比较接受辅助内分泌治疗的乳腺癌幸存者与非癌症患者的食欲和饮食摄入对抵抗运动的反应:一项次要分析。

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Sarah A Purcell, Tanya M Halliday, Edward L Melanson, Anosheh Afghahi, Virginia F Borges, Isabella Sinelli, Marc-Andre Cornier
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引用次数: 0

摘要

接受辅助内分泌治疗的乳腺癌幸存者(BCS)肥胖的风险增加。雌激素和运动抑制非BCS人群的食欲,但它们在BCS中的联合作用尚不清楚。这一次要分析比较了急性抵抗运动(REx)对雌激素抑制的BCS与无癌症(“非BCS”)女性食欲和能量摄入的影响。绝经前无活性BCS (0-III期雌激素受体阳性乳腺癌2例)和非BCS 12例(年龄:37±8;BMI: 29.0±5.1 kg/m2)。与非BCS相比,BCS在早餐后90和120分钟表现出更高的PYY,特别是在REx后(组x时间x条件:p = 0.009, p = 0.005分别)。未观察到胃饥饿素的组效应。与非BCS相比,BCS的身体质量调整后的能量摄入较低(p = 0.036),尽管食欲评分相似。雌激素抑制的BCS在REx后表现出更高的PYY和更低的能量摄入,揭示了低雌激素状态下运动对食欲的新影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparing Appetite and Dietary Intake Responses to Resistance Exercise in Breast Cancer Survivors Undergoing Adjuvant Endocrine Therapy Versus Individuals Without Cancer: A Secondary Analysis.

Breast cancer survivors (BCS) undergoing adjuvant endocrine therapy have increased risk of obesity. Estrogen and exercise suppress appetite in non-BCS populations, but their combined effects in BCS are unknown. This secondary analysis compared the impact of acute resistance exercise (REx) on appetite and energy intake in estrogen-suppressed BCS versus females without cancer ('non-BCS'). Premenopausal inactive BCS (stage 0-III estrogen receptor-positive breast cancer, <5 years post-diagnosis, undergoing estrogen-targeted therapy) and non-BCS completed REx or sedentary (SED) conditions 35 min after a standardized breakfast. Appetite visual analog scales and hormones (ghrelin and peptide-YY [PYY]) were measured before and after breakfast and REx/SED; energy intake was assessed 3 h post-breakfast (1.5 h post-REx or SED). Fifteen BCS (age: 46 ± 7; BMI: 25.0 ± 3.8 kg/m2) and 12 non-BCS (age: 37 ± 8; BMI: 29.0 ± 5.1 kg/m2) were included. BCS showed greater PYY 90 and 120 min post-breakfast compared to non-BCS, particularly after REx (group x time x condition: p = 0.009, p = 0.005, respectively). No group effects were observed for ghrelin. BCS had lower body mass-adjusted energy intake compared to non-BCS (p = 0.036), despite similar appetite ratings. Estrogen-suppressed BCS exhibit heightened PYY and lower energy intake after REx, revealing novel effects of exercise on appetite in a state of low estrogen.

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来源期刊
CiteScore
5.80
自引率
3.40%
发文量
172
审稿时长
3 months
期刊介绍: This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.
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