Associations Between Obesity and Risk of Thyroid Cancer: A Meta-Analysis of Cohort Studies.

IF 2 4区医学 Q3 NUTRITION & DIETETICS

Nutrition and Cancer-An International Journal Pub Date : 2024-10-26 DOI:10.1080/01635581.2024.2419488

Urfa Khairatun Hisan, Seung-Kwon Myung, Giap Viet Nguyen

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Abstract

Previous cohort studies have shown conflicting findings on the associations between obesity and the risk of thyroid cancer. This meta-analysis aimed to investigate the associations between them by using a meta-analysis of cohort studies. PubMed and EMBASE were searched using keywords from inception until November 2023 to identify relevant studies on this topic. Two authors independently reviewed and selected relevant studies according to the predefined criteria. Out of 475 studies searched from the databases, a total of 22 cohort studies were included in the final analysis. In a random-effects meta-analysis, obesity was significantly associated with an increased risk of thyroid cancer [odds ratio (OR), relative risk (RR), or hazard ratio (HR) = 1.33; 95% confidence interval (CI) 1.24 - 1.43]. Obesity was consistently associated with the increased risk of thyroid cancer in the subgroup meta-analyses by various factors such as study type (prospective or retrospective cohort study), gender (male or female), continent (America, Europe, or Asia), and study quality (high or low). This meta-analysis of cohort studies suggests that obesity increases the risk of thyroid cancer.

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肥胖与甲状腺癌风险之间的关系：队列研究的 Meta 分析。

以往的队列研究显示，肥胖与甲状腺癌风险之间的关系存在矛盾。本荟萃分析旨在通过队列研究的荟萃分析来研究两者之间的关系。作者使用关键词检索了从开始到2023年11月的PubMed和EMBASE，以确定与该主题相关的研究。两位作者按照预先设定的标准独立审查并筛选出相关研究。在数据库中搜索到的 475 项研究中，共有 22 项队列研究被纳入最终分析。在随机效应荟萃分析中，肥胖与甲状腺癌风险增加显著相关[几率比（OR）、相对风险（RR）或危险比（HR）=1.33；95%置信区间（CI）1.24 - 1.43]。在按研究类型（前瞻性或回顾性队列研究）、性别（男性或女性）、洲（美洲、欧洲或亚洲）和研究质量（高或低）等不同因素进行的亚组荟萃分析中，肥胖始终与甲状腺癌风险的增加有关。这项队列研究的荟萃分析表明，肥胖会增加罹患甲状腺癌的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition and Cancer-An International Journal 医学-营养学

CiteScore

5.80

自引率

3.40%

发文量

172

审稿时长

3 months

期刊介绍： This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.