Sarah A Purcell, Tanya M Halliday, Edward L Melanson, Anosheh Afghahi, Virginia F Borges, Isabella Sinelli, Marc-Andre Cornier
{"title":"比较接受辅助内分泌治疗的乳腺癌幸存者与非癌症患者的食欲和饮食摄入对抵抗运动的反应:一项次要分析。","authors":"Sarah A Purcell, Tanya M Halliday, Edward L Melanson, Anosheh Afghahi, Virginia F Borges, Isabella Sinelli, Marc-Andre Cornier","doi":"10.1080/01635581.2025.2518611","DOIUrl":null,"url":null,"abstract":"<p><p>Breast cancer survivors (BCS) undergoing adjuvant endocrine therapy have increased risk of obesity. Estrogen and exercise suppress appetite in non-BCS populations, but their combined effects in BCS are unknown. This secondary analysis compared the impact of acute resistance exercise (REx) on appetite and energy intake in estrogen-suppressed BCS versus females without cancer ('non-BCS'). Premenopausal inactive BCS (stage 0-III estrogen receptor-positive breast cancer, <5 years post-diagnosis, undergoing estrogen-targeted therapy) and non-BCS completed REx or sedentary (SED) conditions 35 min after a standardized breakfast. Appetite visual analog scales and hormones (ghrelin and peptide-YY [PYY]) were measured before and after breakfast and REx/SED; energy intake was assessed 3 h post-breakfast (1.5 h post-REx or SED). Fifteen BCS (age: 46 ± 7; BMI: 25.0 ± 3.8 kg/m<sup>2</sup>) and 12 non-BCS (age: 37 ± 8; BMI: 29.0 ± 5.1 kg/m<sup>2</sup>) were included. BCS showed greater PYY 90 and 120 min post-breakfast compared to non-BCS, particularly after REx (group x time x condition: <i>p</i> = 0.009, <i>p</i> = 0.005, respectively). No group effects were observed for ghrelin. BCS had lower body mass-adjusted energy intake compared to non-BCS (<i>p</i> = 0.036), despite similar appetite ratings. Estrogen-suppressed BCS exhibit heightened PYY and lower energy intake after REx, revealing novel effects of exercise on appetite in a state of low estrogen.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-12"},"PeriodicalIF":2.0000,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparing Appetite and Dietary Intake Responses to Resistance Exercise in Breast Cancer Survivors Undergoing Adjuvant Endocrine Therapy Versus Individuals Without Cancer: A Secondary Analysis.\",\"authors\":\"Sarah A Purcell, Tanya M Halliday, Edward L Melanson, Anosheh Afghahi, Virginia F Borges, Isabella Sinelli, Marc-Andre Cornier\",\"doi\":\"10.1080/01635581.2025.2518611\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Breast cancer survivors (BCS) undergoing adjuvant endocrine therapy have increased risk of obesity. Estrogen and exercise suppress appetite in non-BCS populations, but their combined effects in BCS are unknown. This secondary analysis compared the impact of acute resistance exercise (REx) on appetite and energy intake in estrogen-suppressed BCS versus females without cancer ('non-BCS'). Premenopausal inactive BCS (stage 0-III estrogen receptor-positive breast cancer, <5 years post-diagnosis, undergoing estrogen-targeted therapy) and non-BCS completed REx or sedentary (SED) conditions 35 min after a standardized breakfast. Appetite visual analog scales and hormones (ghrelin and peptide-YY [PYY]) were measured before and after breakfast and REx/SED; energy intake was assessed 3 h post-breakfast (1.5 h post-REx or SED). Fifteen BCS (age: 46 ± 7; BMI: 25.0 ± 3.8 kg/m<sup>2</sup>) and 12 non-BCS (age: 37 ± 8; BMI: 29.0 ± 5.1 kg/m<sup>2</sup>) were included. BCS showed greater PYY 90 and 120 min post-breakfast compared to non-BCS, particularly after REx (group x time x condition: <i>p</i> = 0.009, <i>p</i> = 0.005, respectively). No group effects were observed for ghrelin. BCS had lower body mass-adjusted energy intake compared to non-BCS (<i>p</i> = 0.036), despite similar appetite ratings. Estrogen-suppressed BCS exhibit heightened PYY and lower energy intake after REx, revealing novel effects of exercise on appetite in a state of low estrogen.</p>\",\"PeriodicalId\":54701,\"journal\":{\"name\":\"Nutrition and Cancer-An International Journal\",\"volume\":\" \",\"pages\":\"1-12\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-06-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition and Cancer-An International Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/01635581.2025.2518611\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition and Cancer-An International Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/01635581.2025.2518611","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Comparing Appetite and Dietary Intake Responses to Resistance Exercise in Breast Cancer Survivors Undergoing Adjuvant Endocrine Therapy Versus Individuals Without Cancer: A Secondary Analysis.
Breast cancer survivors (BCS) undergoing adjuvant endocrine therapy have increased risk of obesity. Estrogen and exercise suppress appetite in non-BCS populations, but their combined effects in BCS are unknown. This secondary analysis compared the impact of acute resistance exercise (REx) on appetite and energy intake in estrogen-suppressed BCS versus females without cancer ('non-BCS'). Premenopausal inactive BCS (stage 0-III estrogen receptor-positive breast cancer, <5 years post-diagnosis, undergoing estrogen-targeted therapy) and non-BCS completed REx or sedentary (SED) conditions 35 min after a standardized breakfast. Appetite visual analog scales and hormones (ghrelin and peptide-YY [PYY]) were measured before and after breakfast and REx/SED; energy intake was assessed 3 h post-breakfast (1.5 h post-REx or SED). Fifteen BCS (age: 46 ± 7; BMI: 25.0 ± 3.8 kg/m2) and 12 non-BCS (age: 37 ± 8; BMI: 29.0 ± 5.1 kg/m2) were included. BCS showed greater PYY 90 and 120 min post-breakfast compared to non-BCS, particularly after REx (group x time x condition: p = 0.009, p = 0.005, respectively). No group effects were observed for ghrelin. BCS had lower body mass-adjusted energy intake compared to non-BCS (p = 0.036), despite similar appetite ratings. Estrogen-suppressed BCS exhibit heightened PYY and lower energy intake after REx, revealing novel effects of exercise on appetite in a state of low estrogen.
期刊介绍:
This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.