Nutritional Approach on Management of Diarrhea Induced by EGFR-TKI's in Advanced Non-Small Cell Lung Cancer Patients.

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Jenny G Turcott, Daniela Cárdenas-Fernández, Karla Sánchez-Lara, Cittim B Palomares-Palomares, Oscar Arrieta
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引用次数: 0

Abstract

Lung cancer remains the leading cause of cancer-related mortality worldwide. Adenocarcinoma is the most prevalent subtype of Non-Small Cell Lung Cancer (NSCLC), and platinum-based chemotherapy is the standard first-line treatment. However, patients harboring EGFR mutations benefit significantly from tyrosine kinase inhibitor (TKI) therapy, which enhances treatment response, prolongs progression-free survival (PFS), and improves overall survival (OS). Despite these advantages, TKI-associated gastrointestinal toxicity, particularly mucositis and diarrhea, poses a major challenge that often affects treatment adherence and patient quality of life. Effective diarrhea management is crucial for maintaining therapeutic continuity, yet current clinical guidelines primarily focus on pharmacological approaches. This review highlights the critical role of nutritional strategies in preventing and mitigating TKI-induced diarrhea. Due to the irritative effects of TKIs on digestion, dietary modifications are crucial. Patients should avoid greasy, spicy, acidic, and high-fiber foods, along with alcohol, soft drinks, and coffee. Steamed, baked, or boiled foods are recommended. Glutamine and probiotics may aid mucosal recovery and microbiota balance. Ongoing nutritional oversight and individualized dietary guidance are essential for patients with NSCLC undergoing TKI therapy. Future research should establish evidence-based dietary guidelines to optimize treatment tolerance, enhance patient well-being, and improve clinical outcomes.

营养方法治疗晚期非小细胞肺癌患者EGFR-TKI所致腹泻
肺癌仍然是全球癌症相关死亡的主要原因。腺癌是非小细胞肺癌(NSCLC)中最常见的亚型,以铂为基础的化疗是标准的一线治疗。然而,携带EGFR突变的患者从酪氨酸激酶抑制剂(TKI)治疗中获益显著,可以提高治疗反应,延长无进展生存期(PFS),提高总生存期(OS)。尽管有这些优势,tki相关的胃肠道毒性,特别是粘膜炎和腹泻,构成了重大挑战,经常影响治疗依从性和患者的生活质量。有效的腹泻管理对于维持治疗的连续性至关重要,但目前的临床指南主要侧重于药理学方法。这篇综述强调了营养策略在预防和减轻tki引起的腹泻中的关键作用。由于TKIs对消化的刺激作用,饮食调整是至关重要的。患者应避免油腻、辛辣、酸性和高纤维食物,以及酒精、软饮料和咖啡。推荐蒸、烤或煮的食物。谷氨酰胺和益生菌可能有助于粘膜恢复和微生物群平衡。持续的营养监督和个体化饮食指导对于接受TKI治疗的非小细胞肺癌患者至关重要。未来的研究应建立以证据为基础的饮食指南,以优化治疗耐受性,增强患者幸福感,改善临床结果。
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来源期刊
CiteScore
5.80
自引率
3.40%
发文量
172
审稿时长
3 months
期刊介绍: This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.
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