Nutrition and Cancer-An International Journal最新文献_第2页

Association Between Zinc Deficiency and Risk of Thyroid Cancer: A Multi-Institutional Cohort Study. 锌缺乏与甲状腺癌风险之间的关系：一项多机构队列研究。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2026-01-12 DOI: 10.1080/01635581.2026.2613457

Kuo-Chuan Hung, Ting-Sian Yu, Yi-Chen Lai, Chien-Ming Lin, Chih-Ping Yang, Kuo-Mao Lan, I-Wen Chen

{"title":"Association Between Zinc Deficiency and Risk of Thyroid Cancer: A Multi-Institutional Cohort Study.","authors":"Kuo-Chuan Hung, Ting-Sian Yu, Yi-Chen Lai, Chien-Ming Lin, Chih-Ping Yang, Kuo-Mao Lan, I-Wen Chen","doi":"10.1080/01635581.2026.2613457","DOIUrl":"10.1080/01635581.2026.2613457","url":null,"abstract":"Zinc plays a critical role in thyroid hormone metabolism and antioxidant defense, yet its relationship with thyroid cancer remains unclear due to limited and inconsistent evidence from predominantly cross-sectional studies. We conducted a large-scale retrospective cohort study using the TriNetX Research Network to examine the longitudinal association between zinc deficiency (ZD) and thyroid cancer risk over ten years. Among 96,497 propensity score-matched pairs of adults who underwent serum zinc measurements between January 2010 and December 2023, we classified patients as zinc-deficient (serum zinc below 70 μg/dL) or having normal zinc status (70-120 μg/dL), controlling for demographics, comorbidities, preexisting thyroid disorders, and laboratory parameters. While the overall cohort showed no significant association between ZD and thyroid cancer at 5 years (hazard ratio [HR]: 1.13, 95% confidence interval (CI): 0.93-1.37) or 10 years (HR: 1.12, 95% CI: 0.93-1.34), sex-stratified analyses revealed that women with ZD demonstrated significantly increased thyroid cancer risk at both 5 years (HR: 1.37, 95% CI: 1.09-1.72) and 10 years (HR: 1.38, 95% CI: 1.12-1.71), while men showed no association. These findings suggest that ZD may represent a sex-specific modifiable risk factor for thyroid cancer in women, warranting further mechanistic investigation.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"247-255"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Geriatric Nutritional Risk Index and Gastrointestinal Cancer Risk in Older Adults: Insights from the National Health and Nutrition Examination Survey 1999-2020. 老年营养风险指数与老年人胃肠道癌风险的关系：来自1999-2020年全国健康与营养调查的见解

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2025-10-01 DOI: 10.1080/01635581.2025.2567025

Fangzhe Zhou, Lannan He, Meijuan Zhu, Yanhua Zhou, Deng Fan

{"title":"Association Between Geriatric Nutritional Risk Index and Gastrointestinal Cancer Risk in Older Adults: Insights from the National Health and Nutrition Examination Survey 1999-2020.","authors":"Fangzhe Zhou, Lannan He, Meijuan Zhu, Yanhua Zhou, Deng Fan","doi":"10.1080/01635581.2025.2567025","DOIUrl":"10.1080/01635581.2025.2567025","url":null,"abstract":"The Geriatric Nutritional Risk Index (GNRI) is a valuable tool to assess nutritional status in older adults, but its association with gastrointestinal (GI) cancer risk remains unclear. This study aimed to investigate the association between GNRI and GI cancer risk in the elderly population. Data from 18,889 participants aged 60 and older were analyzed from the National Health and Nutrition Examination Survey (NHANES) between 1999-2020. Multivariable logistic regression models were used to examine the association between GNRI and GI cancer risk, adjusting for confounding factors including age, sex, race, education, poverty-income ratio (PIR), smoking status, alcohol drinking, hypertension, and diabetes. Potential non-linear relationships were explored using generalized additive models, smooth curve fitting, and piece-wise regression analysis. A significant negative association was observed between GNRI and GI cancer risk (p = 0.005), after fully adjusting for confounders. Participants in the third quartile of GNRI had a 35% lower risk of GI cancers compared to those in the lowest quartile (p = 0.010). Piece-wise regression analysis identified a GNRI threshold of 95.25. These findings provide evidence that elevated GNRI is remarkably associated with reduced GI cancer risk among geriatric individuals.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"40-49"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Immunotherapy and Overall Survival in Malnourished Patients with Advanced Non-Small Cell Lung Cancer: A Nationwide Retrospective Cohort Study in Japan. 营养不良晚期非小细胞肺癌患者免疫治疗与总生存率的关系：日本一项全国回顾性队列研究

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2025-10-11 DOI: 10.1080/01635581.2025.2569118

Maya Shimasaki, Yasutaka Ihara, Shoichiro Yamamoto, Haruki Takata, Shinji Akiyama

{"title":"Association Between Immunotherapy and Overall Survival in Malnourished Patients with Advanced Non-Small Cell Lung Cancer: A Nationwide Retrospective Cohort Study in Japan.","authors":"Maya Shimasaki, Yasutaka Ihara, Shoichiro Yamamoto, Haruki Takata, Shinji Akiyama","doi":"10.1080/01635581.2025.2569118","DOIUrl":"10.1080/01635581.2025.2569118","url":null,"abstract":"Background: Malnutrition is common among patients with advanced non-small cell lung cancer (NSCLC) and may diminish the survival benefits of immunotherapy. We aimed to evaluate the association between nutritional status-assessed using the Geriatric Nutritional Risk Index (GNRI) at initiation of first-line therapy and overall survival in patients with advanced NSCLC receiving immunotherapy.Methods: We conducted a retrospective cohort study using an administrative claims database. Patients aged ≥18 years who received first-line immunotherapy for newly diagnosed advanced NSCLC between December 2016 and December 2024 were included. GNRI was calculated using the laboratory and anthropometric data closest (within 3 months) to treatment initiation. To examine whether the GNRI modifies the association between immunotherapy as a first-line therapy and overall survival in patients with advanced NSCLC, we used nonlinear multivariable Cox proportional hazards regressions.Results: Among 2461 patients (mean (SD) age: 70.85 (8.97) years; 81% males), the mean (SD) GNRI was 93.20 (12.93). Using GNRI 100 as the reference, lower GNRI values conferred progressively higher risks of death.Conclusion: Routine nutritional screening using GNRI and proactive interventions to maintain a GNRI ≥ 100, may improve overall survival in patients with advanced NSCLC receiving immunotherapy.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"50-58"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low Body Mass Index in Patients With Gastrointestinal Tumors Is Associated With Higher Rates of Postoperative Intensive Care Unit Admission. 胃肠道肿瘤患者的低体重指数与术后重症监护病房住院率较高相关

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2025-10-16 DOI: 10.1080/01635581.2025.2569120

Shi-Ling Liu, Xiong-Feng Huang, Xin An, Xiao-Liang Cheng, Hai-Yin Fan, Jian-Feng Zhu, Zeng Xia, Zhi-Sheng He

{"title":"Low Body Mass Index in Patients With Gastrointestinal Tumors Is Associated With Higher Rates of Postoperative Intensive Care Unit Admission.","authors":"Shi-Ling Liu, Xiong-Feng Huang, Xin An, Xiao-Liang Cheng, Hai-Yin Fan, Jian-Feng Zhu, Zeng Xia, Zhi-Sheng He","doi":"10.1080/01635581.2025.2569120","DOIUrl":"10.1080/01635581.2025.2569120","url":null,"abstract":"Background: Accumulating evidence demonstrated that low body mass index (BMI) is associated with adverse surgical outcomes. This study aimed to investigate the relationship between BMI and postoperative intensive care unit (ICU) admission in patients undergoing surgery for gastrointestinal tumors.Methods: We conducted a retrospective analysis using data from the Vital Signs Database (VitalDB). Patients were stratified into four BMI categories: underweight (BMI <18.5 kg/m2), normal weight (18.5-22.9 kg/m2), overweight (23.0-27.4 kg/m2), and obese (≥27.5 kg/m2). Demographic characteristics, intraoperative variables, in-hospital mortality, and ICU admission rates were analyzed. Binary logistic regression was performed to identify independent predictors of ICU admission.Results: Among 2052 patients analyzed, the underweight group exhibited the highest ICU admission rate (24.1%) compared to normal weight (15.2%), overweight (10.5%), and obese groups (14.5%; p < 0.001). Hospital stays were significantly prolonged in underweight patients (11.4 ± 12.9 days, p < 0.001). Logistic regression identified underweight status as an independent risk factor for ICU admission (odds ratio [OR] 1.78; 95% confidence interval [CI] 1.20-2.64), and it remained an independent risk factor after adjusting for other risk factors (OR 2.17; 95% CI 1.28-3.67).Conclusions: Patients with gastrointestinal tumors and a BMI <18.5 kg/m2 have an increased risk of postoperative ICU admission and prolonged hospital stays.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"59-69"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined Effects of Psychological Intervention and Enhanced Nutritional Support on Postoperative Recovery in Gastric Cancer Patients. 心理干预加营养支持对胃癌患者术后康复的影响。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2025-09-25 DOI: 10.1080/01635581.2025.2564748

Gang Wang, Shengjie Pan

引用次数: 0

Response to the Letter Concerning "Revisiting the Impact of Obesity on Cancer-Specific Survival in Rectal Cancer-Clinical and Translational Implications". 关于“重新审视肥胖对直肠癌癌症特异性生存的影响-临床和转化意义”的信的回应。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2025-11-13 DOI: 10.1080/01635581.2025.2586119

Elvis Obomanu, Tinsae Anebo, Karecia Byfield, Abidemi Akimrinnade, Gabor Varadi

引用次数: 0

Fat or Muscle on Carboplatin Toxicity in NSCLC? 脂肪或肌肉对非小细胞肺癌卡铂毒性的影响？

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2025-11-10 DOI: 10.1080/01635581.2025.2541422

Leticia Bornstein-Quevedo, Alfonso Duenas-Gonzalez

引用次数: 0

Letter to the Editor: Dynamic Deterioration of Nutritional Status During the Preoperative Period in Gastric Cancer. 致编辑：胃癌术前营养状况的动态恶化。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2026-03-27 DOI: 10.1080/01635581.2026.2648853

Pınar Peker

引用次数: 0

Ramadan as a Strategic Clinical Window for Preventative Oncology and Behavioral Reset. 斋月作为预防肿瘤和行为重置的战略临床窗口。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2026-03-25 DOI: 10.1080/01635581.2026.2643938

Ibrahim S Alhussini

引用次数: 0

Adherence to Oral Nutritional Support and Its Effect on Nutritional Status in Pediatric Oncology Patients. 坚持口服营养支持及其对儿科肿瘤患者营养状况的影响。

IF 2.4 4区医学

Nutrition and Cancer-An International Journal Pub Date : 2026-01-01 Epub Date: 2025-12-07 DOI: 10.1080/01635581.2025.2584473

Mehmet Kantar, Derya Hopancı Bıçaklı, Ayşe Özkan, İnci İlhan, Nurdan Taçyıldız, Rejin Kebudi, Nurşah Eker, Zuhal Siviş, Uğur Demirsoy, Bahar Beker, Şule Yeşil, Ali Varan, Bengü Demirağ, İbrahim Bayram, Derya Özyörük, Eda Ataseven, Sonay İncesoy, Sema Büyükkapu, Burcu Tufan, Deniz Kızmazoğlu, Sema Vural, Burçak Kurucu, Çağrı Coşkun, Alihan Sürsal, Emre Özkan, Fatih Özdener

{"title":"Adherence to Oral Nutritional Support and Its Effect on Nutritional Status in Pediatric Oncology Patients.","authors":"Mehmet Kantar, Derya Hopancı Bıçaklı, Ayşe Özkan, İnci İlhan, Nurdan Taçyıldız, Rejin Kebudi, Nurşah Eker, Zuhal Siviş, Uğur Demirsoy, Bahar Beker, Şule Yeşil, Ali Varan, Bengü Demirağ, İbrahim Bayram, Derya Özyörük, Eda Ataseven, Sonay İncesoy, Sema Büyükkapu, Burcu Tufan, Deniz Kızmazoğlu, Sema Vural, Burçak Kurucu, Çağrı Coşkun, Alihan Sürsal, Emre Özkan, Fatih Özdener","doi":"10.1080/01635581.2025.2584473","DOIUrl":"10.1080/01635581.2025.2584473","url":null,"abstract":"Children with cancer frequently suffer from malnutrition caused by their disease and treatments. This study examines the rates of malnutrition, compliance with nutritional therapy, and its impact on nutritional status in pediatric cancer patients. This multicenter cross-sectional study was conducted between 2021 and 2023 at 12 pediatric hematology and oncology clinics. This study included 385 patients (aged 0.3-18 years) with leukemia-lymphoma and solid tumors that are currently on or had newly started oral nutritional supplement (ONS) treatment. Anthropometric measurements, mid-upper-arm-circumference (MUAC), body mass index (BMI), weight-for-age (WFA), were collected, and malnutrition risk was evaluated by the nutrition screening tool for childhood cancer (SCAN). Baseline WFA-based malnutrition was 31.0%, increasing to 38.5%, while SCAN≥3 was 83.8% decreasing to 72.4% at the sixth month. Malnutrition risk was more common in sarcoma and central nervous system tumor patients. ONS adherence decreased across all cancer types during the follow-up period. Adherent patients demonstrated higher BMI scores during the study period and MUAC z-scores in the last 2 months compared to the non-adherent group (P < 0.04). Our study demonstrates that the use of validated nutrition screening tools, together with adherence strategies, can lead to increased weight-for-age and lower malnutrition risk screening scores.","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"145-157"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0