens, Caroline Abud Drumond Costa

{"title":"The Use of Dietary Supplements for the Management of Adverse Effects of Treatment in Children and Adolescents with Leukemia: A Scoping Review.","authors":"Juliana Priebe Steffens, Caroline Abud Drumond Costa","doi":"10.1080/01635581.2024.2435079","DOIUrl":"10.1080/01635581.2024.2435079","url":null,"abstract":"Acute lymphoblastic leukemia is the most prevalent form of leukemia in children and adolescents. Despite high survival rates due to advanced treatments, these therapies often result in significant treatment-related adverse effects. This scoping review explores dietary supplementation strategies for managing these adverse effects in pediatric leukemia patients. Twelve studies were included, involving participants aged between 0.8 and 21 years, all undergoing chemotherapy at various treatment phases. Chemotherapy-related adverse effects identified in this review included gastrointestinal symptoms, cardiometabolic risk factors, hepatotoxicity, osteopathies, neuro-psychiatric effects, hematological disorders, and changes in body composition. The dietary supplements evaluated for managing these effects were probiotics, ginger, glutamine, omega-3, vitamin D, calcium, potassium, honey, chamomile, and medium-chain triglyceride. Most of these supplements showed promising outcomes in reducing or preventing adverse effects. However, there is a demand for more rigorous clinical trials with larger sample sizes and standardized protocols to validate the efficacy of these interventions. Further research to identify optimal dosages, better understand long-term effects, and develop evidence-based guidelines for the use of dietary supplements in managing treatment-related adverse effects in children and adolescents with leukemia is needed.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"334-340"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations Between Obesity and Risk of Thyroid Cancer: A Meta-Analysis of Cohort Studies. 肥胖与甲状腺癌风险之间的关系：队列研究的 Meta 分析。

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-10-26 DOI: 10.1080/01635581.2024.2419488

Urfa Khairatun Hisan, Seung-Kwon Myung, Giap Viet Nguyen

{"title":"Associations Between Obesity and Risk of Thyroid Cancer: A Meta-Analysis of Cohort Studies.","authors":"Urfa Khairatun Hisan, Seung-Kwon Myung, Giap Viet Nguyen","doi":"10.1080/01635581.2024.2419488","DOIUrl":"10.1080/01635581.2024.2419488","url":null,"abstract":"Previous cohort studies have shown conflicting findings on the associations between obesity and the risk of thyroid cancer. This meta-analysis aimed to investigate the associations between them by using a meta-analysis of cohort studies. PubMed and EMBASE were searched using keywords from inception until November 2023 to identify relevant studies on this topic. Two authors independently reviewed and selected relevant studies according to the predefined criteria. Out of 475 studies searched from the databases, a total of 22 cohort studies were included in the final analysis. In a random-effects meta-analysis, obesity was significantly associated with an increased risk of thyroid cancer [odds ratio (OR), relative risk (RR), or hazard ratio (HR) = 1.33; 95% confidence interval (CI) 1.24 - 1.43]. Obesity was consistently associated with the increased risk of thyroid cancer in the subgroup meta-analyses by various factors such as study type (prospective or retrospective cohort study), gender (male or female), continent (America, Europe, or Asia), and study quality (high or low). This meta-analysis of cohort studies suggests that obesity increases the risk of thyroid cancer.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"288-298"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the Combination of Anamorelin and Rehabilitation on Functional and Nutritional Outcomes in Patients with Cancer Cachexia. 阿那莫林与康复治疗相结合对癌症患者功能和营养结果的影响

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-08-29 DOI: 10.1080/01635581.2024.2397060

Makoto Hasegawa, Yohei Sanmoto, Koji Kono

{"title":"Impact of the Combination of Anamorelin and Rehabilitation on Functional and Nutritional Outcomes in Patients with Cancer Cachexia.","authors":"Makoto Hasegawa, Yohei Sanmoto, Koji Kono","doi":"10.1080/01635581.2024.2397060","DOIUrl":"10.1080/01635581.2024.2397060","url":null,"abstract":"Cancer cachexia, characterized by the progressive loss of skeletal muscle mass, leads to functional impairment and poor prognosis. Anamorelin is approved for treating cancer cachexia in Japan; however, the factors influencing its discontinuation and the impact of combining anamorelin with rehabilitation remain unclear. Therefore, we retrospectively analyzed 82 patients with cancer cachexia to identify factors associated with anamorelin discontinuation and assess changes in nutritional status and motor function using non-dominant handgrip strength after 12 wk. Patients received outpatient rehabilitation, combining resistance and aerobic training every two weeks, alongside anamorelin therapy. Our findings indicate that patients with an ECOG performance status of 1 or 2 were less likely to continue anamorelin therapy for 12 wk compared to those with a performance status of 0 (odds ratio 2.71; 95% CI 1.05 - 7.00; p = 0.040). Significant improvements were observed in body weight (48.8 to 53.7 kg, p < 0.001), skeletal muscle mass (6.4 to 6.9 kg/m2, p < 0.001), FAACT score (11.5 to 18.0, p < 0.001), and non-dominant handgrip strength (20.5 to 21.7 kg, p = 0.018) after 12 wk. Early initiation of anamorelin with regular rehabilitation is recommended to enhance nutritional status and motor function in patients with cancer cachexia.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"86-92"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Juzaowan Suppresses Glycolysis in Breast Cancer Cells by Inhibiting the STAT3/C-Myc Axis. 通过抑制 STAT3/C-Myc 轴抑制乳腺癌细胞的糖酵解作用

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-08-29 DOI: 10.1080/01635581.2024.2395066

Yuan Zhou, Liumei Lin, Fei Li, Yuchun Xu, Huatong Peng, Qiang Chen

{"title":"Juzaowan Suppresses Glycolysis in Breast Cancer Cells by Inhibiting the STAT3/C-Myc Axis.","authors":"Yuan Zhou, Liumei Lin, Fei Li, Yuchun Xu, Huatong Peng, Qiang Chen","doi":"10.1080/01635581.2024.2395066","DOIUrl":"10.1080/01635581.2024.2395066","url":null,"abstract":"Background: Breast cancer (BC) is characterized by an increasing incidence and mortality rate. Juzaowan inhibits various malignant processes, although its mechanism in BC remains unclear.Methods: To evaluate the impact of Juzaowan on biological functions of BC cells, cellular assays were done to assess proliferation, migration, invasion, and apoptosis. Bioinformatics was used to identify signaling pathways affected by active ingredients of Juzaowan. BC cells were treated with Juzaowan. Western blot assayed lactate production, glucose consumption, and expression of proteins related to glycolytic pathway and STAT3/C-Myc axis.Results: Juzaowan suppressed BC cell proliferation and increased apoptosis. It downregulated anti-apoptotic protein BCL2 while upregulating pro-apoptotic proteins Bax and cleaved caspase 3. Juzaowan significantly inhibited BC cell migration and invasion. Significant upregulation of E-cadherin and significant downregulation of E-cadherin-binding protein ZEB1, N-cadherin, and vimentin were observed. Bioinformatics analysis and cellular experiments confirmed inhibition of Juzaowan on BC cell glucose uptake and glycolytic pathways-related key metabolic enzymes (GLUT1, PKM2, LDH) expressions. Western blot revealed that Juzaowan induced metabolic alterations in BC cells by impeding STAT3/C-Myc axis.Conclusion: This study elucidated molecular mechanisms of Juzaowan inhibiting BC cell glycolysis by repressing STAT3/C-Myc axis, thus suppressing malignant progression. These findings supported clinical applications of Juzaowan.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"149-163"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prevalence of Sarcopenia in Patients with Solid Tumors Differs Across Regions: A Systematic Review. 不同地区实体瘤患者的 "肌肉疏松症 "患病率存在差异：系统回顾

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-09-22 DOI: 10.1080/01635581.2024.2401648

Maximilian Thormann, Hans-Jonas Meyer, Andreas Wienke, Julius Niehoff, Jan Robert Kröger, Ralf Gutzmer, Mareike Alter, Jan Borggrefe, Alexey Surov

{"title":"The Prevalence of Sarcopenia in Patients with Solid Tumors Differs Across Regions: A Systematic Review.","authors":"Maximilian Thormann, Hans-Jonas Meyer, Andreas Wienke, Julius Niehoff, Jan Robert Kröger, Ralf Gutzmer, Mareike Alter, Jan Borggrefe, Alexey Surov","doi":"10.1080/01635581.2024.2401648","DOIUrl":"10.1080/01635581.2024.2401648","url":null,"abstract":"Objective: The purpose of the meta-analysis was to compare the prevalence of sarcopenia on staging computed tomography (CT) in patients with solid tumors in different world regions. Materials and Methods: MEDLINE, Embase, and SCOPUS literature databases were screened for prevalence of sarcopenia in oncologic patients up to December 2022. Two hundred eighty studies met the inclusion criteria. The methodological quality of the involved studies was checked according to the Quality Assessment of Diagnostic Studies instrument. Results: Two hundred eighty studies with 81,885 patients were included. The prevalence of sarcopenia among all patients was 35.5%. Prevalence of sarcopenia was higher in Europe (45.6%) and North America (41.2%) than in Asia (29.6%). Prevalence rates for the curative cohort were similar in all three regions, with 43.7% in Europe, 41.3% in North America, and 37.4% in Asia. In the palliative cohort, sarcopenia prevalence was higher in Europe (55.7%) and Asia (45.7%) than in North America (34.0%). In the European cohort, prostate cancer (73.9%), esophageal cancer (74.2%), pancreatic cancer (62.5%), and renal cell cancer (65.3%) showed high prevalence rates of sarcopenia. Applied cutoff values differed among regions. Conclusion: Our study shows that prevalence rates for sarcopenia of patients with solid tumors differ between regions and are different for curative and palliative settings. European studies demonstrate high prevalence rates for both settings. There is need for regional harmonization of sarcopenia definitions.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"102-114"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poor Diet Quality is Associated with Premature Senescence of the Immune System in Survivors of Childhood Acute Lymphoblastic Leukaemia. 不良饮食质量与儿童急性淋巴细胞白血病幸存者免疫系统过早衰老有关。

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-03-09 DOI: 10.1080/01635581.2025.2474263

Abderrahim Benmoussa, Tibila Kientega, Sophia Morel, Guillaume B Cardin, Sophie Bérard, Mickaël Wajnberg, Petko Valtchev, Alexandre Blondin Masse, Daniel Curnier, Maja Krajinovic, Caroline Laverdière, Daniel Sinnett, Emile Levy, Sophie Marcoux, Francis Rodier, Valérie Marcil

{"title":"Poor Diet Quality is Associated with Premature Senescence of the Immune System in Survivors of Childhood Acute Lymphoblastic Leukaemia.","authors":"Abderrahim Benmoussa, Tibila Kientega, Sophia Morel, Guillaume B Cardin, Sophie Bérard, Mickaël Wajnberg, Petko Valtchev, Alexandre Blondin Masse, Daniel Curnier, Maja Krajinovic, Caroline Laverdière, Daniel Sinnett, Emile Levy, Sophie Marcoux, Francis Rodier, Valérie Marcil","doi":"10.1080/01635581.2025.2474263","DOIUrl":"10.1080/01635581.2025.2474263","url":null,"abstract":"Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. Contributory factors such as inflammation and oxidative stress, in response to drug therapies, may induce premature aging and cellular senescence with a severe impact on cardiometabolic health. Premature immunoaging through cellular senescence can lead to lower thymic output of T-cell lymphocytes translated into lower circulating T-cell receptor excision circles (TRECs). We hypothesized TRECs levels are associated with diet quality and impacted by oxidative and inflammatory status in survivors of childhood ALL (cALL). Adolescents and young adults cALL survivors from the PETALE cohort (n = 241, 22.1 ± 6.3 years at diagnosis, 49.4% males) were assessed for TREC levels and adherence to six diet quality indexes. Healthy Diet Indicator (HDI) was associated with TREC levels (β = 50.0, p = 0.005, adjusted p = 0.03). Interleukin-6 (IL-6) and C-reactive protein (CRP) were found negatively associated with TREC levels (β = -80 and -80.1, p = 0.017 and 0.026, respectively) HDI. Further analysis revealed IL-6 and CRP to be moderating factors, but not mediators, of the association between HDI and TRECs. This study supports a positive impact of a healthy diet on premature aging of the immune system in survivors of cALL and unveils the moderating role of inflammation in this association.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"490-505"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Modulation of Fatty Acid Oxidation Imparts Stem Cell Protection in Bone Marrow. 膳食调节脂肪酸氧化对骨髓干细胞的保护作用。

IF 2 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.1080/01635581.2025.2459445

Nawaz Ahmed, Sarah Walker, Alessia Roma, Mark D Minden, Paul A Spagnuolo

引用次数: 0